TDR Targets

Basic information

Technical information

TDR Targets ID: 990383
Name: 2-(4-fluorophenyl)-3-pyridin-4-yl-6-(trifluor omethyl)pyrazolo[1,5-a]pyridine
MW: 357.304 | Formula: C19H11F4N3
H donors: 0 H acceptors: 2 LogP: 4.26 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: Fc1ccc(cc1)c1nn2c(c1c1ccncc1)ccc(c2)C(F)(F)F
InChi: 1S/C19H11F4N3/c20-15-4-1-13(2-5-15)18-17(12-7-9-24-10-8-12)16-6-3-14(19(21,22)23)11-26(16)25-18/h1-11H
InChiKey: ORVXSLITIZZMFZ-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

2-(4-fluorophenyl)-3-(4-pyridyl)-6-(trifluoromethyl)pyrazolo[1,5-a]pyridine

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	mitogen-activated protein kinase 14	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Candida albicans	MAP kinase involved in osmoregulation	Get druggable targets OG5_128610	All targets in OG5_128610
Leishmania mexicana	mitogen-activated protein kinase 3, putative,map kinase 3, putative	Get druggable targets OG5_128610	All targets in OG5_128610
Echinococcus granulosus	mitogen activated protein kinase 11	Get druggable targets OG5_128610	All targets in OG5_128610
Echinococcus multilocularis	mitogen activated protein kinase 11	Get druggable targets OG5_128610	All targets in OG5_128610
Leishmania braziliensis	mitogen-activated protein kinase 3, putative,map kinase 3, putative	Get druggable targets OG5_128610	All targets in OG5_128610
Leishmania infantum	mitogen-activated protein kinase 3, putative,map kinase 3, putative	Get druggable targets OG5_128610	All targets in OG5_128610
Echinococcus granulosus	mitogen activated protein kinase 14	Get druggable targets OG5_128610	All targets in OG5_128610
Trypanosoma brucei gambiense	mitogen-activated protein kinase 3, putative	Get druggable targets OG5_128610	All targets in OG5_128610
Leishmania donovani	mitogen-activated protein kinase 3, putative	Get druggable targets OG5_128610	All targets in OG5_128610
Trypanosoma cruzi	mitogen-activated protein kinase 3, putative	Get druggable targets OG5_128610	All targets in OG5_128610
Echinococcus multilocularis	mitogen activated protein kinase 11	Get druggable targets OG5_128610	All targets in OG5_128610
Trypanosoma cruzi	mitogen-activated protein kinase 3, putative	Get druggable targets OG5_128610	All targets in OG5_128610
Trypanosoma brucei	mitogen-activated protein kinase 3, putative	Get druggable targets OG5_128610	All targets in OG5_128610
Brugia malayi	P38 map kinase family protein 2	Get druggable targets OG5_128610	All targets in OG5_128610
Echinococcus multilocularis	mitogen activated protein kinase 14	Get druggable targets OG5_128610	All targets in OG5_128610
Candida albicans	MAP kinase involved in osmoregulation	Get druggable targets OG5_128610	All targets in OG5_128610
Trypanosoma congolense	mitogen-activated protein kinase 3, putative	Get druggable targets OG5_128610	All targets in OG5_128610
Echinococcus multilocularis	mitogen activated protein kinase 14	Get druggable targets OG5_128610	All targets in OG5_128610
Schistosoma japonicum	ko:K04441 p38 MAP kinase, putative	Get druggable targets OG5_128610	All targets in OG5_128610
Leishmania major	mitogen-activated protein kinase 3, putative,map kinase 3, putative	Get druggable targets OG5_128610	All targets in OG5_128610
Loa Loa (eye worm)	CMGC/MAPK/P38 protein kinase	Get druggable targets OG5_128610	All targets in OG5_128610

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Trypanosoma brucei	mitogen-activated protein kinase 5	mitogen-activated protein kinase 14	360 aa	336 aa	33.3 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	MH2 domain-containing protein	0.0244	0.1106	1
Loa Loa (eye worm)	ImpB/MucB/SamB family protein	0.0039	0.0028	0.0164
Trypanosoma brucei	DNA polymerase kappa, putative	0.0039	0.0028	0.0449
Echinococcus granulosus	thioredoxin glutathione reductase	0.0097	0.0332	0.2019
Echinococcus granulosus	terminal deoxycytidyl transferase rev1	0.0039	0.0028	0.017
Trypanosoma cruzi	mitogen-activated protein kinase 3, putative	0.0152	0.0622	1
Leishmania major	DNA polymerase eta, putative	0.0038	0.0022	0.0352
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0039	0.0028	0.0449
Trypanosoma cruzi	trypanothione reductase, putative	0.0097	0.0332	0.5331
Mycobacterium ulcerans	DNA polymerase IV	0.0039	0.0028	0.0028
Trypanosoma brucei	DNA polymerase kappa, putative	0.0039	0.0028	0.0449
Echinococcus granulosus	dna polymerase kappa	0.0039	0.0028	0.017
Loa Loa (eye worm)	transcription factor SMAD2	0.0244	0.1106	1
Echinococcus multilocularis	mitogen activated protein kinase 11	0.0152	0.0622	0.3787
Trypanosoma brucei	DNA polymerase kappa, putative	0.0039	0.0028	0.0449
Wolbachia endosymbiont of Brugia malayi	UDP-N-acetylglucosamine 1-carboxyvinyltransferase	0.1938	1	1
Trypanosoma brucei	DNA polymerase IV, putative	0.0039	0.0028	0.0449
Entamoeba histolytica	myb-like DNA-binding domain containing protein	0.0046	0.0068	1
Echinococcus granulosus	mitogen activated protein kinase 11	0.0152	0.0622	0.3787
Trichomonas vaginalis	r2r3-MYB transcription factor, putative	0.0046	0.0068	0.9831
Trypanosoma cruzi	DNA polymerase eta, putative	0.0064	0.0163	0.2611
Echinococcus multilocularis	mitogen activated protein kinase 14	0.0152	0.0622	0.3787
Leishmania major	DNA polymerase kappa, putative	0.0039	0.0028	0.0449
Leishmania major	DNA polymerase kappa, putative,DNA polymerase IV, putative	0.0039	0.0028	0.0449
Trichomonas vaginalis	DNA polymerase eta, putative	0.0039	0.0028	0.4047
Brugia malayi	TAR-binding protein	0.0066	0.017	0.1533
Schistosoma mansoni	DNA polymerase eta	0.0064	0.0163	0.0989
Brugia malayi	RNA recognition motif domain containing protein	0.0066	0.017	0.1533
Trypanosoma brucei	DNA polymerase kappa, putative	0.0039	0.0028	0.0449
Brugia malayi	ImpB/MucB/SamB family protein	0.0039	0.0028	0.0253
Schistosoma mansoni	rab geranylgeranyl transferase alpha subunit	0.0039	0.0028	0.017
Trichomonas vaginalis	MYB, putative	0.0047	0.0069	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.0039	0.0028	0.0449
Echinococcus granulosus	geminin	0.0347	0.1644	1
Echinococcus multilocularis	mitogen activated protein kinase 14	0.0152	0.0622	0.3787
Loa Loa (eye worm)	thioredoxin reductase	0.0097	0.0332	0.2936
Brugia malayi	MH2 domain containing protein	0.0244	0.1106	1
Loa Loa (eye worm)	CMGC/MAPK/P38 protein kinase	0.0152	0.0622	0.5588
Mycobacterium tuberculosis	Probable UDP-N-acetylglucosamine 1-carboxyvinyltransferase MurA	0.1392	0.7131	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.0039	0.0028	0.0449
Echinococcus granulosus	mitogen activated protein kinase 14	0.0152	0.0622	0.3787
Schistosoma mansoni	hypothetical protein	0.0035	0.001	0.0061
Trichomonas vaginalis	DNA polymerase IV / kappa, putative	0.0039	0.0028	0.4047
Trypanosoma brucei	DNA polymerase kappa, putative	0.0039	0.0028	0.0449
Giardia lamblia	DINP protein human, muc B family	0.0039	0.0028	0.405
Mycobacterium tuberculosis	Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed))	0.0039	0.0028	0.0039
Schistosoma mansoni	tar DNA-binding protein	0.0066	0.017	0.1032
Giardia lamblia	Myb 1-like protein	0.0047	0.0069	1
Echinococcus granulosus	tar DNA binding protein	0.0066	0.017	0.1032
Toxoplasma gondii	Myb family DNA-binding domain-containing protein	0.0047	0.0069	0.0256
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0245	0.1111	0.021
Plasmodium vivax	thioredoxin reductase, putative	0.0097	0.0332	1
Echinococcus granulosus	dna polymerase eta	0.0064	0.0163	0.0989
Mycobacterium ulcerans	UDP-N-acetylglucosamine 1-carboxyvinyltransferase	0.1938	1	1
Entamoeba histolytica	deoxycytidyl transferase, putative	0.0039	0.0028	0.1607
Echinococcus multilocularis	dna polymerase eta	0.0064	0.0163	0.0989
Schistosoma mansoni	tar DNA-binding protein	0.0066	0.017	0.1032
Trypanosoma brucei	DNA polymerase IV, putative	0.0039	0.0028	0.0449
Entamoeba histolytica	myb-like DNA-binding domain containing protein	0.0046	0.0068	1
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0052	0.0096	0.0785
Echinococcus multilocularis	terminal deoxycytidyl transferase rev1	0.0039	0.0028	0.017
Schistosoma mansoni	hypothetical protein	0.0347	0.1644	1
Trypanosoma cruzi	mitogen-activated protein kinase 3, putative	0.0152	0.0622	1
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.0221	0.0982	0.1377
Mycobacterium tuberculosis	Probable reductase	0.0221	0.0982	0.1377
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0037	0.002	0.0124
Loa Loa (eye worm)	hypothetical protein	0.0064	0.0163	0.1392
Mycobacterium ulcerans	3-phosphoshikimate 1-carboxyvinyltransferase	0.0546	0.2693	0.2693
Trichomonas vaginalis	r2r3-MYB transcription factor, putative	0.0046	0.0068	0.9831
Schistosoma mansoni	tar DNA-binding protein	0.0066	0.017	0.1032
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0097	0.0332	0.2019
Mycobacterium tuberculosis	Probable oxidoreductase	0.0245	0.1111	0.1559
Trichomonas vaginalis	MYB72, putative	0.0046	0.0068	0.9831
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0039	0.0028	0.0449
Entamoeba histolytica	myb-like DNA-binding domain containing protein	0.0046	0.0068	1
Trypanosoma brucei	mitogen-activated protein kinase 3, putative	0.0152	0.0622	1
Trypanosoma cruzi	DNA polymerase eta, putative	0.0038	0.0022	0.0352
Schistosoma mansoni	hypothetical protein	0.0037	0.002	0.0124
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0039	0.0028	0.0039
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0052	0.0096	0.0868
Trypanosoma brucei	DNA polymerase kappa, putative	0.0039	0.0028	0.0449
Trypanosoma brucei	unspecified product	0.0039	0.0028	0.0449
Brugia malayi	RNA binding protein	0.0066	0.017	0.1533
Trichomonas vaginalis	pc-MYB2, putative	0.0046	0.0068	0.9831
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0039	0.0028	0.0449
Trichomonas vaginalis	pc-MYB2, putative	0.0046	0.0068	0.9831
Leishmania major	mitogen-activated protein kinase 3, putative,map kinase 3, putative	0.0152	0.0622	1
Schistosoma mansoni	transcription factor LCR-F1	0.0037	0.002	0.0124
Loa Loa (eye worm)	glutathione reductase	0.0097	0.0332	0.2936
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0039	0.0028	0.0449
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0052	0.0096	0.0868
Leishmania major	trypanothione reductase	0.0097	0.0332	0.5331
Schistosoma mansoni	tar DNA-binding protein	0.0066	0.017	0.1032
Trichomonas vaginalis	r2r3-MYB transcription factor, putative	0.0046	0.0068	0.9831
Mycobacterium ulcerans	DNA polymerase IV	0.0039	0.0028	0.0028
Entamoeba histolytica	myb-like DNA-binding domain containing protein	0.0046	0.0068	1
Loa Loa (eye worm)	TAR-binding protein	0.0066	0.017	0.1457
Plasmodium falciparum	glutathione reductase	0.0097	0.0332	1
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0096	0.0785
Trichomonas vaginalis	MYB3r3, putative	0.0046	0.0068	0.9831
Entamoeba histolytica	myb-like DNA-binding domain containing protein	0.0046	0.0068	1
Toxoplasma gondii	thioredoxin reductase	0.0097	0.0332	0.1232
Trypanosoma brucei	DNA polymerase eta, putative	0.0064	0.0163	0.2611
Mycobacterium leprae	PROBABLE UDP-N-ACETYLGLUCOSAMINE 1-CARBOXYVINYLTRANSFERASE MURA	0.1392	0.7131	1
Plasmodium vivax	glutathione reductase, putative	0.0097	0.0332	1
Echinococcus multilocularis	geminin	0.0347	0.1644	1
Trichomonas vaginalis	C-MYB, putative	0.0046	0.0068	0.9831
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.0097	0.0332	0.0465
Toxoplasma gondii	shikimate dehydrogenase substrate binding domain-containing protein	0.0546	0.2693	1
Trichomonas vaginalis	r2r3-MYB transcription factor, putative	0.0046	0.0068	0.9831
Brugia malayi	P38 map kinase family protein 2	0.0152	0.0622	0.5627
Trypanosoma brucei	DNA polymerase IV, putative	0.0039	0.0028	0.0449
Brugia malayi	hypothetical protein	0.0037	0.002	0.0184
Mycobacterium tuberculosis	Probable dehydrogenase	0.0221	0.0982	0.1377
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.0221	0.0982	0.1377
Brugia malayi	Thioredoxin reductase	0.0097	0.0332	0.3
Trypanosoma brucei	DNA polymerase kappa, putative	0.0039	0.0028	0.0449
Trypanosoma brucei	trypanothione reductase	0.0097	0.0332	0.5331
Schistosoma mansoni	terminal deoxycytidyl transferase	0.0039	0.0028	0.017
Schistosoma mansoni	hypothetical protein	0.0347	0.1644	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.0039	0.0028	0.0449
Trichomonas vaginalis	r2r3-MYB transcription factor, putative	0.0047	0.0069	1
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.0221	0.0982	0.1377
Echinococcus multilocularis	dna polymerase kappa	0.0039	0.0028	0.017
Chlamydia trachomatis	phosphoshikimate 1-carboxyl vinyltransferase	0.0546	0.2693	0.2693
Brugia malayi	ImpB/MucB/SamB family protein	0.0064	0.0163	0.147
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0066	0.017	0.1457
Echinococcus multilocularis	mitogen activated protein kinase 11	0.0152	0.0622	0.3787
Leishmania major	DNA polymerase eta, putative	0.0064	0.0163	0.2611
Mycobacterium leprae	probable 3-phosphoshikimate 1-carboxyvinyl transferase AroA (5-ENOLPYRUVYLSHIKIMATE-3-PHOSPHATE SYNTHASE) (EPSP SYNTHASE) (EPSPS	0.0546	0.2693	0.2782
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.0221	0.0982	0.1377
Echinococcus multilocularis	tar DNA binding protein	0.0066	0.017	0.1032
Plasmodium falciparum	thioredoxin reductase	0.0097	0.0332	1
Trichomonas vaginalis	C-MYB, putative	0.0046	0.0068	0.9831
Schistosoma mansoni	tar DNA-binding protein	0.0066	0.017	0.1032
Treponema pallidum	UDP-N-acetylglucosamine 1-carboxyvinyltransferase	0.1938	1	1
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0245	0.1111	0.1559
Trichomonas vaginalis	r2r3-MYB transcription factor, putative	0.0046	0.0068	0.9831
Toxoplasma gondii	ImpB/MucB/SamB family protein	0.0038	0.0022	0.0081
Loa Loa (eye worm)	RNA binding protein	0.0066	0.017	0.1457
Brugia malayi	latrophilin 2 splice variant baaae	0.0035	0.001	0.009
Brugia malayi	glutathione reductase	0.0097	0.0332	0.3
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0037	0.002	0.0124
Trichomonas vaginalis	r2r3-MYB transcription factor, putative	0.0046	0.0068	0.9831
Trichomonas vaginalis	r2r3-MYB transcription factor, putative	0.0047	0.0069	1
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0245	0.1111	0.1559

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 0.2 uM	Inhibition of GST-fused p38alpha expressed in Escherichia coli	ChEMBL.	18818075

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL487781

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 990383