Detailed information for compound 990383

Basic information

Technical information
  • TDR Targets ID: 990383
  • Name: 2-(4-fluorophenyl)-3-pyridin-4-yl-6-(trifluor omethyl)pyrazolo[1,5-a]pyridine
  • MW: 357.304 | Formula: C19H11F4N3
  • H donors: 0 H acceptors: 2 LogP: 4.26 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: Fc1ccc(cc1)c1nn2c(c1c1ccncc1)ccc(c2)C(F)(F)F
  • InChi: 1S/C19H11F4N3/c20-15-4-1-13(2-5-15)18-17(12-7-9-24-10-8-12)16-6-3-14(19(21,22)23)11-26(16)25-18/h1-11H
  • InChiKey: ORVXSLITIZZMFZ-UHFFFAOYSA-N  

Network

Hover on a compound node to display the structore

Synonyms

  • 2-(4-fluorophenyl)-3-(4-pyridyl)-6-(trifluoromethyl)pyrazolo[1,5-a]pyridine

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens mitogen-activated protein kinase 14 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Candida albicans MAP kinase involved in osmoregulation Get druggable targets OG5_128610 All targets in OG5_128610
Echinococcus multilocularis mitogen activated protein kinase 11 Get druggable targets OG5_128610 All targets in OG5_128610
Leishmania donovani mitogen-activated protein kinase 3, putative Get druggable targets OG5_128610 All targets in OG5_128610
Leishmania major mitogen-activated protein kinase 3, putative,map kinase 3, putative Get druggable targets OG5_128610 All targets in OG5_128610
Trypanosoma cruzi mitogen-activated protein kinase 3, putative Get druggable targets OG5_128610 All targets in OG5_128610
Leishmania braziliensis mitogen-activated protein kinase 3, putative,map kinase 3, putative Get druggable targets OG5_128610 All targets in OG5_128610
Trypanosoma brucei mitogen-activated protein kinase 3, putative Get druggable targets OG5_128610 All targets in OG5_128610
Candida albicans MAP kinase involved in osmoregulation Get druggable targets OG5_128610 All targets in OG5_128610
Echinococcus granulosus mitogen activated protein kinase 11 Get druggable targets OG5_128610 All targets in OG5_128610
Trypanosoma brucei gambiense mitogen-activated protein kinase 3, putative Get druggable targets OG5_128610 All targets in OG5_128610
Leishmania mexicana mitogen-activated protein kinase 3, putative,map kinase 3, putative Get druggable targets OG5_128610 All targets in OG5_128610
Leishmania infantum mitogen-activated protein kinase 3, putative,map kinase 3, putative Get druggable targets OG5_128610 All targets in OG5_128610
Loa Loa (eye worm) CMGC/MAPK/P38 protein kinase Get druggable targets OG5_128610 All targets in OG5_128610
Trypanosoma congolense mitogen-activated protein kinase 3, putative Get druggable targets OG5_128610 All targets in OG5_128610
Echinococcus multilocularis mitogen activated protein kinase 11 Get druggable targets OG5_128610 All targets in OG5_128610
Brugia malayi P38 map kinase family protein 2 Get druggable targets OG5_128610 All targets in OG5_128610
Schistosoma japonicum ko:K04441 p38 MAP kinase, putative Get druggable targets OG5_128610 All targets in OG5_128610
Trypanosoma cruzi mitogen-activated protein kinase 3, putative Get druggable targets OG5_128610 All targets in OG5_128610
Echinococcus multilocularis mitogen activated protein kinase 14 Get druggable targets OG5_128610 All targets in OG5_128610
Echinococcus multilocularis mitogen activated protein kinase 14 Get druggable targets OG5_128610 All targets in OG5_128610
Echinococcus granulosus mitogen activated protein kinase 14 Get druggable targets OG5_128610 All targets in OG5_128610

By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma brucei mitogen-activated protein kinase 5 mitogen-activated protein kinase 14 360 aa 336 aa 33.3 %

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0039 0.0028 0.0039
Echinococcus multilocularis dna polymerase kappa 0.0039 0.0028 0.017
Echinococcus granulosus geminin 0.0347 0.1644 1
Plasmodium vivax thioredoxin reductase, putative 0.0097 0.0332 1
Schistosoma mansoni hypothetical protein 0.0037 0.002 0.0124
Schistosoma mansoni terminal deoxycytidyl transferase 0.0039 0.0028 0.017
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0221 0.0982 0.1377
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0097 0.0332 0.0465
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0039 0.0028 0.4047
Echinococcus granulosus dna polymerase eta 0.0064 0.0163 0.0989
Plasmodium vivax glutathione reductase, putative 0.0097 0.0332 1
Trypanosoma brucei DNA polymerase eta, putative 0.0064 0.0163 0.2611
Trypanosoma cruzi DNA polymerase eta, putative 0.0038 0.0022 0.0352
Treponema pallidum UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.1938 1 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0028 0.0449
Echinococcus granulosus mitogen activated protein kinase 11 0.0152 0.0622 0.3787
Trypanosoma brucei mitogen-activated protein kinase 3, putative 0.0152 0.0622 1
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0221 0.0982 0.1377
Giardia lamblia DINP protein human, muc B family 0.0039 0.0028 0.405
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0052 0.0096 0.0868
Plasmodium falciparum glutathione reductase 0.0097 0.0332 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0028 0.0449
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0028 0.0449
Echinococcus multilocularis geminin 0.0347 0.1644 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.0052 0.0096 0.0868
Echinococcus multilocularis mitogen activated protein kinase 11 0.0152 0.0622 0.3787
Leishmania major DNA polymerase kappa, putative 0.0039 0.0028 0.0449
Trypanosoma cruzi DNA polymerase kappa, putative 0.0039 0.0028 0.0449
Trichomonas vaginalis C-MYB, putative 0.0046 0.0068 0.9831
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0047 0.0069 1
Brugia malayi MH2 domain containing protein 0.0244 0.1106 1
Trypanosoma brucei trypanothione reductase 0.0097 0.0332 0.5331
Schistosoma mansoni tar DNA-binding protein 0.0066 0.017 0.1032
Trypanosoma brucei DNA polymerase IV, putative 0.0039 0.0028 0.0449
Schistosoma mansoni hypothetical protein 0.0035 0.001 0.0061
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0066 0.017 0.1457
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0046 0.0068 0.9831
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0245 0.1111 0.021
Trypanosoma brucei DNA polymerase IV, putative 0.0039 0.0028 0.0449
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0039 0.0028 0.017
Trichomonas vaginalis MYB3r3, putative 0.0046 0.0068 0.9831
Trichomonas vaginalis MYB72, putative 0.0046 0.0068 0.9831
Loa Loa (eye worm) CMGC/MAPK/P38 protein kinase 0.0152 0.0622 0.5588
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0046 0.0068 0.9831
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0028 0.0449
Leishmania major trypanothione reductase 0.0097 0.0332 0.5331
Loa Loa (eye worm) MH2 domain-containing protein 0.0244 0.1106 1
Toxoplasma gondii thioredoxin reductase 0.0097 0.0332 0.1232
Mycobacterium tuberculosis Probable reductase 0.0221 0.0982 0.1377
Mycobacterium tuberculosis Probable oxidoreductase 0.0245 0.1111 0.1559
Brugia malayi TAR-binding protein 0.0066 0.017 0.1533
Trypanosoma cruzi DNA polymerase kappa, putative 0.0039 0.0028 0.0449
Trypanosoma cruzi DNA polymerase eta, putative 0.0064 0.0163 0.2611
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0046 0.0068 0.9831
Loa Loa (eye worm) transcription factor SMAD2 0.0244 0.1106 1
Echinococcus multilocularis thioredoxin glutathione reductase 0.0097 0.0332 0.2019
Mycobacterium ulcerans 3-phosphoshikimate 1-carboxyvinyltransferase 0.0546 0.2693 0.2693
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0221 0.0982 0.1377
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0046 0.0068 0.9831
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0028 0.0449
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0052 0.0096 0.0785
Echinococcus multilocularis mitogen activated protein kinase 14 0.0152 0.0622 0.3787
Trichomonas vaginalis MYB, putative 0.0047 0.0069 1
Schistosoma mansoni transcription factor LCR-F1 0.0037 0.002 0.0124
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0037 0.002 0.0124
Echinococcus multilocularis mitogen activated protein kinase 14 0.0152 0.0622 0.3787
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0046 0.0068 0.9831
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0028 0.0449
Leishmania major mitogen-activated protein kinase 3, putative,map kinase 3, putative 0.0152 0.0622 1
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0245 0.1111 0.1559
Brugia malayi hypothetical protein 0.0037 0.002 0.0184
Giardia lamblia Myb 1-like protein 0.0047 0.0069 1
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0039 0.0028 0.0164
Loa Loa (eye worm) hypothetical protein 0.0064 0.0163 0.1392
Wolbachia endosymbiont of Brugia malayi UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.1938 1 1
Plasmodium falciparum thioredoxin reductase 0.0097 0.0332 1
Echinococcus multilocularis mitogen activated protein kinase 11 0.0152 0.0622 0.3787
Mycobacterium tuberculosis Conserved hypothetical protein 0.0039 0.0028 0.0039
Schistosoma mansoni hypothetical protein 0.0347 0.1644 1
Mycobacterium ulcerans UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.1938 1 1
Chlamydia trachomatis phosphoshikimate 1-carboxyl vinyltransferase 0.0546 0.2693 0.2693
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0152 0.0622 1
Trypanosoma brucei unspecified product 0.0039 0.0028 0.0449
Brugia malayi latrophilin 2 splice variant baaae 0.0035 0.001 0.009
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0039 0.0028 0.017
Loa Loa (eye worm) hypothetical protein 0.0052 0.0096 0.0785
Mycobacterium ulcerans DNA polymerase IV 0.0039 0.0028 0.0028
Echinococcus granulosus thioredoxin glutathione reductase 0.0097 0.0332 0.2019
Loa Loa (eye worm) glutathione reductase 0.0097 0.0332 0.2936
Trichomonas vaginalis pc-MYB2, putative 0.0046 0.0068 0.9831
Trichomonas vaginalis C-MYB, putative 0.0046 0.0068 0.9831
Schistosoma mansoni tar DNA-binding protein 0.0066 0.017 0.1032
Echinococcus multilocularis tar DNA binding protein 0.0066 0.017 0.1032
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0046 0.0068 0.9831
Entamoeba histolytica deoxycytidyl transferase, putative 0.0039 0.0028 0.1607
Brugia malayi ImpB/MucB/SamB family protein 0.0039 0.0028 0.0253
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0037 0.002 0.0124
Brugia malayi ImpB/MucB/SamB family protein 0.0064 0.0163 0.147
Echinococcus granulosus tar DNA binding protein 0.0066 0.017 0.1032
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0028 0.0449
Toxoplasma gondii Myb family DNA-binding domain-containing protein 0.0047 0.0069 0.0256
Trypanosoma cruzi DNA polymerase kappa, putative 0.0039 0.0028 0.0449
Brugia malayi glutathione reductase 0.0097 0.0332 0.3
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0038 0.0022 0.0081
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.0046 0.0068 1
Echinococcus granulosus dna polymerase kappa 0.0039 0.0028 0.017
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0028 0.0449
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.0046 0.0068 1
Loa Loa (eye worm) RNA binding protein 0.0066 0.017 0.1457
Trichomonas vaginalis DNA polymerase eta, putative 0.0039 0.0028 0.4047
Trypanosoma brucei DNA polymerase IV, putative 0.0039 0.0028 0.0449
Toxoplasma gondii shikimate dehydrogenase substrate binding domain-containing protein 0.0546 0.2693 1
Mycobacterium leprae PROBABLE UDP-N-ACETYLGLUCOSAMINE 1-CARBOXYVINYLTRANSFERASE MURA 0.1392 0.7131 1
Mycobacterium leprae probable 3-phosphoshikimate 1-carboxyvinyl transferase AroA (5-ENOLPYRUVYLSHIKIMATE-3-PHOSPHATE SYNTHASE) (EPSP SYNTHASE) (EPSPS 0.0546 0.2693 0.2782
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0028 0.0449
Trypanosoma cruzi trypanothione reductase, putative 0.0097 0.0332 0.5331
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.0046 0.0068 1
Leishmania major DNA polymerase eta, putative 0.0064 0.0163 0.2611
Schistosoma mansoni hypothetical protein 0.0347 0.1644 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0028 0.0449
Loa Loa (eye worm) TAR-binding protein 0.0066 0.017 0.1457
Trichomonas vaginalis pc-MYB2, putative 0.0046 0.0068 0.9831
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0245 0.1111 0.1559
Brugia malayi RNA recognition motif domain containing protein 0.0066 0.017 0.1533
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0221 0.0982 0.1377
Brugia malayi P38 map kinase family protein 2 0.0152 0.0622 0.5627
Mycobacterium tuberculosis Probable UDP-N-acetylglucosamine 1-carboxyvinyltransferase MurA 0.1392 0.7131 1
Brugia malayi RNA binding protein 0.0066 0.017 0.1533
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0039 0.0028 0.017
Trypanosoma cruzi DNA polymerase kappa, putative 0.0039 0.0028 0.0449
Schistosoma mansoni tar DNA-binding protein 0.0066 0.017 0.1032
Schistosoma mansoni tar DNA-binding protein 0.0066 0.017 0.1032
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0152 0.0622 1
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0039 0.0028 0.0449
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.0046 0.0068 1
Schistosoma mansoni DNA polymerase eta 0.0064 0.0163 0.0989
Brugia malayi Thioredoxin reductase 0.0097 0.0332 0.3
Mycobacterium ulcerans DNA polymerase IV 0.0039 0.0028 0.0028
Loa Loa (eye worm) thioredoxin reductase 0.0097 0.0332 0.2936
Echinococcus multilocularis dna polymerase eta 0.0064 0.0163 0.0989
Mycobacterium tuberculosis Probable dehydrogenase 0.0221 0.0982 0.1377
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.0046 0.0068 1
Leishmania major DNA polymerase eta, putative 0.0038 0.0022 0.0352
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0047 0.0069 1
Echinococcus granulosus mitogen activated protein kinase 14 0.0152 0.0622 0.3787
Schistosoma mansoni tar DNA-binding protein 0.0066 0.017 0.1032

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 0.2 uM Inhibition of GST-fused p38alpha expressed in Escherichia coli ChEMBL. 18818075

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.