Detailed information for compound 990420

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 408.402 | Formula: C19H24N2O8
  • H donors: 3 H acceptors: 5 LogP: 0.72 Rotable bonds: 14
    Rule of 5 violations (Lipinski): 1
  • SMILES: COC(=O)CNC(=O)[C@@H](NC(=O)/C=C/c1ccc(c(c1)OC)OC)CCC(=O)O
  • InChi: 1S/C19H24N2O8/c1-27-14-7-4-12(10-15(14)28-2)5-8-16(22)21-13(6-9-17(23)24)19(26)20-11-18(25)29-3/h4-5,7-8,10,13H,6,9,11H2,1-3H3,(H,20,26)(H,21,22)(H,23,24)/b8-5+/t13-/m0/s1
  • InChiKey: LSAVDSMWTYAIPK-LJLILKBBSA-N  


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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis ABC transporter, half transporter, putative 0.0021 0.0027 0.0353
Trypanosoma brucei glucose transporter, putative 0.0033 0.0048 0.008
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0021 0.0027 0.0353
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0021 0.0027 0.0045
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0015 0.0201
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0055 0.0089 0.0089
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0025 0.0034 0.0034
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0021 0.0027 0.0353
Brugia malayi hypothetical protein 0.0417 0.076 0.076
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0025 0.0034 0.0034
Trichomonas vaginalis glucose transporter, putative 0.0033 0.0048 0.0638
Toxoplasma gondii protein kinase, putative 0.0299 0.0541 0.089
Loa Loa (eye worm) cytochrome P450 family protein 0.0042 0.0066 0.0066
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0053 0.0086
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0021 0.0026 0.0343
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0021 0.0027 0.0353
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0015 0.0201
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0032 0.0048 0.0078
Plasmodium vivax proline--tRNA ligase, putative 0.0037 0.0056 0.0092
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0025 0.0034 0.0034
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0015 0.0201
Loa Loa (eye worm) hypothetical protein 0.0015 0.0015 0.0015
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0021 0.0027 0.0027
Echinococcus multilocularis solute carrier family 22 0.0015 0.0015 0.0015
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0021 0.0027 0.0353
Entamoeba histolytica transcription factor BTF3, putative 0.0037 0.0056 0.1539
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0053 0.0053
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0023 0.0037
Echinococcus granulosus multidrug resistance protein 1 0.0015 0.0015 0.0015
Leishmania major hypothetical protein, conserved 0.0015 0.0015 0.0025
Brugia malayi Pre-SET motif family protein 0.0209 0.0375 0.0375
Trichomonas vaginalis myo-inositol transporter, putative 0.0015 0.0015 0.0201
Chlamydia trachomatis ABC transporter ATP binding protein/permease 0.0021 0.0027 0.0018
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0032 0.0047 0.0612
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0015 0.0201
Plasmodium falciparum protein kinase 6 0.0448 0.0819 0.1346
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0024 0.0031 0.0414
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0025 0.0034 0.0034
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0023 0.0023
Loa Loa (eye worm) dihydrofolate reductase 0.5404 1 1
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0015 0.0201
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0015 0.0201
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0018 0.003
Trypanosoma brucei unspecified product 0.0019 0.0023 0.0037
Schistosoma mansoni dihydrofolate reductase 0.5404 1 1
Brugia malayi Sugar transporter family protein 0.0015 0.0015 0.0015
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0021 0.0027 0.0353
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0202 0.0362 1
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0021 0.0027 0.0353
Entamoeba histolytica hypothetical protein 0.0024 0.0031 0.0869
Trypanosoma brucei glucose transporter, putative 0.0033 0.0048 0.008
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0015 0.0015 0.0015
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0015 0.0201
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0025 0.0034 0.0034
Toxoplasma gondii isocitrate dehydrogenase 0.0017 0.0018 0.003
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0025 0.0034 0.0034
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0017 0.0018 0.0018
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0207 0.0371 0.0371
Loa Loa (eye worm) hypothetical protein 0.0015 0.0015 0.0015
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0025 0.0034 0.0034
Entamoeba histolytica protein kinase, putative 0.0032 0.0048 0.1317
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0037 0.0056 0.0092
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0023 0.0023
Loa Loa (eye worm) hypothetical protein 0.0019 0.0023 0.0023
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0023 0.0023
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0023 0.0023
Toxoplasma gondii NAC domain-containing protein 0.0037 0.0056 0.0092
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0024 0.0031 0.0031
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0018 0.0022 0.0036
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.0015 0.0015 0.0025
Trypanosoma cruzi hexose transporter, putative 0.0015 0.0015 0.0025
Loa Loa (eye worm) hypothetical protein 0.0015 0.0015 0.0015
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0015 0.0201
Brugia malayi beta-lactamase family protein 0.0035 0.0053 0.0053
Brugia malayi Cytochrome P450 family protein 0.0025 0.0034 0.0034
Trypanosoma brucei glucose transporter 2A 0.0033 0.0048 0.008
Plasmodium falciparum proline--tRNA ligase 0.0037 0.0056 0.0092
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0025 0.0034 0.0034
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0023 0.0037
Loa Loa (eye worm) hypothetical protein 0.0024 0.0031 0.0031
Brugia malayi ABC transporter family protein 0.0021 0.0027 0.0027
Onchocerca volvulus 0.0876 0.1611 1
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.002 0.0025 0.0025
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0021 0.0027 0.0353
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0018 0.0022 0.0022
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0207 0.0371 0.0371
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0021 0.0027 0.0353
Schistosoma mansoni sugar transporter 0.0015 0.0015 0.0015
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0015 0.0201
Echinococcus multilocularis thymidylate synthase 0.0876 0.1611 0.1611
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0025 0.0034 0.0034
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0018 0.0022 0.0036
Trypanosoma cruzi hexose transporter, putative 0.0033 0.0048 0.008
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0027 0.0027
Entamoeba histolytica P-glycoprotein-1 0.0021 0.0027 0.0741
Trichomonas vaginalis abcb9, putative 0.0021 0.0027 0.0353
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0071 0.0071
Loa Loa (eye worm) MBCTL1 0.0055 0.0089 0.0089
Trichomonas vaginalis CAMK family protein kinase 0.0032 0.0048 0.0628
Trichomonas vaginalis esterase, putative 0.0035 0.0053 0.0692
Mycobacterium tuberculosis Probable thymidylate synthase ThyA (ts) (TSASE) 0.0876 0.1611 0.1611
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0053 0.0086
Loa Loa (eye worm) hypothetical protein 0.0015 0.0015 0.0015
Plasmodium vivax sugar transporter, putative 0.0015 0.0015 0.0025
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0027 0.0045
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0031 0.0051
Trichomonas vaginalis taga, putative 0.0021 0.0027 0.0353
Leishmania major lysyl-tRNA synthetase, putative 0.0024 0.0031 0.0052
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0018 0.0018
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0071 0.0071
Loa Loa (eye worm) hypothetical protein 0.0018 0.002 0.002
Mycobacterium ulcerans sugar transporter 0.0015 0.0015 0.0015
Entamoeba histolytica P-glycoprotein 5, putative 0.0021 0.0027 0.0741
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0023 0.0023
Loa Loa (eye worm) hypothetical protein 0.0015 0.0015 0.0015
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0202 0.0362 0.0596
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0032 0.0047 0.0047
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0015 0.0201
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0023 0.0023
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.002 0.0025 0.0025
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0043 0.0043
Leishmania major DNA polymerase kappa, putative 0.0019 0.0023 0.0037
Entamoeba histolytica hypothetical protein 0.0035 0.0053 0.1458
Schistosoma mansoni multidrug resistance protein 0.0021 0.0027 0.0027
Trypanosoma cruzi hexose transporter, putative 0.0033 0.0048 0.008
Schistosoma mansoni multidrug resistance protein 0.0021 0.0027 0.0027
Mycobacterium leprae conserved hypothetical protein 0.0035 0.0053 0.0053
Schistosoma mansoni multidrug resistance protein 0.0021 0.0027 0.0027
Mycobacterium tuberculosis Probable transmembrane multidrug efflux pump 0.0021 0.0027 0.0027
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0043 0.0071
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0071 0.0071
Loa Loa (eye worm) cytochrome P450 0.0025 0.0034 0.0034
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0012 0.0019
Schistosoma mansoni hypothetical protein 0.0035 0.0053 0.0053
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0171 0.0304 0.05
Loa Loa (eye worm) multidrug resistance protein 3 0.0021 0.0027 0.0027
Plasmodium falciparum multidrug resistance protein 1 0.0021 0.0027 0.0044
Brugia malayi hypothetical protein 0.0015 0.0015 0.0015
Toxoplasma gondii ABC1 family protein 0.0035 0.0053 0.0086
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0037 0.0056 0.0092
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.0053 0.0053
Loa Loa (eye worm) hypothetical protein 0.0048 0.0077 0.0077
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.0022 0.0022
Brugia malayi major facilitator superfamily protein 0.0015 0.0015 0.0015
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0071 0.0071
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0032 0.0047 0.1284
Schistosoma mansoni hypothetical protein 0.0677 0.1243 0.1243
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0025 0.0034 0.0034
Entamoeba histolytica protein kinase, putative 0.0032 0.0048 0.1317
Echinococcus multilocularis 0.0025 0.0034 0.0034
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0032 0.0048 0.0079
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0025 0.0034 0.0034
Loa Loa (eye worm) sugar transporter 0.0106 0.0184 0.0184
Trypanosoma brucei glucose transporter, putative 0.0033 0.0048 0.008
Onchocerca volvulus 0.0048 0.0077 0.0385
Mycobacterium tuberculosis Hypothetical protein 0.0417 0.076 0.076
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0071 0.0071
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0309 0.056 0.056
Schistosoma mansoni protein kinase 0.0032 0.0048 0.0048
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0056 0.0734
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.0027 0.0045
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0032 0.0047 0.0047
Trichomonas vaginalis ABC transporter, half transporter, putative 0.0021 0.0027 0.0353
Echinococcus multilocularis synaptic vesicle 2 protein 0.0015 0.0015 0.0015
Echinococcus granulosus importin subunit beta 1 0.0029 0.0041 0.0041
Loa Loa (eye worm) cytochrome P450 family protein 0.0082 0.014 0.014
Echinococcus granulosus SAM and MBT domain containing protein 0.0048 0.0077 0.0077
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0035 0.0053 0.0053
Loa Loa (eye worm) cytochrome P450 family protein 0.0042 0.0066 0.0066
Brugia malayi beta-lactamase 0.0035 0.0053 0.0053
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0024 0.0031 0.0052
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0043 0.0043
Brugia malayi Pre-SET motif family protein 0.003 0.0043 0.0043
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0017 0.0018 0.003
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0017 0.0018 0.003
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0015 0.0201
Echinococcus granulosus geminin 0.0677 0.1243 0.1243
Loa Loa (eye worm) hypothetical protein 0.0035 0.0053 0.0053
Brugia malayi lysyl-tRNA synthetase 0.0024 0.0031 0.0031
Trypanosoma brucei unspecified product 0.0013 0.0012 0.0019
Echinococcus granulosus multidrug resistance protein 1 0.0021 0.0027 0.0027
Onchocerca volvulus 0.0035 0.0053 0.0234
Loa Loa (eye worm) hypothetical protein 0.0021 0.0026 0.0026
Echinococcus multilocularis expressed protein 0.0207 0.0371 0.0371
Echinococcus multilocularis ATP binding cassette sub family B 0.0021 0.0026 0.0026
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0023 0.0037
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0023 0.0023
Loa Loa (eye worm) hypothetical protein 0.0015 0.0015 0.0015
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0021 0.0027 0.0353
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0025 0.0034 0.0034
Brugia malayi isocitrate dehydrogenase 0.0017 0.0018 0.0018
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0021 0.0027 0.0353
Trypanosoma brucei glucose transporter, putative 0.0033 0.0048 0.008
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0055 0.0089 0.0089
Plasmodium falciparum importin beta, putative 0.0029 0.0041 0.0068
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0042 0.0066 0.0066
Schistosoma mansoni sugar transporter 0.0015 0.0015 0.0015
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0025 0.0034 0.0034
Treponema pallidum exodeoxyribonuclease (exoA) 0.0018 0.0022 1
Trypanosoma cruzi cytochrome P450, putative 0.0042 0.0066 0.0109
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0021 0.0027 0.0027
Entamoeba histolytica hypothetical protein 0.0035 0.0053 0.1458
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0043 0.0043
Echinococcus multilocularis multidrug resistance protein 1 0.0021 0.0027 0.0027
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0043 0.0043
Giardia lamblia DINP protein human, muc B family 0.0019 0.0023 0.4874
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0025 0.0034 0.0034
Echinococcus granulosus transcription factor btf3 0.0037 0.0056 0.0056
Schistosoma mansoni transcription factor btf3 0.0037 0.0056 0.0056
Mycobacterium tuberculosis Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) 0.5404 1 1
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0025 0.0034 0.0034
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0023 0.0037
Toxoplasma gondii sugar transporter ST2 0.0015 0.0015 0.0025
Brugia malayi Cytochrome P450 family protein 0.0082 0.014 0.014
Loa Loa (eye worm) hypothetical protein 0.0236 0.0426 0.0426
Loa Loa (eye worm) major facilitator superfamily transporter 0.0015 0.0015 0.0015
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0032 0.0048 0.0048
Plasmodium falciparum calcium-dependent protein kinase 4 0.0032 0.0048 0.0079
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0048 0.0638
Trypanosoma cruzi hexose transporter 0.0033 0.0048 0.008
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0025 0.0034 0.0034
Brugia malayi beta-lactamase family protein 0.0035 0.0053 0.0053
Onchocerca volvulus 0.0238 0.0428 0.2589
Plasmodium vivax hexose transporter 0.0106 0.0184 0.0302
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase, putative 0.0063 0.0104 0.0172
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0032 0.0048 0.0048
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0017 0.0018 0.0018
Plasmodium vivax importin-beta 2, putative 0.0029 0.0041 0.0068
Mycobacterium ulcerans integral membrane transport protein 0.0015 0.0015 0.0015
Loa Loa (eye worm) hypothetical protein 0.0015 0.0015 0.0015
Echinococcus multilocularis snurportin 1 0.0309 0.056 0.056
Trichomonas vaginalis ABC transporter, putative 0.0021 0.0027 0.0353
Leishmania major myo-inositol/proton symporter (MIT) 0.0015 0.0015 0.0025
Brugia malayi Cytochrome P450 family protein 0.0042 0.0066 0.0066
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0021 0.0027 0.0027
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase 0.3288 0.6081 1
Schistosoma mansoni myelin transcription factor 1 myt1 0.0055 0.0089 0.0089
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0015 0.0201
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0032 0.0047 0.0047
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.0022 0.0022
Leishmania major ATP-binding cassette protein subfamily B, member 2, putative 0.0021 0.0027 0.0044
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0021 0.0027 0.0027
Mycobacterium tuberculosis Probable lipase LipD 0.0035 0.0053 0.0053
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0025 0.0034 0.0034
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0032 0.0048 0.0048
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0037 0.0056 0.0092
Schistosoma mansoni protein kinase 0.0032 0.0048 0.0048
Entamoeba histolytica P-glycoprotein-2 0.0021 0.0027 0.0741
Loa Loa (eye worm) thymidylate synthase 0.0876 0.1611 0.1611
Leishmania major glucose transporter, lmgt1 0.0033 0.0048 0.008
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0025 0.0034 0.0034
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0025 0.0034 0.0034
Onchocerca volvulus 0.003 0.0043 0.0176
Trypanosoma brucei THT1 - hexose transporter, putative 0.0033 0.0048 0.008
Leishmania major hypothetical protein, conserved 0.0035 0.0053 0.0086
Trypanosoma brucei cytochrome P450, putative 0.0042 0.0066 0.0109
Entamoeba histolytica P-glyco protein 6, putative 0.0021 0.0027 0.0741
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0018 0.0022 0.0036
Loa Loa (eye worm) hypothetical protein 0.0035 0.0053 0.0053
Loa Loa (eye worm) sugar transporter 0.0015 0.0015 0.0015
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0031 0.0411
Trypanosoma cruzi hexose transporter, putative 0.0018 0.0021 0.0034
Echinococcus granulosus expressed protein 0.0207 0.0371 0.0371
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0053 0.0692
Schistosoma mansoni hypothetical protein 0.0025 0.0034 0.0034
Entamoeba histolytica P-glycoprotein-5 0.0021 0.0027 0.0741
Leishmania major glucose transporter/membrane transporter D2, putative 0.0033 0.0048 0.008
Schistosoma mansoni sex comb on midleg homolog 0.0048 0.0077 0.0077
Echinococcus multilocularis SAM and MBT domain containing protein 0.0048 0.0077 0.0077
Echinococcus granulosus multidrug resistance protein 1 0.0021 0.0027 0.0027
Echinococcus multilocularis solute carrier family 22 0.0015 0.0015 0.0015
Leishmania major glucose transporter, lmgt2 0.0033 0.0048 0.008
Brugia malayi hypothetical protein 0.0236 0.0426 0.0426
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0032 0.0048 0.0048
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0023 0.0023
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0018 0.0018
Echinococcus multilocularis isocitrate dehydrogenase 0.0017 0.0018 0.0018
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0015 0.0201
Trichomonas vaginalis glucose transporter, putative 0.0015 0.0015 0.0201
Echinococcus multilocularis transcription factor btf3 0.0037 0.0056 0.0056
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0015 0.0201
Schistosoma mansoni importin beta-1 0.0029 0.0041 0.0041
Brugia malayi Major Facilitator Superfamily protein 0.0015 0.0015 0.0015
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0027 0.0027
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0071 0.0071
Leishmania major cytochrome p450-like protein 0.0042 0.0066 0.0109
Loa Loa (eye worm) hypothetical protein 0.0015 0.0015 0.0015
Trichomonas vaginalis glucose transporter, putative 0.0033 0.0048 0.0638
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0025 0.0034 0.0034
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0025 0.0034 0.0034
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0041 0.0068
Toxoplasma gondii isocitrate dehydrogenase 0.0017 0.0018 0.003
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0025 0.0034 0.0034
Mycobacterium tuberculosis Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter) 0.0015 0.0015 0.0015
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0015 0.0201
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0032 0.0048 0.0048
Trypanosoma brucei glucose transporter, putative 0.0033 0.0048 0.008
Loa Loa (eye worm) hypothetical protein 0.0055 0.0089 0.0089
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.0043 0.0043
Giardia lamblia Hexose transporter 0.0015 0.0015 0.3291
Brugia malayi Cam kinase protein 1 0.0032 0.0048 0.0048
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0025 0.0034 0.0034
Trichomonas vaginalis conserved hypothetical protein 0.0207 0.0371 0.4885
Trichomonas vaginalis sugar transport protein, putative 0.0015 0.0015 0.0201
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0015 0.0201
Loa Loa (eye worm) hypothetical protein 0.0032 0.0047 0.0047
Brugia malayi hypothetical protein 0.0015 0.0015 0.0015
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0023 0.0037
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0023 0.0037
Giardia lamblia Prolyl-tRNA synthetase 0.0032 0.0047 1
Loa Loa (eye worm) isocitrate dehydrogenase 0.0017 0.0018 0.0018
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0015 0.0201
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.0022 0.0022
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0071 0.0071
Entamoeba histolytica P-glycoprotein-2, putative 0.0021 0.0027 0.0741
Brugia malayi Isocitrate dehydrogenase 0.0017 0.0018 0.0018
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.0015 0.0015 0.0015
Plasmodium falciparum calcium-dependent protein kinase 3 0.0032 0.0048 0.0079
Trichomonas vaginalis rotamase, putative 0.0202 0.0362 0.4766
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0053 0.0692
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0025 0.0034 0.0034
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0022 0.0036
Loa Loa (eye worm) hypothetical protein 0.003 0.0043 0.0043
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0023 0.0023
Leishmania major basic transcription factor 3a, putative 0.0037 0.0056 0.0092
Schistosoma mansoni hypothetical protein 0.0296 0.0535 0.0535
Loa Loa (eye worm) beta-lactamase 0.0035 0.0053 0.0053
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0015 0.0201
Mycobacterium ulcerans dihydrofolate reductase DfrA 0.5404 1 1
Trichomonas vaginalis conserved hypothetical protein 0.0417 0.076 1
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0015 0.0201
Loa Loa (eye worm) hypothetical protein 0.0035 0.0053 0.0053
Onchocerca volvulus 0.0035 0.0053 0.0234
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0015 0.0015 0.0015
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0032 0.0048 0.0048
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0021 0.0027 0.0027
Trypanosoma brucei transcription factor BTF3, putative 0.0037 0.0056 0.0092
Mycobacterium leprae putative cytochrome p450 0.0025 0.0034 0.0034
Schistosoma mansoni rotamase 0.0207 0.0371 0.0371
Loa Loa (eye worm) hypothetical protein 0.0015 0.0015 0.0015
Onchocerca volvulus 0.0035 0.0053 0.0234
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.0022 0.0022
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0023 0.0037
Schistosoma mansoni cytochrome P450 0.0025 0.0034 0.0034
Echinococcus granulosus multidrug resistance protein 1 0.0015 0.0015 0.0015
Plasmodium falciparum basic transcription factor 3b, putative 0.0037 0.0056 0.0092
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0023 0.0037
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0025 0.0034 0.0034
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0055 0.0089 0.0089
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0021 0.0027 0.0353
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0783 0.1439 0.1439
Loa Loa (eye worm) hypothetical protein 0.0035 0.0053 0.0053
Mycobacterium tuberculosis Conserved protein 0.0035 0.0053 0.0053
Schistosoma mansoni hypothetical protein 0.0106 0.0184 0.0184
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0037 0.0056 0.0092
Entamoeba histolytica hypothetical protein 0.0023 0.0031 0.0863
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0053 0.0692
Mycobacterium leprae Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.002 0.0025 0.0025
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0063 0.0104 0.0172
Brugia malayi multidrug resistance protein 3 0.0021 0.0027 0.0027
Leishmania major protein kinase, putative 0.0032 0.0048 0.0078
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0015 0.0201
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.0027 0.0045
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0202 0.0362 0.0596
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0041 0.0068
Plasmodium falciparum calcium-dependent protein kinase 2 0.0032 0.0048 0.0079
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0106 0.0184 0.0184
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.0015 0.0015 0.1466
Echinococcus granulosus dna polymerase kappa 0.0019 0.0023 0.0023
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0025 0.0034 0.0034
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0032 0.0048 0.0048
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0017 0.0018 0.0018
Leishmania major GTP-binding protein, putative 0.0021 0.0027 0.0045
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0023 0.0037
Loa Loa (eye worm) hypothetical protein 0.0029 0.0041 0.0041
Plasmodium falciparum lysine--tRNA ligase 0.0024 0.0031 0.0052
Brugia malayi mbt repeat family protein 0.0048 0.0077 0.0077
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0015 0.0201
Mycobacterium tuberculosis Probable conserved integral membrane transport protein 0.0015 0.0015 0.0015
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0025 0.0034 0.0055
Toxoplasma gondii HEAT repeat-containing protein 0.0029 0.0041 0.0068
Echinococcus granulosus General substrate transporter 0.0091 0.0156 0.0156
Echinococcus granulosus calcium dependent protein kinase 0.003 0.0044 0.0044
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0015 0.0201
Trypanosoma brucei THT1 - hexose transporter, putative 0.0033 0.0048 0.008
Brugia malayi hypothetical protein 0.0035 0.0053 0.0053
Leishmania major p-glycoprotein 0.0021 0.0027 0.0044
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0021 0.0027 0.0027
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0202 0.0362 0.0596
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0025 0.0034 0.0034
Trichomonas vaginalis set domain proteins, putative 0.0238 0.0428 0.5637
Plasmodium falciparum calcium-dependent protein kinase 1 0.0032 0.0048 0.0079
Toxoplasma gondii PPIC-type PPIASE domain-containing protein 0.0063 0.0104 0.0172
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.0015 0.0015 0.0015
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0106 0.0184 0.0184
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0032 0.0047 0.0047
Entamoeba histolytica deoxycytidyl transferase, putative 0.0019 0.0023 0.0626
Brugia malayi Sugar transporter family protein 0.0106 0.0184 0.0184
Entamoeba histolytica hypothetical protein 0.0035 0.0053 0.1458
Schistosoma mansoni DNA polymerase eta 0.0019 0.0023 0.0023
Mycobacterium ulcerans lipase LipD 0.0035 0.0053 0.0053
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0018 0.0018
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0024 0.0031 0.0052
Trypanosoma cruzi transcription factor btf3, putative 0.0037 0.0056 0.0092
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0018 0.0022 0.0601
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0025 0.0034 0.0034
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0106 0.0184 0.0184
Echinococcus granulosus solute carrier family 22 0.0015 0.0015 0.0015
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0027 0.0045
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0053 0.0053
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0048 0.0077 0.0077
Echinococcus granulosus survival motor neuron protein 1 0.0236 0.0426 0.0426
Plasmodium falciparum calcium-dependent protein kinase 5 0.0032 0.0048 0.0079
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0053 0.0086
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0022 0.0036
Loa Loa (eye worm) hypothetical protein 0.0015 0.0015 0.0015
Brugia malayi major facilitator superfamily protein 0.0015 0.0015 0.0015
Echinococcus multilocularis geminin 0.0677 0.1243 0.1243
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0015 0.0201
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0025 0.0034 0.0034
Loa Loa (eye worm) hypothetical protein 0.0032 0.0048 0.0048
Onchocerca volvulus 0.0021 0.0027 0.0072
Brugia malayi RNA, U transporter 1 0.0082 0.014 0.014
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0031 0.0411
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0053 0.0053
Loa Loa (eye worm) CYP4Cod1 0.0042 0.0066 0.0066
Echinococcus granulosus Sugar transporter ERD6 protein 0.0015 0.0015 0.0015
Echinococcus granulosus synaptic vesicle 2 protein 0.0015 0.0015 0.0015
Leishmania major dihydrofolate reductase-thymidylate synthase 0.3288 0.6081 1
Leishmania major peptidyl-prolyl cis-trans isomerase, putative 0.0063 0.0104 0.0172
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0021 0.0027 0.5861
Entamoeba histolytica Ran family GTPase 0.0021 0.0027 0.0752
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0025 0.0034 0.0034
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0032 0.0047 0.0047
Plasmodium vivax basic transcription factor 3b, putative 0.0037 0.0056 0.0092
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0056 0.0734
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0223 0.0402 0.0402
Echinococcus multilocularis solute carrier family 22 0.0015 0.0015 0.0015
Mycobacterium tuberculosis Conserved protein 0.0035 0.0053 0.0053
Plasmodium vivax multidrug resistance protein 1, putative 0.0021 0.0027 0.0044
Chlamydia trachomatis dihydrofolate reductase 0.5404 1 1
Echinococcus granulosus solute carrier family 22 0.0015 0.0015 0.0015
Schistosoma mansoni sugar transporter 0.0015 0.0015 0.0015
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0032 0.0048 0.0079
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0048 0.0638
Brugia malayi Importin beta-1 subunit 0.0029 0.0041 0.0041
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0017 0.0018 0.0018
Toxoplasma gondii lysine-tRNA ligase 0.0024 0.0031 0.0052
Mycobacterium ulcerans beta-lactamase 0.0035 0.0053 0.0053
Mycobacterium leprae DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) 0.5404 1 1
Loa Loa (eye worm) mbt repeat family protein 0.0048 0.0077 0.0077
Loa Loa (eye worm) hypothetical protein 0.0026 0.0035 0.0035
Trypanosoma brucei THT1 - hexose transporter, putative 0.0033 0.0048 0.008
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0023 0.0298
Trypanosoma brucei glucose transporter, putative 0.0033 0.0048 0.008
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0015 0.0201
Schistosoma mansoni serine/threonine protein kinase 0.0032 0.0048 0.0048
Brugia malayi Cytochrome P450 family protein 0.0042 0.0066 0.0066
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0015 0.0201
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0032 0.0048 0.0079
Mycobacterium ulcerans hypothetical protein 0.0035 0.0053 0.0053
Plasmodium vivax SET domain protein, putative 0.003 0.0043 0.0071
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0025 0.0034 0.0034
Trypanosoma brucei glucose transporter, putative 0.0033 0.0048 0.008
Schistosoma mansoni glucose transporter 0.0015 0.0015 0.0015
Echinococcus granulosus solute carrier family 22 0.0015 0.0015 0.0015
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0032 0.0048 0.0048
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0021 0.0027 0.0353
Echinococcus granulosus multidrug resistance protein 1 0.0021 0.0027 0.0027
Plasmodium vivax CDK-related protein kinase 6, putative 0.0448 0.0819 0.1346
Schistosoma mansoni sex comb on midleg homolog 0.0048 0.0077 0.0077
Plasmodium falciparum major facilitator superfamily domain-containing protein, putative 0.0015 0.0015 0.0025
Echinococcus multilocularis polycomb protein SCMH1 0.0048 0.0077 0.0077
Plasmodium falciparum hexose transporter 0.0106 0.0184 0.0302
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0024 0.0031 0.0031
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0025 0.0034 0.0055
Loa Loa (eye worm) hypothetical protein 0.0015 0.0015 0.0015
Trypanosoma cruzi cytochrome P450, putative 0.0042 0.0066 0.0109
Loa Loa (eye worm) ATP-binding cassette sub-family B member 2 0.0021 0.0027 0.0027
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0017 0.0018 0.003
Echinococcus granulosus polycomb protein SCMH1 0.0048 0.0077 0.0077
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0053 0.0053
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0021 0.0027 0.0353
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase, putative 0.0417 0.076 0.125
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0023 0.0037
Trypanosoma brucei sugar transporter, putative 0.0015 0.0015 0.0025
Schistosoma mansoni survival motor neuron protein 0.0048 0.0077 0.0077
Giardia lamblia Lysyl-tRNA synthetase 0.0024 0.0031 0.6767
Schistosoma mansoni hypothetical protein 0.0677 0.1243 0.1243
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0032 0.0047 0.0047
Echinococcus multilocularis multidrug resistance protein 1 0.0021 0.0027 0.0027
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0021 0.0027 0.0353
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0053 0.0053
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0032 0.0048 0.0048
Loa Loa (eye worm) hypothetical protein 0.0035 0.0053 0.0053
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0053 0.0053
Echinococcus multilocularis dihydrofolate reductase 0.5404 1 1
Brugia malayi cytochrome P450 0.0025 0.0034 0.0034
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0021 0.0027 0.0027
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0021 0.0027 0.0027
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0053 0.0053
Trichomonas vaginalis ABC transporter, putative 0.0021 0.0027 0.0353
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0063 0.0104 0.0172
Schistosoma mansoni lysyl-tRNA synthetase 0.0024 0.0031 0.0031
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0015 0.0201
Chlamydia trachomatis lysine--tRNA ligase 0.0024 0.0031 0.0023
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0023 0.0023
Loa Loa (eye worm) hypothetical protein 0.0032 0.0047 0.0047
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0053 0.0053
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0106 0.0184 0.0184
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0032 0.0048 0.0048
Schistosoma mansoni glucose transport protein 0.0106 0.0184 0.0184
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0202 0.0362 0.0596
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0071 0.0071
Brugia malayi Major Facilitator Superfamily protein 0.0015 0.0015 0.0015
Brugia malayi Major Facilitator Superfamily protein 0.0015 0.0015 0.0015
Schistosoma mansoni smdr2 0.0021 0.0027 0.0027
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0053 0.0692
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0023 0.0037
Echinococcus multilocularis multidrug resistance protein 1 0.0015 0.0015 0.0015
Loa Loa (eye worm) hypothetical protein 0.0021 0.0027 0.0027
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0037 0.0056 0.0092
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0015 0.0201
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0021 0.0027 0.0353
Echinococcus granulosus solute carrier family 22 0.0015 0.0015 0.0015
Wolbachia endosymbiont of Brugia malayi parvulin-like peptidyl-prolyl isomerase, PPID 0.0063 0.0104 1
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0209 0.0375 0.0375
Mycobacterium tuberculosis Conserved protein 0.0035 0.0053 0.0053
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0106 0.0184 0.0184
Brugia malayi Dihydrofolate reductase 0.5404 1 1
Mycobacterium tuberculosis Probable esterase LipL 0.0035 0.0053 0.0053
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase 0.3288 0.6081 1
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0013 0.0012 0.0012
Schistosoma mansoni ran 0.0021 0.0027 0.0027
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative 0.3288 0.6081 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0015 0.0015
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0106 0.0184 0.0184
Loa Loa (eye worm) ICD-1 protein 0.0037 0.0056 0.0056
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0012 0.0019
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0027 0.0027
Schistosoma mansoni bifunctional dihydrofolate reductase-thymidylate synthase 0.0876 0.1611 0.1611
Trichomonas vaginalis ran, putative 0.0021 0.0027 0.0359
Trypanosoma cruzi transcription factor btf3, putative 0.0037 0.0056 0.0092
Mycobacterium leprae Probable lipase LipE 0.0035 0.0053 0.0053
Trichomonas vaginalis rotamase, putative 0.0207 0.0371 0.4885
Toxoplasma gondii sugar transporter ST1 0.0015 0.0015 0.0025
Schistosoma mansoni ran 0.0021 0.0027 0.0027
Schistosoma mansoni glucose transport protein 0.0106 0.0184 0.0184
Plasmodium vivax calcium-dependent protein kinase, putative 0.0032 0.0048 0.0079
Leishmania major DNA polymerase eta, putative 0.0019 0.0023 0.0037
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0023 0.0037
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0071 0.0071
Toxoplasma gondii facilitative glucose transporter GT1 0.0106 0.0184 0.0302
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0032 0.0048 0.0079
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0021 0.0027 0.0353
Loa Loa (eye worm) major facilitator superfamily transporter 0.0015 0.0015 0.0015
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0015 0.0201
Brugia malayi mbt repeat family protein 0.0048 0.0077 0.0077
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0053 0.0692
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0018 0.003
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0018 0.0022 0.4683
Echinococcus granulosus histone acetyltransferase MYST2 0.0055 0.0089 0.0089
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0053 0.0086
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0015 0.0201
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0048 0.0077 0.0385
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0035 0.0053 0.0053
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0032 0.0047 0.0047
Trypanosoma brucei ULK family serine/threonine-protein kinase, putative 0.0007 0.0002 0.0003
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0032 0.0048 0.0048
Loa Loa (eye worm) hypothetical protein 0.0021 0.0027 0.0027
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0015 0.0201
Loa Loa (eye worm) hypothetical protein 0.0015 0.0015 0.0015
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0021 0.0027 0.0353
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.0053 0.0053
Toxoplasma gondii sugar transporter ST3 0.0015 0.0015 0.0025
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0023 0.0037
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase 0.3288 0.6081 1
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0031 0.0411
Leishmania major cytochrome p450-like protein 0.0025 0.0034 0.0055
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0025 0.0034 0.0055
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0193 0.0345 0.0345
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0022 0.0287
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0032 0.0048 0.0079
Trichomonas vaginalis abcb9, putative 0.0021 0.0027 0.0353
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0171 0.0304 0.05
Mycobacterium tuberculosis Probable hydrolase 0.0035 0.0053 0.0053
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0023 0.0037
Schistosoma mansoni hypothetical protein 0.0048 0.0077 0.0077
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0015 0.0201
Echinococcus granulosus thymidylate synthase 0.0876 0.1611 0.1611
Trypanosoma cruzi glucose transporter, putative 0.0015 0.0015 0.0025
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0043 0.0043
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0017 0.0018 0.003
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0015 0.0201
Echinococcus granulosus lysyl tRNA synthetase 0.0024 0.0031 0.0031
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0015 0.0015 0.0198
Echinococcus multilocularis dna polymerase eta 0.0019 0.0023 0.0023
Leishmania major glucose transporter, lmgt3 0.0033 0.0048 0.008
Leishmania major importin beta-1 subunit, putative 0.0023 0.0031 0.0051
Trypanosoma cruzi DNA polymerase eta, putative 0.0019 0.0023 0.0037
Toxoplasma gondii exonuclease III APE 0.0018 0.0022 0.0036
Echinococcus multilocularis lysyl tRNA synthetase 0.0024 0.0031 0.0031
Toxoplasma gondii cytochrome p450 superfamily protein 0.0025 0.0034 0.0055
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0012 0.0019
Echinococcus granulosus dna polymerase eta 0.0019 0.0023 0.0023
Schistosoma mansoni glucose transport protein 0.0106 0.0184 0.0184
Mycobacterium leprae Conserved hypothetical protein 0.0025 0.0034 0.0034
Loa Loa (eye worm) hypothetical protein 0.0015 0.0015 0.0015
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0025 0.0034 0.0055
Brugia malayi thymidylate synthase 0.0876 0.1611 0.1611
Loa Loa (eye worm) hypothetical protein 0.0015 0.0015 0.0015
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0022 0.0287
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0193 0.0345 0.0345
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0025 0.0034 0.0034
Echinococcus multilocularis survival motor neuron protein 1 0.0236 0.0426 0.0426
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0021 0.0027 0.0353
Mycobacterium tuberculosis Probable lipase LipE 0.0035 0.0053 0.0053
Echinococcus multilocularis General substrate transporter 0.0091 0.0156 0.0156
Echinococcus granulosus dihydrofolate reductase 0.5404 1 1
Trypanosoma brucei unspecified product 0.0013 0.0012 0.0019
Trichomonas vaginalis ABC transporter, putative 0.0021 0.0027 0.0353
Trichomonas vaginalis ABC transporter, putative 0.0021 0.0027 0.0353
Echinococcus multilocularis solute carrier family 22 0.0015 0.0015 0.0015
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0023 0.0298
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0024 0.0031 0.0031
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0023 0.0037
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0027 0.0027
Leishmania major cytochrome p450-like protein 0.0025 0.0034 0.0055
Schistosoma mansoni hypothetical protein 0.0309 0.056 0.056
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0025 0.0034 0.0034
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0021 0.0027 0.0353
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0025 0.0034 0.0034
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.0043 0.0043
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0025 0.0034 0.0034
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0025 0.0034 0.0034
Onchocerca volvulus 0.0048 0.0077 0.0387
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0015 0.0201
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0018 0.0022 0.0036
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0015 0.0201
Toxoplasma gondii ATP-binding cassette transporter ABC.B1 0.0021 0.0027 0.0044
Trichomonas vaginalis abcb9, putative 0.0021 0.0027 0.0353
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0041 0.0041
Entamoeba histolytica hypothetical protein 0.0035 0.0053 0.1458
Echinococcus granulosus snurportin 1 0.0309 0.056 0.056
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0018 0.003
Trypanosoma brucei glucose transporter 1E 0.0033 0.0048 0.008
Toxoplasma gondii peptidylprolyl isomerase 0.0202 0.0362 0.0596
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.0023 0.0023
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0015 0.0201
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0018 0.0022 0.2087
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0053 0.0053
Echinococcus granulosus 5'partial|ATP binding cassette sub family B 0.0021 0.0026 0.0026
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0025 0.0034 0.0034
Trypanosoma brucei glucose transporter, putative 0.0033 0.0048 0.008
Brugia malayi beta-NAC-like protein 0.0037 0.0056 0.0056
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0048 0.0077 0.0077
Loa Loa (eye worm) hypothetical protein 0.0035 0.0053 0.0053
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0023 0.0037
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0021 0.0027 0.0044
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0025 0.0034 0.0034
Brugia malayi Sugar transporter family protein 0.0015 0.0015 0.0015
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0032 0.0048 0.0079
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.0023 0.0023
Trichomonas vaginalis conserved hypothetical protein 0.0106 0.0184 0.2415
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0106 0.0184 0.0184
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0023 0.0037
Echinococcus granulosus cytochrome P450 2K1 0.0025 0.0034 0.0034
Plasmodium falciparum mitogen-activated protein kinase 2 0.0171 0.0304 0.05
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0048 0.0638
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0015 0.0201
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0037 0.0056 0.0092
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0021 0.0027 0.0353
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0015 0.0201
Echinococcus multilocularis histone acetyltransferase MYST2 0.0055 0.0089 0.0089
Brugia malayi hypothetical protein 0.0015 0.0015 0.0015
Entamoeba histolytica P-glycoprotein-2 0.0021 0.0027 0.0741
Entamoeba histolytica hypothetical protein 0.0037 0.0056 0.1539
Mycobacterium ulcerans thymidylate synthase 0.0876 0.1611 0.1611
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0015 0.0201
Plasmodium falciparum protein kinase 7 0.0299 0.0541 0.089
Plasmodium vivax lysine--tRNA ligase, putative 0.0024 0.0031 0.0052
Schistosoma mansoni ap endonuclease 0.0018 0.0022 0.0022
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0056 0.0734
Giardia lamblia Sugar-proton symporter 0.0015 0.0015 0.3291
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.0027 0.0045
Mycobacterium ulcerans prolyl-tRNA synthetase 0.0011 0.0009 0.0009
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0021 0.0027 0.0027
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0025 0.0034 0.0055
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0035 0.0053 0.0053
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase 0.3288 0.6081 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0023 0.0037
Mycobacterium leprae PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) 0.0876 0.1611 0.1611
Trypanosoma brucei DNA polymerase eta, putative 0.0019 0.0023 0.0037
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0025 0.0034 0.0034
Schistosoma mansoni ap endonuclease 0.0018 0.0022 0.0022
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0018 0.0022 0.0022
Schistosoma mansoni protein kinase 0.0032 0.0048 0.0048
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0015 0.0201
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0048 0.0638
Schistosoma mansoni sugar transporter 0.0015 0.0015 0.0015
Schistosoma mansoni lysyl-tRNA synthetase 0.0024 0.0031 0.0031
Trypanosoma cruzi hexose transporter, putative 0.0033 0.0048 0.008
Toxoplasma gondii transporter, major facilitator family protein 0.0015 0.0015 0.0025
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0106 0.0184 0.0184
Echinococcus multilocularis calcium dependent protein kinase 0.003 0.0044 0.0044
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0025 0.0034 0.0034
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0015 0.0201
Trypanosoma cruzi sugar transporter, putative 0.0015 0.0015 0.0025
Echinococcus multilocularis importin subunit beta 1 0.0029 0.0041 0.0041
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0048 0.0638

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 50.4 uM Inhibition of pig kidney microsomal aminopeptidase N after 30 mins by UV-VIS spectrophotometry ChEMBL. 19339187
IC50 (binding) = 79.6 uM Inhibition of MMP2 ChEMBL. 19339187

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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