Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | CXXC zinc finger family protein | 0.0032 | 0.4331 | 0.4856 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0028 | 0.3713 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.042 | 0.5 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0017 | 0.2052 | 0.1681 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0017 | 0.2052 | 0.2238 |
Schistosoma mansoni | cpg binding protein | 0.0034 | 0.4619 | 0.4619 |
Schistosoma mansoni | hypothetical protein | 0.0017 | 0.2052 | 0.2052 |
Toxoplasma gondii | histone lysine methyltransferase SET1 | 0.006 | 0.8854 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.5275 | 0.615 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.042 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.042 | 0.5 |
Schistosoma mansoni | cpg binding protein | 0.0032 | 0.4331 | 0.4331 |
Echinococcus multilocularis | cpg binding protein | 0.0034 | 0.4619 | 0.6015 |
Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.0007 | 0.042 | 0.5 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.001 | 0.0839 | 0.0453 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0007 | 0.042 | 0.5 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0051 | 0.7328 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0017 | 0.2052 | 0.2052 |
Trichomonas vaginalis | helicase, putative | 0.0007 | 0.042 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0028 | 0.3713 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.042 | 0.5 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0051 | 0.7328 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0051 | 0.7328 | 0.7328 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0051 | 0.7328 | 0.7328 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0051 | 0.7328 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0055 | 0.8052 | 1 |
Schistosoma mansoni | cpg binding protein | 0.0034 | 0.4619 | 0.4619 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.2052 | 0.1681 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.042 | 0.5 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0017 | 0.2052 | 0.1704 |
Onchocerca volvulus | 0.0032 | 0.4331 | 0.5 | |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0051 | 0.7328 | 1 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0028 | 0.3713 | 0.5 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0028 | 0.3713 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0012 | 0.1265 | 0.1265 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0017 | 0.2052 | 0.2238 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0007 | 0.042 | 0.5 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0028 | 0.3713 | 0.5 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0017 | 0.2052 | 0.2238 |
Schistosoma mansoni | hypothetical protein | 0.0038 | 0.5275 | 0.5275 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.042 | 0.5 |
Loa Loa (eye worm) | CXXC zinc finger family protein | 0.0032 | 0.4331 | 0.4842 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0007 | 0.042 | 0.5 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0017 | 0.2052 | 0.1704 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0007 | 0.042 | 0.5 |
Echinococcus multilocularis | Ataxin 2, N terminal,domain containing protein | 0.0012 | 0.1265 | 0.108 |
Brugia malayi | hypothetical protein | 0.0018 | 0.214 | 0.1826 |
Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.0007 | 0.042 | 0.5 |
Echinococcus granulosus | cpg binding protein | 0.0034 | 0.4619 | 0.6015 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0007 | 0.042 | 0.5 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0028 | 0.3713 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.042 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0017 | 0.2052 | 0.2052 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0028 | 0.3713 | 0.5 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0017 | 0.2052 | 0.2238 |
Brugia malayi | hypothetical protein | 0.0028 | 0.3713 | 0.4001 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0055 | 0.8052 | 1 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0051 | 0.7328 | 0.8997 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0051 | 0.7328 | 0.7328 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.3713 | 0.3984 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0051 | 0.7328 | 0.9 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0038 | 0.5275 | 0.616 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0007 | 0.042 | 0.5 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.001 | 0.0839 | 0.0453 |
Schistosoma mansoni | hypothetical protein | 0.0017 | 0.2052 | 0.2052 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.042 | 0.5 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0055 | 0.8052 | 1 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0008 | 0.0531 | 0.0531 |
Echinococcus multilocularis | GPCR, family 2 | 0.0017 | 0.2052 | 0.2238 |
Echinococcus granulosus | GPCR family 2 | 0.0017 | 0.2052 | 0.2238 |
Echinococcus granulosus | Ataxin 2 N terminaldomain containing protein | 0.0012 | 0.1265 | 0.108 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0055 | 0.8052 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.042 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | > 30 uM | Inhibition of human erythrocytes mu-calpain after 30 mins by fluorometric assay using pep1 as substrate | ChEMBL. | 19419206 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.