Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0037 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 1 | 0.5 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0037 | 1 | 0.5 |
Brugia malayi | oxidoreductase, aldo/keto reductase family protein | 0.0037 | 1 | 0.5 |
Leishmania major | prostaglandin f synthase, putative | 0.0037 | 1 | 0.5 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0037 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0037 | 1 | 1 |
Schistosoma mansoni | aldo-keto reductase | 0.0037 | 1 | 0.5 |
Leishmania major | aldehyde reductase, putative,oxidoreductase, putative | 0.0037 | 1 | 0.5 |
Loa Loa (eye worm) | oxidoreductase | 0.0037 | 1 | 0.5 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0037 | 1 | 0.5 |
Echinococcus granulosus | aldo keto reductase | 0.0037 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0037 | 1 | 0.5 |
Onchocerca volvulus | 0.0037 | 1 | 0.5 | |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0037 | 1 | 0.5 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0037 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0037 | 1 | 0.5 |
Loa Loa (eye worm) | oxidoreductase | 0.0037 | 1 | 0.5 |
Onchocerca volvulus | 0.0037 | 1 | 0.5 | |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0037 | 1 | 0.5 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0037 | 1 | 1 |
Toxoplasma gondii | aldose reductase, putative | 0.0037 | 1 | 0.5 |
Brugia malayi | oxidoreductase, aldo/keto reductase family protein | 0.0037 | 1 | 0.5 |
Mycobacterium leprae | PROBABLE OXIDOREDUCTASE | 0.0037 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase | 0.0037 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0037 | 1 | 0.5 |
Trypanosoma cruzi | aldo-keto reductase | 0.0037 | 1 | 0.5 |
Brugia malayi | oxidoreductase, aldo/keto reductase family protein | 0.0037 | 1 | 0.5 |
Echinococcus multilocularis | aldo keto reductase | 0.0037 | 1 | 1 |
Onchocerca volvulus | 0.0037 | 1 | 0.5 | |
Trypanosoma cruzi | aldo/keto reductase, putative | 0.0037 | 1 | 0.5 |
Trichomonas vaginalis | dihydrodiol dehydrogenase, putative | 0.0037 | 1 | 0.5 |
Onchocerca volvulus | 0.0037 | 1 | 0.5 | |
Entamoeba histolytica | aldose reductase, putative | 0.0037 | 1 | 0.5 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0037 | 1 | 1 |
Giardia lamblia | Aldose reductase | 0.0037 | 1 | 0.5 |
Trichomonas vaginalis | aldo/keto reductase, putative | 0.0037 | 1 | 0.5 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0037 | 1 | 0.5 |
Onchocerca volvulus | 0.0037 | 1 | 0.5 | |
Trypanosoma brucei | aldo-keto reductase, putative | 0.0037 | 1 | 0.5 |
Trichomonas vaginalis | dihydrodiol dehydrogenase, putative | 0.0037 | 1 | 0.5 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0037 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0037 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0037 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0037 | 1 | 0.5 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0037 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0037 | 1 | 1 |
Echinococcus granulosus | hypothetical protein | 0.0037 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0037 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase | 0.0037 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0037 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase | 0.0037 | 1 | 1 |
Loa Loa (eye worm) | oxidoreductase | 0.0037 | 1 | 0.5 |
Mycobacterium ulcerans | oxidoreductase | 0.0037 | 1 | 0.5 |
Loa Loa (eye worm) | oxidoreductase | 0.0037 | 1 | 0.5 |
Loa Loa (eye worm) | oxidoreductase | 0.0037 | 1 | 0.5 |
Leishmania major | prostaglandin f2-alpha synthase/D-arabinose dehydrogenase | 0.0037 | 1 | 0.5 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0037 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase | 0.0037 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0037 | 1 | 1 |
Entamoeba histolytica | aldose reductase, putative | 0.0037 | 1 | 0.5 |
Leishmania major | aldo-keto reductase-like protein | 0.0037 | 1 | 0.5 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0037 | 1 | 1 |
Schistosoma mansoni | aldo-keto reductase | 0.0037 | 1 | 0.5 |
Trichomonas vaginalis | dihydrodiol dehydrogenase, putative | 0.0037 | 1 | 0.5 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0037 | 1 | 1 |
Trichomonas vaginalis | aldo/keto reductase, putative | 0.0037 | 1 | 0.5 |
Giardia lamblia | Aldose reductase | 0.0037 | 1 | 0.5 |
Entamoeba histolytica | aldose reductase, putative | 0.0037 | 1 | 0.5 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0037 | 1 | 0.5 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0037 | 1 | 0.5 |
Onchocerca volvulus | 0.0037 | 1 | 0.5 | |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0037 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase | 0.0037 | 1 | 1 |
Schistosoma mansoni | pol-related | 0.0037 | 1 | 0.5 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0037 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0037 | 1 | 1 |
Trichomonas vaginalis | aldo/keto reductase, putative | 0.0037 | 1 | 0.5 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0037 | 1 | 0.5 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0037 | 1 | 1 |
Trypanosoma brucei | prostaglandin f synthase | 0.0037 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | > 100 uM | Antiproliferative activity against human SW1573 cells after 48 hrs by SRB assay | ChEMBL. | 18789684 |
GI50 (functional) | > 100 uM | Antiproliferative activity against human T47D cells after 48 hrs by SRB assay | ChEMBL. | 18789684 |
GI50 (functional) | > 100 uM | Antiproliferative activity against human WiDr cells after 48 hrs by SRB assay | ChEMBL. | 18789684 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.