Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0061 | 0 | 0.5 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0061 | 0 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0061 | 0 | 0.5 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0061 | 0 | 0.5 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0061 | 0 | 0.5 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0061 | 0 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0061 | 0 | 0.5 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0061 | 0 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0061 | 0 | 0.5 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0061 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0578 | 1 | 1 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0061 | 0 | 0.5 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0061 | 0 | 0.5 |
Schistosoma mansoni | coup transcription factor | 0.0061 | 0 | 0.5 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0061 | 0 | 0.5 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0061 | 0 | 0.5 |
Echinococcus granulosus | FTZ F1 alpha | 0.0061 | 0 | 0.5 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0061 | 0 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0061 | 0 | 0.5 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0061 | 0 | 0.5 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0061 | 0 | 0.5 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0061 | 0 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor | 0.0061 | 0 | 0.5 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0061 | 0 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0061 | 0 | 0.5 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0061 | 0 | 0.5 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0061 | 0 | 0.5 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0061 | 0 | 0.5 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0061 | 0 | 0.5 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0061 | 0 | 0.5 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0061 | 0 | 0.5 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0061 | 0 | 0.5 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0578 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (binding) | Inhibition of HIV1 RT | ChEMBL. | 10395524 | |
IC50 (binding) | = 79.7 ug ml-1 | Inhibition of tyrosine kinase p56-lck | ChEMBL. | 10395524 |
IZ (functional) | = 1 mm | Antibacterial activity against Escherichia coli at 50 ug/disk | ChEMBL. | 10395524 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.