Detailed information for compound 990161

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 430.499 | Formula: C25H26N4O3
  • H donors: 2 H acceptors: 2 LogP: 4.32 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cc(O)c2c(c1)n(C)c1c(c2=O)cc(c(c1)N1CCN(CC1)c1ccccc1)N
  • InChi: 1S/C25H26N4O3/c1-27-20-15-21(29-10-8-28(9-11-29)16-6-4-3-5-7-16)19(26)14-18(20)25(31)24-22(27)12-17(32-2)13-23(24)30/h3-7,12-15,30H,8-11,26H2,1-2H3
  • InChiKey: YKOPRSJFJDKETD-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis spcc417.12 protein, putative 0.0074 0.0412 0.2501
Schistosoma mansoni topbp1 0.003 0.0135 0.0243
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0105 0.2265
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.018 0.0325
Mycobacterium tuberculosis Probable lipase LipD 0.0037 0.018 0.0464
Brugia malayi nuclear hormone receptor 0.0241 0.1454 0.2575
Toxoplasma gondii histone lysine-specific demethylase 0.0042 0.0208 0.2919
Loa Loa (eye worm) hypothetical protein 0.0241 0.1454 0.2575
Echinococcus multilocularis epidermal growth factor receptor 0.0481 0.2953 0.294
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0021 0.0083 0.2434
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0066 0.0987
Echinococcus multilocularis snurportin 1 0.0305 0.1849 0.1834
Loa Loa (eye worm) hypothetical protein 0.0037 0.018 0.026
Trypanosoma cruzi trypanothione reductase, putative 0.0062 0.0336 1
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0021 0.0083 0.1541
Loa Loa (eye worm) hypothetical protein 0.0074 0.0412 0.0681
Echinococcus granulosus ferritin 0.0026 0.0109 0.0163
Plasmodium vivax hypothetical protein, conserved 0.0042 0.0208 0.5735
Schistosoma mansoni hypothetical protein 0.0048 0.0249 0.045
Brugia malayi nuclear hormone receptor family member nhr-6 0.0114 0.0659 0.113
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0037 0.018 0.0464
Echinococcus granulosus acetylcholinesterase 0.0439 0.2689 0.4836
Schistosoma mansoni cpg binding protein 0.0057 0.0305 0.0551
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0074 0.0412 0.0394
Loa Loa (eye worm) hypothetical protein 0.0095 0.0544 0.0921
Schistosoma mansoni hypothetical protein 0.0206 0.1234 0.2227
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0114 0.0659 0.0641
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0042 0.0208 0.5735
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0241 0.1454 0.2575
Trichomonas vaginalis ubiquitin-conjugating enzyme E2, putative 0.0037 0.0181 0.099
Onchocerca volvulus 0.0114 0.0659 0.4389
Loa Loa (eye worm) hypothetical protein 0.0114 0.0659 0.113
Schistosoma mansoni chromosome transmission fidelity factor 0.003 0.0135 0.0243
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0066 0.0987
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0109 0.0631 0.1108
Loa Loa (eye worm) carboxylesterase 0.0074 0.0412 0.0681
Schistosoma mansoni ubiquitin conjugating enzyme 13 0.0037 0.0181 0.0327
Toxoplasma gondii histone lysine-specific demethylase LSD1/BHC110/KDMA1A 0.0045 0.023 0.3289
Trichomonas vaginalis glucosylceramidase, putative 0.0258 0.1558 1
Brugia malayi nuclear hormone receptor family member odr-7 0.0114 0.0659 0.113
Toxoplasma gondii HEAT repeat-containing protein 0.0029 0.0127 0.1531
Echinococcus granulosus dynamin 0.0042 0.021 0.0346
Toxoplasma gondii exonuclease III APE 0.0019 0.0066 0.0502
Loa Loa (eye worm) hypothetical protein 0.003 0.0135 0.0177
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0036 0.0173 0.0378
Mycobacterium tuberculosis Probable hydrolase 0.0037 0.018 0.0464
Schistosoma mansoni amine oxidase 0.0042 0.0208 0.0376
Trichomonas vaginalis glucosylceramidase, putative 0.0258 0.1558 1
Loa Loa (eye worm) hypothetical protein 0.0042 0.0208 0.0312
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.003 0.0135 0.0686
Mycobacterium tuberculosis Probable oxidoreductase 0.0021 0.0083 0.0174
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0241 0.1454 0.2575
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0241 0.1454 0.2575
Plasmodium falciparum thioredoxin reductase 0.0062 0.0336 1
Plasmodium vivax dynamin-like protein, putative 0.0042 0.021 0.5776
Brugia malayi Latrophilin receptor protein 2 0.0095 0.0544 0.0921
Leishmania major 4-coumarate:coa ligase-like protein 0.0048 0.0249 0.7083
Schistosoma mansoni ferritin 0.0026 0.0109 0.0196
Entamoeba histolytica acyl-coA synthetase, putative 0.0048 0.0249 0.3665
Mycobacterium tuberculosis Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) 0.0549 0.3375 1
Brugia malayi Pax transcription activation domain interacting protein 0.003 0.0135 0.0177
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0241 0.1454 0.2575
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0021 0.0083 0.1541
Schistosoma mansoni cpg binding protein 0.006 0.0326 0.0588
Loa Loa (eye worm) hypothetical protein 0.0206 0.1234 0.2175
Trichomonas vaginalis glucosylceramidase, putative 0.0178 0.1061 0.6751
Plasmodium vivax acyl-CoA synthetase, putative 0.0036 0.0173 0.4548
Loa Loa (eye worm) hypothetical protein 0.0037 0.018 0.026
Echinococcus multilocularis thioredoxin glutathione reductase 0.0062 0.0336 0.0318
Trypanosoma cruzi UDP-galactopyranose mutase 0.0042 0.0208 0.5735
Loa Loa (eye worm) hypothetical protein 0.0114 0.0659 0.113
Onchocerca volvulus 0.0074 0.0412 0.2645
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0241 0.1454 0.26
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0241 0.1454 0.2575
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0241 0.1454 0.2575
Loa Loa (eye worm) hypothetical protein 0.0048 0.0249 0.0385
Loa Loa (eye worm) hypothetical protein 0.0301 0.1829 0.3255
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0114 0.0659 0.0641
Schistosoma mansoni hypothetical protein 0.0109 0.0631 0.1138
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0114 0.0659 0.4389
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0093 0.0529 0.0954
Mycobacterium ulcerans carboxylesterase, LipT 0.0074 0.0412 0.1042
Schistosoma mansoni tyrosine kinase 0.0286 0.1736 0.3133
Toxoplasma gondii NADPH-glutathione reductase 0.0021 0.0083 0.0785
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0135 0.0686
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0066 0.0987
Trypanosoma brucei BRCA1 C Terminus (BRCT) domain containing protein, putative 0.003 0.0135 0.3265
Brugia malayi Carboxylesterase family protein 0.0074 0.0412 0.0681
Plasmodium falciparum importin beta, putative 0.0029 0.0127 0.3008
Echinococcus granulosus neuroligin 0.0074 0.0412 0.0712
Loa Loa (eye worm) hypothetical protein 0.0025 0.0105 0.0123
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0135 0.0686
Schistosoma mansoni hypothetical protein 0.0011 0.0019 0.0034
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0014 0.0037 0.0037
Trichomonas vaginalis glucosylceramidase, putative 0.0258 0.1558 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0048 0.0249 0.0589
Onchocerca volvulus 0.0074 0.0412 0.2645
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0021 0.0083 0.1541
Trichomonas vaginalis glucosylceramidase, putative 0.0169 0.1004 0.6379
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0021 0.0083 0.1541
Schistosoma mansoni nuclear receptor nhr-48 0.0114 0.0659 0.1189
Brugia malayi Calcitonin receptor-like protein seb-1 0.0301 0.1829 0.3255
Echinococcus multilocularis epidermal growth factor receptor 0.0896 0.554 0.5532
Loa Loa (eye worm) hypothetical protein 0.0036 0.0173 0.0247
Loa Loa (eye worm) hypothetical protein 0.003 0.0135 0.0177
Loa Loa (eye worm) hypothetical protein 0.0074 0.0412 0.0681
Brugia malayi nuclear receptor RXR 0.0114 0.0659 0.113
Loa Loa (eye worm) hypothetical protein 0.0042 0.0208 0.0312
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0093 0.0529 0.0511
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0258 0.1558 0.2763
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0014 0.0037 0.0037
Echinococcus granulosus beta LACTamase domain containing family member 0.0037 0.018 0.0292
Schistosoma mansoni ferritin 0.0026 0.0109 0.0196
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0241 0.1454 0.26
Onchocerca volvulus 0.0048 0.0249 0.1499
Loa Loa (eye worm) hypothetical protein 0.0127 0.0744 0.1285
Brugia malayi beta-lactamase 0.0037 0.018 0.026
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0093 0.0529 0.0954
Echinococcus granulosus thyroid hormone receptor alpha 0.0114 0.0659 0.1159
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0021 0.0083 0.1541
Loa Loa (eye worm) hypothetical protein 0.0114 0.0659 0.113
Mycobacterium leprae PROBABLE BACTERIOFERRITIN BFRA 0.0026 0.0109 0.3392
Loa Loa (eye worm) hypothetical protein 0.0439 0.2689 0.4819
Toxoplasma gondii dynamin-related protein DRPA 0.0042 0.021 0.294
Loa Loa (eye worm) hypothetical protein 0.0114 0.0659 0.113
Brugia malayi Carboxylesterase family protein 0.0439 0.2689 0.4819
Brugia malayi nuclear receptor NHR-88 0.0241 0.1454 0.2575
Entamoeba histolytica Activator 1 140 kDa subunit, putative 0.003 0.0135 0.1772
Brugia malayi AMP-binding enzyme family protein 0.0048 0.0249 0.0385
Loa Loa (eye worm) hypothetical protein 0.0236 0.1422 0.2517
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0021 0.0083 0.0084
Brugia malayi AMP-binding enzyme family protein 0.0048 0.0249 0.0385
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0066 0.0086
Trichomonas vaginalis glucosylceramidase, putative 0.0258 0.1558 1
Loa Loa (eye worm) hypothetical protein 0.003 0.0135 0.0177
Loa Loa (eye worm) hypothetical protein 0.0114 0.0659 0.113
Loa Loa (eye worm) hypothetical protein 0.003 0.0135 0.0177
Loa Loa (eye worm) hypothetical protein 0.0114 0.0659 0.113
Brugia malayi Protein kinase domain containing protein 0.0286 0.1736 0.3087
Mycobacterium tuberculosis Bacterioferritin BfrB 0.0026 0.0109 0.0251
Brugia malayi Dynamin central region family protein 0.0042 0.021 0.0314
Echinococcus multilocularis ecdysone induced protein 78C 0.0241 0.1454 0.1438
Echinococcus multilocularis FTZ F1 alpha 0.0241 0.1454 0.1438
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0114 0.0659 0.0641
Trypanosoma brucei trypanothione reductase 0.0062 0.0336 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0014 0.0037 0.0037
Trichomonas vaginalis antibiotic synthetase, putative 0.0014 0.0037 0.0047
Schistosoma mansoni ferritin 0.0026 0.0109 0.0196
Trichomonas vaginalis glucosylceramidase, putative 0.0169 0.1004 0.6379
Mycobacterium ulcerans bacterioferritin BfrB 0.0026 0.0109 0.02
Toxoplasma gondii dynamin gtpase 0.0028 0.0121 0.1426
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0093 0.0529 0.0894
Mycobacterium ulcerans NAD-dependent DNA ligase LigA 0.003 0.0135 0.0271
Plasmodium vivax importin-beta 2, putative 0.0029 0.0127 0.3008
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0062 0.0336 0.0929
Loa Loa (eye worm) hypothetical protein 0.0042 0.0208 0.0312
Brugia malayi hypothetical protein 0.0114 0.0659 0.113
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0048 0.0249 0.0589
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0021 0.0083 0.2434
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0241 0.1454 0.2625
Entamoeba histolytica dynamin-like protein 0.0042 0.021 0.3017
Onchocerca volvulus Bile acid receptor homolog 0.0241 0.1454 1
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0105 0.2265
Onchocerca volvulus 0.0074 0.0412 0.2645
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0114 0.0659 0.0641
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0241 0.1454 0.2575
Plasmodium falciparum thioredoxin reductase 0.0021 0.0083 0.1541
Loa Loa (eye worm) hypothetical protein 0.0074 0.0412 0.0681
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0014 0.0037 0.0037
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0048 0.0249 0.0669
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0014 0.0037 0.0033
Echinococcus multilocularis GPCR, family 2 0.0095 0.0544 0.0526
Mycobacterium ulcerans dehydrogenase 0.0042 0.0208 0.0477
Onchocerca volvulus 0.0037 0.018 0.1009
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0258 0.1558 0.2763
Schistosoma mansoni Lysine-specific histone demethylase 1 0.0042 0.0208 0.0376
Brugia malayi hypothetical protein 0.0016 0.0049 0.0023
Echinococcus granulosus epidermal growth factor receptor 0.0481 0.2953 0.5314
Loa Loa (eye worm) hypothetical protein 0.0127 0.0744 0.1285
Trypanosoma cruzi BRCA1 C Terminus (BRCT) domain containing protein, putative 0.003 0.0135 0.3265
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0034 0.0161 0.0406
Mycobacterium ulcerans hypothetical protein 0.0048 0.0249 0.0589
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0074 0.0412 0.0712
Schistosoma mansoni ap endonuclease 0.0019 0.0066 0.012
Loa Loa (eye worm) TK/INSR protein kinase 0.0286 0.1736 0.3087
Leishmania major 4-coumarate:coa ligase-like protein 0.0048 0.0249 0.7083
Echinococcus multilocularis ferritin 0.0026 0.0109 0.009
Entamoeba histolytica acyl-CoA synthetase, putative 0.0048 0.0249 0.3665
Echinococcus multilocularis importin subunit beta 1 0.0029 0.0127 0.0108
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0014 0.0037 0.0019
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0237 0.1425 0.4181
Chlamydia trachomatis protoporphyrinogen oxidase 0.0042 0.0208 1
Entamoeba histolytica hypothetical protein 0.0109 0.0631 1
Schistosoma mansoni nuclear hormone receptor 0.0114 0.0659 0.1189
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0105 0.1153
Brugia malayi hypothetical protein 0.0025 0.0105 0.0123
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0066 0.0987
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0021 0.0083 0.1541
Entamoeba histolytica hypothetical protein 0.003 0.0135 0.1772
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0127 0.0744 0.1285
Mycobacterium tuberculosis Conserved hypothetical protein 0.0042 0.0208 0.0548
Loa Loa (eye worm) hypothetical protein 0.0036 0.0173 0.0247
Brugia malayi hypothetical protein 0.003 0.0135 0.0177
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.018 0.0984
Leishmania major hypothetical protein, conserved 0.0037 0.018 0.4784
Trichomonas vaginalis glucosylceramidase, putative 0.0258 0.1558 1
Plasmodium vivax replication factor C subunit 1, putative 0.003 0.0135 0.3265
Echinococcus multilocularis beta LACTamase domain containing family member 0.0037 0.018 0.0162
Mycobacterium tuberculosis Probable lipase LipE 0.0037 0.018 0.0464
Echinococcus granulosus carboxylesterase 5A 0.0439 0.2689 0.4836
Mycobacterium ulcerans monoamine oxidase 0.0042 0.0208 0.0477
Loa Loa (eye worm) hypothetical protein 0.003 0.0135 0.0177
Loa Loa (eye worm) CXXC zinc finger family protein 0.0057 0.0305 0.0488
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0095 0.0544 0.0951
Echinococcus granulosus snurportin 1 0.0305 0.1849 0.3315
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0241 0.1454 0.2625
Loa Loa (eye worm) hypothetical protein 0.0045 0.023 0.035
Schistosoma mansoni hypothetical protein 0.0404 0.2471 0.4459
Trypanosoma brucei dynamin-1-like protein 0.0042 0.021 0.5776
Mycobacterium tuberculosis Probable esterase LipL 0.0037 0.018 0.0464
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.0066 0.0642
Brugia malayi Nuclear hormone receptor-like 1 0.0241 0.1454 0.2575
Echinococcus granulosus cpg binding protein 0.006 0.0326 0.0556
Schistosoma mansoni hypothetical protein 0.0095 0.0544 0.0981
Brugia malayi hypothetical protein 0.0042 0.0208 0.0312
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.018 0.0984
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0127 0.0744 0.0727
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0241 0.1454 1
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.018 0.4784
Trypanosoma cruzi trypanothione reductase, putative 0.0021 0.0083 0.1541
Echinococcus multilocularis protoporphyrinogen oxidase 0.0042 0.0208 0.019
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0021 0.0083 0.1541
Trichomonas vaginalis glucosylceramidase, putative 0.0169 0.1004 0.6379
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.018 0.0984
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0066 0.0241
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0095 0.0544 0.0526
Loa Loa (eye worm) hypothetical protein 0.0127 0.0744 0.1285
Loa Loa (eye worm) beta-lactamase 0.0037 0.018 0.026
Toxoplasma gondii ABC1 family protein 0.0037 0.018 0.2435
Echinococcus granulosus acetylcholinesterase 0.0439 0.2689 0.4836
Echinococcus multilocularis dynamin 1 protein 0.0042 0.021 0.0191
Schistosoma mansoni acetylcholinesterase 0.0074 0.0412 0.0743
Schistosoma mansoni acetyl-CoA synthetase 0.0014 0.0037 0.0067
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0286 0.1736 0.3109
Plasmodium vivax ubiquitin-conjugating enzyme E2 N, putative 0.0037 0.0181 0.4815
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0016 0.0047 0.0019
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0066 0.0241
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0021 0.0083 0.1541
Echinococcus multilocularis replication factor c subunit 1 0.003 0.0135 0.0116
Plasmodium falciparum acyl-CoA synthetase 0.0036 0.0173 0.4548
Treponema pallidum bacterioferrin (TpF1) 0.0026 0.0109 0.6215
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0014 0.0037 0.0037
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0093 0.0416
Schistosoma mansoni tyrosine kinase 0.0896 0.554 1
Echinococcus multilocularis lysine specific histone demethylase 1A 0.0042 0.0208 0.019
Brugia malayi ATP dependent DNA ligase C terminal region family protein 0.003 0.0135 0.0177
Schistosoma mansoni nuclear receptor 0.0114 0.0659 0.1189
Brugia malayi Nuclear hormone receptor-like 1 0.0127 0.0744 0.1285
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0127 0.0744 0.1343
Loa Loa (eye worm) ubiquitin conjugating enzyme protein 13 0.0037 0.0181 0.0262
Trichomonas vaginalis antibiotic synthetase, putative 0.0014 0.0037 0.0047
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.018 0.0325
Brugia malayi Dynamin 0.0045 0.023 0.035
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0127 0.0744 0.1314
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0257 0.1552 0.2752
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0241 0.1454 0.1438
Loa Loa (eye worm) hypothetical protein 0.0439 0.2689 0.4819
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0241 0.1454 0.26
Echinococcus multilocularis dnaJ subfamily B 0.0404 0.2471 0.2457
Brugia malayi hypothetical protein 0.0109 0.0631 0.1079
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0241 0.1454 0.2575
Loa Loa (eye worm) steroid hormone receptor 0.0241 0.1454 0.2575
Brugia malayi CXXC zinc finger family protein 0.0057 0.0305 0.0488
Loa Loa (eye worm) hypothetical protein 0.0048 0.0249 0.0385
Loa Loa (eye worm) hypothetical protein 0.0074 0.0412 0.0681
Loa Loa (eye worm) hypothetical protein 0.0074 0.0412 0.0681
Loa Loa (eye worm) hypothetical protein 0.0074 0.0412 0.0681
Loa Loa (eye worm) acetylcholinesterase 1 0.0439 0.2689 0.4819
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0048 0.0249 1
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0241 0.1454 0.26
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0127 0.3008
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0021 0.0083 0.1541
Echinococcus granulosus FTZ F1 alpha 0.0241 0.1454 0.26
Onchocerca volvulus Protein ultraspiracle homolog 0.0241 0.1454 1
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0241 0.1454 0.2575
Echinococcus granulosus thioredoxin glutathione reductase 0.0062 0.0336 0.0575
Loa Loa (eye worm) hypothetical protein 0.0037 0.018 0.026
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0105 0.2265
Plasmodium falciparum dynamin-like protein 0.0042 0.021 0.5776
Loa Loa (eye worm) carboxylesterase 0.0074 0.0412 0.0681
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0093 0.0529 0.0924
Echinococcus granulosus survival motor neuron protein 1 0.0236 0.1422 0.2541
Schistosoma mansoni amine oxidase 0.0042 0.0208 0.0376
Onchocerca volvulus 0.0114 0.0659 0.4389
Trichomonas vaginalis dynamin, putative 0.0042 0.021 0.1178
Loa Loa (eye worm) nuclear receptor NHR-67 0.0114 0.0659 0.113
Trichomonas vaginalis ferritin, putative 0.0026 0.0109 0.0518
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0093 0.0416
Echinococcus multilocularis carboxylesterase 5A 0.0439 0.2689 0.2675
Plasmodium vivax thioredoxin reductase, putative 0.0062 0.0336 1
Schistosoma mansoni apoferritin-2 0.0026 0.0109 0.0196
Trichomonas vaginalis dynamin, putative 0.0042 0.021 0.1178
Loa Loa (eye worm) thioredoxin reductase 0.0062 0.0336 0.0543
Schistosoma mansoni thyroid hormone receptor 0.0241 0.1454 0.2625
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0114 0.0659 0.113
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0114 0.0659 0.1189
Loa Loa (eye worm) hypothetical protein 0.0241 0.1454 0.2575
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0241 0.1454 0.2625
Loa Loa (eye worm) hypothetical protein 0.0037 0.018 0.026
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0037 0.018 0.0464
Brugia malayi beta-lactamase family protein 0.0037 0.018 0.026
Schistosoma mansoni hypothetical protein 0.0095 0.0544 0.0981
Mycobacterium leprae PROBABLE DNA LIGASE [NAD DEPENDENT] LIGA (POLYDEOXYRIBONUCLEOTIDE SYNTHASE [NAD+]) 0.003 0.0135 0.4609
Echinococcus multilocularis dynamin 1 0.0045 0.023 0.0211
Echinococcus granulosus neuropeptide receptor A26 0.0462 0.283 0.509
Brugia malayi F/Y-rich N-terminus family protein 0.0017 0.0058 0.0038
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0021 0.0083 0.0116
Echinococcus granulosus mixed lineage leukemia protein mll 0.0014 0.0037 0.0034
Trypanosoma cruzi ubiquitin-conjugating enzyme E2, putative 0.0037 0.0181 0.4815
Trypanosoma cruzi FHA domain containing protein, putative 0.003 0.0135 0.3265
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0241 0.1454 0.26
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.003 0.0135 0.0686
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0037 0.018 0.0398
Plasmodium vivax hypothetical protein, conserved 0.0042 0.0208 0.5735
Schistosoma mansoni ferritin light chain 0.0026 0.0109 0.0196
Brugia malayi Ubiquitin conjugating enzyme protein 13 0.0037 0.0181 0.0262
Mycobacterium ulcerans oxidoreductase 0.0042 0.0208 0.0477
Schistosoma mansoni nuclear hormone receptor 0.0114 0.0659 0.1189
Echinococcus granulosus neuropeptide s receptor 0.0462 0.283 0.509
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0066 0.0987
Treponema pallidum NADH oxidase 0.0021 0.0083 0.2434
Brugia malayi hypothetical protein 0.0114 0.0659 0.113
Brugia malayi Carboxylesterase family protein 0.0074 0.0412 0.0681
Mycobacterium leprae Probable lipase LipE 0.0037 0.018 0.6754
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0095 0.0544 0.0951
Mycobacterium ulcerans lipase LipD 0.0037 0.018 0.0398
Brugia malayi Carboxylesterase family protein 0.0074 0.0412 0.0681
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0036 0.0173 0.7171
Brugia malayi nuclear receptor RXR 0.0127 0.0744 0.1285
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0014 0.0037 0.0019
Brugia malayi topoisomerase 0.003 0.0135 0.0177
Leishmania major ubiquitin-conjugating enzyme e2, putative 0.0037 0.0181 0.4815
Loa Loa (eye worm) TAR-binding protein 0.0257 0.1552 0.2752
Brugia malayi hypothetical protein 0.0074 0.0412 0.0681
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0066 0.0082
Mycobacterium tuberculosis Conserved protein 0.0037 0.018 0.0464
Schistosoma mansoni BC026374 protein (S09 family) 0.0074 0.0412 0.0743
Brugia malayi beta-lactamase family protein 0.0037 0.018 0.026
Loa Loa (eye worm) nuclear hormone receptor 0.0114 0.0659 0.113
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0018 0.0059 0.0041
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0241 0.1454 0.1438
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0439 0.2689 0.4853
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0066 0.0048
Onchocerca volvulus 0.003 0.0135 0.0689
Schistosoma mansoni zinc finger protein 0.0114 0.0659 0.1189
Schistosoma mansoni tar DNA-binding protein 0.0257 0.1552 0.2801
Plasmodium vivax dynamin protein, putative 0.0042 0.021 0.5776
Brugia malayi Carboxylesterase family protein 0.0074 0.0412 0.0681
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0135 0.0686
Onchocerca volvulus 0.0048 0.0249 0.1495
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0034 0.0161 0.0406
Loa Loa (eye worm) hypothetical protein 0.0042 0.0208 0.0312
Toxoplasma gondii ATPase, AAA family protein 0.003 0.0135 0.1662
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0114 0.0659 0.4389
Trypanosoma brucei dynamin-1-like protein 0.0042 0.021 0.5776
Trichomonas vaginalis dynamin, putative 0.0042 0.021 0.1178
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0066 0.0987
Echinococcus multilocularis nibrin 0.003 0.0135 0.0116
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0014 0.0037 0.0037
Echinococcus multilocularis expressed protein 0.0026 0.0109 0.009
Echinococcus granulosus para nitrobenzyl esterase 0.0074 0.0412 0.0712
Trichomonas vaginalis dynamin, putative 0.0042 0.021 0.1178
Schistosoma mansoni tar DNA-binding protein 0.0257 0.1552 0.2801
Echinococcus granulosus insulin receptor 0.0286 0.1736 0.3109
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0021 0.0083 0.1541
Schistosoma mansoni importin beta-1 0.0029 0.0127 0.0229
Echinococcus multilocularis neuropeptide s receptor 0.0462 0.283 0.2816
Echinococcus granulosus dynamin 1 0.0045 0.023 0.0382
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0241 0.1454 0.2575
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0021 0.0083 0.1541
Leishmania major 4-coumarate:coa ligase-like protein 0.0048 0.0249 0.7083
Trypanosoma cruzi hypothetical protein, conserved 0.003 0.0135 0.3265
Schistosoma mansoni dynamin 0.0045 0.023 0.0415
Plasmodium vivax hypothetical protein, conserved 0.0037 0.018 0.4784
Loa Loa (eye worm) hypothetical protein 0.003 0.0135 0.0177
Wolbachia endosymbiont of Brugia malayi bacterioferritin/cytochrome b1 0.0026 0.0109 0.6215
Onchocerca volvulus 0.0042 0.0208 0.121
Brugia malayi amine oxidase, flavin-containing family protein 0.0042 0.0208 0.0312
Leishmania major GTP-binding protein, putative 0.0042 0.021 0.5776
Loa Loa (eye worm) TK/EGFR protein kinase 0.0896 0.554 1
Mycobacterium tuberculosis Conserved protein 0.0037 0.018 0.0464
Loa Loa (eye worm) hypothetical protein 0.0241 0.1454 0.2575
Brugia malayi conserved hypotetical protein 0.0114 0.0659 0.113
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0034 0.0161 0.0406
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0241 0.1454 0.1438
Schistosoma mansoni dynamin 0.0042 0.021 0.0378
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0036 0.0173 0.0443
Schistosoma mansoni nuclear hormone receptor 0.0241 0.1454 0.2625
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0074 0.0412 0.0743
Echinococcus multilocularis 0.0277 0.168 0.1664
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0021 0.0083 0.0128
Brugia malayi hypothetical protein 0.0127 0.0744 0.1285
Leishmania major hypothetical protein, conserved 0.0025 0.0105 0.2265
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0241 0.1454 0.26
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.003 0.0135 0.0686
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0241 0.1454 0.2575
Echinococcus multilocularis nuclear receptor nhr 48 0.0114 0.0659 0.0641
Echinococcus granulosus expressed protein 0.0026 0.0109 0.0163
Brugia malayi nuclear receptor NHR-67 0.0114 0.0659 0.113
Onchocerca volvulus 0.0241 0.1454 1
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0014 0.0037 0.0037
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0066 0.0125
Loa Loa (eye worm) hypothetical protein 0.0074 0.0412 0.0681
Echinococcus granulosus lysine specific histone demethylase 1A 0.0042 0.0208 0.0343
Loa Loa (eye worm) hypothetical protein 0.0241 0.1454 0.2575
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0021 0.0083 0.0128
Loa Loa (eye worm) hypothetical protein 0.0114 0.0659 0.113
Mycobacterium ulcerans esterase/lipase LipP 0.0037 0.018 0.0398
Plasmodium falciparum lysine-specific histone demethylase 1, putative 0.0042 0.0208 0.5735
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0021 0.0083 0.0064
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0014 0.0037 0.0037
Mycobacterium tuberculosis Carboxylesterase LipT 0.0074 0.0412 0.1156
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0074 0.0412 0.0743
Loa Loa (eye worm) hypothetical protein 0.0114 0.0659 0.113
Toxoplasma gondii poly(ADP-ribose) polymerase catalytic domain-containing protein 0.003 0.0135 0.1662
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0048 0.0249 0.0589
Brugia malayi RNA binding protein 0.0257 0.1552 0.2752
Giardia lamblia Dynamin 0.0042 0.021 1
Mycobacterium tuberculosis Possible oxidoreductase 0.0042 0.0208 0.0548
Treponema pallidum DNA ligase (lig) 0.003 0.0135 1
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0481 0.2953 0.5314
Loa Loa (eye worm) hypothetical protein 0.0042 0.0208 0.0312
Schistosoma mansoni DNA ligase IV 0.003 0.0135 0.0243
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0301 0.1829 0.3255
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0021 0.0083 0.1541
Loa Loa (eye worm) hypothetical protein 0.0127 0.0744 0.1285
Schistosoma mansoni tyrosine kinase 0.0476 0.2921 0.5273
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0021 0.0083 0.1541
Loa Loa (eye worm) hypothetical protein 0.0037 0.018 0.026
Schistosoma mansoni apoferritin-2 0.0026 0.0109 0.0196
Leishmania major UDP-galactopyranose mutase 0.0042 0.0208 0.5735
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0241 0.1454 0.2575
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0093 0.0416
Schistosoma mansoni transcription factor LCR-F1 0.0109 0.0631 0.1138
Trichomonas vaginalis glucosylceramidase, putative 0.0169 0.1004 0.6379
Brugia malayi TAR-binding protein 0.0257 0.1552 0.2752
Schistosoma mansoni tyrosine kinase 0.0481 0.2953 0.533
Wolbachia endosymbiont of Brugia malayi NAD-dependent DNA ligase, Lig 0.003 0.0135 1
Echinococcus multilocularis neuropeptide receptor A26 0.0462 0.283 0.2816
Loa Loa (eye worm) hypothetical protein 0.0114 0.0659 0.113
Entamoeba histolytica acyl-CoA synthetase, putative 0.0048 0.0249 0.3665
Plasmodium falciparum protoporphyrinogen oxidase 0.0042 0.0208 0.5735
Mycobacterium ulcerans beta-lactamase 0.0037 0.018 0.0398
Loa Loa (eye worm) hypothetical protein 0.0241 0.1454 0.2575
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0021 0.0083 0.0174
Echinococcus granulosus GPCR family 2 0.0095 0.0544 0.0951
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0014 0.0037 0.0153
Chlamydia trachomatis DNA ligase 0.003 0.0135 0.411
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0093 0.0529 0.0924
Brugia malayi AMP-binding enzyme family protein 0.0048 0.0249 0.0385
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.003 0.0135 0.0686
Plasmodium falciparum replication factor C subunit 1, putative 0.003 0.0135 0.3265
Brugia malayi Thioredoxin reductase 0.0062 0.0336 0.0543
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0114 0.0659 0.0641
Schistosoma mansoni ap endonuclease 0.0019 0.0066 0.012
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0016 0.0047 0.0019
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0048 0.0249 1
Echinococcus granulosus BC026374 protein S09 family 0.0074 0.0412 0.0712
Trichomonas vaginalis mercuric reductase, putative 0.0021 0.0083 0.0349
Entamoeba histolytica dynamin-1-like protein, putative 0.0042 0.021 0.3017
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0095 0.0544 0.0526
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0021 0.0083 0.015
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0241 0.1454 0.2575
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0014 0.0037 0.0068
Schistosoma mansoni topbp1 0.003 0.0135 0.0243
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0241 0.1454 0.26
Onchocerca volvulus 0.0057 0.0305 0.1895
Loa Loa (eye worm) hypothetical protein 0.0042 0.0208 0.0312
Onchocerca volvulus 0.0074 0.0412 0.2645
Plasmodium falciparum ubiquitin-conjugating enzyme E2 N, putative 0.0037 0.0181 0.4815
Schistosoma mansoni survival motor neuron protein 0.0048 0.0249 0.045
Loa Loa (eye worm) hypothetical protein 0.0048 0.0249 0.0385
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0305 0.1849 0.3293
Mycobacterium ulcerans bacterioferritin BfrA 0.0026 0.0109 0.02
Brugia malayi nuclear hormone receptor 0.0114 0.0659 0.113
Schistosoma mansoni hypothetical protein 0.0305 0.1849 0.3338
Loa Loa (eye worm) hypothetical protein 0.0114 0.0659 0.113
Plasmodium falciparum glutathione reductase 0.0062 0.0336 1
Trichomonas vaginalis esterase, putative 0.0037 0.018 0.0984
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0105 0.2265
Trypanosoma brucei ubiquitin-protein ligase, putative 0.0037 0.0181 0.4815
Loa Loa (eye worm) hypothetical protein 0.0036 0.0173 0.0247
Echinococcus granulosus nuclear receptor nhr 48 0.0114 0.0659 0.1159
Brugia malayi hypothetical protein 0.0236 0.1422 0.2517
Echinococcus granulosus ecdysone induced protein 78C 0.0241 0.1454 0.26
Trichomonas vaginalis dynamin, putative 0.0042 0.021 0.1178
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0109 0.0631 0.0613
Loa Loa (eye worm) hypothetical protein 0.0037 0.018 0.026
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0021 0.0083 0.0785
Loa Loa (eye worm) hypothetical protein 0.0114 0.0659 0.113
Brugia malayi Importin beta-1 subunit 0.0029 0.0127 0.0163
Brugia malayi DKFZp564C0469 protein 0.003 0.0135 0.0177
Trichomonas vaginalis glucosylceramidase, putative 0.0258 0.1558 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0048 0.0249 0.0669
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0241 0.1454 0.2575
Brugia malayi RNA recognition motif domain containing protein 0.0257 0.1552 0.2752
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0034 0.0161 0.0406
Loa Loa (eye worm) hypothetical protein 0.0036 0.0173 0.0247
Schistosoma mansoni gliotactin 0.0074 0.0412 0.0743
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0014 0.0037 0.0037
Toxoplasma gondii ubiquitin-conjugating enzyme subfamily protein 0.0037 0.0181 0.2451
Mycobacterium ulcerans acyl-CoA synthetase 0.0048 0.0249 0.0589
Giardia lamblia NADH oxidase lateral transfer candidate 0.0021 0.0083 0.1158
Loa Loa (eye worm) hypothetical protein 0.0241 0.1454 0.2575
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0048 0.0249 0.0386
Trichomonas vaginalis glucosylceramidase, putative 0.0178 0.1061 0.6751
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0135 0.0686
Schistosoma mansoni ferritin 0.0026 0.0109 0.0196
Mycobacterium ulcerans protoporphyrinogen oxidase 0.0042 0.0208 0.0477
Brugia malayi orphan nuclear receptor NR2E1 0.0114 0.0659 0.113
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0114 0.0659 0.1189
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0135 0.0686
Schistosoma mansoni tar DNA-binding protein 0.0257 0.1552 0.2801
Trypanosoma cruzi hypothetical protein, conserved 0.003 0.0135 0.3265
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0048 0.0249 0.0589
Loa Loa (eye worm) histone methyltransferase 0.0018 0.0059 0.004
Brugia malayi Carboxylesterase family protein 0.0439 0.2689 0.4819
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0021 0.0083 0.1541
Onchocerca volvulus 0.0018 0.0061 0.017
Loa Loa (eye worm) hypothetical protein 0.0029 0.0127 0.0163
Brugia malayi ecdysone receptor 0.0114 0.0659 0.113
Schistosoma mansoni tyrosine kinase 0.0286 0.1736 0.3133
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0241 0.1454 0.2625
Loa Loa (eye worm) latrophilin receptor protein 2 0.0095 0.0544 0.0921
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0037 0.018 0.026
Loa Loa (eye worm) DR-78 0.0114 0.0659 0.113
Mycobacterium tuberculosis Conserved protein 0.0037 0.018 0.0464
Schistosoma mansoni dynamin 0.0045 0.023 0.0415
Schistosoma mansoni tyrosine kinase 0.0476 0.2921 0.5273
Schistosoma mansoni steroid hormone receptor ad4bp 0.0241 0.1454 0.2625
Brugia malayi ubiquitin conjugating enzyme protein 13 0.0037 0.0181 0.0262
Loa Loa (eye worm) hypothetical protein 0.0241 0.1454 0.2575
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0021 0.0083 0.2176
Trichomonas vaginalis glutathione reductase, putative 0.0021 0.0083 0.0349
Loa Loa (eye worm) hypothetical protein 0.0114 0.0659 0.113
Echinococcus multilocularis para nitrobenzyl esterase 0.0074 0.0412 0.0394
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.018 0.4784
Brugia malayi photoreceptor-specific nuclear receptor 0.0241 0.1454 0.2575
Echinococcus granulosus dynamin 1 protein 0.0042 0.021 0.0346
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0093 0.0529 0.0954
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0021 0.0083 0.0174
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0021 0.0083 0.1541
Toxoplasma gondii dynamin-related protein DRPB 0.0042 0.021 0.294
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0591 0.3634 1
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0021 0.0083 0.1541
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0114 0.0659 0.113
Echinococcus multilocularis survival motor neuron protein 1 0.0236 0.1422 0.1406
Echinococcus multilocularis insulin receptor 0.0286 0.1736 0.172
Echinococcus multilocularis neuroligin 0.0074 0.0412 0.0394
Trichomonas vaginalis glucosylceramidase, putative 0.0169 0.1004 0.6379
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0093 0.1883
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0241 0.1454 0.2625
Trypanosoma cruzi ubiquitin-conjugating enzyme E2, putative 0.0037 0.0181 0.4815
Onchocerca volvulus 0.0074 0.0412 0.2645
Plasmodium vivax protoporphyrinogen oxidase, putative 0.0042 0.0208 0.5735
Loa Loa (eye worm) hypothetical protein 0.0114 0.0659 0.113
Trichomonas vaginalis ubiquitin-conjugating enzyme E2, putative 0.0037 0.0181 0.099
Brugia malayi latrophilin 2 splice variant baaae 0.0206 0.1234 0.2175
Brugia malayi steroid hormone receptor 0.0241 0.1454 0.2575
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0114 0.0659 0.1159
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0066 0.0054
Trichomonas vaginalis replication factor C large subunit, putative 0.003 0.0135 0.0686
Echinococcus multilocularis 0.0042 0.0208 0.019
Schistosoma mansoni thyroid hormone receptor 0.0241 0.1454 0.2625
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0074 0.0412 0.1156
Schistosoma mansoni tar DNA-binding protein 0.0257 0.1552 0.2801
Plasmodium vivax glutathione reductase, putative 0.0062 0.0336 1
Onchocerca volvulus 0.0037 0.018 0.1009
Mycobacterium ulcerans acyl-CoA synthetase 0.0048 0.0249 0.0589
Brugia malayi glutathione reductase 0.0062 0.0336 0.0543
Echinococcus multilocularis thyroid hormone receptor alpha 0.0241 0.1454 0.1438
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0105 0.2265
Entamoeba histolytica hypothetical protein 0.0023 0.0093 0.1086
Schistosoma mansoni Protoporphyrinogen oxidase chloroplast/mitochondrial precursor 0.0042 0.0208 0.0376
Toxoplasma gondii thioredoxin reductase 0.0062 0.0336 0.509
Loa Loa (eye worm) hypothetical protein 0.0036 0.0173 0.0247
Schistosoma mansoni hypothetical protein 0.0095 0.0544 0.0981
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0127 0.3008
Plasmodium vivax lysine-specific histone demethylase 1, putative 0.0042 0.0208 0.5735
Loa Loa (eye worm) hypothetical protein 0.0241 0.1454 0.2575
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0095 0.0544 0.0921
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0018 0.0059 0.0073
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0093 0.0529 0.0511
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0241 0.1454 0.2575
Schistosoma mansoni tar DNA-binding protein 0.0257 0.1552 0.2801
Trichomonas vaginalis interferon-induced GTP-binding protein mx, putative 0.0042 0.021 0.1178
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0301 0.1829 0.3255
Trypanosoma cruzi UDP-galactopyranose mutase 0.0042 0.0208 0.5735
Brugia malayi SWIRM domain containing protein 0.0042 0.0208 0.0312
Brugia malayi Nuclear hormone receptor E75 0.0114 0.0659 0.113
Schistosoma mansoni RAR-like nuclear receptor 0.0241 0.1454 0.2625
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0074 0.0412 0.1156
Brugia malayi tailless protein 0.0114 0.0659 0.113
Leishmania major importin beta-1 subunit, putative 0.0023 0.0093 0.1883
Brugia malayi hypothetical protein 0.003 0.0135 0.0177
Loa Loa (eye worm) hypothetical protein 0.0127 0.0744 0.1285
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0074 0.0412 0.0743
Echinococcus multilocularis dynamin 0.0042 0.021 0.0191
Trichomonas vaginalis mgm1, putative 0.0042 0.021 0.1178
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0105 0.2265
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0241 0.1454 0.2575
Brugia malayi hypothetical protein 0.0127 0.0744 0.1285
Echinococcus multilocularis ubiquitin conjugating enzyme E2 N 0.0037 0.0181 0.0162
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.018 0.0984
Echinococcus granulosus epidermal growth factor receptor 0.0896 0.554 1
Brugia malayi Nuclear hormone receptor-like 1 0.0127 0.0744 0.1285
Echinococcus multilocularis cpg binding protein 0.006 0.0326 0.0308
Echinococcus granulosus ubiquitin conjugating enzyme E2 N 0.0037 0.0181 0.0294
Echinococcus granulosus replication factor c subunit 1 0.003 0.0135 0.021
Echinococcus granulosus lysine specific histone demethylase 1A 0.0042 0.0208 0.0343
Brugia malayi nuclear receptor NHR-88 0.0114 0.0659 0.113
Mycobacterium tuberculosis Probable bacterioferritin BfrA 0.0026 0.0109 0.0251
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0241 0.1454 0.1438
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0014 0.0037 0.0034
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0241 0.1454 0.2575
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0241 0.1454 0.2575
Brugia malayi RNA, U transporter 1 0.0081 0.0455 0.076
Loa Loa (eye worm) RNA binding protein 0.0257 0.1552 0.2752
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0241 0.1454 0.2625
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0021 0.0083 0.1541
Plasmodium falciparum dynamin-like protein 0.0042 0.021 0.5776
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0014 0.0037 0.0037
Trichomonas vaginalis glucosylceramidase, putative 0.0169 0.1004 0.6379
Loa Loa (eye worm) ubiquitin conjugating enzyme protein 13 0.0037 0.0181 0.0262
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0021 0.0083 0.0128
Echinococcus multilocularis acetylcholinesterase 0.0439 0.2689 0.2675
Trichomonas vaginalis glucosylceramidase, putative 0.0169 0.1004 0.6379
Onchocerca volvulus 0.0037 0.018 0.1009
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.018 0.0984
Brugia malayi Steroid receptor seven-up type 2 0.0241 0.1454 0.2575
Onchocerca volvulus Glucosylceramidase homolog 0.0169 0.1004 0.6826
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0066 0.0054
Mycobacterium leprae conserved hypothetical protein 0.0037 0.018 0.6754
Schistosoma mansoni tyrosine kinase 0.0481 0.2953 0.533
Schistosoma mansoni tyrosine kinase 0.0476 0.2921 0.5273
Schistosoma mansoni nuclear receptor 0.0114 0.0659 0.1189
Echinococcus granulosus Nuclear hormone receptor HR96 0.0114 0.0659 0.1159
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0591 0.3634 1
Echinococcus granulosus tar DNA binding protein 0.0257 0.1552 0.2776
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0286 0.1736 0.172
Echinococcus granulosus Nuclear hormone receptor HR96 0.0114 0.0659 0.1159
Loa Loa (eye worm) glutathione reductase 0.0062 0.0336 0.0543
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0014 0.0037 0.0018
Echinococcus multilocularis BC026374 protein (S09 family) 0.0074 0.0412 0.0394
Brugia malayi ecdysteroid receptor 0.0241 0.1454 0.2575
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0014 0.0037 0.0037
Toxoplasma gondii histone lysine methyltransferase SET1 0.0108 0.0624 1
Schistosoma mansoni neuroligin 3 (S09 family) 0.0074 0.0412 0.0743
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0114 0.0659 0.1159
Brugia malayi Furin-like cysteine rich region family protein 0.0896 0.554 1
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0241 0.1454 0.1438
Entamoeba histolytica hypothetical protein 0.0109 0.0631 1
Echinococcus granulosus nibrin 0.003 0.0135 0.021
Schistosoma mansoni cpg binding protein 0.006 0.0326 0.0588
Trypanosoma cruzi dynamin-1-like protein 0.0042 0.021 0.5776
Echinococcus granulosus importin subunit beta 1 0.0029 0.0127 0.0196
Leishmania major trypanothione reductase 0.0062 0.0336 1
Entamoeba histolytica hypothetical protein 0.0109 0.0631 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0241 0.1454 0.2575
Plasmodium falciparum glutathione reductase 0.0021 0.0083 0.1541
Schistosoma mansoni retinoic acid receptor RXR 0.0241 0.1454 0.2625
Mycobacterium leprae PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) 0.0042 0.0208 0.8096
Entamoeba histolytica ubiquitin-conjugating enzyme family protein 0.0037 0.0181 0.2541
Loa Loa (eye worm) carboxylesterase 0.0439 0.2689 0.4819
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0074 0.0412 0.2501
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0021 0.0083 0.0174
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0021 0.0083 0.1541
Entamoeba histolytica hypothetical protein 0.0109 0.0631 1
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0048 0.0249 0.0589
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0241 0.1454 0.1438
Schistosoma mansoni ferritin light chain 0.0026 0.0109 0.0196
Mycobacterium ulcerans hypothetical protein 0.0037 0.018 0.0398
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0021 0.0083 0.1541
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0241 0.1454 0.2575
Brugia malayi Dynamin 0.0045 0.023 0.035
Echinococcus multilocularis tar DNA binding protein 0.0257 0.1552 0.1536
Loa Loa (eye worm) DRP-1 protein 0.0042 0.021 0.0314
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0093 0.0529 0.0894
Brugia malayi Nuclear hormone receptor E75 0.0114 0.0659 0.113
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0121 0.0705 0.1273
Schistosoma mansoni hypothetical protein 0.0095 0.0544 0.0981
Trichomonas vaginalis dynamin, putative 0.0042 0.021 0.1178
Echinococcus multilocularis acetylcholinesterase 0.0439 0.2689 0.2675
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0037 0.018 0.0464
Trypanosoma brucei hypothetical protein, conserved 0.0037 0.018 0.4784
Giardia lamblia Replication factor C, subunit 1 0.003 0.0135 0.4756
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0021 0.0083 0.1541
Schistosoma mansoni coup transcription factor 0.0241 0.1454 0.2625
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0127 0.0744 0.1343
Echinococcus granulosus dnaJ subfamily B 0.0404 0.2471 0.4441
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0037 0.018 0.026

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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