Detailed information for compound 989050

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 351.356 | Formula: C19H17N3O4
  • H donors: 2 H acceptors: 3 LogP: 2.97 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: COC(=O)[C@H]1N[C@H](c2cccc(c2)[N+](=O)[O-])c2c(C1)c1ccccc1[nH]2
  • InChi: 1S/C19H17N3O4/c1-26-19(23)16-10-14-13-7-2-3-8-15(13)20-18(14)17(21-16)11-5-4-6-12(9-11)22(24)25/h2-9,16-17,20-21H,10H2,1H3/t16-,17+/m0/s1
  • InChiKey: WTZMWVYGTPUZFA-DLBZAZTESA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.003 0.0104 0.0104
Plasmodium vivax vivapain-2 0.0017 0.0006 0.0117
Treponema pallidum bacterioferrin (TpF1) 0.0026 0.0072 0.1051
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0099 0.0295
Loa Loa (eye worm) hypothetical protein 0.003 0.0104 0.036
Schistosoma mansoni retinoid-x-receptor (RXR) 0.003 0.0104 0.0104
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0242 0.1634 0.5659
Echinococcus granulosus transcription factor Dp 1 0.0038 0.0159 0.0159
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0023 0.0053 0.0053
Leishmania major cathepsin L-like protease 0.0017 0.0006 0.0077
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0092 0.0552 0.6011
Schistosoma mansoni 6-phosphofructokinase 0.011 0.068 0.068
Echinococcus granulosus histone acetyltransferase MYST2 0.0053 0.0269 0.0269
Brugia malayi nuclear hormone receptor 0.003 0.0104 0.036
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0066 0.036 0.5291
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0018 0.0254
Loa Loa (eye worm) hypothetical protein 0.0047 0.0222 0.077
Brugia malayi Thioredoxin reductase 0.0047 0.0223 0.0772
Mycobacterium ulcerans bacterioferritin BfrB 0.0026 0.0072 0.1051
Onchocerca volvulus 0.0473 0.3303 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0006 0.0016
Trichomonas vaginalis phosphofructokinase, putative 0.011 0.068 0.2055
Echinococcus granulosus peptidase Clp S14 family 0.0051 0.0251 0.0251
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0079 0.0458 0.0458
Schistosoma mansoni hypothetical protein 0.0079 0.0458 0.0458
Brugia malayi Nuclear hormone receptor family member nhr-41 0.003 0.0104 0.036
Loa Loa (eye worm) hypothetical protein 0.003 0.0104 0.036
Loa Loa (eye worm) hypothetical protein 0.0053 0.0269 0.0932
Brugia malayi Nuclear hormone receptor family member nhr-19 0.003 0.0104 0.036
Trichomonas vaginalis PIKK family atypical protein kinase 0.0055 0.0279 0.0842
Toxoplasma gondii ABC1 family protein 0.0074 0.042 0.9459
Loa Loa (eye worm) hypothetical protein 0.0079 0.0458 0.1586
Trichomonas vaginalis glucosylceramidase, putative 0.0167 0.1091 0.3302
Entamoeba histolytica phosphofructokinase, putative 0.011 0.068 0.7414
Trypanosoma brucei trypanothione reductase 0.0047 0.0223 0.3269
Leishmania major hypothetical protein, conserved 0.0074 0.042 0.6178
Echinococcus multilocularis tar DNA binding protein 0.0254 0.1724 0.1724
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0066 0.036 0.1247
Echinococcus multilocularis beta LACTamase domain containing family member 0.0074 0.042 0.042
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0351 0.5164
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0351 0.5164
Schistosoma mansoni tar DNA-binding protein 0.0254 0.1724 0.1724
Entamoeba histolytica hypothetical protein 0.0017 0.001 0.004
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0018 0.0254
Schistosoma mansoni intermediate filament proteins 0.0056 0.0285 0.0285
Loa Loa (eye worm) PHD-finger family protein 0.0021 0.0038 0.0132
Echinococcus granulosus importin subunit beta 1 0.003 0.0104 0.0104
Brugia malayi Nuclear hormone receptor family member nhr-49 0.003 0.0104 0.036
Brugia malayi 6-phosphofructokinase 0.011 0.068 0.2353
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0092 0.0552 0.1912
Schistosoma mansoni Tr4/Tr2 (homologue) 0.003 0.0104 0.0104
Echinococcus multilocularis thyroid hormone receptor alpha 0.041 0.2849 0.2849
Loa Loa (eye worm) fibroinase 0.0017 0.0006 0.0022
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0254 0.1724 0.5971
Plasmodium vivax vivapain-2 0.0017 0.0006 0.0117
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.003 0.0104 0.036
Schistosoma mansoni myelin transcription factor 1 myt1 0.0053 0.0269 0.0269
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0017 0.0006 0.0022
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0056 0.0285 0.0988
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0018 0.0254
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0037 0.0153 0.0153
Trichomonas vaginalis PIKK family atypical protein kinase 0.005 0.0245 0.0737
Brugia malayi beta-lactamase family protein 0.0074 0.042 0.1456
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.003 0.0104 0.0296
Schistosoma mansoni hypothetical protein 0.0285 0.1942 0.1942
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0051 0.0251 0.2659
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0351 0.5164
Echinococcus multilocularis GPCR, family 2 0.0079 0.0458 0.0458
Trypanosoma cruzi cysteine peptidase, putative 0.0065 0.0351 0.5164
Mycobacterium tuberculosis Probable lipase LipE 0.0074 0.042 0.1266
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0031 0.0108 0.1571
Loa Loa (eye worm) latrophilin receptor protein 2 0.0079 0.0458 0.1586
Trypanosoma brucei hypothetical protein, conserved 0.0074 0.042 0.6178
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.003 0.0104 0.0104
Trichomonas vaginalis penicillin-binding protein, putative 0.0074 0.042 0.1269
Brugia malayi Cathepsin L-like precursor 0.0017 0.0006 0.0022
Leishmania major importin beta-1 subunit, putative 0.0025 0.0062 0.09
Trichomonas vaginalis PIKK family atypical protein kinase 0.0069 0.0381 0.115
Trichomonas vaginalis PIKK family atypical protein kinase 0.0055 0.0283 0.0854
Schistosoma mansoni steroid hormone receptor ad4bp 0.003 0.0104 0.0104
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0047 0.0223 0.067
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0242 0.1634 0.5659
Trypanosoma cruzi target of rapamycin kinase 3 0.0074 0.0416 0.6113
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0018 0.0254
Onchocerca volvulus 0.0074 0.042 0.1256
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0251 0.1699 0.5883
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0018 0.0254
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0031 0.0108 0.0108
Loa Loa (eye worm) 6-phosphofructokinase 0.011 0.068 0.2353
Mycobacterium tuberculosis Probable reductase 0.0107 0.0658 0.1983
Loa Loa (eye worm) hypothetical protein 0.0074 0.042 0.1456
Echinococcus multilocularis histone acetyltransferase MYST2 0.0053 0.0269 0.0269
Echinococcus multilocularis cysteine protease 0.0017 0.0006 0.0006
Brugia malayi Cathepsin L-like precursor 0.0017 0.0006 0.0022
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0078 0.0444 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0018 0.0254
Leishmania major DNA polymerase eta, putative 0.0019 0.0018 0.0254
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0018 0.0254
Leishmania major cathepsin L-like protease 0.0065 0.0351 0.5164
Schistosoma mansoni ferritin 0.0026 0.0072 0.0072
Trypanosoma cruzi PAB1-binding protein , putative 0.0053 0.0265 0.3886
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0018 0.0254
Echinococcus multilocularis transcription factor Dp 1 0.0038 0.0159 0.0159
Onchocerca volvulus 0.0074 0.042 0.1256
Loa Loa (eye worm) thioredoxin reductase 0.0047 0.0223 0.0772
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.001 0.0027
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0092 0.0552 0.6011
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.003 0.0104 0.0104
Giardia lamblia GTOR 0.0092 0.0552 1
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.0018 0.0052
Plasmodium vivax ataxin-2 like protein, putative 0.0053 0.0265 0.5949
Loa Loa (eye worm) hypothetical protein 0.0074 0.042 0.1456
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.011 0.068 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0006 0.0016
Echinococcus granulosus lamin 0.0056 0.0285 0.0285
Echinococcus multilocularis cathepsin L cysteine protease 0.0017 0.0006 0.0006
Schistosoma mansoni cellular tumor antigen P53 0.0051 0.0254 0.0254
Echinococcus multilocularis zinc finger protein 0.002 0.003 0.003
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0017 0.001 0.0035
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.006 0.0314 0.0314
Mycobacterium tuberculosis Bacterioferritin BfrB 0.0026 0.0072 0.0215
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0018 0.0052
Onchocerca volvulus 0.006 0.0314 0.0935
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0018 0.0064
Schistosoma mansoni ferritin light chain 0.0026 0.0072 0.0072
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0006 0.0016
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0242 0.1634 0.1634
Onchocerca volvulus 0.0047 0.0222 0.0655
Echinococcus granulosus lamin dm0 0.0056 0.0285 0.0285
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0017 0.001 0.004
Brugia malayi Probable ClpP-like protease 0.0078 0.0444 0.1539
Schistosoma mansoni tar DNA-binding protein 0.0254 0.1724 0.1724
Trichomonas vaginalis penicillin-binding protein, putative 0.0074 0.042 0.1269
Echinococcus granulosus dna polymerase eta 0.0019 0.0018 0.0018
Echinococcus granulosus geminin 0.1241 0.8863 0.8863
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.003 0.0104 0.0104
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0062 0.0185
Loa Loa (eye worm) hypothetical protein 0.0056 0.0285 0.0988
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0074 0.0416 0.6113
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0108 0.0323
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0184 0.1218 0.1218
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0351 0.5164
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0017 0.0006 0.0006
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0104 0.1515
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0018 0.0254
Trichomonas vaginalis PIKK family atypical protein kinase 0.0092 0.0552 0.1669
Trichomonas vaginalis PIKK family atypical protein kinase 0.005 0.0245 0.0737
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.003 0.0104 0.036
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0078 0.0444 0.5535
Leishmania major cathepsin L-like protease 0.0065 0.0351 0.5164
Leishmania major cysteine peptidase A (CPA) 0.0017 0.0006 0.0077
Trichomonas vaginalis D-aminoacylase, putative 0.0074 0.042 0.1269
Trichomonas vaginalis PIKK family atypical protein kinase 0.0074 0.0415 0.1254
Entamoeba histolytica deoxycytidyl transferase, putative 0.0019 0.0018 0.0133
Trichomonas vaginalis glucosylceramidase, putative 0.0254 0.1724 0.5219
Brugia malayi Nuclear hormone receptor family member nhr-31 0.003 0.0104 0.036
Trichomonas vaginalis esterase, putative 0.0074 0.042 0.1269
Echinococcus granulosus tar DNA binding protein 0.0254 0.1724 0.1724
Trichomonas vaginalis phosphofructokinase, putative 0.011 0.068 0.2055
Schistosoma mansoni ferritin 0.0026 0.0072 0.0072
Plasmodium falciparum glutathione reductase 0.0047 0.0223 0.5005
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0079 0.0458 0.0458
Echinococcus granulosus cathepsin l1 0.0017 0.0006 0.0006
Plasmodium vivax glutathione reductase, putative 0.0047 0.0223 0.5005
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0242 0.1634 0.1634
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0017 0.001 0.0035
Echinococcus multilocularis ferritin 0.0026 0.0072 0.0072
Trichomonas vaginalis importin beta-1, putative 0.0025 0.0062 0.0185
Mycobacterium tuberculosis Conserved protein 0.0074 0.042 0.1266
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0066 0.036 0.036
Schistosoma mansoni tar DNA-binding protein 0.0254 0.1724 0.1724
Brugia malayi RNA, U transporter 1 0.0087 0.051 0.1767
Echinococcus multilocularis polycomb protein SCMH1 0.0047 0.0222 0.0222
Brugia malayi TAR-binding protein 0.0254 0.1724 0.5971
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0031 0.0105 0.1091
Onchocerca volvulus 0.003 0.0104 0.0296
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0006 0.0016
Brugia malayi phosphofructokinase 0.011 0.068 0.2353
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0051 0.0251 0.0755
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0066 0.036 0.3896
Brugia malayi nuclear receptor NHR-88 0.003 0.0104 0.036
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.003 0.0104 0.0104
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0077 0.0442 0.0442
Echinococcus granulosus GPCR family 2 0.0079 0.0458 0.0458
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0017 0.0006 0.0117
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.003 0.0099 0.1016
Schistosoma mansoni fkbp-rapamycin associated protein 0.0017 0.001 0.001
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0017 0.001 0.001
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0037 0.0153 0.0153
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0078 0.0444 1
Brugia malayi Nuclear hormone receptor family member nhr-1 0.003 0.0104 0.036
Schistosoma mansoni bromodomain containing protein 0.0066 0.0358 0.0358
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0078 0.0444 0.0444
Loa Loa (eye worm) hypothetical protein 0.003 0.0104 0.036
Loa Loa (eye worm) hypothetical protein 0.003 0.0104 0.036
Brugia malayi RNA binding protein 0.0254 0.1724 0.5971
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0031 0.0105 0.0316
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0016 0.0001 0.0004
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.006 0.0314 0.0314
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0242 0.1634 0.1634
Echinococcus multilocularis serine protein kinase ATM 0.0017 0.001 0.001
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.003 0.0099 0.2199
Schistosoma mansoni cathepsin F (C01 family) 0.0017 0.0006 0.0006
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0006 0.0016
Loa Loa (eye worm) hypothetical protein 0.0027 0.0077 0.0268
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.003 0.0104 0.0104
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0018 0.0018
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0017 0.0006 0.0016
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0018 0.0254
Echinococcus multilocularis geminin 0.1241 0.8863 0.8863
Loa Loa (eye worm) hypothetical protein 0.004 0.0171 0.0593
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0027 0.0077 0.1705
Echinococcus multilocularis cysteine protease 0.0017 0.0006 0.0006
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0066 0.036 0.5291
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0031 0.0108 0.1571
Echinococcus granulosus nuclear receptor 2DBD gamma 0.003 0.0104 0.0104
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0184 0.1218 0.1218
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0031 0.0108 0.0108
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0006 0.0016
Trichomonas vaginalis set domain proteins, putative 0.0473 0.3303 1
Loa Loa (eye worm) hypothetical protein 0.0078 0.0444 0.1539
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0027 0.0077 0.0077
Toxoplasma gondii hypothetical protein 0.0027 0.0077 0.1705
Loa Loa (eye worm) glutathione reductase 0.0047 0.0223 0.0772
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0351 0.5164
Brugia malayi Cathepsin L-like precursor 0.0017 0.0006 0.0022
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0242 0.1634 0.1634
Plasmodium falciparum thioredoxin reductase 0.0047 0.0223 0.5005
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0018 0.0254
Trichomonas vaginalis PIKK family atypical protein kinase 0.005 0.0245 0.0737
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0018 0.0254
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0006 0.0016
Schistosoma mansoni hypothetical protein 0.0079 0.0458 0.0458
Trichomonas vaginalis PIKK family atypical protein kinase 0.0069 0.0381 0.115
Loa Loa (eye worm) hypothetical protein 0.0044 0.0203 0.0704
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0018 0.0064
Trichomonas vaginalis PIKK family atypical protein kinase 0.0074 0.0415 0.1254
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0018 0.0254
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0006 0.0016
Loa Loa (eye worm) hypothetical protein 0.0017 0.0006 0.0022
Schistosoma mansoni zinc finger protein 0.002 0.003 0.003
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0078 0.0444 0.6532
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0031 0.0105 0.0316
Echinococcus granulosus nuclear receptor 2DBD gamma 0.003 0.0104 0.0104
Mycobacterium tuberculosis Probable bacterioferritin BfrA 0.0026 0.0072 0.0215
Plasmodium falciparum importin beta, putative 0.003 0.0104 0.2319
Schistosoma mansoni nuclear hormone receptor 0.003 0.0104 0.0104
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.003 0.0104 0.0104
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0242 0.1634 0.1634
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0062 0.0185
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.003 0.0104 0.0104
Schistosoma mansoni hypothetical protein 0.0325 0.2236 0.2236
Loa Loa (eye worm) hypothetical protein 0.0026 0.007 0.0243
Loa Loa (eye worm) inositol-1 0.0031 0.0105 0.0365
Loa Loa (eye worm) hypothetical protein 0.0051 0.0254 0.088
Trichomonas vaginalis phosphofructokinase, putative 0.011 0.068 0.2055
Trichomonas vaginalis PIKK family atypical protein kinase 0.0092 0.0552 0.1669
Toxoplasma gondii phosphofructokinase PFKII 0.003 0.0099 0.2199
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.003 0.0104 0.0104
Brugia malayi Steroid receptor seven-up type 2 0.003 0.0104 0.036
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0024 0.0055 0.0055
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0066 0.036 0.036
Echinococcus multilocularis thioredoxin glutathione reductase 0.0047 0.0223 0.0223
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0017 0.001 0.013
Echinococcus multilocularis tumor protein p63 0.035 0.2416 0.2416
Loa Loa (eye worm) bromodomain containing protein 0.0018 0.0016 0.0055
Onchocerca volvulus Bile acid receptor homolog 0.003 0.0104 0.0296
Brugia malayi Cathepsin L-like precursor 0.0017 0.0006 0.0022
Wolbachia endosymbiont of Brugia malayi bacterioferritin/cytochrome b1 0.0026 0.0072 0.1609
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0092 0.0552 0.8122
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0063 0.0187
Loa Loa (eye worm) phosphatidylinositol 3 0.0031 0.0108 0.0373
Loa Loa (eye worm) hypothetical protein 0.003 0.0104 0.036
Leishmania major DNA polymerase kappa, putative 0.0019 0.0018 0.0254
Plasmodium vivax 6-phosphofructokinase, putative 0.003 0.0099 0.2199
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0031 0.0105 0.1537
Echinococcus granulosus snurportin 1 0.0325 0.2236 0.2236
Loa Loa (eye worm) hypothetical protein 0.0074 0.042 0.1456
Schistosoma mansoni cathepsin F (C01 family) 0.0017 0.0006 0.0006
Echinococcus granulosus methyl CpG binding domain protein 2 0.0018 0.0011 0.0011
Brugia malayi beta-lactamase family protein 0.0074 0.042 0.1456
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.006 0.0314 0.0314
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0066 0.036 0.1247
Brugia malayi Nuclear hormone receptor family member nhr-40 0.003 0.0104 0.036
Plasmodium vivax importin-beta 2, putative 0.003 0.0104 0.2319
Brugia malayi Intermediate filament tail domain containing protein 0.0056 0.0285 0.0988
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0078 0.0444 0.0444
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.003 0.0104 0.0104
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0006 0.0016
Schistosoma mansoni ferritin light chain 0.0026 0.0072 0.0072
Echinococcus granulosus FTZ F1 alpha 0.003 0.0104 0.0104
Trichomonas vaginalis glucosylceramidase, putative 0.0176 0.1156 0.3499
Onchocerca volvulus 0.0056 0.0285 0.0846
Brugia malayi Cathepsin L-like precursor 0.0017 0.0006 0.0022
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.003 0.0099 0.1436
Plasmodium falciparum ataxin-2 like protein, putative 0.0053 0.0265 0.5949
Toxoplasma gondii phosphofructokinase domain-containing protein 0.003 0.0099 0.2199
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0074 0.042 0.042
Trichomonas vaginalis D-aminoacylase, putative 0.0074 0.042 0.1269
Schistosoma mansoni peptidase Clp (S14 family) 0.0078 0.0444 0.0444
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0077 0.0442 0.0442
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0017 0.001 0.013
Loa Loa (eye worm) hypothetical protein 0.003 0.0104 0.036
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.003 0.0104 0.036
Echinococcus multilocularis SAM and MBT domain containing protein 0.0047 0.0222 0.0222
Echinococcus granulosus histone lysine methyltransferase setb 0.0077 0.0442 0.0442
Brugia malayi latrophilin 2 splice variant baaae 0.0172 0.1124 0.3894
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0092 0.0552 0.8122
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0092 0.0552 0.8122
Trichomonas vaginalis glucosylceramidase, putative 0.0254 0.1724 0.5219
Trichomonas vaginalis glucosylceramidase, putative 0.0254 0.1724 0.5219
Trichomonas vaginalis PIKK family atypical protein kinase 0.0069 0.0381 0.115
Entamoeba histolytica phosphofructokinase, putative 0.011 0.068 0.7414
Brugia malayi hypothetical protein 0.0143 0.0914 0.3166
Onchocerca volvulus 0.0051 0.0254 0.0752
Toxoplasma gondii thioredoxin reductase 0.0047 0.0223 0.5005
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0062 0.0331 0.0331
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0062 0.0331 0.0331
Loa Loa (eye worm) TAR-binding protein 0.0254 0.1724 0.5971
Echinococcus multilocularis lamin dm0 0.0056 0.0285 0.0285
Trichomonas vaginalis PIKK family atypical protein kinase 0.005 0.0244 0.0736
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0107 0.0658 0.1983
Echinococcus granulosus cathepsin l cysteine peptidase 0.0017 0.0006 0.0006
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0018 0.0254
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0092 0.0552 0.8122
Loa Loa (eye worm) transcription factor SMAD2 0.0119 0.0745 0.2582
Loa Loa (eye worm) 6-phosphofructokinase 0.011 0.068 0.2353
Brugia malayi hypothetical protein 0.0053 0.0265 0.0917
Toxoplasma gondii 6-phosphofructokinase 0.003 0.0099 0.2199
Trypanosoma cruzi DNA polymerase eta, putative 0.0019 0.0018 0.0254
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0099 0.0295
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.006 0.0314 0.707
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0351 0.5164
Brugia malayi Latrophilin receptor protein 2 0.0079 0.0458 0.1586
Brugia malayi Importin beta-1 subunit 0.003 0.0104 0.036
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0074 0.042 0.1266
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0031 0.0108 0.1571
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0074 0.042 0.042
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0018 0.0254
Loa Loa (eye worm) hypothetical protein 0.0019 0.002 0.0069
Schistosoma mansoni tar DNA-binding protein 0.0254 0.1724 0.1724
Loa Loa (eye worm) hypothetical protein 0.0053 0.0265 0.0917
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0018 0.0018
Trichomonas vaginalis inositol monophosphatase, putative 0.0031 0.0105 0.0316
Toxoplasma gondii LsmAD domain-containing protein 0.0053 0.0265 0.5949
Trichomonas vaginalis PIKK family atypical protein kinase 0.0092 0.0552 0.1669
Onchocerca volvulus 0.0074 0.042 0.1256
Echinococcus granulosus beta LACTamase domain containing family member 0.0074 0.042 0.042
Brugia malayi ecdysteroid receptor 0.003 0.0104 0.036
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0092 0.0552 0.8122
Brugia malayi Nuclear hormone receptor family member nhr-25 0.003 0.0104 0.036
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0143 0.0914 0.0914
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.003 0.0104 0.0104
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0057 0.0299 0.0299
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0242 0.1634 0.1634
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0006 0.0016
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0078 0.0444 1
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0018 0.0064
Mycobacterium tuberculosis Probable dehydrogenase 0.0107 0.0658 0.1983
Trichomonas vaginalis phosphofructokinase, putative 0.011 0.068 0.2055
Schistosoma mansoni hypothetical protein 0.0021 0.0038 0.0038
Mycobacterium ulcerans lipase LipD 0.0074 0.042 0.6178
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0018 0.0052
Mycobacterium tuberculosis Probable hydrolase 0.0074 0.042 0.1266
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.011 0.068 0.2048
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0017 0.0006 0.0016
Toxoplasma gondii cathepsin CPL 0.0017 0.0006 0.0117
Trichomonas vaginalis PIKK family atypical protein kinase 0.006 0.0318 0.0958
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0104 0.1515
Loa Loa (eye worm) MH2 domain-containing protein 0.0119 0.0745 0.2582
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0006 0.0016
Trypanosoma cruzi hypothetical protein, conserved 0.0074 0.042 0.6178
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.003 0.0104 0.036
Schistosoma mansoni importin beta-1 0.003 0.0104 0.0104
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0016 0.0001 0.0001
Loa Loa (eye worm) ctsf protein 0.0017 0.0006 0.0022
Brugia malayi intermediate filament protein 0.0056 0.0285 0.0988
Loa Loa (eye worm) beta-lactamase 0.0074 0.042 0.1456
Plasmodium vivax SET domain protein, putative 0.006 0.0314 0.707
Echinococcus granulosus fetal alzheimer antigen falz 0.0023 0.0053 0.0053
Echinococcus granulosus thioredoxin glutathione reductase 0.0047 0.0223 0.0223
Schistosoma mansoni hypothetical protein 0.0172 0.1124 0.1124
Brugia malayi hypothetical protein 0.0034 0.013 0.0449
Brugia malayi Inositol-1 0.0031 0.0105 0.0365
Loa Loa (eye worm) hypothetical protein 0.0026 0.007 0.0243
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0415 0.2888 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0006 0.0016
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0107 0.0658 0.1983
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0325 0.2236 0.7744
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0017 0.0006 0.0022
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0027 0.0077 0.1114
Trichomonas vaginalis PIKK family atypical protein kinase 0.0074 0.0415 0.1254
Trichomonas vaginalis glucosylceramidase, putative 0.0167 0.1091 0.3302
Schistosoma mansoni inositol monophosphatase 0.0031 0.0105 0.0105
Schistosoma mansoni lamin 0.0056 0.0285 0.0285
Echinococcus granulosus ferritin 0.0026 0.0072 0.0072
Schistosoma mansoni sex comb on midleg homolog 0.0047 0.0222 0.0222
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0027 0.0082 0.0245
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0024 0.0055 0.0055
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0108 0.0323
Mycobacterium leprae Probable lipase LipE 0.0074 0.042 0.5178
Echinococcus multilocularis inositol monophosphatase 1 0.0031 0.0105 0.0105
Loa Loa (eye worm) cysteine protease 0.0017 0.0006 0.0022
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0031 0.0105 0.1537
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0027 0.0077 0.0077
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.001 0.0027
Echinococcus granulosus dna polymerase kappa 0.0019 0.0018 0.0018
Trichomonas vaginalis PIKK family atypical protein kinase 0.0055 0.0279 0.0842
Loa Loa (eye worm) hypothetical protein 0.0172 0.1124 0.3894
Loa Loa (eye worm) hypothetical protein 0.0042 0.0189 0.0654
Brugia malayi Calcitonin receptor-like protein seb-1 0.0251 0.1699 0.5883
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0006 0.0016
Trypanosoma brucei DNA polymerase eta, putative 0.0019 0.0018 0.0254
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.038 0.2629 0.2629
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0047 0.0222 0.0222
Entamoeba histolytica hypothetical protein 0.0143 0.0914 1
Echinococcus granulosus serine protein kinase ATM 0.0017 0.001 0.001
Brugia malayi mbt repeat family protein 0.0047 0.0222 0.077
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0027 0.0077 0.0064
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.003 0.0104 0.036
Trypanosoma cruzi trypanothione reductase, putative 0.0047 0.0223 0.3269
Loa Loa (eye worm) hypothetical protein 0.0019 0.0024 0.0085
Schistosoma mansoni apoferritin-2 0.0026 0.0072 0.0072
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0031 0.0105 0.2353
Brugia malayi photoreceptor-specific nuclear receptor 0.003 0.0104 0.036
Brugia malayi Nuclear hormone receptor family member nhr-25 0.003 0.0104 0.036
Schistosoma mansoni microtubule-associated protein tau 0.1399 1 1
Echinococcus granulosus retinoic acid receptor rxr beta a 0.003 0.0104 0.0104
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0074 0.042 0.1456
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0119 0.0744 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0006 0.0016
Entamoeba histolytica hypothetical protein 0.0025 0.0062 0.0616
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0107 0.0658 0.1983
Echinococcus multilocularis peptidase Clp (S14 family) 0.0051 0.0251 0.0251
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0108 0.0323
Trichomonas vaginalis PIKK family atypical protein kinase 0.0055 0.0283 0.0854
Loa Loa (eye worm) mbt repeat family protein 0.0047 0.0222 0.077
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.003 0.0099 0.2199
Brugia malayi mbt repeat family protein 0.0047 0.0222 0.077
Trichomonas vaginalis glucosylceramidase, putative 0.0254 0.1724 0.5219
Loa Loa (eye worm) hypothetical protein 0.0019 0.0018 0.0064
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0074 0.042 0.1456
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0254 0.1724 0.5971
Loa Loa (eye worm) hypothetical protein 0.0074 0.042 0.1456
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0053 0.0269 0.0269
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.003 0.0104 0.036
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0019 0.0024 0.0525
Onchocerca volvulus Protein ultraspiracle homolog 0.003 0.0104 0.0296
Schistosoma mansoni coup transcription factor 0.003 0.0104 0.0104
Loa Loa (eye worm) hypothetical protein 0.0074 0.042 0.1456
Schistosoma mansoni hypothetical protein 0.0079 0.0458 0.0458
Echinococcus multilocularis 6 phosphofructokinase 0.011 0.068 0.068
Trichomonas vaginalis PIKK family atypical protein kinase 0.0069 0.0381 0.115
Brugia malayi Bromodomain containing protein 0.004 0.0171 0.0591
Brugia malayi steroid hormone receptor 0.003 0.0104 0.036
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0006 0.0016
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0074 0.042 0.1266
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0018 0.0254
Brugia malayi PHD-finger family protein 0.0026 0.007 0.0243
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0178 0.117 0.3531
Trichomonas vaginalis PIKK family atypical protein kinase 0.005 0.0244 0.0736
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0119 0.0744 0.2244
Echinococcus multilocularis ecdysone induced protein 78C 0.003 0.0104 0.0104
Trichomonas vaginalis glucosylceramidase, putative 0.0167 0.1091 0.3302
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.003 0.0104 0.0104
Onchocerca volvulus 0.0056 0.0285 0.0846
Loa Loa (eye worm) hypothetical protein 0.003 0.0104 0.036
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0047 0.0222 0.0655
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0006 0.0016
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0031 0.0108 0.1571
Echinococcus granulosus zinc finger protein 0.002 0.003 0.003
Trichomonas vaginalis glucosylceramidase, putative 0.0254 0.1724 0.5219
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0006 0.0016
Brugia malayi Bromodomain containing protein 0.0078 0.0446 0.1543
Schistosoma mansoni hypothetical protein 0.038 0.2629 0.2629
Toxoplasma gondii FATC domain-containing protein 0.0017 0.001 0.0199
Brugia malayi Nuclear hormone receptor-like 1 0.003 0.0104 0.036
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0018 0.0254
Schistosoma mansoni retinoic acid receptor RXR 0.003 0.0104 0.0104
Mycobacterium ulcerans 6-phosphofructokinase 0.011 0.068 1
Giardia lamblia DINP protein human, muc B family 0.0019 0.0018 0.0313
Toxoplasma gondii target of rapamycin (TOR), putative 0.0069 0.0381 0.8568
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0079 0.0458 0.0458
Trichomonas vaginalis glucosylceramidase, putative 0.0167 0.1091 0.3302
Schistosoma mansoni thyroid hormone receptor 0.041 0.2849 0.2849
Echinococcus granulosus tumor protein p63 0.035 0.2416 0.2416
Schistosoma mansoni ferritin 0.0026 0.0072 0.0072
Mycobacterium tuberculosis Conserved protein 0.0074 0.042 0.1266
Echinococcus granulosus SAM and MBT domain containing protein 0.0047 0.0222 0.0222
Loa Loa (eye worm) hypothetical protein 0.003 0.0104 0.036
Plasmodium vivax 6-phosphofructokinase, putative 0.003 0.0099 0.2199
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0079 0.0458 0.0458
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0006 0.0016
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0066 0.036 0.5291
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0017 0.001 0.013
Trypanosoma cruzi importin beta-1 subunit, putative 0.0025 0.0062 0.09
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0351 0.5164
Plasmodium vivax thioredoxin reductase, putative 0.0047 0.0223 0.5005
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0023 0.0053 0.0053
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0027 0.0082 0.0145
Trypanosoma cruzi PAB1-binding protein , putative 0.0053 0.0265 0.3886
Loa Loa (eye worm) hypothetical protein 0.0073 0.0414 0.1432
Loa Loa (eye worm) hypothetical protein 0.0017 0.001 0.0035
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0006 0.0016
Brugia malayi glutathione reductase 0.0047 0.0223 0.0772
Loa Loa (eye worm) hypothetical protein 0.0055 0.0278 0.0963
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0017 0.001 0.001
Mycobacterium tuberculosis Probable oxidoreductase 0.0119 0.0744 0.2244
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0031 0.0105 0.1537
Plasmodium falciparum cysteine proteinase falcipain 3 0.0017 0.0006 0.0117
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0066 0.036 0.036
Schistosoma mansoni DNA polymerase eta 0.0019 0.0018 0.0018
Echinococcus granulosus intermediate filament protein 0.0056 0.0285 0.0285
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0099 0.0295
Schistosoma mansoni 6-phosphofructokinase 0.011 0.068 0.068
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0031 0.0108 0.0373
Mycobacterium ulcerans beta-lactamase 0.0074 0.042 0.6178
Echinococcus multilocularis importin subunit beta 1 0.003 0.0104 0.0104
Trichomonas vaginalis PIKK family atypical protein kinase 0.0079 0.0454 0.1373
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0143 0.0914 0.0914
Trichomonas vaginalis D-aminoacylase, putative 0.0074 0.042 0.1269
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0006 0.0016
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0038 0.0161 0.236
Echinococcus multilocularis expressed protein 0.0026 0.0072 0.0072
Entamoeba histolytica hypothetical protein 0.0143 0.0914 1
Brugia malayi Pre-SET motif family protein 0.006 0.0314 0.1089
Brugia malayi N-terminal motif family protein 0.0178 0.117 0.4053
Leishmania major hypothetical protein, conserved 0.0053 0.0265 0.3886
Trichomonas vaginalis 6-phosphofructokinase, putative 0.003 0.0099 0.0295
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0053 0.0269 0.0932
Schistosoma mansoni sex comb on midleg homolog 0.0047 0.0222 0.0222
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0018 0.0018
Loa Loa (eye worm) phosphatidylinositol 3 0.0092 0.0552 0.1912
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0024 0.0071
Echinococcus granulosus inositol monophosphatase 1 0.0031 0.0105 0.0105
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0053 0.0269 0.0269
Loa Loa (eye worm) steroid hormone receptor 0.003 0.0104 0.036
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0351 0.5164
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0018 0.0254
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.003 0.0104 0.036
Entamoeba histolytica hypothetical protein 0.0143 0.0914 1
Trypanosoma cruzi cruzipain precursor, putative 0.0065 0.0351 0.5164
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.001 0.0027
Leishmania major cathepsin L-like protease 0.0065 0.0351 0.5164
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.011 0.068 1
Trichomonas vaginalis glucosylceramidase, putative 0.0176 0.1156 0.3499
Loa Loa (eye worm) RNA binding protein 0.0254 0.1724 0.5971
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0044 0.02 0.2927
Schistosoma mansoni RAR-like nuclear receptor 0.003 0.0104 0.0104
Leishmania major phosphatidylinositol 3-kinase, putative 0.0031 0.0108 0.1571
Trypanosoma cruzi hypothetical protein, conserved 0.0074 0.042 0.6178
Brugia malayi MH2 domain containing protein 0.0119 0.0745 0.2582
Trichomonas vaginalis PIKK family atypical protein kinase 0.0055 0.0283 0.0854
Trypanosoma brucei unspecified product 0.0019 0.0018 0.0254
Mycobacterium leprae conserved hypothetical protein 0.0074 0.042 0.5178
Leishmania major cathepsin L-like protease 0.0017 0.0006 0.0077
Schistosoma mansoni hypothetical protein 0.0143 0.0914 0.0914
Trypanosoma cruzi major cysteine proteinase, putative 0.0051 0.0251 0.3688
Schistosoma mansoni hypothetical protein 0.0079 0.0458 0.0458
Schistosoma mansoni hypothetical protein 0.0024 0.0055 0.0055
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0108 0.0323
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0018 0.0018
Brugia malayi beta-lactamase 0.0074 0.042 0.1456
Loa Loa (eye worm) hypothetical protein 0.0074 0.042 0.1456
Schistosoma mansoni apoferritin-2 0.0026 0.0072 0.0072
Onchocerca volvulus Glucosylceramidase homolog 0.0167 0.1091 0.3291
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0027 0.0077 0.1705
Trichomonas vaginalis PIKK family atypical protein kinase 0.005 0.0244 0.0736
Brugia malayi Cathepsin L-like precursor 0.0017 0.0006 0.0022
Trichomonas vaginalis glucosylceramidase, putative 0.0254 0.1724 0.5219
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0017 0.001 0.001
Trypanosoma cruzi cysteine peptidase, putative 0.0017 0.0006 0.0077
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0018 0.0254
Mycobacterium tuberculosis Probable esterase LipL 0.0074 0.042 0.1266
Loa Loa (eye worm) hypothetical protein 0.0251 0.1699 0.5883
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0107 0.0658 0.8714
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0351 0.5164
Brugia malayi Nuclear hormone receptor family member nhr-14 0.003 0.0104 0.036
Mycobacterium tuberculosis Conserved protein 0.0074 0.042 0.1266
Leishmania major trypanothione reductase 0.0047 0.0223 0.3269
Echinococcus granulosus ecdysone induced protein 78C 0.003 0.0104 0.0104
Entamoeba histolytica phosphofructokinase, putative 0.011 0.068 0.7414
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.003 0.0099 0.2199
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.038 0.2629 0.2629
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0092 0.0552 0.8122
Schistosoma mansoni methyl-cpg binding protein mbd 0.0018 0.0011 0.0011
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0017 0.0006 0.0006
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0074 0.0416 0.6113
Loa Loa (eye worm) hypothetical protein 0.003 0.0104 0.036
Trichomonas vaginalis PIKK family atypical protein kinase 0.0062 0.0332 0.1002
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0031 0.0105 0.1537
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0119 0.0744 0.2244
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0351 0.5164
Schistosoma mansoni methyl-cpg binding protein mbd 0.0018 0.0011 0.0011
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0018 0.0011 0.0011
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0474 0.3313 1
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0099 0.0295
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0017 0.0006 0.0117
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0074 0.042 0.1266
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0079 0.0458 0.1586
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0251 0.1699 0.5883
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0059 0.0311 0.4565
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0078 0.0444 0.6532
Plasmodium vivax hypothetical protein, conserved 0.0074 0.042 0.9459
Loa Loa (eye worm) MBCTL1 0.0053 0.0269 0.0932
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0016 0.0001 0.0001
Echinococcus multilocularis musashi 0.0056 0.0285 0.0285
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0092 0.0552 0.0552
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0016 0.0001 0.0001
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0066 0.036 0.5291
Schistosoma mansoni lamin 0.0056 0.0285 0.0285
Echinococcus granulosus 6 phosphofructokinase 0.011 0.068 0.068
Echinococcus multilocularis microtubule associated protein 2 0.1399 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0074 0.0415 0.1254
Trypanosoma brucei PAB1-binding protein , putative 0.0053 0.0265 0.3886
Schistosoma mansoni ferritin 0.0026 0.0072 0.0072
Trichomonas vaginalis PIKK family atypical protein kinase 0.0069 0.0381 0.115
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0031 0.0108 0.1571
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0018 0.0018
Plasmodium falciparum ataxin-2 like protein, putative 0.0053 0.0265 0.5949
Trichomonas vaginalis PIKK family atypical protein kinase 0.0069 0.0381 0.115
Leishmania major ATP-dependent phosphofructokinase 0.011 0.068 1
Echinococcus multilocularis cathepsin L cysteine protease 0.0017 0.0006 0.0006
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0107 0.0658 0.1983
Brugia malayi Nuclear hormone receptor family member nhr-3 0.003 0.0104 0.036
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.003 0.0104 0.036
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0254 0.1724 0.5971
Loa Loa (eye worm) intermediate filament protein 0.0056 0.0285 0.0988
Leishmania major cathepsin L-like protease 0.0017 0.0006 0.0077
Leishmania major cathepsin L-like protease 0.0017 0.0006 0.0077
Trichomonas vaginalis PIKK family atypical protein kinase 0.0069 0.0381 0.115
Trichomonas vaginalis PIKK family atypical protein kinase 0.005 0.0245 0.0737
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.011 0.068 1
Echinococcus multilocularis dna polymerase eta 0.0019 0.0018 0.0018
Brugia malayi Nuclear hormone receptor family member nhr-19 0.003 0.0104 0.036
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0092 0.0552 0.0552
Echinococcus granulosus cathepsin L cysteine proteinase 0.0017 0.0006 0.0006
Echinococcus granulosus polycomb protein SCMH1 0.0047 0.0222 0.0222
Trichomonas vaginalis glucosylceramidase, putative 0.0167 0.1091 0.3302
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0108 0.0323
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0351 0.5164
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0074 0.042 0.6178
Trichomonas vaginalis PIKK family atypical protein kinase 0.0074 0.0415 0.1254
Brugia malayi RNA recognition motif domain containing protein 0.0254 0.1724 0.5971
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0031 0.0105 0.1537
Trypanosoma cruzi cysteine peptidase, putative 0.0065 0.0351 0.5164
Toxoplasma gondii HEAT repeat-containing protein 0.003 0.0104 0.2319
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.003 0.0099 0.2199
Echinococcus granulosus expressed protein 0.0026 0.0072 0.0072
Loa Loa (eye worm) phosphofructokinase 0.011 0.068 0.2353
Leishmania major cathepsin L-like protease 0.0017 0.0006 0.0077
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0077 0.0442 0.0442
Schistosoma mansoni tar DNA-binding protein 0.0254 0.1724 0.1724
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.003 0.0104 0.036
Mycobacterium ulcerans bacterioferritin BfrA 0.0026 0.0072 0.1051
Echinococcus multilocularis lamin 0.0056 0.0285 0.0285
Loa Loa (eye worm) hypothetical protein 0.0077 0.0442 0.1532
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0031 0.0108 0.0108
Schistosoma mansoni inositol monophosphatase 0.0031 0.0105 0.0105
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.0018 0.0052
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.011 0.068 0.9038
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.003 0.0104 0.0104
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0078 0.0444 1
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0099 0.0295
Schistosoma mansoni hypothetical protein 0.1241 0.8863 0.8863
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0078 0.0444 1
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.003 0.0104 0.0104
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0051 0.0251 0.0755
Trichomonas vaginalis ferritin, putative 0.0026 0.0072 0.0216
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0031 0.0105 0.2353
Mycobacterium ulcerans hypothetical protein 0.0074 0.042 0.6178
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0018 0.0254
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0092 0.0552 0.0552
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0006 0.0016
Schistosoma mansoni transcription factor LCR-F1 0.0143 0.0914 0.0914
Entamoeba histolytica hypothetical protein 0.0143 0.0914 1
Trypanosoma cruzi cysteine peptidase, putative 0.0065 0.0351 0.5164
Loa Loa (eye worm) hypothetical protein 0.0178 0.117 0.4053
Brugia malayi 6-phosphofructokinase 0.011 0.068 0.2353
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0006 0.0016
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0099 0.0295
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0006 0.0016
Brugia malayi cytoplasmic intermediate filament protein 0.003 0.0099 0.0342
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0078 0.0444 1
Entamoeba histolytica protein kinase rad3, putative 0.0017 0.001 0.004
Echinococcus multilocularis snurportin 1 0.0325 0.2236 0.2236
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.003 0.0099 0.1768
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0078 0.0444 0.6532
Echinococcus multilocularis FTZ F1 alpha 0.003 0.0104 0.0104
Trichomonas vaginalis glucosylceramidase, putative 0.0167 0.1091 0.3302
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0078 0.0444 1
Brugia malayi Papain family cysteine protease containing protein 0.0017 0.0006 0.0022
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.003 0.0099 0.0342
Brugia malayi Pre-SET motif family protein 0.0415 0.2888 1
Schistosoma mansoni thyroid hormone receptor 0.041 0.2849 0.2849
Mycobacterium ulcerans esterase/lipase LipP 0.0074 0.042 0.6178
Mycobacterium tuberculosis Probable lipase LipD 0.0074 0.042 0.1266
Trichomonas vaginalis glucosylceramidase, putative 0.0167 0.1091 0.3302
Schistosoma mansoni hypothetical protein 0.1241 0.8863 0.8863
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0242 0.1634 0.1634

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 22.2 uM Antitrypanosomal activity against epimastigotes of Trypanosoma cruzi Y after 96 hrs by Neubauer haemocytometer ChEMBL. 18504061

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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