TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 323.267 | Formula: C16H12F3NO3
H donors: 0 H acceptors: 2 LogP: 3.52 Rotable bonds: 1
Rule of 5 violations (Lipinski): 1
SMILES: O=C1CC(Cc2c1c(C)c1c(n2)cc2c(c1)OCO2)C(F)(F)F
InChi: 1S/C16H12F3NO3/c1-7-9-4-13-14(23-6-22-13)5-10(9)20-11-2-8(16(17,18)19)3-12(21)15(7)11/h4-5,8H,2-3,6H2,1H3
InChiKey: VPMOPCVRQWHZQD-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	glucosylceramidase, putative	0.0196	0.1886	0.6209
Onchocerca volvulus		0.0051	0.0281	0.1255
Treponema pallidum	hexokinase (hxk)	0.0082	0.0619	0.5
Schistosoma mansoni	methyl-cpg binding protein mbd	0.0114	0.0972	0.2121
Trypanosoma brucei	PHD-zinc-finger like domain containing protein, putative	0.0042	0.0181	0.0277
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.024	0.2367	0.5259
Leishmania major	4-coumarate:coa ligase-like protein	0.0052	0.0282	0.061
Trypanosoma brucei	hexokinase	0.0082	0.0619	0.1711
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0035	0.0096	0.0256
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor1	0.0104	0.0858	0.2492
Loa Loa (eye worm)	bromodomain containing protein	0.0118	0.1017	0.2059
Toxoplasma gondii	LsmAD domain-containing protein	0.0057	0.0346	0.1757
Toxoplasma gondii	hypothetical protein	0.005	0.0267	0.0944
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0074	0.0529	0.3646
Loa Loa (eye worm)	hexokinase type II	0.0082	0.0619	0.1254
Loa Loa (eye worm)	hypothetical protein	0.013	0.1147	0.2323
Schistosoma mansoni	hexokinase	0.0082	0.0619	0.1313
Trypanosoma cruzi	JmjC domain, hydroxylase, putative	0.0042	0.0175	0.0258
Echinococcus granulosus	cpg binding protein	0.0045	0.0211	0.0267
Schistosoma mansoni	hypothetical protein	0.0036	0.0114	0.0154
Trypanosoma brucei	mitochondrial DNA polymerase beta-PAK	0.0147	0.1341	0.407
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0077	0.0564	0.1814
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0036	0.0114	0.0042
Brugia malayi	hypothetical protein	0.0098	0.0799	0.1514
Loa Loa (eye worm)	hypothetical protein	0.0272	0.2722	0.5512
Brugia malayi	hypothetical protein	0.0042	0.0173	0.0328
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0036	0.0114	0.0018
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0172	0.161	0.3585
Trypanosoma cruzi	DNA polymerase beta thumb, putative	0.0044	0.0195	0.0325
Plasmodium vivax	hypothetical protein, conserved	0.0044	0.0201	0.0628
Brugia malayi	PHD-finger family protein	0.013	0.1147	0.2176
Echinococcus multilocularis	methyl CpG binding domain protein 2	0.0114	0.0972	0.0884
Trypanosoma brucei	DNA polymerase beta thumb, putative	0.0044	0.0195	0.0325
Trichomonas vaginalis	glucosylceramidase, putative	0.0196	0.1886	0.6209
Echinococcus multilocularis	peregrin	0.0146	0.1322	0.1238
Echinococcus multilocularis	Jumonji, AT rich interactive domain 1B	0.0056	0.0335	0.0242
Brugia malayi	jmjC domain containing protein	0.0425	0.4415	0.8371
Mycobacterium ulcerans	acyl-CoA synthetase	0.0052	0.0282	0.1041
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.0039	0.0138	0.0165
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0115	0.0979	0.0892
Loa Loa (eye worm)	PHD-finger family protein	0.013	0.1147	0.2323
Brugia malayi	CXXC zinc finger family protein	0.0031	0.0051	0.0096
Loa Loa (eye worm)	hexokinase	0.0051	0.0281	0.0569
Leishmania major	target of rapamycin kinase (TOR) kinase 3	0.0082	0.0624	0.1728
Schistosoma mansoni	acetyl-CoA C-acetyltransferase	0.0152	0.1397	0.3096
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0056	0.0331	0.1036
Schistosoma mansoni	tar DNA-binding protein	0.0073	0.0524	0.1095
Toxoplasma gondii	PHD-finger domain-containing protein	0.013	0.1147	1
Schistosoma mansoni	hypothetical protein	0.0393	0.406	0.9203
Loa Loa (eye worm)	hypothetical protein	0.0079	0.0581	0.1176
Trypanosoma cruzi	JmjC domain, hydroxylase, putative	0.0042	0.0175	0.0258
Loa Loa (eye worm)	hypothetical protein	0.0287	0.2883	0.5837
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0056	0.0331	0.1036
Echinococcus granulosus	lysine specific demethylase 5A	0.0172	0.161	0.3506
Trypanosoma cruzi	DNA polymerase beta thumb, putative	0.0044	0.0195	0.0325
Onchocerca volvulus	Glucosylceramidase homolog	0.0196	0.1886	1
Schistosoma mansoni	hypothetical protein	0.0102	0.0842	0.1824
Trypanosoma cruzi	PAB1-binding protein , putative	0.0057	0.0346	0.0817
Onchocerca volvulus		0.0082	0.0619	0.3099
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0052	0.0282	0.1597
Entamoeba histolytica	phosphatidylinositol3-kinaseTor2, putative	0.0104	0.0858	1
Brugia malayi	TAR-binding protein	0.0073	0.0524	0.0994
Trypanosoma brucei	mitochondrial DNA polymerase beta	0.0311	0.3154	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0082	0.0623	0.2011
Trypanosoma cruzi	PAB1-binding protein , putative	0.0057	0.0346	0.0817
Schistosoma mansoni	hypothetical protein	0.0079	0.0581	0.1225
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0115	0.0983	0.1992
Echinococcus granulosus	phd:f box containing protein	0.0042	0.0175	0.0183
Loa Loa (eye worm)	jmjC domain-containing protein	0.0042	0.0175	0.0354
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0164	0.1525	1
Trichomonas vaginalis	glucosylceramidase, putative	0.0299	0.3025	1
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.04	0.4143	0.4086
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0035	0.0096	0.0256
Brugia malayi	PHD-finger family protein	0.0057	0.0341	0.0647
Loa Loa (eye worm)	jmjC domain-containing protein	0.0172	0.161	0.326
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0082	0.0623	0.2011
Brugia malayi	Hexokinase family protein	0.0082	0.0619	0.1174
Brugia malayi	jmjC domain containing protein	0.0042	0.0175	0.0332
Brugia malayi	hypothetical protein	0.0037	0.0121	0.0229
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0104	0.0858	0.1627
Brugia malayi	RNA binding protein	0.0073	0.0524	0.0994
Echinococcus multilocularis	hexokinase	0.0082	0.0619	0.0528
Brugia malayi	AF-10 protein	0.0042	0.0181	0.0343
Trypanosoma brucei	hexokinase, putative	0.0082	0.0619	0.1711
Echinococcus multilocularis	jumonji domain containing 1A	0.0042	0.0175	0.008
Entamoeba histolytica	acyl-coA synthetase, putative	0.0052	0.0282	0.1597
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0052	0.0282	0.1597
Schistosoma mansoni	phosphatidylinositol 3-and 4-kinase	0.0035	0.0096	0.0113
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.005	0.0265	0.05
Brugia malayi	Bromodomain containing protein	0.0503	0.5274	1
Trypanosoma brucei	ISWI complex protein	0.0102	0.0842	0.244
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0346	0.07
Brugia malayi	O-Glycosyl hydrolase family 30 protein	0.0299	0.3025	0.5736
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0052	0.0282	0.5
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0036	0.0114	0.0042
Leishmania major	hypothetical protein, conserved	0.0102	0.0842	0.244
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	0.0104	0.0858	0.2492
Echinococcus granulosus	hexokinase type 2	0.0082	0.0619	0.1212
Loa Loa (eye worm)	jmjC domain-containing protein	0.0268	0.2676	0.542
Schistosoma mansoni	transcription factor LCR-F1	0.0042	0.0173	0.0289
Trichomonas vaginalis	glucosylceramidase, putative	0.0299	0.3025	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0062	0.0397	0.1256
Mycobacterium ulcerans	acyl-CoA synthetase	0.0052	0.0282	0.1041
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0056	0.033	0.1033
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0042	0.0173	0.0078
Leishmania major	target of rapamycin (TOR) kinase 1, putative	0.0104	0.0858	0.2492
Trypanosoma brucei	phosphatidylinositol 3-kinase tor, putative	0.0049	0.0254	0.0516
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0077	0.0564	0.1814
Brugia malayi	jmjC domain containing protein	0.0042	0.0175	0.0332
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0082	0.0623	0.2011
Brugia malayi	jmjC domain containing protein	0.0042	0.0175	0.0332
Echinococcus granulosus	peregrin	0.0146	0.1322	0.284
Plasmodium falciparum	phd finger protein, putative	0.013	0.1147	1
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0138	0.028
Leishmania major	4-coumarate:coa ligase-like protein	0.0052	0.0282	0.061
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0175	0.0354
Brugia malayi	RNA recognition motif domain containing protein	0.0073	0.0524	0.0994
Loa Loa (eye worm)	MH2 domain-containing protein	0.0275	0.2758	0.5585
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0073	0.0524	0.1061
Schistosoma mansoni	cpg binding protein	0.0045	0.0211	0.0377
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor2	0.0104	0.0858	0.2492
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.024	0.2367	0.2293
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0077	0.0564	0.1814
Schistosoma mansoni	tar DNA-binding protein	0.0073	0.0524	0.1095
Loa Loa (eye worm)	TAR-binding protein	0.0073	0.0524	0.1061
Brugia malayi	latrophilin 2 splice variant baaae	0.0079	0.0581	0.1102
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0175	0.0354
Loa Loa (eye worm)	RNA binding protein	0.0073	0.0524	0.1061
Loa Loa (eye worm)	hypothetical protein	0.0115	0.0979	0.1983
Loa Loa (eye worm)	PHD-finger family protein	0.0138	0.1236	0.2503
Schistosoma mansoni	tar DNA-binding protein	0.0073	0.0524	0.1095
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0077	0.0564	0.1814
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0035	0.0096	0.0256
Echinococcus multilocularis	hexokinase	0.0082	0.0619	0.0528
Toxoplasma gondii	target of rapamycin (TOR), putative	0.0077	0.0564	0.4005
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.0425	0.4415	1
Loa Loa (eye worm)	hypothetical protein	0.0222	0.2173	0.4401
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0088	0.069	0.2234
Loa Loa (eye worm)	hypothetical protein	0.0256	0.2547	0.5158
Trypanosoma brucei	Phosphatidylinositol 3-kinase tor1	0.0104	0.0858	0.2492
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0056	0.033	0.1033
Mycobacterium ulcerans	acyl-CoA synthetase	0.0052	0.0282	0.1041
Onchocerca volvulus	Alhambra homolog	0.013	0.1147	0.5976
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0035	0.0096	0.0182
Echinococcus granulosus	lysine specific demethylase 6a	0.0042	0.0175	0.0183
Echinococcus multilocularis	JmjC domain containing protein 4	0.0042	0.0175	0.008
Onchocerca volvulus		0.0082	0.0619	0.3099
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0147	0.1341	0.407
Schistosoma mansoni	phosphatidylserine receptor	0.0042	0.0175	0.0294
Schistosoma mansoni	hypothetical protein	0.013	0.1147	0.2524
Echinococcus multilocularis	PHD finger protein rhinoceros	0.013	0.1147	0.1062
Schistosoma mansoni	hypothetical protein	0.0042	0.0173	0.0289
Brugia malayi	MH2 domain containing protein	0.0275	0.2758	0.523
Echinococcus multilocularis	hexokinase	0.0082	0.0619	0.0528
Loa Loa (eye worm)	hypothetical protein	0.0098	0.0799	0.1617
Echinococcus granulosus	methyl CpG binding domain protein 2	0.0114	0.0972	0.2028
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0104	0.0858	0.2791
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0115	0.0983	0.1865
Brugia malayi	Latrophilin receptor protein 2	0.0036	0.0114	0.0216
Schistosoma mansoni	phd/f-box containing protein	0.0042	0.0175	0.0294
Trypanosoma brucei	target of rapamycin kinase 3, putative	0.0082	0.0624	0.1728
Plasmodium vivax	hexokinase, putative	0.0082	0.0619	0.4768
Plasmodium falciparum	conserved Plasmodium membrane protein, unknown function	0.0044	0.0201	0.0628
Brugia malayi	AMP-binding enzyme family protein	0.0052	0.0282	0.0535
Loa Loa (eye worm)	O-glycosyl hydrolase family 30 protein	0.0299	0.3025	0.6126
Plasmodium falciparum	hexokinase	0.0082	0.0619	0.4768
Trypanosoma cruzi	hexokinase, putative	0.0082	0.0619	0.1711
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0062	0.0397	0.1256
Plasmodium vivax	hypothetical protein, conserved	0.013	0.1147	1
Loa Loa (eye worm)	transcription factor SMAD2	0.0275	0.2758	0.5585
Schistosoma mansoni	hypothetical protein	0.0393	0.406	0.9203
Leishmania major	mitochondrial DNA polymerase beta	0.0311	0.3154	1
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0036	0.0114	0.0231
Echinococcus multilocularis	tar DNA binding protein	0.0073	0.0524	0.0432
Echinococcus multilocularis	GPCR, family 2	0.0036	0.0114	0.0018
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0052	0.0282	0.1189
Schistosoma mansoni	bromodomain containing protein	0.0424	0.4408	1
Schistosoma mansoni	bromodomain-containing nuclear protein 1 brd1	0.013	0.1147	0.2524
Entamoeba histolytica	hexokinase 2	0.0082	0.0619	0.6514
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0065	0.0431	0.0882
Brugia malayi	jmjC domain containing protein	0.0172	0.161	0.3053
Brugia malayi	hypothetical protein	0.0057	0.0346	0.0656
Echinococcus granulosus	hexokinase	0.0082	0.0619	0.1212
Loa Loa (eye worm)	jmjC domain-containing protein	0.0042	0.0175	0.0354
Echinococcus granulosus	PHD finger protein rhinoceros	0.013	0.1147	0.2435
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0172	0.161	0.3585
Echinococcus multilocularis	lysine specific demethylase 5A	0.0157	0.1449	0.1367
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0077	0.0564	0.1814
Loa Loa (eye worm)	hypothetical protein	0.0098	0.0799	0.1617
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0056	0.0331	0.1036
Entamoeba histolytica	FKBP-rapamycin associated protein (FRAP), putative	0.0104	0.0858	1
Entamoeba histolytica	hexokinase 1	0.0082	0.0619	0.6514
Echinococcus granulosus	GPCR family 2	0.0036	0.0114	0.0042
Echinococcus granulosus	FKBP12 rapamycin complex associated protein	0.0104	0.0858	0.1765
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0056	0.0331	0.1036
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0104	0.0858	0.2791
Brugia malayi	Hexokinase family protein	0.0051	0.0281	0.0533
Schistosoma mansoni	protein phosphatase 2C	0.0042	0.0175	0.0294
Loa Loa (eye worm)	hypothetical protein	0.0115	0.0983	0.1992
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0115	0.0979	0.2138
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.04	0.4143	0.9371
Trypanosoma brucei	hexokinase	0.0082	0.0619	0.1711
Leishmania major	hexokinase, putative	0.0082	0.0619	0.1711
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0035	0.0096	0.0256
Leishmania major	hypothetical protein, conserved	0.0057	0.0346	0.0817
Schistosoma mansoni	hypothetical protein	0.0036	0.0114	0.0154
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0138	0.028
Echinococcus granulosus	tar DNA binding protein	0.0073	0.0524	0.0992
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0042	0.0173	0.0178
Echinococcus granulosus	hexokinase	0.0082	0.0619	0.1212
Echinococcus multilocularis	lysine specific demethylase 6a	0.0042	0.0175	0.008
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0069	0.0481	0.1535
Schistosoma mansoni	methyl-cpg binding protein mbd	0.0114	0.0972	0.2121
Toxoplasma gondii	PHD-finger domain-containing protein	0.013	0.1147	1
Trichomonas vaginalis	glucosylceramidase, putative	0.0196	0.1886	0.6209
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0052	0.0282	0.1189
Schistosoma mansoni	hypothetical protein	0.0138	0.1236	0.2728
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0052	0.0282	0.5
Leishmania major	4-coumarate:coa ligase-like protein	0.0052	0.0282	0.061
Plasmodium vivax	JmjC domain containing protein	0.0042	0.0175	0.0365
Schistosoma mansoni	ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related	0.0042	0.0175	0.0294
Echinococcus multilocularis	geminin	0.0393	0.406	0.4002
Trichomonas vaginalis	glucosylceramidase, putative	0.0196	0.1886	0.6209
Trichomonas vaginalis	glucosylceramidase, putative	0.0299	0.3025	1
Trypanosoma cruzi	ISWI complex protein	0.0102	0.0842	0.244
Plasmodium falciparum	JmjC domain-containing protein, putative	0.0042	0.0175	0.0365
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0104	0.0858	0.2791
Schistosoma mansoni	jumonji domain containing protein	0.0338	0.3448	0.7799
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0341	0.0691
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0082	0.0623	0.2011
Trichomonas vaginalis	glucosylceramidase, putative	0.0207	0.2003	0.6599
Echinococcus multilocularis	zinc finger protein	0.0132	0.1178	0.1092
Schistosoma mansoni	hypothetical protein	0.0036	0.0114	0.0154
Toxoplasma gondii	WD domain, G-beta repeat-containing protein	0.0042	0.0181	0.006
Echinococcus granulosus	JmjC domain containing protein 4	0.0042	0.0175	0.0183
Loa Loa (eye worm)	hypothetical protein	0.003	0.0047	0.0095
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0282	0.0572
Trichomonas vaginalis	glucosylceramidase, putative	0.0299	0.3025	1
Echinococcus multilocularis	cpg binding protein	0.0045	0.0211	0.0117
Trypanosoma brucei	JmjC domain, hydroxylase, putative	0.0042	0.0175	0.0258
Brugia malayi	hexokinase	0.0082	0.0619	0.1174
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0282	0.0572
Loa Loa (eye worm)	phosphatidylinositol 3	0.0035	0.0096	0.0194
Echinococcus granulosus	Jumonji AT rich interactive domain 1B	0.0056	0.0335	0.0554
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0138	0.028
Echinococcus granulosus	jumonji domain containing protein	0.0181	0.171	0.3737
Brugia malayi	Bromodomain containing protein	0.0146	0.1322	0.2507
Schistosoma mansoni	tar DNA-binding protein	0.0073	0.0524	0.1095
Plasmodium falciparum	ataxin-2 like protein, putative	0.0057	0.0346	0.2058
Loa Loa (eye worm)	hexokinase	0.0082	0.0619	0.1254
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0052	0.0282	0.1041
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	0.0311	0.3154	1
Trypanosoma brucei	PHD-zinc-finger like domain containing protein, putative	0.0042	0.0181	0.0277
Giardia lamblia	PHD finger protein 15	0.013	0.1147	1
Loa Loa (eye worm)	hypothetical protein	0.0472	0.4938	1
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0053	0.0301	0.0672
Echinococcus granulosus	fetal alzheimer antigen falz	0.0152	0.1397	0.3012
Echinococcus granulosus	histone lysine methyltransferase setb	0.0115	0.0979	0.2045
Plasmodium falciparum	ataxin-2 like protein, putative	0.0057	0.0346	0.2058
Echinococcus multilocularis	jumonji domain containing protein	0.0181	0.171	0.1629
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0052	0.0282	0.1041
Trypanosoma cruzi	ISWI complex protein	0.0102	0.0842	0.244
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0035	0.0096	0.0256
Leishmania major	target of rapamycin (TOR) kinase 2, putative	0.0104	0.0858	0.2492
Schistosoma mansoni	eyes absent homolog	0.0098	0.0799	0.1724
Chlamydia trachomatis	acylglycerophosphoethanolamine acyltransferase	0.0039	0.0138	0.5
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0282	0.0572
Trichomonas vaginalis	glucosylceramidase, putative	0.0207	0.2003	0.6599
Onchocerca volvulus		0.0052	0.0282	0.1262
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0036	0.0114	0.0216
Trypanosoma cruzi	target of rapamycin kinase 3	0.0082	0.0624	0.1728
Schistosoma mansoni	tar DNA-binding protein	0.0073	0.0524	0.1095
Trichomonas vaginalis	glucosylceramidase, putative	0.0196	0.1886	0.6209
Schistosoma mansoni	hypothetical protein	0.0036	0.0114	0.0154
Leishmania major	hypothetical protein, conserved	0.0042	0.0175	0.0258
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0036	0.0114	0.0018
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0052	0.0282	0.1041
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0062	0.0397	0.1256
Schistosoma mansoni	zinc finger protein	0.0102	0.0842	0.1824
Echinococcus multilocularis	hexokinase type 2	0.0082	0.0619	0.0528
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0082	0.0623	0.2011
Echinococcus granulosus	hexokinase	0.0082	0.0619	0.1212
Brugia malayi	AMP-binding enzyme family protein	0.0052	0.0282	0.0535
Plasmodium vivax	ataxin-2 like protein, putative	0.0057	0.0346	0.2058
Leishmania major	mitochondrial DNA polymerase beta-PAK, putative	0.0147	0.1341	0.407
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0031	0.0051	0.0103
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0138	0.028
Echinococcus granulosus	zinc finger protein	0.0132	0.1178	0.2504
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0115	0.0983	0.1865
Schistosoma mansoni	ataxia telangiectasia mutated (atm)-related	0.0104	0.0858	0.1861
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0052	0.0282	0.1041
Schistosoma mansoni	jumonji domain containing protein	0.0042	0.0175	0.0294
Loa Loa (eye worm)	jmjC domain-containing protein	0.0042	0.0175	0.0354
Schistosoma mansoni	cpg binding protein	0.0031	0.0051	0.0009
Trichomonas vaginalis	glucosylceramidase, putative	0.0196	0.1886	0.6209
Schistosoma mansoni	hypothetical protein	0.0042	0.0181	0.0307
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	0.0311	0.3154	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0077	0.0564	0.1814
Echinococcus multilocularis	phd:f box containing protein	0.0042	0.0175	0.008
Echinococcus multilocularis	FKBP12 rapamycin complex associated protein	0.0104	0.0858	0.077
Mycobacterium ulcerans	hypothetical protein	0.0164	0.1525	1
Toxoplasma gondii	hexokinase	0.0082	0.0619	0.457
Toxoplasma gondii	PHD-finger domain-containing protein	0.0042	0.0181	0.006
Brugia malayi	AMP-binding enzyme family protein	0.0052	0.0282	0.0535
Schistosoma mansoni	zinc finger protein	0.0132	0.1178	0.2593
Trichomonas vaginalis	glucosylceramidase, putative	0.0299	0.3025	1
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.0425	0.4415	0.4361
Trypanosoma cruzi	hexokinase, putative	0.0082	0.0619	0.1711
Trichomonas vaginalis	glucosylceramidase, putative	0.0196	0.1886	0.6209
Echinococcus granulosus	geminin	0.0393	0.406	0.9179
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0061	0.039	0.1233
Trypanosoma brucei	PAB1-binding protein , putative	0.0057	0.0346	0.0817
Brugia malayi	jmjC domain containing protein	0.0042	0.0175	0.0332
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0056	0.033	0.1033
Echinococcus multilocularis	fetal alzheimer antigen, falz	0.0152	0.1397	0.1314
Trypanosoma brucei	FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative	0.0043	0.0188	0.03
Onchocerca volvulus		0.0082	0.0619	0.3099
Loa Loa (eye worm)	hexokinase	0.0082	0.0619	0.1254
Schistosoma mansoni	cpg binding protein	0.0045	0.0211	0.0377
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0077	0.0564	0.1814
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0044	0.0195	0.0325
Echinococcus granulosus	jumonji domain containing 1A	0.0042	0.0175	0.0183
Brugia malayi	F/Y-rich N-terminus family protein	0.0065	0.0426	0.0807
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0067	0.0456	0.1453
Brugia malayi	Bromodomain containing protein	0.0256	0.2542	0.482
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0061	0.039	0.1233
Trichomonas vaginalis	glucosylceramidase, putative	0.0299	0.3025	1
Loa Loa (eye worm)	phosphatidylinositol 3	0.0104	0.0858	0.1738
Mycobacterium ulcerans	hypothetical protein	0.0052	0.0282	0.1041
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0114	0.0231
Leishmania major	hexokinase, putative	0.0082	0.0619	0.1711
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0138	0.028
Onchocerca volvulus	Hexokinase homolog	0.0051	0.0281	0.1255
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0115	0.0979	0.2138
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0331	0.067
Brugia malayi	PHD-finger family protein	0.0168	0.1572	0.298

Activities

Activity type	Activity value	Assay description	Source	Reference
Inhibition (functional)	< 20 %	Growth inhibition of human MCF7 cells at 10 uM relative to control	ChEMBL.	18541426
Inhibition (functional)	< 20 %	Growth inhibition of human T47D cells at 10 uM relative to control	ChEMBL.	18541426
Inhibition (functional)	< 20 %	Growth inhibition of human HOP92 cells at 10 uM relative to control	ChEMBL.	18541426
Inhibition (functional)	< 20 %	Growth inhibition of human HCT116 cells at 10 uM relative to control	ChEMBL.	18541426
Inhibition (functional)	< 20 %	Growth inhibition of human HT29 cells at 10 uM relative to control	ChEMBL.	18541426
Inhibition (functional)	< 20 %	Growth inhibition of human CCRF-CEM cells at 10 uM relative to control	ChEMBL.	18541426
Inhibition (functional)	< 20 %	Growth inhibition of human CAKI1 cells at 10 uM relative to control	ChEMBL.	18541426
Inhibition (functional)	< 20 %	Growth inhibition of human 786-0 cells at 10 uM relative to control	ChEMBL.	18541426
Inhibition (functional)	< 20 %	Growth inhibition of human UACC257 cells at 10 uM relative to control	ChEMBL.	18541426
Inhibition (functional)	< 20 %	Growth inhibition of human SK-MEL-28 cells at 10 uM relative to control	ChEMBL.	18541426
Inhibition (functional)	< 20 %	Growth inhibition of human MOLT4 cells at 10 uM relative to control	ChEMBL.	18541426
Inhibition (functional)	= 25 %	Growth inhibition of human SNB75 cells at 10 uM relative to control	ChEMBL.	18541426
Inhibition (functional)	= 32 %	Growth inhibition of human SF295 cells at 10 uM relative to control	ChEMBL.	18541426
Inhibition (functional)	= 67 %	Growth inhibition of human A549 cells at 10 uM relative to control	ChEMBL.	18541426

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL487268

Bibliographic References

No literature references available for this target.

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Detailed information for compound 989504