Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0212 | 0.6507 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0212 | 0.6507 | 1 |
Trypanosoma brucei | mitochondrial DNA polymerase beta-PAK | 0.0144 | 0.397 | 0.3871 |
Echinococcus multilocularis | acetylcholinesterase | 0.0212 | 0.6507 | 1 |
Leishmania major | mitochondrial DNA polymerase beta-PAK, putative | 0.0144 | 0.397 | 0.3259 |
Echinococcus granulosus | tyrosyl DNA phosphodiesterase 1 | 0.0067 | 0.1054 | 0.162 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0052 | 0.0513 | 0.0358 |
Schistosoma mansoni | hypothetical protein | 0.0169 | 0.4917 | 0.7084 |
Brugia malayi | Carboxylesterase family protein | 0.0212 | 0.6507 | 1 |
Loa Loa (eye worm) | tyrosyl-DNA phosphodiesterase | 0.0067 | 0.1054 | 0.1035 |
Echinococcus multilocularis | tyrosyl DNA phosphodiesterase 1 | 0.0067 | 0.1054 | 0.162 |
Echinococcus multilocularis | acetylcholinesterase | 0.0212 | 0.6507 | 1 |
Trypanosoma brucei | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0067 | 0.1054 | 0.0907 |
Mycobacterium ulcerans | hypothetical protein | 0.016 | 0.4582 | 0.5 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0067 | 0.1054 | 0.0907 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0067 | 0.1054 | 0.0907 |
Trypanosoma brucei | mitochondrial DNA polymerase beta | 0.0304 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0212 | 0.6507 | 1 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.016 | 0.4582 | 0.5 |
Toxoplasma gondii | hypothetical protein | 0.0049 | 0.0398 | 0.5 |
Entamoeba histolytica | tyrosyl-DNA phosphodiesterase, putative | 0.0067 | 0.1054 | 0.5 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0304 | 1 | 1 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0144 | 0.397 | 0.3871 |
Echinococcus multilocularis | geminin | 0.0169 | 0.4917 | 0.7556 |
Brugia malayi | Carboxylesterase family protein | 0.0212 | 0.6507 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0212 | 0.6507 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0212 | 0.6507 | 1 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0304 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0212 | 0.6507 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0169 | 0.4917 | 0.7084 |
Echinococcus granulosus | geminin | 0.0169 | 0.4917 | 0.7556 |
Brugia malayi | Tyrosyl-DNA phosphodiesterase family protein | 0.0067 | 0.1054 | 0.1035 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0212 | 0.6507 | 1 |
Echinococcus granulosus | carboxylesterase 5A | 0.0212 | 0.6507 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0212 | 0.6507 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | = 32.2 % | Analgesic activity in Wistar albino mouse assessed as protection against acetic acid-induced writhing at 20 mg/kg, po administered 30 mins prior to acetic acid challenge measured after 30 mins | ChEMBL. | 18486995 |
Activity (functional) | = 47.49 % | Analgesic activity in Wistar albino mouse assessed as protection against acetic acid-induced writhing at 40 mg/kg, po administered 30 mins prior to acetic acid challenge measured after 30 mins | ChEMBL. | 18486995 |
LD50 (ADMET) | = 175 mg Kg-1 | Acute toxicity in po dosed Wistar albino mouse assessed as mortality after 24 hrs by Karber's arithmetical method | ChEMBL. | 18486995 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.