Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Bos taurus | Dopamine D1 receptor | Starlite/ChEMBL | References |
Bos taurus | Dopamine D2 receptor | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Schistosoma japonicum | 5-hydroxytryptamine receptor, putative | Get druggable targets OG5_132667 | All targets in OG5_132667 |
Schistosoma japonicum | 5-hydroxytryptamine receptor 1, putative | Get druggable targets OG5_132667 | All targets in OG5_132667 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Onchocerca volvulus | RB1-inducible coiled-coil protein 1 homolog | Dopamine D2 receptor | 444 aa | 479 aa | 22.8 % |
Echinococcus granulosus | biogenic amine 5HT receptor | Dopamine D2 receptor | 444 aa | 430 aa | 30.5 % |
Schistosoma japonicum | ko:K04145 dopamine receptor D2, putative | Dopamine D2 receptor | 444 aa | 432 aa | 30.6 % |
Schistosoma japonicum | Octopamine receptor, putative | Dopamine D2 receptor | 444 aa | 456 aa | 28.7 % |
Schistosoma mansoni | biogenic amine receptor | Dopamine D2 receptor | 444 aa | 455 aa | 29.5 % |
Schistosoma japonicum | ko:K04135 adrenergic receptor, alpha 1a, putative | Dopamine D1 receptor | 446 aa | 398 aa | 33.9 % |
Echinococcus granulosus | g protein coupled receptor | Dopamine D2 receptor | 444 aa | 457 aa | 21.7 % |
Onchocerca volvulus | Dopamine D2 receptor | 444 aa | 464 aa | 27.4 % | |
Schistosoma japonicum | ko:K04207 neuropeptide Y receptor Y5, putative | Dopamine D2 receptor | 444 aa | 386 aa | 19.9 % |
Schistosoma japonicum | ko:K04145 dopamine receptor D2, putative | Dopamine D2 receptor | 444 aa | 464 aa | 29.3 % |
Onchocerca volvulus | Dopamine D1 receptor | 446 aa | 359 aa | 21.4 % | |
Schistosoma mansoni | biogenic amine (5HT) receptor | Dopamine D1 receptor | 446 aa | 393 aa | 32.3 % |
Echinococcus multilocularis | g protein coupled receptor | Dopamine D2 receptor | 444 aa | 465 aa | 21.7 % |
Echinococcus multilocularis | serotonin receptor | Dopamine D2 receptor | 444 aa | 446 aa | 31.8 % |
Schistosoma mansoni | amine GPCR | Dopamine D2 receptor | 444 aa | 424 aa | 32.3 % |
Schistosoma japonicum | ko:K04136 adrenergic receptor, alpha 1b, putative | Dopamine D2 receptor | 444 aa | 438 aa | 29.9 % |
Echinococcus granulosus | alpha 1A adrenergic receptor | Dopamine D2 receptor | 444 aa | 466 aa | 20.2 % |
Schistosoma mansoni | biogenic amine (dopamine) receptor | Dopamine D2 receptor | 444 aa | 493 aa | 26.8 % |
Onchocerca volvulus | Dopamine D2 receptor | 444 aa | 417 aa | 23.3 % | |
Schistosoma mansoni | muscarinic acetylcholine (GAR) receptor | Dopamine D2 receptor | 444 aa | 489 aa | 24.5 % |
Loa Loa (eye worm) | hypothetical protein | Dopamine D1 receptor | 446 aa | 370 aa | 24.3 % |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 61.9 nM | Displacement of [3H]Spiperone from dopamine D2 receptor in bovine caudate nuclei synaptosomal membrane by liquid scintillation spectrometry | ChEMBL. | 18006194 |
Ki (binding) | > 1000 nM | Displacement of [3H]SCH23390 from dopamine D1 receptor in bovine caudate nuclei synaptosomal membrane by liquid scintillation spectrometry | ChEMBL. | 18006194 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.