Detailed information for compound 988557

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 358.397 | Formula: C20H18N6O
  • H donors: 3 H acceptors: 4 LogP: 2.3 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCNC(=O)Nc1nc2c([nH]1)c(cc(c2)c1cccnc1)c1cccnc1
  • InChi: 1S/C20H18N6O/c1-2-23-20(27)26-19-24-17-10-15(13-5-3-7-21-11-13)9-16(18(17)25-19)14-6-4-8-22-12-14/h3-12H,2H2,1H3,(H3,23,24,25,26,27)
  • InChiKey: CWLNVKFAQINOMH-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Staphylococcus aureus DNA gyrase Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Plasmodium falciparum DNA gyrase subunit A Get druggable targets OG5_129568 All targets in OG5_129568
Theileria parva DNA gyrase subunit A, putative Get druggable targets OG5_129568 All targets in OG5_129568
Mycobacterium ulcerans DNA gyrase subunit A Get druggable targets OG5_129568 All targets in OG5_129568
Plasmodium berghei DNA gyrase subunit A, putative Get druggable targets OG5_129568 All targets in OG5_129568
Toxoplasma gondii DNA gyrase/topoisomerase IV, A subunit domain-containing protein Get druggable targets OG5_129568 All targets in OG5_129568
Wolbachia endosymbiont of Brugia malayi DNA gyrase subunit A Get druggable targets OG5_129568 All targets in OG5_129568
Plasmodium yoelii DNA gyrase subunit a-related Get druggable targets OG5_129568 All targets in OG5_129568
Chlamydia trachomatis DNA gyrase subunit A Get druggable targets OG5_129568 All targets in OG5_129568
Babesia bovis DNA gyrase A subunit, putative Get druggable targets OG5_129568 All targets in OG5_129568
Treponema pallidum DNA gyrase, subunit A (gyrA) Get druggable targets OG5_129568 All targets in OG5_129568
Mycobacterium tuberculosis DNA gyrase (subunit A) GyrA (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) Get druggable targets OG5_129568 All targets in OG5_129568
Plasmodium vivax DNA gyrase subunit A, putative Get druggable targets OG5_129568 All targets in OG5_129568
Neospora caninum DNA gyrase subunit A, putative Get druggable targets OG5_129568 All targets in OG5_129568
Mycobacterium leprae Probable DNA gyrase (subunit A) GyrA (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (Type II DNA topoisomerase) Get druggable targets OG5_129568 All targets in OG5_129568
Plasmodium knowlesi DNA gyrase subunit A, putative Get druggable targets OG5_129568 All targets in OG5_129568
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Leishmania braziliensis DNA topoisomerase ii DNA gyrase   644 aa 675 aa 23.0 %
Loa Loa (eye worm) TOPoisomerase family member DNA gyrase   644 aa 668 aa 26.2 %
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative DNA gyrase   644 aa 615 aa 22.6 %
Trypanosoma congolense DNA topoisomerase II, putative DNA gyrase   644 aa 617 aa 24.8 %
Echinococcus multilocularis DNA topoisomerase 2 alpha DNA gyrase   644 aa 612 aa 25.8 %
Theileria parva DNA gyrase subunit B, putative DNA gyrase   644 aa 638 aa 37.1 %
Plasmodium falciparum DNA topoisomerase 2 DNA gyrase   644 aa 647 aa 23.2 %
Trypanosoma congolense DNA topoisomerase II, putative DNA gyrase   644 aa 678 aa 22.9 %
Onchocerca volvulus DNA gyrase   644 aa 624 aa 25.8 %
Schistosoma mansoni DNA topoisomerase II DNA gyrase   644 aa 633 aa 24.3 %
Trypanosoma cruzi DNA topoisomerase II, putative DNA gyrase   644 aa 674 aa 23.0 %
Plasmodium berghei DNA gyrase subunit B, putative DNA gyrase   644 aa 662 aa 36.3 %
Trypanosoma brucei DNA topoisomerase ii DNA gyrase   644 aa 619 aa 25.7 %
Trypanosoma brucei DNA topoisomerase II alpha, putative DNA gyrase   644 aa 676 aa 23.4 %
Chlamydia trachomatis DNA gyrase subunit B DNA gyrase   644 aa 561 aa 55.3 %
Candida albicans DNA topoisomerase II similar to S. cerevisiae TOP2 (YNL088W) DNA gyrase   644 aa 625 aa 25.6 %
Mycobacterium tuberculosis DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) DNA gyrase   644 aa 661 aa 53.0 %
Trypanosoma cruzi DNA topoisomerase II, putative DNA gyrase   644 aa 674 aa 23.0 %
Candida albicans DNA topoisomerase II similar to S. cerevisiae TOP2 (YNL088W) DNA gyrase   644 aa 625 aa 25.6 %
Theileria parva DNA topoisomerase II, putative DNA gyrase   644 aa 683 aa 23.9 %
Trypanosoma brucei gambiense DNA topoisomerase II, putative DNA gyrase   644 aa 676 aa 23.4 %
Plasmodium knowlesi DNA gyrase subunit B, putative DNA gyrase   644 aa 517 aa 36.0 %
Brugia malayi DNA topoisomerase II, alpha isozyme DNA gyrase   644 aa 659 aa 24.3 %
Leishmania infantum mitochondrial DNA topoisomerase II DNA gyrase   644 aa 624 aa 23.2 %
Echinococcus granulosus DNA topoisomerase 2 alpha DNA gyrase   644 aa 613 aa 25.9 %
Leishmania major mitochondrial DNA topoisomerase II DNA gyrase   644 aa 624 aa 23.1 %
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative DNA gyrase   644 aa 615 aa 22.6 %
Brugia malayi Probable DNA topoisomerase II DNA gyrase   644 aa 672 aa 25.9 %
Leishmania major DNA topoisomerase ii DNA gyrase   644 aa 672 aa 23.4 %
Leishmania donovani DNA topoisomerase ii DNA gyrase   644 aa 666 aa 23.4 %
Wolbachia endosymbiont of Brugia malayi DNA gyrase, topoisomerase II, B subunit, GyrB DNA gyrase   644 aa 561 aa 50.4 %
Leishmania mexicana mitochondrial DNA topoisomerase II DNA gyrase   644 aa 620 aa 23.4 %
Entamoeba histolytica DNA topoisomerase II, putative DNA gyrase   644 aa 544 aa 25.0 %
Trypanosoma congolense DNA topoisomerase II, putative DNA gyrase   644 aa 678 aa 22.7 %
Brugia malayi DNA gyrase/topoisomerase IV, A subunit family protein DNA gyrase   644 aa 548 aa 25.7 %
Trypanosoma brucei gambiense DNA topoisomerase II, putative DNA gyrase   644 aa 666 aa 23.4 %
Onchocerca volvulus DNA gyrase   644 aa 618 aa 26.5 %
Leishmania infantum DNA topoisomerase ii DNA gyrase   644 aa 666 aa 23.6 %
Onchocerca volvulus Ectoderm-expressed 4 homolog DNA gyrase   644 aa 673 aa 24.1 %
Dictyostelium discoideum DNA topoisomerase II DNA gyrase   644 aa 655 aa 23.8 %
Leishmania mexicana DNA topoisomerase ii DNA gyrase   644 aa 668 aa 23.1 %
Leishmania braziliensis mitochondrial DNA topoisomerase II DNA gyrase   644 aa 622 aa 23.8 %
Trypanosoma brucei DNA topoisomerase II beta, putative DNA gyrase   644 aa 570 aa 24.0 %
Toxoplasma gondii DNA topoisomerase 2, putative DNA gyrase   644 aa 664 aa 24.1 %
Neospora caninum hypothetical protein DNA gyrase   644 aa 693 aa 24.1 %
Mycobacterium leprae Probable DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (Type II DNA topoisomerase) DNA gyrase   644 aa 667 aa 53.1 %
Trypanosoma brucei gambiense DNA topoisomerase II, putative DNA gyrase   644 aa 619 aa 25.7 %
Leishmania donovani mitochondrial DNA topoisomerase II DNA gyrase   644 aa 624 aa 23.2 %
Babesia bovis DNA topoisomerase II, putative DNA gyrase   644 aa 587 aa 22.7 %
Mycobacterium ulcerans DNA gyrase subunit B DNA gyrase   644 aa 663 aa 54.0 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major beta tubulin 0.0303 1 1
Trypanosoma brucei alpha tubulin 0.0201 0.6224 0.6224
Entamoeba histolytica hypothetical protein 0.0186 0.5688 0.5561
Echinococcus granulosus tubulin delta chain 0.0066 0.1265 0.1006
Mycobacterium ulcerans DNA gyrase subunit A 0.0136 0.3845 1
Leishmania major beta tubulin 0.0303 1 1
Trichomonas vaginalis tubulin alpha chain, putative 0.0303 1 1
Trichomonas vaginalis conserved hypothetical protein 0.0066 0.1265 0.1006
Leishmania major beta tubulin 0.0303 1 1
Echinococcus multilocularis Tubulin alpha 1 chain 0.0201 0.6224 0.6113
Trypanosoma cruzi zeta tubulin, putative 0.0066 0.1265 0.1265
Schistosoma mansoni hypothetical protein 0.0186 0.5688 0.5561
Loa Loa (eye worm) alpha-tubulin isotype 2 0.0135 0.3786 0.3602
Leishmania major beta tubulin 0.0303 1 1
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0201 0.6224 0.6113
Echinococcus multilocularis tubulin epsilon chain 0.0152 0.4442 0.4278
Brugia malayi tubulin alpha chain - mouse 0.0201 0.6224 0.6113
Leishmania major alpha tubulin 0.0201 0.6224 0.6224
Trichomonas vaginalis NAD(P)H dehydrogenase, putative 0.0078 0.1698 0.1452
Schistosoma mansoni tubulin subunit alpha 0.0066 0.1265 0.1006
Leishmania major beta tubulin 0.0303 1 1
Entamoeba histolytica tubulin alpha-1 chain 0.0201 0.6224 0.6113
Wolbachia endosymbiont of Brugia malayi DNA gyrase subunit A 0.0136 0.3845 1
Loa Loa (eye worm) tubulin alpha-3 chain 0.0115 0.3047 0.2841
Trypanosoma brucei beta tubulin 0.0303 1 1
Schistosoma mansoni tubulin subunit beta 0.0303 1 1
Giardia lamblia Delta tubulin 0.0066 0.1265 0.1121
Brugia malayi hypothetical protein 0.0186 0.5688 0.5561
Echinococcus multilocularis tubulin gamma 1 chain 0.0152 0.4442 0.4278
Echinococcus granulosus Tubulin alpha 1 chain 0.0201 0.6224 0.6113
Giardia lamblia Beta tubulin 0.0303 1 1
Echinococcus multilocularis tubulin, beta 4A class IVa 0.0303 1 1
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0135 0.3786 0.3602
Trypanosoma brucei alpha tubulin 0.0201 0.6224 0.6224
Echinococcus granulosus Tubulin alpha 1 chain 0.0201 0.6224 0.6113
Trichomonas vaginalis conserved hypothetical protein 0.0078 0.1698 0.1452
Echinococcus granulosus aryl hydrocarbon receptor 0.013 0.3598 0.3409
Trichomonas vaginalis tubulin epsilon chain, putative 0.0303 1 1
Trichomonas vaginalis conserved hypothetical protein 0.0078 0.1698 0.1452
Echinococcus multilocularis tubulin alpha 1C chain 0.0201 0.6224 0.6113
Echinococcus granulosus tubulin alpha chain 0.0201 0.6224 0.6113
Echinococcus multilocularis tubulin delta chain 0.0066 0.1265 0.1006
Echinococcus granulosus tubulin beta 1 chain 0.0303 1 1
Echinococcus multilocularis tubulin subunit beta 0.0303 1 1
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0066 0.1265 0.1006
Schistosoma mansoni tubulin subunit alpha 0.0201 0.6224 0.6113
Wolbachia endosymbiont of Brugia malayi DNA gyrase, topoisomerase II, B subunit, GyrB 0.0072 0.1464 0.0773
Mycobacterium leprae cell division protein FtsZ 0.0066 0.1265 1
Echinococcus multilocularis Tubulin beta 2C chain 0.0303 1 1
Trichomonas vaginalis tubulin beta chain, putative 0.0201 0.6224 0.6113
Echinococcus granulosus tubulin subunit beta 0.0303 1 1
Leishmania major beta tubulin 0.0303 1 1
Trypanosoma brucei epsilon tubulin 0.0152 0.4442 0.4442
Giardia lamblia Epsilon tubulin 0.0066 0.1265 0.1121
Entamoeba histolytica hypothetical protein 0.0186 0.5688 0.5561
Mycobacterium tuberculosis DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) 0.0072 0.1464 0.0773
Leishmania major alpha tubulin 0.0201 0.6224 0.6224
Echinococcus multilocularis tubulin alpha chain 0.0201 0.6224 0.6113
Trypanosoma brucei beta tubulin 0.0152 0.4442 0.4442
Echinococcus granulosus nuclear factor of activated T cells 5 0.015 0.4362 0.4195
Trichomonas vaginalis NAD(P)H dehydrogenase, putative 0.0078 0.1698 0.1452
Plasmodium falciparum alpha tubulin 2 0.0201 0.6224 0.6113
Trichomonas vaginalis tubulin epsilon chain, putative 0.0201 0.6224 0.6113
Schistosoma mansoni alpha tubulin 0.0201 0.6224 0.6113
Onchocerca volvulus 0.0045 0.0481 0.0586
Echinococcus granulosus tubulin alpha 1C chain 0.0201 0.6224 0.6113
Entamoeba histolytica tubulin family protein 0.0303 1 1
Brugia malayi aryl hydrocarbon receptor AHR-1 0.0113 0.3005 0.2798
Echinococcus granulosus Tubulin beta 2C chain 0.0303 1 1
Trichomonas vaginalis conserved hypothetical protein 0.0078 0.1698 0.1452
Leishmania major alpha tubulin 0.0201 0.6224 0.6224
Trichomonas vaginalis tubulin gamma chain, putative 0.0303 1 1
Trichomonas vaginalis tubulin, putative 0.0086 0.2004 0.1767
Leishmania major beta tubulin 0.0303 1 1
Leishmania major alpha tubulin 0.0201 0.6224 0.6224
Plasmodium vivax tubulin gamma chain, putative 0.0152 0.4442 0.4278
Trypanosoma brucei beta tubulin 0.0303 1 1
Plasmodium vivax DNA gyrase subunit A, putative 0.0136 0.3845 0.3662
Leishmania major beta tubulin 0.0303 1 1
Schistosoma mansoni tubulin subunit gamma 0.0152 0.4442 0.4278
Entamoeba histolytica hypothetical protein 0.0186 0.5688 0.5561
Echinococcus granulosus tubulin alpha 3 chain 0.0201 0.6224 0.6113
Schistosoma mansoni tubulin subunit epsilon 0.0152 0.4442 0.4278
Schistosoma mansoni tubulin subunit beta 0.0303 1 1
Trypanosoma cruzi beta tubulin, putative 0.0303 1 1
Schistosoma mansoni transcription factor LCR-F1 0.0186 0.5688 0.5561
Trichomonas vaginalis tubulin alpha chain, putative 0.0086 0.2004 0.1767
Entamoeba histolytica tubulin family protein 0.0303 1 1
Schistosoma mansoni alpha tubulin 0.0201 0.6224 0.6113
Entamoeba histolytica hypothetical protein 0.0186 0.5688 0.5561
Plasmodium falciparum tubulin delta chain, putative 0.0066 0.1265 0.1006
Brugia malayi Cell division protein ftsZ 0.0066 0.1265 0.1006
Loa Loa (eye worm) alpha-tubulin 0.0201 0.6224 0.6113
Echinococcus multilocularis Tubulin alpha 1 chain 0.0201 0.6224 0.6113
Echinococcus granulosus tubulin alpha chain 0.0201 0.6224 0.6113
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.004 0.0288 0.0288
Schistosoma mansoni tubulin subunit beta 0.0303 1 1
Leishmania major alpha tubulin 0.0201 0.6224 0.6224
Echinococcus multilocularis tubulin alpha chain 0.0201 0.6224 0.6113
Trichomonas vaginalis conserved hypothetical protein 0.0066 0.1265 0.1006
Leishmania major alpha tubulin 0.0201 0.6224 0.6224
Plasmodium falciparum tubulin beta chain 0.0303 1 1
Echinococcus multilocularis Tubulin alpha 1 chain 0.0201 0.6224 0.6113
Trichomonas vaginalis tubulin beta-1 chain, putative 0.0066 0.1265 0.1006
Echinococcus granulosus tubulin alpha 3 chain 0.0201 0.6224 0.6113
Loa Loa (eye worm) hypothetical protein 0.0201 0.6224 0.6113
Trichomonas vaginalis tubulin, putative 0.0066 0.1265 0.1006
Echinococcus granulosus Tubulin beta 2C chain 0.0303 1 1
Trypanosoma cruzi alpha tubulin, putative 0.0201 0.6224 0.6224
Plasmodium vivax tubulin beta chain, putative 0.0303 1 1
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0115 0.3047 0.2841
Trichomonas vaginalis tubulin epsilon chain, putative 0.0201 0.6224 0.6113
Trichomonas vaginalis conserved hypothetical protein 0.0078 0.1698 0.1452
Leishmania major epsilon tubulin, putative 0.0152 0.4442 0.4442
Leishmania major beta tubulin 0.0303 1 1
Trichomonas vaginalis tubulin alpha chain, putative 0.0152 0.4442 0.4278
Leishmania major gamma-tubulin 0.0152 0.4442 0.4442
Trichomonas vaginalis tubulin beta chain, putative 0.0303 1 1
Leishmania major alpha tubulin 0.0201 0.6224 0.6224
Echinococcus granulosus Tubulin alpha 1 chain 0.0201 0.6224 0.6113
Trichomonas vaginalis tubulin gamma chain, putative 0.0152 0.4442 0.4278
Trypanosoma cruzi tubulin delta chain 0.0066 0.1265 0.1265
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0186 0.5688 0.5561
Trypanosoma cruzi tubulin gamma chain 0.0152 0.4442 0.4442
Brugia malayi Tubulin gamma chain 0.0152 0.4442 0.4278
Echinococcus granulosus Tubulin beta 2C chain 0.0303 1 1
Trypanosoma brucei tubulin gamma chain 0.0152 0.4442 0.4442
Echinococcus granulosus peroxisome assembly protein 26 0.0201 0.6224 0.6113
Trypanosoma cruzi epsilon tubulin, putative 0.0152 0.4442 0.4442
Treponema pallidum DNA gyrase, subunit B (gyrB) 0.0072 0.1464 0.0773
Schistosoma mansoni tubulin subunit beta 0.0303 1 1
Loa Loa (eye worm) tubulin gamma chain 0.0152 0.4442 0.4278
Loa Loa (eye worm) hypothetical protein 0.0113 0.3005 0.2798
Leishmania major delta tubulin, putative 0.0066 0.1265 0.1265
Trichomonas vaginalis conserved hypothetical protein 0.0058 0.0981 0.0714
Leishmania major beta tubulin 0.0303 1 1
Echinococcus multilocularis beta tubulin 0.0303 1 1
Leishmania major alpha tubulin 0.0201 0.6224 0.6224
Trypanosoma cruzi epsilon tubulin, putative 0.0152 0.4442 0.4442
Trypanosoma brucei DNA topoisomerase ii 0.004 0.0288 0.0288
Giardia lamblia Alpha-tubulin 0.0201 0.6224 0.6162
Mycobacterium ulcerans DNA gyrase subunit B 0.0072 0.1464 0.2964
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0066 0.1265 0.1006
Trichomonas vaginalis conserved hypothetical protein 0.0078 0.1698 0.1452
Echinococcus multilocularis aryl hydrocarbon receptor 0.013 0.3598 0.3409
Loa Loa (eye worm) tubulin alpha 2 0.0048 0.0609 0.0331
Loa Loa (eye worm) tubulin beta chain 0.0303 1 1
Echinococcus granulosus tubulin gamma 1 chain 0.0152 0.4442 0.4278
Entamoeba histolytica tubulin alpha chain, putative 0.0201 0.6224 0.6113
Trichomonas vaginalis tubulin beta chain, putative 0.0201 0.6224 0.6113
Leishmania major alpha tubulin 0.0201 0.6224 0.6224
Echinococcus granulosus tubulin beta 4A class IVa 0.0303 1 1
Leishmania major beta tubulin 0.0303 1 1
Trichomonas vaginalis conserved hypothetical protein 0.0078 0.1698 0.1452
Trichomonas vaginalis conserved hypothetical protein 0.0078 0.1698 0.1452
Echinococcus granulosus tubulin alpha chain 0.0201 0.6224 0.6113
Loa Loa (eye worm) beta-tubulin 0.0303 1 1
Chlamydia trachomatis DNA gyrase subunit A 0.0136 0.3845 1
Giardia lamblia NADPH oxidoreductase, putative 0.0078 0.1698 0.1562
Brugia malayi Tubulin alpha-2 chain 0.0201 0.6224 0.6113
Brugia malayi PAS domain containing protein 0.006 0.1036 0.077
Trichomonas vaginalis conserved hypothetical protein 0.0078 0.1698 0.1452
Echinococcus multilocularis tubulin alpha chain 0.0201 0.6224 0.6113
Plasmodium falciparum tubulin gamma chain 0.0152 0.4442 0.4278
Brugia malayi tubulin alpha-2 chain 0.0201 0.6224 0.6113
Mycobacterium ulcerans cell division protein FtsZ 0.0066 0.1265 0.2374
Echinococcus multilocularis tubulin alpha chain 0.0201 0.6224 0.6113
Plasmodium falciparum DNA gyrase subunit A 0.0136 0.3845 0.3662
Echinococcus multilocularis Tubulin beta 2C chain 0.0303 1 1
Loa Loa (eye worm) hypothetical protein 0.0114 0.3024 0.2817
Trichomonas vaginalis tubulin epsilon chain, putative 0.0303 1 1
Echinococcus multilocularis tubulin alpha chain 0.0201 0.6224 0.6113
Trichomonas vaginalis conserved hypothetical protein 0.0078 0.1698 0.1452
Loa Loa (eye worm) tubulin beta-4 chain 0.0303 1 1
Echinococcus multilocularis Tubulin beta 2C chain 0.0303 1 1
Leishmania major beta tubulin 0.0303 1 1
Giardia lamblia Gamma tubulin 0.0152 0.4442 0.4351
Toxoplasma gondii DNA gyrase/topoisomerase IV, A subunit domain-containing protein 0.0136 0.3845 0.3662
Brugia malayi Tubulin alpha-2 chain 0.0201 0.6224 0.6113
Loa Loa (eye worm) tubulin alpha 2 0.0135 0.3786 0.3602
Brugia malayi Tubulin beta chain 0.0066 0.1265 0.1006
Plasmodium vivax tubulin alpha chain, putative 0.0201 0.6224 0.6113
Plasmodium vivax DNA gyrase subunit B, putative 0.0072 0.1464 0.1211
Brugia malayi Tubulin beta chain 0.0086 0.2004 0.1767
Trichomonas vaginalis tubulin, putative 0.0086 0.2004 0.1767
Echinococcus granulosus Tubulin beta 2C chain 0.0303 1 1
Echinococcus multilocularis transfer RNA-Lys 0.0044 0.0462 0.0179
Leishmania major mitochondrial DNA topoisomerase II 0.004 0.0288 0.0288
Toxoplasma gondii beta tubulin 0.0303 1 1
Leishmania major beta tubulin 0.0303 1 1
Echinococcus multilocularis nuclear factor of activated T cells 5 0.015 0.4362 0.4195
Loa Loa (eye worm) tubulin beta-1 chain 0.0303 1 1
Trypanosoma brucei alpha tubulin 0.0201 0.6224 0.6224
Brugia malayi beta-tubulin, identical 0.0303 1 1
Giardia lamblia Alpha-tubulin 0.0201 0.6224 0.6162
Schistosoma mansoni single-minded 0.006 0.1036 0.077
Echinococcus multilocularis tubulin subunit TubB 0.0201 0.6224 0.6113
Giardia lamblia Beta tubulin 0.0303 1 1
Leishmania major beta tubulin 0.0303 1 1
Trypanosoma brucei tubulin delta chain 0.0066 0.1265 0.1265
Trypanosoma cruzi zeta tubulin, putative 0.0066 0.1265 0.1265
Trichomonas vaginalis conserved hypothetical protein 0.0078 0.1698 0.1452
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0086 0.2004 0.1767
Trichomonas vaginalis tubulin beta chain, putative 0.0201 0.6224 0.6113
Echinococcus multilocularis peroxisome assembly protein 26 0.0201 0.6224 0.6113
Leishmania major beta tubulin 0.0303 1 1
Trypanosoma brucei alpha tubulin, putative 0.0086 0.2004 0.2004
Schistosoma mansoni tubulin subunit beta 0.0303 1 1
Brugia malayi Tubulin alpha chain 0.0201 0.6224 0.6113
Entamoeba histolytica tubulin gamma chain 0.0152 0.4442 0.4278
Trypanosoma brucei zeta tubulin, putative 0.0066 0.1265 0.1265
Trypanosoma brucei epsilon tubulin 0.0152 0.4442 0.4442
Loa Loa (eye worm) tubulin beta chain 0.0066 0.1265 0.1006
Treponema pallidum DNA gyrase, subunit A (gyrA) 0.0136 0.3845 1
Echinococcus granulosus alpha tubulin 0.0201 0.6224 0.6113
Giardia lamblia Beta tubulin 0.0303 1 1
Trypanosoma brucei alpha tubulin 0.0201 0.6224 0.6224
Schistosoma mansoni alpha tubulin 0.0201 0.6224 0.6113
Trichomonas vaginalis tubulin epsilon chain, putative 0.0066 0.1265 0.1006
Echinococcus granulosus tubulin alpha chain 0.0201 0.6224 0.6113
Echinococcus granulosus tubulin alpha chain 0.0201 0.6224 0.6113
Trichomonas vaginalis NAD(P)H dehydrogenase, putative 0.0078 0.1698 0.1452
Brugia malayi alpha-tubulin 0.0201 0.6224 0.6113
Loa Loa (eye worm) hypothetical protein 0.0115 0.3047 0.2841
Loa Loa (eye worm) tubulin alpha chain 0.0201 0.6224 0.6113
Echinococcus multilocularis tubulin alpha 3 chain 0.0201 0.6224 0.6113
Loa Loa (eye worm) hypothetical protein 0.0135 0.3786 0.3602
Trichomonas vaginalis tubulin beta chain, putative 0.0201 0.6224 0.6113
Trypanosoma brucei beta tubulin 0.0303 1 1
Echinococcus multilocularis beta tubulin 0.0303 1 1
Trichomonas vaginalis tubulin gamma chain, putative 0.0152 0.4442 0.4278
Leishmania major alpha tubulin 0.0201 0.6224 0.6224
Leishmania major zeta tubulin, putative 0.0066 0.1265 0.1265
Echinococcus granulosus tubulin alpha 1C chain 0.0201 0.6224 0.6113
Trichomonas vaginalis conserved hypothetical protein 0.0078 0.1698 0.1452
Echinococcus granulosus tubulin subunit TubB 0.0201 0.6224 0.6113
Loa Loa (eye worm) hypothetical protein 0.0129 0.3579 0.3389
Trypanosoma brucei beta tubulin 0.0303 1 1
Plasmodium falciparum alpha tubulin 1 0.0201 0.6224 0.6113
Trichomonas vaginalis tubulin beta chain, putative 0.0201 0.6224 0.6113
Trichomonas vaginalis conserved hypothetical protein 0.0078 0.1698 0.1452
Echinococcus granulosus Tubulin beta 2C chain 0.0303 1 1
Echinococcus granulosus tubulin epsilon chain 0.0152 0.4442 0.4278
Echinococcus granulosus beta tubulin 0.0303 1 1
Trypanosoma brucei epsilon tubulin 0.0152 0.4442 0.4442
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0152 0.4442 0.4278
Schistosoma mansoni aryl hydrocarbon receptor 0.0174 0.5233 0.5092
Schistosoma mansoni tubulin subunit delta 0.0066 0.1265 0.1006
Schistosoma mansoni tubulin subunit beta 0.0066 0.1265 0.1006
Plasmodium falciparum DNA gyrase subunit B 0.0072 0.1464 0.1211
Leishmania major alpha tubulin 0.0201 0.6224 0.6224
Toxoplasma gondii alpha-tubulin I, putative 0.0201 0.6224 0.6113
Echinococcus multilocularis Tubulin beta 2C chain 0.0303 1 1
Trypanosoma brucei zeta tubulin 0.0066 0.1265 0.1265
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.004 0.0288 0.0288
Onchocerca volvulus 0.0129 0.3579 1
Loa Loa (eye worm) BEN-1 protein 0.0303 1 1
Trichomonas vaginalis tubulin, putative 0.0303 1 1
Echinococcus granulosus beta tubulin 0.0303 1 1
Loa Loa (eye worm) tubulin beta-2A chain 0.0303 1 1
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0186 0.5688 0.5561
Plasmodium vivax tubulin epsilon chain, putative 0.0152 0.4442 0.4278
Mycobacterium tuberculosis DNA gyrase (subunit A) GyrA (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) 0.0136 0.3845 1
Schistosoma mansoni tubulin subunit alpha 0.0201 0.6224 0.6113
Giardia lamblia NADPH oxidoreductase, putative 0.0078 0.1698 0.1562
Brugia malayi bHLH-PAS transcription factor 0.0044 0.0462 0.0179
Loa Loa (eye worm) BEN-1 protein 0.0303 1 1
Trichomonas vaginalis tubulin beta chain, putative 0.0201 0.6224 0.6113
Echinococcus multilocularis Tubulin beta 2C chain 0.0303 1 1
Trichomonas vaginalis tubulin gamma chain, putative 0.0066 0.1265 0.1006
Leishmania major beta tubulin 0.0303 1 1
Brugia malayi Tubulin alpha chain 0.0066 0.1265 0.1006
Echinococcus multilocularis tubulin alpha 0.0152 0.4442 0.4278
Toxoplasma gondii beta-tubulin, putative 0.0303 1 1
Echinococcus granulosus single minded 2 0.0044 0.0462 0.0179
Loa Loa (eye worm) alpha-tubulin 0.0201 0.6224 0.6113
Giardia lamblia NADPH oxidoreductase, putative 0.0078 0.1698 0.1562
Trypanosoma cruzi tubulin delta chain 0.0066 0.1265 0.1265
Leishmania major beta tubulin 0.0303 1 1
Loa Loa (eye worm) tubulin alpha chain 0.0201 0.6224 0.6113
Loa Loa (eye worm) tubulin alpha 2 0.0135 0.3786 0.3602
Echinococcus multilocularis tubulin beta 1 chain 0.0303 1 1
Leishmania major alpha tubulin 0.0201 0.6224 0.6224
Trichomonas vaginalis conserved hypothetical protein 0.0078 0.1698 0.1452
Toxoplasma gondii alpha tubulin TUBA1 0.0201 0.6224 0.6113
Echinococcus granulosus tubulin alpha 0.0152 0.4442 0.4278
Echinococcus multilocularis hypothetical protein 0.0201 0.6224 0.6113
Schistosoma mansoni tubulin subunit alpha 0.0201 0.6224 0.6113
Trichomonas vaginalis tubulin beta chain, putative 0.0086 0.2004 0.1767
Plasmodium vivax delta tubulin, putative 0.0066 0.1265 0.1006
Trichomonas vaginalis tubulin alpha chain, putative 0.0086 0.2004 0.1767
Plasmodium vivax tubulin alpha chain, putative 0.0201 0.6224 0.6113
Plasmodium falciparum tubulin epsilon chain, putative 0.0152 0.4442 0.4278
Schistosoma mansoni tubulin subunit beta 0.0303 1 1
Onchocerca volvulus 0.0086 0.2004 0.5214
Toxoplasma gondii beta-1 tubulin, putative 0.0303 1 1
Loa Loa (eye worm) tubulin alpha-2 chain 0.0201 0.6224 0.6113
Echinococcus multilocularis tubulin alpha 3 chain 0.0201 0.6224 0.6113
Leishmania major beta tubulin 0.0303 1 1
Trichomonas vaginalis tubulin alpha chain, putative 0.0086 0.2004 0.1767
Echinococcus multilocularis tubulin alpha 1C chain 0.0201 0.6224 0.6113

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 0.017 uM Inhibition of Staphylococcus aureus DNA gyrase ChEMBL. 18690678

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.