Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Bacillus anthracis | Dihydrofolate reductase | Starlite/ChEMBL | References |
Candida albicans | dihydrofolate reductase | Starlite/ChEMBL | References |
Homo sapiens | dihydrofolate reductase | Starlite/ChEMBL | References |
Staphylococcus aureus | Dihydrofolate reductase | Starlite/ChEMBL | No references |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 68 nM | Inhibition of methicillin-resistant Staphylococcus aureus DHFR | ChEMBL. | No reference |
IC50 (binding) | = 100 nM | Inhibition of Candida albicans DHFR | ChEMBL. | 23375226 |
IC50 (binding) | = 1280 nM | Inhibition of human DHFR | ChEMBL. | 23375226 |
IC50 (binding) | = 0.1 uM | Inhibition of Candida albicans DHFR expressed in Escherichia coli BL21 (DE3) assessed as rate of NADPH consumption using dihydrofolate as substrate | ChEMBL. | 19560363 |
IC50 (binding) | = 0.89 uM | Inhibition of Bacillus anthracis recombinant DHFR expressed in mouse M15 cells assessed as rate of enzyme-dependent NADPH oxidation | ChEMBL. | 19007108 |
IC50 (binding) | = 0.89 uM | Inhibition of wild type Bacillus anthracis recombinant DHFR | ChEMBL. | 20882962 |
IC50 (binding) | = 1.28 uM | Inhibition of human DHFR assessed as rate of enzyme-dependent NADPH oxidation | ChEMBL. | 19007108 |
IC50 (binding) | = 1.28 uM | Inhibition of human DHFR assessed as rate of NADPH consumption using dihydrofolate as substrate | ChEMBL. | 19560363 |
Ki (binding) | = 0.3 uM | Inhibition of wild type Bacillus anthracis recombinant DHFR | ChEMBL. | 20882962 |
MIC (functional) | = 78 ug ml-1 | Antifungal activity against Candida albicans by alamar blue assay | ChEMBL. | 19560363 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
3 literature references were collected for this gene.