Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0268 | 0.1158 | 0.1187 |
Loa Loa (eye worm) | pyruvate kinase | 0.0038 | 0.0055 | 0.0056 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.0091 | 0.0093 |
Trypanosoma brucei | pyruvate kinase 1, putative | 0.0038 | 0.0055 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0096 | 0.0334 | 0.0342 |
Brugia malayi | nuclear hormone receptor | 0.0096 | 0.0334 | 0.0287 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0052 | 0.0122 | 0.2412 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.0091 | 0.0093 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0096 | 0.0334 | 0.0342 |
Echinococcus multilocularis | nuclear receptor subfamily 4 group A | 0.0045 | 0.0091 | 0.0648 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.0091 | 0.0093 |
Plasmodium falciparum | pyruvate kinase | 0.0038 | 0.0055 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0096 | 0.0334 | 0.0342 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0096 | 0.0334 | 0.0287 |
Brugia malayi | ecdysone receptor | 0.0045 | 0.0091 | 0.0037 |
Echinococcus multilocularis | pyruvate kinase | 0.0038 | 0.0055 | 0.0334 |
Schistosoma mansoni | survival motor neuron protein | 0.0055 | 0.0136 | 0.2897 |
Echinococcus granulosus | nuclear receptor subfamily 4 group A | 0.0045 | 0.0091 | 0.0325 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.0117 | 0.012 |
Loa Loa (eye worm) | hypothetical protein | 0.0096 | 0.0334 | 0.0342 |
Toxoplasma gondii | pyruvate kinase PyK1 | 0.0038 | 0.0055 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0096 | 0.0334 | 0.0287 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0096 | 0.0334 | 0.0287 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0096 | 0.0334 | 0.2777 |
Echinococcus multilocularis | pyruvate kinase | 0.0038 | 0.0055 | 0.0334 |
Trypanosoma cruzi | pyruvate kinase 2, putative | 0.0038 | 0.0055 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.0091 | 0.0093 |
Schistosoma mansoni | nuclear receptor nhr-48 | 0.0045 | 0.0091 | 0.1284 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0096 | 0.0334 | 0.0287 |
Loa Loa (eye worm) | nuclear hormone receptor | 0.0045 | 0.0091 | 0.0093 |
Echinococcus multilocularis | nuclear receptor nhr 48 | 0.0045 | 0.0091 | 0.0648 |
Onchocerca volvulus | 0.0055 | 0.0136 | 0.0081 | |
Loa Loa (eye worm) | hypothetical protein | 0.0096 | 0.0334 | 0.0342 |
Schistosoma mansoni | ecdysone-induced protein 78c (dr-78) | 0.0051 | 0.0117 | 0.2218 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0096 | 0.0334 | 0.028 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.0091 | 0.0093 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0096 | 0.0334 | 0.028 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0096 | 0.0334 | 0.2777 |
Brugia malayi | Nuclear hormone receptor E75 | 0.0045 | 0.0091 | 0.0037 |
Echinococcus granulosus | Nuclear hormone receptor HR96 | 0.0045 | 0.0091 | 0.0325 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0096 | 0.0334 | 0.2528 |
Brugia malayi | ecdysteroid receptor | 0.0096 | 0.0334 | 0.0287 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0096 | 0.0334 | 1 |
Brugia malayi | steroid hormone receptor | 0.0096 | 0.0334 | 0.0287 |
Chlamydia trachomatis | pyruvate kinase | 0.0038 | 0.0055 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.0091 | 0.0093 |
Onchocerca volvulus | Nuclear receptor subfamily 6 group A member 1 homolog | 0.0045 | 0.0091 | 0.0036 |
Schistosoma mansoni | thyroid hormone receptor | 0.0096 | 0.0334 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0096 | 0.0334 | 0.0342 |
Loa Loa (eye worm) | nuclear receptor NHR-67 | 0.0045 | 0.0091 | 0.0093 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0096 | 0.0334 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0096 | 0.0334 | 0.0342 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0096 | 0.0334 | 0.2777 |
Brugia malayi | nuclear hormone receptor | 0.2063 | 0.9757 | 1 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0051 | 0.0117 | 0.0064 |
Onchocerca volvulus | 0.0045 | 0.0091 | 0.0036 | |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0096 | 0.0334 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0055 | 0.0056 |
Echinococcus granulosus | Nuclear hormone receptor HR96 | 0.0045 | 0.0091 | 0.0325 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0052 | 0.0122 | 0.0924 |
Brugia malayi | hypothetical protein | 0.0051 | 0.0117 | 0.0064 |
Brugia malayi | orphan nuclear receptor NR2E1 | 0.0045 | 0.0091 | 0.0037 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0096 | 0.0334 | 1 |
Schistosoma mansoni | nuclear hormone receptor | 0.0045 | 0.0091 | 0.1284 |
Mycobacterium tuberculosis | Probable pyruvate kinase PykA | 0.0038 | 0.0055 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.0117 | 0.012 |
Plasmodium vivax | pyruvate kinase, putative | 0.0038 | 0.0055 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.0091 | 0.0093 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.0117 | 0.012 |
Giardia lamblia | Pyruvate kinase | 0.0038 | 0.0055 | 0.5 |
Loa Loa (eye worm) | nuclear receptor nhr-7B | 0.2063 | 0.9757 | 1 |
Brugia malayi | conserved hypotetical protein | 0.0045 | 0.0091 | 0.0037 |
Schistosoma mansoni | nuclear receptor | 0.0045 | 0.0091 | 0.1284 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.0117 | 0.012 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.0091 | 0.0093 |
Loa Loa (eye worm) | hypothetical protein | 0.2017 | 0.954 | 0.9778 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0096 | 0.0334 | 0.0287 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0096 | 0.0334 | 0.2777 |
Schistosoma mansoni | coup transcription factor | 0.0096 | 0.0334 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0052 | 0.0122 | 0.2412 |
Loa Loa (eye worm) | hypothetical protein | 0.0096 | 0.0334 | 0.0342 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0096 | 0.0334 | 0.0287 |
Leishmania major | pyruvate kinase | 0.0038 | 0.0055 | 0.5 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0052 | 0.0122 | 0.0069 |
Schistosoma mansoni | hepatocyte nuclear factor 4-alpha (hnf-4-alpha) | 0.0045 | 0.0091 | 0.1284 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0096 | 0.0334 | 0.2777 |
Brugia malayi | nuclear receptor subfamily 1, group D, member 1, putative | 0.0045 | 0.0091 | 0.0037 |
Schistosoma mansoni | zinc finger protein | 0.0045 | 0.0091 | 0.1284 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0096 | 0.0334 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.0091 | 0.0093 |
Loa Loa (eye worm) | DR-78 | 0.0045 | 0.0091 | 0.0093 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0052 | 0.0122 | 0.061 |
Loa Loa (eye worm) | hypothetical protein | 0.0096 | 0.0334 | 0.0342 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0096 | 0.0334 | 0.2528 |
Schistosoma mansoni | nuclear receptor | 0.0045 | 0.0091 | 0.1284 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0052 | 0.0122 | 0.0125 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.0091 | 0.0093 |
Echinococcus granulosus | FTZ F1 alpha | 0.0096 | 0.0334 | 0.2528 |
Echinococcus multilocularis | nuclear receptor subfamily 1 group D | 0.0051 | 0.0117 | 0.0876 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0096 | 0.0334 | 0.2777 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.0091 | 0.0093 |
Schistosoma mansoni | hypothetical protein | 0.0055 | 0.0136 | 0.2897 |
Brugia malayi | nuclear receptor RXR | 0.0051 | 0.0117 | 0.0064 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0096 | 0.0334 | 0.2777 |
Brugia malayi | nuclear receptor NHR-88 | 0.0096 | 0.0334 | 0.0287 |
Trypanosoma brucei | pyruvate kinase 1 | 0.0038 | 0.0055 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.0051 | 0.0117 | 0.012 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0096 | 0.0334 | 0.2777 |
Echinococcus multilocularis | retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha | 0.0045 | 0.0091 | 0.0648 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0096 | 0.0334 | 0.0287 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0045 | 0.0091 | 0.0325 |
Brugia malayi | nuclear hormone receptor family member nhr-6 | 0.0045 | 0.0091 | 0.0037 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0096 | 0.0334 | 1 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0268 | 0.1158 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0096 | 0.0334 | 0.0287 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0096 | 0.0334 | 0.0287 |
Echinococcus granulosus | thyroid hormone receptor alpha | 0.0045 | 0.0091 | 0.0325 |
Entamoeba histolytica | pyruvate kinase, putative | 0.0026 | 0 | 0.5 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0096 | 0.0334 | 1 |
Brugia malayi | nuclear receptor NHR-88 | 0.0045 | 0.0091 | 0.0037 |
Brugia malayi | Nuclear hormone receptor E75 | 0.0045 | 0.0091 | 0.0037 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0096 | 0.0334 | 0.0342 |
Onchocerca volvulus | 0.0096 | 0.0334 | 0.028 | |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0096 | 0.0334 | 0.0287 |
Loa Loa (eye worm) | hypothetical protein | 0.0096 | 0.0334 | 0.0342 |
Trichomonas vaginalis | pyruvate kinase, putative | 0.0038 | 0.0055 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0096 | 0.0334 | 1 |
Onchocerca volvulus | 0.0045 | 0.0091 | 0.0036 | |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0051 | 0.0117 | 0.0064 |
Schistosoma mansoni | nuclear hormone receptor superfamily protein-related | 0.0045 | 0.0091 | 0.1284 |
Leishmania major | pyruvate kinase | 0.0038 | 0.0055 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0096 | 0.0334 | 0.0342 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0096 | 0.0334 | 0.2528 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.0091 | 0.0093 |
Brugia malayi | tailless protein | 0.0045 | 0.0091 | 0.0037 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0096 | 0.0334 | 0.0287 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0096 | 0.0334 | 0.0287 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0096 | 0.0334 | 0.0342 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0096 | 0.0334 | 0.0287 |
Mycobacterium leprae | Probable pyruvate kinase PykA | 0.0038 | 0.0055 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0096 | 0.0334 | 0.2528 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0096 | 0.0334 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.0117 | 0.012 |
Brugia malayi | hypothetical protein | 0.0045 | 0.0091 | 0.0037 |
Trichomonas vaginalis | pyruvate kinase, putative | 0.0038 | 0.0055 | 0.5 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0052 | 0.0122 | 0.061 |
Mycobacterium ulcerans | pyruvate kinase | 0.0038 | 0.0055 | 0.5 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0096 | 0.0334 | 0.2777 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0055 | 0.0136 | 0.0083 |
Onchocerca volvulus | Nuclear receptor subfamily 6 group A member 1 homolog | 0.0045 | 0.0091 | 0.0036 |
Schistosoma mansoni | nuclear hormone receptor | 0.0096 | 0.0334 | 1 |
Loa Loa (eye worm) | pyruvate kinase | 0.0038 | 0.0055 | 0.0056 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0096 | 0.0334 | 0.0342 |
Echinococcus granulosus | nuclear receptor nhr 48 | 0.0045 | 0.0091 | 0.0325 |
Loa Loa (eye worm) | hypothetical protein | 0.0096 | 0.0334 | 0.0342 |
Echinococcus multilocularis | Nuclear hormone receptor HR96 | 0.0045 | 0.0091 | 0.0648 |
Loa Loa (eye worm) | pyruvate kinase | 0.0038 | 0.0055 | 0.0056 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0096 | 0.0334 | 0.0287 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0096 | 0.0334 | 0.2528 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0096 | 0.0334 | 0.0287 |
Brugia malayi | hypothetical protein | 0.0268 | 0.1158 | 0.1137 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0096 | 0.0334 | 0.2528 |
Schistosoma mansoni | nuclear hormone receptor | 0.0045 | 0.0091 | 0.1284 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0052 | 0.0122 | 0.2412 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0096 | 0.0334 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0096 | 0.0334 | 0.0287 |
Echinococcus granulosus | nuclear receptor subfamily 1 group D | 0.0051 | 0.0117 | 0.0561 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0268 | 0.1158 | 1 |
Brugia malayi | hypothetical protein | 0.0045 | 0.0091 | 0.0037 |
Brugia malayi | nuclear hormone receptor family member odr-7 | 0.0045 | 0.0091 | 0.0037 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0052 | 0.0122 | 0.0924 |
Brugia malayi | nuclear receptor RXR | 0.0045 | 0.0091 | 0.0037 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0051 | 0.0117 | 0.2218 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.0091 | 0.0093 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0096 | 0.0334 | 0.2528 |
Brugia malayi | nuclear receptor NHR-67 | 0.0045 | 0.0091 | 0.0037 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0045 | 0.0091 | 0.0648 |
Echinococcus multilocularis | Nuclear hormone receptor HR96 | 0.0045 | 0.0091 | 0.0648 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0096 | 0.0334 | 0.0342 |
Trypanosoma cruzi | pyruvate kinase 2, putative | 0.0038 | 0.0055 | 0.5 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0096 | 0.0334 | 0.2528 |
Brugia malayi | hypothetical protein | 0.0051 | 0.0117 | 0.0064 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (functional) | = 7 % | Antimycobacterial activity against Mycobacterium tuberculosis H37Rv at 6.25 ug/ml after 4 days by microplate alamar blue assay | ChEMBL. | 18977145 |
LC50 (ADMET) | = 126.91 ug ml-1 | Cytotoxicity against HEK293 cells after 72 hrs by MTT assay | ChEMBL. | 18977145 |
MIC (functional) | > 6.25 ug ml-1 | Antimycobacterial activity against Mycobacterium tuberculosis H37Rv after 4 days by microplate alamar blue assay | ChEMBL. | 18977145 |
pKb (functional) | Antagonist activity at guinea pig ileum histamine H1 receptor at 0.3 x 10'4 M | ChEMBL. | 18977145 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.