Detailed information for compound 989175

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 405.442 | Formula: C21H27NO7
  • H donors: 1 H acceptors: 5 LogP: 4 Rotable bonds: 11
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCCC(C(=O)OCC1(CO)OC(=O)/C(=C\c2ccc(cc2)[N+](=O)[O-])/C1)CC
  • InChi: 1S/C21H27NO7/c1-3-5-6-16(4-2)19(24)28-14-21(13-23)12-17(20(25)29-21)11-15-7-9-18(10-8-15)22(26)27/h7-11,16,23H,3-6,12-14H2,1-2H3/b17-11-
  • InChiKey: AQWODVHYXIDBMB-BOPFTXTBSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Mus musculus protein kinase C, alpha Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) AGC/PKC/ALPHA protein kinase Get druggable targets OG5_129482 All targets in OG5_129482
Schistosoma japonicum Protein kinase C alpha type, putative Get druggable targets OG5_129482 All targets in OG5_129482
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_129482 All targets in OG5_129482
Candida albicans protein kinase C similar to S. cerevisiae PKC1 (YBL105C) Get druggable targets OG5_129482 All targets in OG5_129482
Echinococcus multilocularis telomerase reverse transcriptase subunit Get druggable targets OG5_129482 All targets in OG5_129482
Echinococcus multilocularis RNA directed DNA polymerase Get druggable targets OG5_129482 All targets in OG5_129482
Candida albicans protein kinase C similar to S. cerevisiae PKC1 (YBL105C) Get druggable targets OG5_129482 All targets in OG5_129482
Echinococcus granulosus protein kinase C gamma type Get druggable targets OG5_129482 All targets in OG5_129482
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_129482 All targets in OG5_129482
Echinococcus granulosus Protein kinase C brain isozyme Get druggable targets OG5_129482 All targets in OG5_129482
Schistosoma japonicum Protein kinase C alpha type, putative Get druggable targets OG5_129482 All targets in OG5_129482
Schistosoma japonicum IPR000477,RNA-directed DNA polymerase (Reverse transcriptase),domain-containing Get druggable targets OG5_129482 All targets in OG5_129482
Echinococcus granulosus RNA directed DNA polymerase Get druggable targets OG5_129482 All targets in OG5_129482
Brugia malayi Protein kinase c protein 2 Get druggable targets OG5_129482 All targets in OG5_129482
Schistosoma japonicum Protein kinase C gamma type, putative Get druggable targets OG5_129482 All targets in OG5_129482
Echinococcus multilocularis serine threonine protein kinase Get druggable targets OG5_129482 All targets in OG5_129482
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_129482 All targets in OG5_129482
Schistosoma japonicum Calcium-dependent protein kinase C, putative Get druggable targets OG5_129482 All targets in OG5_129482
Echinococcus multilocularis Protein kinase C, brain isozyme Get druggable targets OG5_129482 All targets in OG5_129482
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_129482 All targets in OG5_129482
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus Coagulation factor 5 8 type C terminal 0.0042 0.0019 0.0019
Trypanosoma cruzi Silent information regulator 2 related protein 1 0.0333 0.0475 1
Trypanosoma brucei serine peptidase, clan SB, family S8-like protein 0.0307 0.0434 0.9085
Echinococcus granulosus serine:threonine protein kinase N2 0.007 0.0064 0.0064
Mycobacterium tuberculosis Probable multifunctional mycocerosic acid synthase membrane-associated Mas 0.0055 0.004 0.0965
Brugia malayi Doublecortin family protein 0.0082 0.0083 0.0076
Toxoplasma gondii histone lysine-specific demethylase 0.0084 0.0086 0.1707
Schistosoma mansoni c4b-binding protein beta chain 0.0035 0.0008 0.0008
Echinococcus multilocularis protein kinase c epsilon type 0.0105 0.0118 0.0147
Echinococcus multilocularis Estrogen regulated protein EP45 0.0042 0.0019 0.0023
Echinococcus multilocularis chromatin regulatory protein sir2 0.0333 0.0475 0.0593
Echinococcus multilocularis integrin beta 2 0.3145 0.4877 0.6096
Schistosoma mansoni hypothetical protein 0.1277 0.1952 0.1952
Loa Loa (eye worm) hypothetical protein 0.0114 0.0132 0.0126
Loa Loa (eye worm) sirtuin 4 0.0049 0.003 0.0024
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.3923 0.6094 1
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0019 0.0031
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0049 0.003 0.005
Schistosoma mansoni matrix metallopeptidase-9 (M10 family) 0.0034 0.0006 0.0006
Brugia malayi Pepsin A precursor 0.0034 0.0007 0.0001
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0282 0.0395 0.0648
Brugia malayi Protein kinase domain containing protein 0.0067 0.0059 0.0052
Schistosoma mansoni growth factor receptor-bound protein 0.0126 0.0151 0.0151
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.3923 0.6094 1
Giardia lamblia High cysteine protein 0.0125 0.015 0.0387
Plasmodium falciparum transcriptional regulatory protein sir2a 0.0049 0.003 0.0547
Toxoplasma gondii F5/8 type C domain-containing protein 0.0042 0.0019 0.0372
Plasmodium vivax hypothetical protein, conserved 0.0084 0.0086 0.1542
Trichomonas vaginalis Clan AA, family A1, cathepsin D-like aspartic peptidase 0.0034 0.0007 0.0012
Echinococcus granulosus lysine specific histone demethylase 1A 0.0084 0.0086 0.0086
Brugia malayi hypothetical protein 0.0117 0.0137 0.0131
Trichomonas vaginalis conserved hypothetical protein 0.1277 0.1952 0.3204
Plasmodium vivax apical sushi protein, putative 0.0035 0.0008 0.0137
Mycobacterium tuberculosis Probable polyketide synthase Pks7 0.0055 0.004 0.0965
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.6417 1 1
Onchocerca volvulus 0.0035 0.0008 0.0018
Schistosoma mansoni lipoxygenase 0.0493 0.0725 0.0725
Onchocerca volvulus 0.0042 0.0019 0.0189
Echinococcus multilocularis NAD dependent deacetylase sirtuin 6 0.0049 0.003 0.0038
Plasmodium falciparum plasmepsin VIII, putative 0.0034 0.0007 0.0126
Loa Loa (eye worm) hypothetical protein 0.0053 0.0037 0.0031
Brugia malayi ADAM-TS Spacer 1 family protein 0.0052 0.0036 0.0029
Brugia malayi SWIRM domain containing protein 0.0035 0.0009 0.0002
Loa Loa (eye worm) hypothetical protein 0.0718 0.1077 0.1071
Mycobacterium ulcerans Type I modular polyketide synthase 0.0052 0.0035 0.0745
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.0036 0.001 0.0004
Loa Loa (eye worm) hypothetical protein 0.0036 0.001 0.0004
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0019 0.0031
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0282 0.0395 0.0648
Echinococcus granulosus epidermal growth factor receptor 0.0398 0.0576 0.0576
Schistosoma mansoni chromatin regulatory protein sir2 0.0333 0.0475 0.0475
Brugia malayi Furin-like cysteine rich region family protein 0.0398 0.0576 0.057
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.1559 0.2394 0.3928
Schistosoma mansoni chromatin regulatory protein sir2 0.0049 0.003 0.003
Onchocerca volvulus 0.0082 0.0083 0.1165
Loa Loa (eye worm) hypothetical protein 0.0042 0.0019 0.0012
Trichomonas vaginalis conserved hypothetical protein 0.1277 0.1952 0.3204
Schistosoma mansoni protein kinase 0.0127 0.0152 0.0152
Loa Loa (eye worm) hypothetical protein 0.0035 0.0009 0.0002
Echinococcus multilocularis serine protease inhibitor 0.0042 0.0019 0.0023
Echinococcus multilocularis Estrogen regulated protein EP45 0.0042 0.0019 0.0023
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0041 0.0018 0.0315
Mycobacterium ulcerans polyketide synthase 0.0052 0.0035 0.0745
Brugia malayi Reprolysin 0.0053 0.0036 0.0029
Mycobacterium ulcerans oxidoreductase 0.0084 0.0086 0.2054
Loa Loa (eye worm) hypothetical protein 0.0089 0.0093 0.0087
Mycobacterium tuberculosis Probable polyketide synthase Pks5 0.0053 0.0037 0.0874
Echinococcus granulosus MAM 0.0067 0.0059 0.0059
Brugia malayi Eukaryotic aspartyl protease family protein 0.0034 0.0007 0.0001
Entamoeba histolytica PH domain containing protein kinase, putative 0.007 0.0064 0.1185
Toxoplasma gondii PA14 domain-containing protein 0.0042 0.0019 0.0372
Plasmodium falciparum plasmepsin X 0.0034 0.0007 0.0126
Loa Loa (eye worm) hypothetical protein 0.0042 0.0019 0.0012
Schistosoma mansoni hypothetical protein 0.0042 0.0019 0.0019
Schistosoma mansoni btb and poz domain-containing protein 0.0042 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.0042 0.0019 0.0012
Trichomonas vaginalis hypothetical protein 0.0042 0.0019 0.0031
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0126 0.0151 0.0145
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0019 0.0031
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0084 0.0086 0.2054
Loa Loa (eye worm) CMGC/MAPK/JNK protein kinase 0.0225 0.0305 0.0299
Echinococcus granulosus Tolloid protein 1 0.0038 0.0013 0.0013
Loa Loa (eye worm) integrin beta-2 0.425 0.6607 0.6604
Schistosoma mansoni protein kinase 0.0127 0.0152 0.0152
Onchocerca volvulus Fatty acid synthase homolog 0.0099 0.0108 0.1554
Echinococcus granulosus Estrogen regulated protein EP45 0.0042 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.0035 0.0008 0.0001
Loa Loa (eye worm) proprotein convertase 2 0.1559 0.2394 0.2389
Loa Loa (eye worm) pregnancy-associated plasma protein-E 0.0035 0.0008 0.0001
Loa Loa (eye worm) doublecortin family protein 0.0082 0.0083 0.0076
Onchocerca volvulus 0.0042 0.0019 0.0189
Echinococcus granulosus RNA directed DNA polymerase 0.0048 0.0028 0.0028
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0282 0.0395 0.0648
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0034 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0042 0.0019 0.0012
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0127 0.0152 0.0152
Echinococcus multilocularis serine:threonine protein kinase N2 0.0089 0.0093 0.0116
Loa Loa (eye worm) hypothetical protein 0.0125 0.015 0.0143
Echinococcus multilocularis Coagulation factor 5 8 type, C terminal 0.0042 0.0019 0.0023
Toxoplasma gondii subtilisin SUB1 0.0282 0.0395 0.7867
Plasmodium vivax hypothetical protein, conserved 0.0084 0.0086 0.1542
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0333 0.0475 1
Loa Loa (eye worm) hypothetical protein 0.012 0.0141 0.0134
Schistosoma mansoni subfamily M12A unassigned peptidase (M12 family) 0.0038 0.0013 0.0013
Mycobacterium tuberculosis Possible arabinofuranosyltransferase AftD 0.0042 0.0019 0.0421
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.1559 0.2394 0.3928
Loa Loa (eye worm) apoptosis regulator protein 0.0053 0.0037 0.0031
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0282 0.0395 0.0648
Schistosoma mansoni hypothetical protein 0.0053 0.0037 0.0037
Giardia lamblia Tenascin-like 0.0125 0.015 0.0387
Echinococcus granulosus lipoxygenase domain containing protein 0.0082 0.0083 0.0083
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD 0.0052 0.0035 0.0745
Brugia malayi Serpin protein 6 0.0042 0.0019 0.0012
Loa Loa (eye worm) hypothetical protein 0.6417 1 1
Loa Loa (eye worm) serpin 0.0042 0.0019 0.0012
Loa Loa (eye worm) hypothetical protein 0.0455 0.0665 0.0659
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0282 0.0395 0.0648
Giardia lamblia Sirtuin type 2 0.0049 0.003 0.006
Loa Loa (eye worm) aspartic protease BmAsp-2 0.0034 0.0007 0.0001
Toxoplasma gondii type I fatty acid synthase, putative 0.0055 0.004 0.0798
Trichomonas vaginalis conserved hypothetical protein 0.1277 0.1952 0.3204
Echinococcus granulosus plasminogen activator inhibitor 2 0.0042 0.0019 0.0019
Echinococcus multilocularis SWI:SNF complex subunit SMARCC2 0.0035 0.0009 0.0011
Trypanosoma cruzi subtilisin-like serine peptidase, putative 0.0307 0.0434 0.9085
Echinococcus granulosus serine protease inhibitor 0.0042 0.0019 0.0019
Plasmodium vivax aspartyl proteinase, putative 0.0034 0.0007 0.0126
Onchocerca volvulus 0.0137 0.0168 0.2476
Trichomonas vaginalis conserved hypothetical protein 0.1277 0.1952 0.3204
Leishmania major UDP-galactopyranose mutase 0.0084 0.0086 0.1805
Echinococcus granulosus fibrillin 2 0.0125 0.015 0.015
Loa Loa (eye worm) hypothetical protein 0.0282 0.0395 0.0389
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0084 0.0086 0.2054
Onchocerca volvulus 0.0042 0.0019 0.0188
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0333 0.0475 0.0779
Trichomonas vaginalis proprotein convertase subtilisin/kexin type, putative 0.1277 0.1952 0.3204
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0282 0.0395 0.0648
Schistosoma mansoni bcl-2 homologous antagonist/killer (bak) 0.0053 0.0037 0.0037
Schistosoma mansoni loxhd1 0.0082 0.0083 0.0083
Echinococcus multilocularis telomerase reverse transcriptase subunit 0.0048 0.0028 0.0035
Brugia malayi hypothetical protein 0.0034 0.0007 0.0001
Plasmodium vivax plasmepsin V, putative 0.0385 0.0556 1
Echinococcus multilocularis neuroendocrine convertase 2 0.4054 0.63 0.7874
Echinococcus granulosus integrin beta 2 0.3145 0.4877 0.4877
Echinococcus multilocularis lysine specific histone demethylase 1A 0.0416 0.0604 0.0755
Onchocerca volvulus 0.0451 0.0659 1
Mycobacterium tuberculosis Probable polyketide synthase Pks1 0.0039 0.0015 0.0327
Trypanosoma brucei subtilisin peptidase 0.0282 0.0395 0.8224
Trichomonas vaginalis conserved hypothetical protein 0.1277 0.1952 0.3204
Loa Loa (eye worm) angiotensin-converting enzyme family protein 0.0622 0.0928 0.0922
Mycobacterium leprae PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) 0.0084 0.0086 0.2054
Toxoplasma gondii subtilisin SUB2 0.0282 0.0395 0.7867
Schistosoma mansoni integrin alpha-ps 0.0748 0.1124 0.1124
Trichomonas vaginalis hypothetical protein 0.0125 0.015 0.0246
Brugia malayi aspartic protease BmAsp-1, identical 0.0034 0.0007 0.0001
Loa Loa (eye worm) WD40 repeat protein 0.0137 0.0168 0.0162
Brugia malayi Hypothetical subtilase-type proteinase F21H12.6 in chromosome II 0.0282 0.0395 0.0389
Brugia malayi EGF-like domain containing protein 0.0125 0.015 0.0143
Mycobacterium leprae Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas 0.0055 0.004 0.0882
Entamoeba histolytica arginine N-methyltransferase protein, putative 0.0046 0.0026 0.0379
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0333 0.0475 0.0779
Mycobacterium ulcerans membrane-anchored mycosin MycP3 0.0282 0.0395 1
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0019 0.0031
Schistosoma mansoni chromatin regulatory protein sir2 0.0333 0.0475 0.0475
Loa Loa (eye worm) hypothetical protein 0.0082 0.0083 0.0076
Toxoplasma gondii aspartyl protease ASP3 0.0034 0.0007 0.014
Toxoplasma gondii subtilisin SUB12 0.0282 0.0395 0.7867
Echinococcus multilocularis lipoxygenase domain containing protein 0.0082 0.0083 0.0103
Loa Loa (eye worm) hypothetical protein 0.0035 0.0008 0.0001
Schistosoma mansoni serine protease inhibitors serpins 0.0042 0.0019 0.0019
Giardia lamblia Hypothetical protein 0.0333 0.0475 0.1279
Loa Loa (eye worm) bone morphogenetic protein 1b 0.0038 0.0013 0.0006
Brugia malayi protein kinase C II. 0.0105 0.0118 0.0112
Brugia malayi hypothetical protein 0.0035 0.0008 0.0001
Onchocerca volvulus 0.0282 0.0395 0.5954
Loa Loa (eye worm) hypothetical protein 0.0424 0.0617 0.0611
Schistosoma mansoni site-1 peptidase (S08 family) 0.0282 0.0395 0.0395
Brugia malayi serpin 0.0042 0.0019 0.0012
Trypanosoma cruzi subtilisin peptidase 0.0282 0.0395 0.8224
Schistosoma mansoni amine oxidase 0.0084 0.0086 0.0086
Brugia malayi Subtilase family protein 0.0282 0.0395 0.0389
Echinococcus multilocularis fibrillin 2 0.0125 0.015 0.0187
Loa Loa (eye worm) hypothetical protein 0.0035 0.0008 0.0001
Onchocerca volvulus 0.0125 0.015 0.2195
Trypanosoma cruzi Silent information regulator 2 related protein 1 0.0333 0.0475 1
Mycobacterium leprae Probable polyketide synthase Pks1 0.0055 0.004 0.0882
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0282 0.0395 0.0648
Echinococcus multilocularis Polycystic kidney disease protein 0.0082 0.0083 0.0103
Trichomonas vaginalis conserved hypothetical protein 0.1277 0.1952 0.3204
Schistosoma mansoni Lysine-specific histone demethylase 1 0.0416 0.0604 0.0604
Plasmodium vivax aspartyl protease, putative 0.0034 0.0007 0.0126
Echinococcus granulosus lysine specific histone demethylase 1A 0.0416 0.0604 0.0604
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0282 0.0395 0.0648
Mycobacterium tuberculosis Probable alanine and proline rich membrane-anchored mycosin MycP2 (serine protease) (subtilisin-like protease) (subtilase-like) 0.0282 0.0395 1
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0049 0.003 0.005
Echinococcus multilocularis NAD dependent deacetylase sirtuin 3 0.0333 0.0475 0.0593
Brugia malayi amine oxidase, flavin-containing family protein 0.012 0.0141 0.0134
Trypanosoma cruzi UDP-galactopyranose mutase 0.0084 0.0086 0.1327
Onchocerca volvulus 0.0067 0.0059 0.0798
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0493 0.0725 0.0907
Brugia malayi neuroendocrine convertase 1 precursor 0.4054 0.63 0.6297
Echinococcus granulosus protein kinase C gamma type 0.007 0.0063 0.0063
Schistosoma mansoni subfamily M12B unassigned peptidase (M12 family) 0.009 0.0094 0.0094
Loa Loa (eye worm) hypothetical protein 0.0416 0.0604 0.0598
Loa Loa (eye worm) integrin alpha pat-2 0.2056 0.3172 0.3168
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0493 0.0725 0.0725
Trypanosoma cruzi UDP-galactopyranose mutase 0.0084 0.0086 0.1327
Brugia malayi hypothetical protein 0.0082 0.0083 0.0076
Echinococcus granulosus discoidin domain receptor 0.0042 0.0019 0.0019
Plasmodium falciparum subtilisin-like protease 2 0.0282 0.0395 0.7109
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0019 0.0031
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0052 0.0035 0.0829
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0019 0.0031
Leishmania major subtilisin-like serine peptidase 0.0282 0.0395 0.8322
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC 0.0055 0.004 0.0882
Entamoeba histolytica NAD-dependent deacetylase 1, putative 0.0049 0.003 0.0469
Loa Loa (eye worm) hypothetical protein 0.0034 0.0007 0.0001
Mycobacterium tuberculosis Transcriptional regulatory protein 0.0049 0.003 0.0718
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0282 0.0395 0.0648
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0019 0.0031
Echinococcus granulosus serine protease inhibitor 0.0042 0.0019 0.0019
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0282 0.0395 0.0648
Echinococcus granulosus integrin alpha 3 0.1076 0.1638 0.1638
Echinococcus multilocularis integrin alpha ps 0.0748 0.1124 0.1405
Schistosoma mansoni dock 0.0042 0.0019 0.0019
Plasmodium falciparum plasmepsin VI 0.0034 0.0007 0.0126
Toxoplasma gondii serpin (serine proteinase inhibitor) superfamily protein 0.0042 0.0019 0.0374
Loa Loa (eye worm) aspartic protease BmAsp-1 0.0034 0.0007 0.0001
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0282 0.0395 0.0648
Echinococcus multilocularis proprotein convertase subtilisin:kexin type 5 0.3923 0.6094 0.7617
Echinococcus multilocularis discoidin domain containing receptor 2 0.0042 0.0019 0.0023
Brugia malayi Apoptosis regulator proteins, Bcl-2 family protein 0.0053 0.0037 0.0031
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0038 0.0013 0.0013
Trypanosoma cruzi Silent information regulator 2 related protein 3 0.0049 0.003 0.0093
Giardia lamblia Neurogenic locus notch-like protein 0.0125 0.015 0.0387
Plasmodium falciparum plasmepsin IV 0.0034 0.0007 0.0126
Mycobacterium ulcerans Type I modular polyketide synthase 0.0052 0.0035 0.0745
Brugia malayi BmSERPIN, truncated 0.0042 0.0019 0.0012
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0019 0.0031
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0034 0.0007 0.0007
Brugia malayi SWIRM domain containing protein 0.0451 0.0659 0.0653
Loa Loa (eye worm) transcriptional regulator 0.0049 0.003 0.0024
Echinococcus multilocularis 0.5141 0.8001 1
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase subunit type II alpha 0.0111 0.0127 0.012
Loa Loa (eye worm) hypothetical protein 0.0065 0.0056 0.0049
Onchocerca volvulus 0.0035 0.0008 0.0018
Onchocerca volvulus 0.0067 0.0059 0.0798
Trichomonas vaginalis alpha-L-fucosidase, putative 0.0042 0.0019 0.0031
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0049 0.003 0.005
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0083 0.0084 0.0105
Toxoplasma gondii type I fatty acid synthase, putative 0.0039 0.0014 0.0288
Schistosoma mansoni hypothetical protein 0.0053 0.0037 0.0037
Loa Loa (eye worm) serpin 0.0042 0.0019 0.0012
Brugia malayi Protein kinase c protein 2 0.0065 0.0055 0.0049
Brugia malayi Integrin alpha cytoplasmic region family protein 0.1014 0.1541 0.1536
Echinococcus granulosus microsomal glutathione S transferase 3 0.0341 0.0488 0.0488
Plasmodium falciparum protoporphyrinogen oxidase 0.0084 0.0086 0.1542
Brugia malayi transcriptional regulator, Sir2 family protein 0.0049 0.003 0.0024
Echinococcus granulosus EGFP:Bcl2 fusion protein 0.067 0.1002 0.1002
Trypanosoma brucei Silent information regulator 2 related protein 1 0.0333 0.0475 1
Giardia lamblia High cysteine membrane protein Group 2 0.2364 0.3654 1
Echinococcus multilocularis protoporphyrinogen oxidase 0.0084 0.0086 0.0107
Plasmodium vivax aspartyl protease, putative 0.0034 0.0007 0.0126
Loa Loa (eye worm) hypothetical protein 0.0038 0.0013 0.0006
Echinococcus multilocularis membrane bound transcription factor site 1 0.0282 0.0395 0.0494
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.1559 0.2394 0.3928
Loa Loa (eye worm) hypothetical protein 0.0034 0.0007 0.0001
Leishmania major sir2-family protein-like protein 0.0049 0.003 0.064
Schistosoma mansoni membrane associated proteins in eicosanoid and glutathione metabolism family member 0.1489 0.2284 0.2284
Loa Loa (eye worm) serpin protein 6 0.0042 0.0019 0.0012
Toxoplasma gondii eukaryotic aspartyl protease superfamily protein 0.0034 0.0007 0.014
Mycobacterium ulcerans Sir2-like regulatory protein 0.0049 0.003 0.0633
Loa Loa (eye worm) hypothetical protein 0.1014 0.1541 0.1536
Echinococcus granulosus RUN 0.0082 0.0083 0.0083
Loa Loa (eye worm) transcriptional regulator 0.0333 0.0475 0.0469
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0055 0.004 0.0882
Echinococcus multilocularis c4b binding protein beta chain 0.0035 0.0008 0.0009
Echinococcus granulosus NAD dependent deacetylase sirtuin 6 0.0049 0.003 0.003
Toxoplasma gondii SWIRM domain-containing protein 0.0035 0.0009 0.017
Toxoplasma gondii subtilisin SUB10 0.0282 0.0395 0.7867
Brugia malayi celfurPC protein 0.5141 0.8001 0.8
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0019 0.0031
Echinococcus granulosus furin 0.6417 1 1
Brugia malayi Sex muscle abnormal protein 5 0.0126 0.0151 0.0145
Mycobacterium ulcerans NAD-dependent deacetylase 0.0049 0.003 0.0633
Echinococcus multilocularis serine protease inhibitor 0.0042 0.0019 0.0023
Loa Loa (eye worm) subtilase 0.0282 0.0395 0.0389
Echinococcus multilocularis discoidin domain containing receptor 2 0.0042 0.0019 0.0023
Echinococcus granulosus Polycystic kidney disease protein 0.0082 0.0083 0.0083
Echinococcus multilocularis growth factor receptor bound protein 2 0.0126 0.0151 0.0189
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0282 0.0395 0.0648
Onchocerca volvulus 0.0035 0.0008 0.0018
Mycobacterium tuberculosis Probable thioesterase TesA 0.0046 0.0025 0.0577
Schistosoma mansoni chromatin regulatory protein sir2 0.0049 0.003 0.003
Loa Loa (eye worm) TK/EGFR protein kinase 0.0398 0.0576 0.057
Trichomonas vaginalis WD repeat domain, putative 0.0137 0.0168 0.0276
Echinococcus granulosus Bcl 2 ous antagonist:killer 0.0053 0.0037 0.0037
Toxoplasma gondii subtilisin SUB4 0.0282 0.0395 0.7867
Onchocerca volvulus 0.0108 0.0122 0.1773
Schistosoma mansoni subfamily S8B non-peptidase homologue (S08 family) 0.1559 0.2394 0.2394
Loa Loa (eye worm) hypothetical protein 0.0042 0.0019 0.0012
Trichomonas vaginalis conserved hypothetical protein 0.1277 0.1952 0.3204
Schistosoma mansoni hypothetical protein 0.0053 0.0037 0.0037
Brugia malayi pregnancy-associated plasma protein-A 0.0035 0.0008 0.0001
Brugia malayi hypothetical protein 0.0042 0.0019 0.0012
Schistosoma mansoni atypical protein kinase C 0.0033 0.0005 0.0005
Brugia malayi serpin 0.0042 0.0019 0.0012
Schistosoma mansoni chromatin regulatory protein sir2 0.0049 0.003 0.003
Brugia malayi Angiotensin-converting enzyme family protein 0.0622 0.0928 0.0922
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.1559 0.2394 0.3928
Toxoplasma gondii beta-ketoacyl synthase, N-terminal domain-containing protein 0.0035 0.0009 0.018
Echinococcus multilocularis 0.0084 0.0086 0.0107
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0084 0.0086 0.1542
Onchocerca volvulus 0.0035 0.0008 0.0018
Brugia malayi hypothetical protein 0.0035 0.0008 0.0001
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0282 0.0395 0.0648
Schistosoma mansoni serine protease inhibitors serpins 0.0042 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.0042 0.0019 0.0012
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0051 0.0034 0.0797
Onchocerca volvulus 0.0034 0.0007 0.0009
Loa Loa (eye worm) hypothetical protein 0.0042 0.0019 0.0012
Echinococcus multilocularis protein will die slowly 0.0137 0.0168 0.021
Toxoplasma gondii F5/8 type C domain-containing protein 0.0042 0.0019 0.0372
Schistosoma mansoni serine protease inhibitors serpins 0.0042 0.0019 0.0019
Plasmodium falciparum plasmepsin III 0.0034 0.0007 0.0126
Echinococcus granulosus proprotein convertase subtilisin:kexin type 5 0.3923 0.6094 0.6094
Echinococcus multilocularis NAD dependent deacetylase sirtuin 7 0.0049 0.003 0.0038
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0019 0.0031
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0282 0.0395 0.0648
Toxoplasma gondii aspartyl proteinase (eimepsin), putative 0.0034 0.0007 0.014
Echinococcus multilocularis discoidin domain containing receptor 2 0.0042 0.0019 0.0023
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0034 0.0007 0.0007
Brugia malayi serpin 0.0042 0.0019 0.0012
Echinococcus multilocularis cathepsin d (lysosomal aspartyl protease) 0.0034 0.0007 0.0009
Mycobacterium ulcerans proline rich membrane-anchored mycosin MycP5 0.0282 0.0395 1
Echinococcus granulosus integrin alpha ps 0.0813 0.1226 0.1226
Loa Loa (eye worm) fatty acid synthase 0.0054 0.0038 0.0032
Toxoplasma gondii subtilisin SUB8 0.0282 0.0395 0.7867
Schistosoma mansoni intracisternal A-particle retropepsin (A02 family) 0.1258 0.1923 0.1923
Echinococcus multilocularis integrin alpha 3 0.1076 0.1638 0.2047
Schistosoma mansoni memapsin-2 (A01 family) 0.0034 0.0007 0.0007
Echinococcus granulosus NAD dependent deacetylase sirtuin 3 0.0333 0.0475 0.0475
Onchocerca volvulus 0.0035 0.0008 0.0018
Toxoplasma gondii MAPEG family protein 0.0341 0.0488 0.9707
Plasmodium falciparum LCCL domain-containing protein 0.0042 0.0019 0.0337
Schistosoma mansoni serine/threonine protein kinase 0.0083 0.0084 0.0084
Plasmodium vivax subtilisin-like protease 2, putative 0.0282 0.0395 0.7109
Loa Loa (eye worm) hypothetical protein 0.0035 0.0008 0.0001
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0019 0.0031
Entamoeba histolytica serine protease inhibitor, putative 0.0042 0.0019 0.022
Plasmodium falciparum plasmepsin V 0.0385 0.0556 1
Giardia lamblia Neurogenic locus Notch protein precursor 0.0125 0.015 0.0387
Giardia lamblia Transcriptional regulator, Sir2 family 0.0049 0.003 0.006
Brugia malayi hypothetical protein 0.0067 0.0059 0.0052
Plasmodium vivax plasmepsin IV, putative 0.0034 0.0007 0.0126
Brugia malayi Integrin beta pat-3 precursor 0.425 0.6607 0.6604
Plasmodium vivax multidomain scavenger receptor, putative 0.0082 0.0083 0.1484
Schistosoma mansoni discoidin domain receptor 0.0042 0.0019 0.0019
Mycobacterium ulcerans dehydrogenase 0.0084 0.0086 0.2054
Plasmodium falciparum subtilisin-like protease 1 0.0282 0.0395 0.7109
Echinococcus granulosus protein kinase c iota type 0.0033 0.0005 0.0005
Onchocerca volvulus 0.0035 0.0008 0.0018
Onchocerca volvulus 0.0035 0.0008 0.0018
Schistosoma mansoni serpin 0.0042 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.0648 0.0967 0.0961
Brugia malayi serpin (BmSERPIN) 0.0042 0.0019 0.0012
Loa Loa (eye worm) hypothetical protein 0.0084 0.0086 0.0079
Echinococcus granulosus c4b binding protein beta chain 0.0035 0.0008 0.0008
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0034 0.0007 0.0007
Plasmodium vivax aspartyl protease, putative 0.0034 0.0007 0.0126
Schistosoma mansoni family A2 unassigned peptidase (A02 family) 0.0229 0.0312 0.0312
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0282 0.0395 0.0648
Brugia malayi Stress-activated protein kinase jnk-1 0.0225 0.0305 0.0299
Schistosoma mansoni hypothetical protein 0.0358 0.0515 0.0515
Toxoplasma gondii aspartyl protease ASP1 0.0034 0.0007 0.014
Onchocerca volvulus 0.0042 0.0019 0.0189
Loa Loa (eye worm) AGC/PKC/ALPHA protein kinase 0.0052 0.0034 0.0028
Brugia malayi GCC2 and GCC3 family protein 0.0044 0.0022 0.0016
Onchocerca volvulus 0.0082 0.0083 0.1165
Loa Loa (eye worm) hypothetical protein 0.0046 0.0026 0.002
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0049 0.003 0.0469
Entamoeba histolytica hypothetical protein 0.0046 0.0026 0.0379
Brugia malayi hypothetical protein 0.0035 0.0008 0.0001
Brugia malayi hypothetical protein 0.0042 0.0019 0.0012
Onchocerca volvulus 0.0042 0.0019 0.0188
Toxoplasma gondii subtilisin SUB11 0.0282 0.0395 0.7867
Brugia malayi proprotein convertase 2 0.4054 0.63 0.6297
Loa Loa (eye worm) hypothetical protein 0.0049 0.003 0.0024
Schistosoma mansoni rab6-interacting 0.0082 0.0083 0.0083
Brugia malayi Kelch motif family protein 0.0672 0.1006 0.1
Giardia lamblia High cysteine protein 0.0125 0.015 0.0387
Plasmodium vivax lysine-specific histone demethylase 1, putative 0.0084 0.0086 0.1542
Loa Loa (eye worm) hypothetical protein 0.009 0.0094 0.0088
Trichomonas vaginalis conserved hypothetical protein 0.1277 0.1952 0.3204
Schistosoma mansoni integrin alpha 0.1465 0.2247 0.2247
Mycobacterium ulcerans protoporphyrinogen oxidase 0.0084 0.0086 0.2054
Echinococcus multilocularis integrin alpha ps 0.0813 0.1226 0.1532
Chlamydia trachomatis protoporphyrinogen oxidase 0.0084 0.0086 0.5
Plasmodium falciparum apical sushi protein 0.0035 0.0008 0.0137
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.1559 0.2394 0.3928
Echinococcus granulosus c-Jun N-terminal kinases 0.0225 0.0305 0.0305
Loa Loa (eye worm) endoprotease bli-4 0.6417 1 1
Brugia malayi serpin 0.0042 0.0019 0.0012
Toxoplasma gondii protease inhibitor PI1 0.0042 0.0019 0.0374
Loa Loa (eye worm) hypothetical protein 0.0044 0.0022 0.0016
Brugia malayi serpin precursor 0.0042 0.0019 0.0012
Schistosoma mansoni serine protease inhibitors serpins 0.0042 0.0019 0.0019
Echinococcus granulosus integrin alpha ps 0.0358 0.0515 0.0515
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0049 0.003 0.005
Giardia lamblia Serpin 1 0.0042 0.0019 0.0028
Entamoeba histolytica hypothetical protein, conserved 0.0049 0.003 0.0469
Onchocerca volvulus 0.0035 0.0008 0.0018
Echinococcus multilocularis epidermal growth factor receptor 0.0398 0.0576 0.072
Loa Loa (eye worm) hypothetical protein 0.0067 0.0059 0.0052
Echinococcus granulosus fibrillin 1 0.0127 0.0152 0.0152
Schistosoma mansoni rab6-interacting 0.0082 0.0083 0.0083
Trichomonas vaginalis hypothetical protein 0.1277 0.1952 0.3204
Mycobacterium ulcerans polyketide synthase Pks13 0.0079 0.0077 0.1833
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0019 0.0031
Schistosoma mansoni tyrosine kinase 0.0398 0.0576 0.0576
Loa Loa (eye worm) aspartyl protease 6 0.0034 0.0007 0.0001
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0049 0.003 0.005
Onchocerca volvulus 0.0034 0.0007 0.0009
Echinococcus multilocularis subfamily M12B unassigned peptidase 0.009 0.0094 0.0118
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0282 0.0395 0.0648
Schistosoma mansoni Protoporphyrinogen oxidase chloroplast/mitochondrial precursor 0.0084 0.0086 0.0086
Loa Loa (eye worm) hypothetical protein 0.0042 0.0019 0.0012
Schistosoma mansoni SWI/SNF complex-related 0.0035 0.0009 0.0009
Mycobacterium leprae PROBABLE CONSERVED TRANSMEMBRANE PROTEIN 0.0042 0.0019 0.0333
Loa Loa (eye worm) hypothetical protein 0.0067 0.0059 0.0052
Onchocerca volvulus 0.0042 0.0019 0.0189
Brugia malayi hypothetical protein 0.0035 0.0008 0.0001
Echinococcus granulosus peptidase s8 s53 subtilisin kexin sedolisin 0.0282 0.0395 0.0395
Brugia malayi hypothetical protein 0.0035 0.0008 0.0001
Loa Loa (eye worm) hypothetical protein 0.0082 0.0083 0.0076
Schistosoma mansoni chromatin regulatory protein sir2 0.0333 0.0475 0.0475
Loa Loa (eye worm) hypothetical protein 0.0084 0.0086 0.0079
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0333 0.0475 1
Echinococcus multilocularis discoidin domain receptor 0.0042 0.0019 0.0023
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0105 0.0118 0.0112
Trichomonas vaginalis conserved hypothetical protein 0.0282 0.0395 0.0648
Brugia malayi EGF-like domain containing protein 0.0125 0.015 0.0143
Echinococcus granulosus cathepsin d lysosomal aspartyl protease 0.0034 0.0007 0.0007
Plasmodium falciparum LCCL domain-containing protein 0.0042 0.0019 0.0337
Plasmodium vivax subtilisin-like serine protease, putative 0.0282 0.0395 0.7109
Schistosoma mansoni adam (A disintegrin and metalloprotease 0.0117 0.0137 0.0137
Onchocerca volvulus 0.0036 0.001 0.0057
Schistosoma mansoni serine/threonine protein kinase 0.0225 0.0305 0.0305
Trichomonas vaginalis conserved hypothetical protein 0.1277 0.1952 0.3204
Schistosoma mansoni protein kinase 0.0127 0.0152 0.0152
Echinococcus multilocularis Peptidase S8 S53, subtilisin kexin sedolisin 0.0282 0.0395 0.0494
Echinococcus granulosus adam 17 protease 0.0037 0.0012 0.0012
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0052 0.0035 0.0829
Trypanosoma cruzi subtilisin-like serine peptidase, putative 0.0307 0.0434 0.9085
Trichomonas vaginalis conserved hypothetical protein 0.0282 0.0395 0.0648
Toxoplasma gondii subtilisin SUB6 0.0282 0.0395 0.7867
Schistosoma mansoni serine protease inhibitors serpins 0.0042 0.0019 0.0019
Brugia malayi Sushi domain 0.0035 0.0008 0.0001
Schistosoma mansoni septate junction protein 0.0051 0.0033 0.0033
Echinococcus granulosus protein will die slowly 0.0137 0.0168 0.0168
Loa Loa (eye worm) serpin 0.0042 0.0019 0.0012
Schistosoma mansoni dihydroceramide desaturase 0.0037 0.0012 0.0012
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0282 0.0395 0.0648
Mycobacterium leprae PROBABLE MEMBRANE-ANCHORED MYCOSIN MYCP3 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-3) 0.0282 0.0395 1
Echinococcus multilocularis Blood coagulation inhibitor, Disintegrin 0.0037 0.0012 0.0015
Plasmodium falciparum plasmepsin VII 0.0034 0.0007 0.0126
Echinococcus multilocularis RUN 0.0082 0.0083 0.0103
Schistosoma mansoni integrin beta subunit 0.2498 0.3863 0.3863
Brugia malayi serpin (BmSERPIN) 0.0042 0.0019 0.0012
Brugia malayi hypothetical protein 0.0046 0.0026 0.002
Mycobacterium tuberculosis Polyketide synthase Pks2 0.0053 0.0037 0.0874
Echinococcus multilocularis Bcl 2 ous antagonist:killer 0.0053 0.0037 0.0046
Toxoplasma gondii histone deacetylase SIR2 0.0049 0.003 0.0605
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0049 0.003 0.005
Loa Loa (eye worm) hypothetical protein 0.0042 0.0019 0.0012
Echinococcus multilocularis adam 0.0243 0.0334 0.0417
Mycobacterium tuberculosis Probable membrane-anchored mycosin MycP4 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-4) 0.0282 0.0395 1
Schistosoma mansoni lipoxygenase 0.0345 0.0493 0.0493
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0019 0.0031
Plasmodium falciparum plasmepsin I 0.0034 0.0007 0.0126
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.0052 0.0035 0.0028
Plasmodium falciparum plasmepsin II 0.0034 0.0007 0.0126
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0052 0.0035 0.0745
Toxoplasma gondii aspartyl protease 0.0034 0.0007 0.014
Brugia malayi Protein kinase domain containing protein 0.0042 0.0019 0.0012
Brugia malayi hypothetical protein 0.0648 0.0967 0.0961
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0282 0.0395 0.0648
Giardia lamblia Tenascin-X 0.0125 0.015 0.0387
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0034 0.0007 0.0007
Brugia malayi Will die slowly protein 0.0137 0.0168 0.0162
Onchocerca volvulus 0.0035 0.0008 0.0018
Giardia lamblia Tenascin-37 0.0125 0.015 0.0387
Echinococcus granulosus lipoxygenase domain containing protein 0.0082 0.0083 0.0083
Loa Loa (eye worm) hypothetical protein 0.0125 0.015 0.0143
Echinococcus multilocularis integrin alpha ps 0.0358 0.0515 0.0643
Mycobacterium leprae Possible secreted protease 0.0282 0.0395 1
Loa Loa (eye worm) hypothetical protein 0.2495 0.3859 0.3855
Onchocerca volvulus 0.0042 0.0019 0.0189
Mycobacterium tuberculosis Polyketide synthase Pks12 0.0055 0.004 0.0965
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0282 0.0395 0.0648
Trypanosoma brucei SIR2-like protein 4, putative 0.0049 0.003 0.0093
Schistosoma mansoni serpin 0.0042 0.0019 0.0019
Echinococcus granulosus discoidin domain containing receptor 2 0.0042 0.0019 0.0019
Mycobacterium tuberculosis Probable membrane-anchored mycosin MycP3 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-3) 0.0282 0.0395 1
Toxoplasma gondii histone deacetylase SIR2-like 0.0049 0.003 0.0605
Echinococcus granulosus Blood coagulation inhibitor Disintegrin 0.0037 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.0125 0.015 0.0143
Onchocerca volvulus 0.0042 0.0019 0.0189
Mycobacterium tuberculosis Probable polyketide synthase Pks8 0.0042 0.0019 0.0432
Loa Loa (eye worm) hypothetical protein 0.0042 0.0019 0.0012
Echinococcus granulosus protein kinase c epsilon type 0.0105 0.0118 0.0118
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0049 0.003 0.005
Echinococcus granulosus membrane bound transcription factor site 1 0.0282 0.0395 0.0395
Echinococcus multilocularis protein jagged 2 0.0125 0.015 0.0187
Plasmodium vivax NAD-dependent deacetylase, putative 0.0049 0.003 0.0547
Echinococcus granulosus adam 0.0243 0.0334 0.0334
Plasmodium falciparum LCCL domain-containing protein 0.0082 0.0083 0.1484
Mycobacterium leprae PROBABLE PROLINE RICH MEMBRANE-ANCHORED MYCOSIN MYCP5 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-5) 0.0282 0.0395 1
Mycobacterium leprae PROBABLE THIOESTERASE TESA 0.0046 0.0025 0.0491
Trypanosoma brucei Silent information regulator 2 related protein 3 0.0049 0.003 0.0093
Toxoplasma gondii hypothetical protein 0.0125 0.015 0.2981
Loa Loa (eye worm) hypothetical protein 0.0067 0.0059 0.0052
Echinococcus multilocularis disintegrin and metalloproteinase 0.0037 0.0012 0.0015
Brugia malayi NAD-dependent deacetylase SIRT1 0.0049 0.003 0.0024
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0051 0.0034 0.0027
Brugia malayi serpin 0.0042 0.0019 0.0012
Brugia malayi BmSERPIN 0.0042 0.0019 0.0012
Mycobacterium ulcerans polyketide synthase 0.0055 0.004 0.0882
Toxoplasma gondii F5/8 type C domain-containing protein 0.0042 0.0019 0.0372
Schistosoma mansoni cathepsin D (A01 family) 0.0034 0.0007 0.0007
Mycobacterium tuberculosis Possible oxidoreductase 0.0084 0.0086 0.2126
Loa Loa (eye worm) hypothetical protein 0.0052 0.0036 0.0029
Brugia malayi AMP-binding enzyme family protein 0.0051 0.0034 0.0027
Loa Loa (eye worm) hypothetical protein 0.0416 0.0604 0.0598
Schistosoma mansoni amine oxidase 0.0084 0.0086 0.0086
Echinococcus multilocularis nuclear receptor 2C2 associated protein 0.0042 0.0019 0.0023
Plasmodium vivax protoporphyrinogen oxidase, putative 0.0084 0.0086 0.1542
Plasmodium falciparum lysine-specific histone demethylase 1, putative 0.0084 0.0086 0.1542
Brugia malayi EGF-like domain containing protein 0.0125 0.015 0.0143
Brugia malayi EGF-like domain containing protein 0.0125 0.015 0.0143
Trichomonas vaginalis alpha-L-fucosidase, putative 0.0042 0.0019 0.0031
Mycobacterium ulcerans thioesterase 0.0046 0.0025 0.0491
Echinococcus multilocularis lipoxygenase domain containing protein 0.0082 0.0083 0.0103
Trichomonas vaginalis conserved hypothetical protein 0.1277 0.1952 0.3204
Schistosoma mansoni integrin alpha-ps 0.0455 0.0665 0.0665
Brugia malayi aspartic protease BmAsp-2, identical 0.0034 0.0007 0.0001
Schistosoma mansoni cathepsin D (A01 family) 0.0034 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0035 0.0008 0.0001
Loa Loa (eye worm) reprolysin 0.009 0.0094 0.0088
Loa Loa (eye worm) serpin 0.0042 0.0019 0.0012
Brugia malayi Integrin alpha pat-2 precursor 0.1465 0.2247 0.2242
Trichomonas vaginalis leucine-rich repeat protein, BspA family 0.1277 0.1952 0.3204
Schistosoma mansoni site-1 peptidase (S08 family) 0.0282 0.0395 0.0395
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA 0.0052 0.0035 0.0745
Trichomonas vaginalis conserved hypothetical protein 0.0282 0.0395 0.0648
Schistosoma mansoni serine protease inhibitors serpins 0.0042 0.0019 0.0019
Trichomonas vaginalis neuroendocrine convertase 2 precursor, putative 0.1277 0.1952 0.3204
Echinococcus multilocularis microsomal glutathione S transferase 3 0.0341 0.0488 0.0609
Schistosoma mansoni growth factor receptor-bound protein 0.0126 0.0151 0.0151
Brugia malayi transcriptional regulator, Sir2 family protein 0.0333 0.0475 0.0469
Toxoplasma gondii aspartyl protease ASP5 0.0351 0.0502 1
Schistosoma mansoni tripeptidyl-peptidase II (S08 family) 0.0282 0.0395 0.0395
Toxoplasma gondii subtilisin SUB9 0.0282 0.0395 0.7867
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0034 0.0007 0.0007
Brugia malayi hypothetical protein 0.0034 0.0007 0.0001
Giardia lamblia NAD-dependent histone deacetylase Sir2 0.0049 0.003 0.006
Mycobacterium leprae Polyketide synthase Pks13 0.0079 0.0077 0.1833
Echinococcus granulosus NAD dependent deacetylase sirtuin 7 0.0049 0.003 0.003
Echinococcus granulosus C type lectin domian containing protein 0.0035 0.0008 0.0008
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0019 0.0031
Trypanosoma cruzi Silent information regulator 2 related protein 3 0.0049 0.003 0.0093
Mycobacterium ulcerans monoamine oxidase 0.0084 0.0086 0.2054
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0282 0.0395 0.0648
Trypanosoma cruzi serine peptidase, clan SB, family S8-like protein 0.0282 0.0395 0.8224
Loa Loa (eye worm) hypothetical protein 0.0037 0.0012 0.0005
Plasmodium falciparum plasmepsin IX 0.0034 0.0007 0.0126
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.1559 0.2394 0.3928
Brugia malayi ADAMTS-like protease 0.0052 0.0036 0.0029
Toxoplasma gondii rhoptry neck protein RON1 0.0035 0.0008 0.0151
Brugia malayi angiogenesis inhibito 0.0052 0.0036 0.0029
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0052 0.0035 0.0829
Brugia malayi hypothetical protein 0.0082 0.0083 0.0076
Echinococcus multilocularis C type lectin domian containing protein 0.0035 0.0008 0.0009
Plasmodium vivax aspartyl proteinase, putative 0.0034 0.0007 0.0126
Loa Loa (eye worm) hypothetical protein 0.0061 0.0049 0.0043
Echinococcus granulosus NAD dependent deacetylase sirtuin 1 0.0049 0.003 0.003
Brugia malayi hypothetical protein 0.0035 0.0008 0.0001
Schistosoma mansoni microsomal glutathione s-transferase 0.0341 0.0488 0.0488
Schistosoma mansoni hypothetical protein 0.0082 0.0083 0.0083
Loa Loa (eye worm) transcriptional regulator 0.0049 0.003 0.0024
Schistosoma mansoni hypothetical protein 0.0137 0.0168 0.0168
Loa Loa (eye worm) hypothetical protein 0.0125 0.015 0.0143
Brugia malayi hypothetical protein 0.0084 0.0086 0.0079
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0038 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0035 0.0008 0.0001
Echinococcus multilocularis Furin 1 0.1559 0.2394 0.2992
Plasmodium falciparum transcriptional regulatory protein sir2b 0.0049 0.003 0.0547
Echinococcus multilocularis protein kinase c iota type 0.0033 0.0005 0.0006
Brugia malayi serpin 0.0042 0.0019 0.0012
Mycobacterium ulcerans membrane-anchored serine protease (mycosin), MycP4 0.0282 0.0395 1
Plasmodium falciparum subtilisin-like protease 3 0.0282 0.0395 0.7109
Toxoplasma gondii subtilisin SUB5 0.0282 0.0395 0.7867
Echinococcus multilocularis Tolloid protein 1 0.0038 0.0013 0.0016
Mycobacterium tuberculosis Probable membrane bound polyketide synthase Pks6 0.0079 0.0077 0.1908
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsB 0.0041 0.0018 0.0315
Echinococcus granulosus chromatin regulatory protein sir2 0.0333 0.0475 0.0475
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0101 0.0111 0.0105
Onchocerca volvulus 0.0051 0.0034 0.0415
Mycobacterium tuberculosis Probable proline rich membrane-anchored mycosin MycP5 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-5) 0.0282 0.0395 1
Echinococcus multilocularis serine threonine protein kinase 0.007 0.0063 0.0079
Echinococcus granulosus serine protease inhibitor 0.0042 0.0019 0.0019
Trichomonas vaginalis conserved hypothetical protein 0.0282 0.0395 0.0648
Brugia malayi Membrane-bound transcription factor site-1 protease precursor 0.0282 0.0395 0.0389
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0111 0.0127 0.012
Schistosoma mansoni hypothetical protein 0.0067 0.0059 0.0059
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0009 0.0014
Loa Loa (eye worm) hypothetical protein 0.0052 0.0036 0.0029
Echinococcus granulosus Protein kinase C brain isozyme 0.0083 0.0084 0.0084
Schistosoma mansoni hypothetical protein 0.0067 0.0059 0.0059
Trichomonas vaginalis conserved hypothetical protein 0.1277 0.1952 0.3204
Echinococcus granulosus SWI:SNF complex subunit SMARCC2 0.0035 0.0009 0.0009
Schistosoma mansoni serine/threonine protein kinase 0.0083 0.0084 0.0084
Plasmodium vivax LCCL domain-containing protein 0.0042 0.0019 0.0337
Trichomonas vaginalis teneurin and N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase, putative 0.0125 0.015 0.0246
Loa Loa (eye worm) hypothetical protein 0.0034 0.0007 0.0001
Schistosoma mansoni furin-1 (S08 family) 0.2777 0.4301 0.4301
Echinococcus granulosus disintegrin and metalloproteinase 0.0037 0.0012 0.0012
Echinococcus granulosus Estrogen regulated protein EP45 0.0042 0.0019 0.0019
Echinococcus granulosus discoidin domain containing receptor 2 0.0042 0.0019 0.0019
Leishmania major silent information regulator 2, putative 0.0333 0.0475 1
Onchocerca volvulus 0.0035 0.0008 0.0018
Echinococcus multilocularis c Jun NH2 terminal kinase 0.0225 0.0305 0.0381
Mycobacterium ulcerans thioesterase TesA 0.0046 0.0025 0.0491
Echinococcus multilocularis fibrillin 1 0.014 0.0173 0.0216
Trichomonas vaginalis conserved hypothetical protein 0.0282 0.0395 0.0648
Toxoplasma gondii rhoptry neck protein RON9 0.0035 0.0008 0.0151
Echinococcus granulosus discoidin domain containing receptor 2 0.0042 0.0019 0.0019
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0049 0.003 0.005
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0282 0.0395 0.0648
Brugia malayi hypothetical protein 0.0035 0.0008 0.0001
Mycobacterium tuberculosis Conserved hypothetical protein 0.0084 0.0086 0.2126
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0019 0.0031
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0049 0.003 0.005
Plasmodium vivax hypothetical protein, conserved 0.0049 0.003 0.0547
Loa Loa (eye worm) hypothetical protein 0.0036 0.001 0.0004
Echinococcus granulosus neuroendocrine convertase 2 0.4054 0.63 0.63
Loa Loa (eye worm) TK/ALK protein kinase 0.0067 0.0059 0.0052
Toxoplasma gondii subtilisin SUB7 0.0282 0.0395 0.7867
Mycobacterium tuberculosis Polyketide synthase Pks13 0.0079 0.0077 0.1908
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB 0.0041 0.0018 0.0315
Schistosoma mansoni apoptosis regulator bax 0.0053 0.0037 0.0037
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0034 0.0007 0.0007
Toxoplasma gondii histone lysine-specific demethylase LSD1/BHC110/KDMA1A 0.0084 0.0086 0.1707
Echinococcus granulosus growth factor receptor bound protein 2 0.0126 0.0151 0.0151
Echinococcus multilocularis MAM 0.0067 0.0059 0.0073
Trichomonas vaginalis beta-hexosaminidase B, putative 0.0042 0.0019 0.0031
Brugia malayi transcriptional regulator, Sir2 family protein 0.0049 0.003 0.0024
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0127 0.0152 0.019
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0034 0.0007 0.0007
Mycobacterium ulcerans multifunctional mycocerosic acid synthase membrane-associated Mas 0.0055 0.004 0.0882
Echinococcus multilocularis EGFP:Bcl2 fusion protein 0.067 0.1002 0.1252
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0009 0.0014
Echinococcus granulosus subfamily M12B unassigned peptidase 0.009 0.0094 0.0094
Schistosoma mansoni serine/threonine protein kinase 0.0105 0.0118 0.0118
Brugia malayi Disintegrin family protein 0.0037 0.0012 0.0005
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0282 0.0395 0.0648
Echinococcus multilocularis NAD dependent deacetylase sirtuin 1 0.0049 0.003 0.0038
Giardia lamblia Furin precursor putative serine protease 0.1277 0.1952 0.5333
Schistosoma mansoni polycystin 1-related 0.0082 0.0083 0.0083
Echinococcus multilocularis RNA directed DNA polymerase 0.0048 0.0028 0.0035
Plasmodium vivax LCCL domain-containing protein 0.0042 0.0019 0.0337
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0282 0.0395 0.0648
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.0282 0.0395 0.0395
Onchocerca volvulus 0.0095 0.0103 0.1473
Loa Loa (eye worm) hypothetical protein 0.1107 0.1686 0.1681
Loa Loa (eye worm) hypothetical protein 0.0048 0.0028 0.0022
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0034 0.0007 0.0007
Mycobacterium ulcerans Type I modular polyketide synthase 0.0052 0.0035 0.0745
Giardia lamblia hypothetical protein 0.0125 0.015 0.0387
Schistosoma mansoni subfamily M12B unassigned peptidase (M12 family) 0.009 0.0094 0.0094
Echinococcus granulosus Furin 1 0.1559 0.2394 0.2394
Leishmania major NAD dependent deacetylase, putative,transcriptional regulator, Sir2 family protein, nicotinic acid mononucleotide 5,6-dimethylbe 0.0049 0.003 0.064
Loa Loa (eye worm) kelch domain-containing protein family protein 0.0672 0.1006 0.1
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0282 0.0395 0.0648
Schistosoma mansoni chromatin regulatory protein sir2 0.0049 0.003 0.003
Schistosoma mansoni discoidin domain receptor 0.0042 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.0035 0.0008 0.0001
Loa Loa (eye worm) hypothetical protein 0.0451 0.0659 0.0653
Giardia lamblia Tenascin precursor 0.0125 0.015 0.0387
Plasmodium vivax subtilisin-like protease 1 0.0282 0.0395 0.7109
Loa Loa (eye worm) hypothetical protein 0.0042 0.0019 0.0012

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 73.5 nM Displacement of [3H]PDBu form mouse PKCalpha by scintillation counting ChEMBL. 18698758

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.