Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | carboxylesterase | 0.0081 | 0.9856 | 0.9827 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0064 | 0.6832 | 0.659 |
Trichomonas vaginalis | dihydrodiol dehydrogenase, putative | 0.0034 | 0.17 | 0.5 |
Plasmodium falciparum | ATP-dependent Clp protease proteolytic subunit | 0.0082 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0034 | 0.17 | 0.5 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0034 | 0.17 | 0.5 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0034 | 0.17 | 0.17 |
Loa Loa (eye worm) | hypothetical protein | 0.0055 | 0.5293 | 0.4329 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0034 | 0.17 | 0.5 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0081 | 0.9856 | 0.9827 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0034 | 0.17 | 0.5 |
Entamoeba histolytica | aldose reductase, putative | 0.0034 | 0.17 | 0.5 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0064 | 0.6925 | 0.6294 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0064 | 0.6832 | 0.6183 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0048 | 0.4118 | 0.4118 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0048 | 0.4118 | 0.2913 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0034 | 0.17 | 0.17 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0034 | 0.17 | 0.5 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0034 | 0.17 | 0.5 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0064 | 0.6832 | 0.6832 |
Trichomonas vaginalis | aldo/keto reductase, putative | 0.0034 | 0.17 | 0.5 |
Trypanosoma cruzi | aldo-keto reductase | 0.0034 | 0.17 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0081 | 0.9856 | 0.9827 |
Onchocerca volvulus | 0.0034 | 0.17 | 0.5 | |
Trypanosoma brucei | prostaglandin f synthase | 0.0034 | 0.17 | 0.5 |
Onchocerca volvulus | 0.0034 | 0.17 | 0.5 | |
Onchocerca volvulus | 0.0034 | 0.17 | 0.5 | |
Echinococcus granulosus | ATP dependent Clp protease proteolytic subunit | 0.0082 | 1 | 1 |
Mycobacterium leprae | ATP-dependent Clp protease proteolytic subunit 1 | 0.0028 | 0.0712 | 0.0712 |
Echinococcus granulosus | aldo keto reductase | 0.0034 | 0.17 | 0.17 |
Toxoplasma gondii | aldose reductase, putative | 0.0034 | 0.17 | 0.1064 |
Echinococcus granulosus | peptidase Clp S14 family | 0.0054 | 0.5118 | 0.5118 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0081 | 0.9856 | 0.9856 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0064 | 0.6832 | 0.9824 |
Echinococcus multilocularis | 3 hydroxyacyl coenzyme A dehydrogenase type 2 | 0.0064 | 0.6925 | 0.6925 |
Echinococcus granulosus | aldo keto reductase | 0.0034 | 0.17 | 0.17 |
Giardia lamblia | Aldose reductase | 0.0034 | 0.17 | 0.5 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0034 | 0.17 | 0.5 |
Trichomonas vaginalis | dihydrodiol dehydrogenase, putative | 0.0034 | 0.17 | 0.5 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0048 | 0.4118 | 0.4118 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0034 | 0.17 | 0.17 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0048 | 0.4118 | 0.2913 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0034 | 0.17 | 0.17 |
Echinococcus multilocularis | aldo keto reductase | 0.0034 | 0.17 | 0.17 |
Chlamydia trachomatis | ATP-dependent Clp protease proteolytic subunit | 0.0082 | 1 | 0.5 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0064 | 0.6832 | 0.6183 |
Brugia malayi | Carboxylesterase family protein | 0.0081 | 0.9856 | 0.9827 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0064 | 0.6832 | 0.6832 |
Schistosoma mansoni | 3-hydroxyacyl-CoA dehydrogenase | 0.0064 | 0.6925 | 0.6294 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0034 | 0.17 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | ATP-dependent Clp protease proteolytic subunit | 0.0082 | 1 | 0.5 |
Giardia lamblia | Aldose reductase | 0.0034 | 0.17 | 0.5 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0064 | 0.6832 | 0.6183 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0034 | 0.17 | 0.17 |
Trichomonas vaginalis | aldo/keto reductase, putative | 0.0034 | 0.17 | 0.5 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0034 | 0.17 | 0.17 |
Plasmodium vivax | ATP-dependent Clp protease proteolytic subunit, putative | 0.0082 | 1 | 1 |
Onchocerca volvulus | 0.0034 | 0.17 | 0.5 | |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0034 | 0.17 | 0.17 |
Loa Loa (eye worm) | inward rectifying k channel family protein 1 | 0.0055 | 0.5293 | 0.4329 |
Mycobacterium tuberculosis | Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) | 0.0054 | 0.5118 | 0.6542 |
Mycobacterium ulcerans | ATP-dependent Clp protease proteolytic subunit | 0.0082 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0034 | 0.17 | 0.17 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0034 | 0.17 | 0.17 |
Echinococcus granulosus | acetylcholinesterase | 0.0081 | 0.9856 | 0.9856 |
Mycobacterium leprae | PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) | 0.0082 | 1 | 1 |
Echinococcus granulosus | carboxylesterase 5A | 0.0081 | 0.9856 | 0.9856 |
Echinococcus multilocularis | acetylcholinesterase | 0.0081 | 0.9856 | 0.9856 |
Mycobacterium tuberculosis | Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) | 0.0054 | 0.5118 | 0.6542 |
Mycobacterium leprae | PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) | 0.0054 | 0.5118 | 0.5118 |
Trypanosoma brucei | aldo-keto reductase, putative | 0.0034 | 0.17 | 0.5 |
Echinococcus multilocularis | aldo keto reductase | 0.0034 | 0.17 | 0.17 |
Entamoeba histolytica | aldose reductase, putative | 0.0034 | 0.17 | 0.5 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0064 | 0.6925 | 0.6294 |
Trichomonas vaginalis | dihydrodiol dehydrogenase, putative | 0.0034 | 0.17 | 0.5 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0064 | 0.6832 | 0.6183 |
Echinococcus multilocularis | aldo keto reductase | 0.0034 | 0.17 | 0.17 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0048 | 0.4118 | 0.4118 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0034 | 0.17 | 0.17 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0034 | 0.17 | 0.5 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0034 | 0.17 | 0.17 |
Trypanosoma cruzi | aldo/keto reductase, putative | 0.0034 | 0.17 | 0.5 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0034 | 0.17 | 0.5 |
Mycobacterium leprae | PROBABLE OXIDOREDUCTASE | 0.0034 | 0.17 | 0.17 |
Loa Loa (eye worm) | hypothetical protein | 0.0055 | 0.5293 | 0.4329 |
Echinococcus granulosus | aldo keto reductase | 0.0034 | 0.17 | 0.17 |
Treponema pallidum | ATP-dependent Clp protease proteolytic subunit | 0.0082 | 1 | 1 |
Trichomonas vaginalis | aldo/keto reductase, putative | 0.0034 | 0.17 | 0.5 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0064 | 0.6832 | 0.6183 |
Loa Loa (eye worm) | hypothetical protein | 0.0082 | 1 | 1 |
Toxoplasma gondii | ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein | 0.0082 | 1 | 1 |
Echinococcus granulosus | 3 hydroxyacyl coenzyme A dehydrogenase type 2 | 0.0064 | 0.6925 | 0.6925 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0034 | 0.17 | 0.17 |
Entamoeba histolytica | aldose reductase, putative | 0.0034 | 0.17 | 0.5 |
Leishmania major | 3-oxoacyl-(acyl-carrier protein) reductase, putative | 0.0064 | 0.6925 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0048 | 0.4118 | 0.2913 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0034 | 0.17 | 0.17 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0034 | 0.17 | 0.17 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0034 | 0.17 | 0.17 |
Mycobacterium tuberculosis | Probable short-chain type dehydrogenase/reductase | 0.0064 | 0.6925 | 1 |
Onchocerca volvulus | 0.0034 | 0.17 | 0.5 | |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0034 | 0.17 | 0.17 |
Echinococcus multilocularis | ATP dependent Clp protease proteolytic subunit | 0.0082 | 1 | 1 |
Brugia malayi | 3-hydroxyacyl-CoA dehydrogenase type II | 0.0064 | 0.6925 | 0.6294 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0048 | 0.4118 | 0.2913 |
Onchocerca volvulus | 0.0034 | 0.17 | 0.5 | |
Chlamydia trachomatis | ATP-dependent Clp protease proteolytic subunit | 0.0082 | 1 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0081 | 0.9856 | 0.9856 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0034 | 0.17 | 0.5 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0034 | 0.17 | 0.17 |
Echinococcus granulosus | hypothetical protein | 0.0034 | 0.17 | 0.17 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0064 | 0.6832 | 0.9824 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0034 | 0.17 | 0.5 |
Toxoplasma gondii | hypothetical protein | 0.0055 | 0.5293 | 0.4933 |
Loa Loa (eye worm) | hypothetical protein | 0.0081 | 0.9856 | 0.9827 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0081 | 0.9856 | 0.9827 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0034 | 0.17 | 0.17 |
Echinococcus multilocularis | aldo keto reductase | 0.0034 | 0.17 | 0.17 |
Echinococcus multilocularis | acetylcholinesterase | 0.0081 | 0.9856 | 0.9856 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0034 | 0.17 | 0.17 |
Mycobacterium ulcerans | ATP-dependent Clp protease proteolytic subunit | 0.0082 | 1 | 1 |
Loa Loa (eye worm) | 3-hydroxyacyl-CoA dehydrogenase type II | 0.0056 | 0.5525 | 0.4608 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0048 | 0.4118 | 0.2913 |
Loa Loa (eye worm) | hypothetical protein | 0.0055 | 0.5293 | 0.4329 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0034 | 0.17 | 0.17 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0048 | 0.4118 | 0.4118 |
Toxoplasma gondii | ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein | 0.0082 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0081 | 0.9856 | 0.9827 |
Schistosoma mansoni | peptidase Clp (S14 family) | 0.0082 | 1 | 1 |
Echinococcus multilocularis | peptidase Clp (S14 family) | 0.0054 | 0.5118 | 0.5118 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 43.9 uM | Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum FCR3 | ChEMBL. | 17502414 |
IC50 (functional) | = 44.3 uM | Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum D6 | ChEMBL. | 17502414 |
IC50 (functional) | = 52.6 uM | Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum Bre1 | ChEMBL. | 17502414 |
IC50 (functional) | = 57.8 uM | Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum IMT031 | ChEMBL. | 17502414 |
IC50 (functional) | = 95.3 uM | Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 | ChEMBL. | 17502414 |
IC50 (functional) | = 103 uM | Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum W2 | ChEMBL. | 17502414 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.