Detailed information for compound 990430

Basic information

Technical information
  • TDR Targets ID: 990430
  • Name: (2R)-1-(2,3-dichlorophenoxy)-3-[[1-(4-methoxy phenyl)-2-methylpropan-2-yl]amino]propan-2-ol
  • MW: 398.323 | Formula: C20H25Cl2NO3
  • H donors: 2 H acceptors: 1 LogP: 4.65 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1)CC(NC[C@H](COc1cccc(c1Cl)Cl)O)(C)C
  • InChi: 1S/C20H25Cl2NO3/c1-20(2,11-14-7-9-16(25-3)10-8-14)23-12-15(24)13-26-18-6-4-5-17(21)19(18)22/h4-10,15,23-24H,11-13H2,1-3H3/t15-/m1/s1
  • InChiKey: DWAKJSOEJNKPME-OAHLLOKOSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (2R)-1-(2,3-dichlorophenoxy)-3-[[2-(4-methoxyphenyl)-1,1-dimethyl-ethyl]amino]propan-2-ol
  • (2R)-1-(2,3-dichlorophenoxy)-3-[[2-(4-methoxyphenyl)-1,1-dimethylethyl]amino]propan-2-ol
  • (2R)-1-(2,3-dichlorophenoxy)-3-[[1-(4-methoxyphenyl)-2-methyl-propan-2-yl]amino]propan-2-ol

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens adrenoceptor beta 2, surface Starlite/ChEMBL References
Homo sapiens calcium-sensing receptor Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni metabotropic glutamate receptor Get druggable targets OG5_127276 All targets in OG5_127276
Schistosoma japonicum Metabotropic glutamate receptor 7 precursor, putative Get druggable targets OG5_127276 All targets in OG5_127276
Schistosoma japonicum Metabotropic glutamate receptor 7 precursor, putative Get druggable targets OG5_127276 All targets in OG5_127276
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni tyrosine kinase 0.0052 0.0034 0.0034
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0352 0.0421 0.0682
Schistosoma mansoni SWI/SNF complex-related 0.0043 0.0023 0.0023
Brugia malayi EGF-like domain containing protein 0.0162 0.0176 0.0176
Loa Loa (eye worm) matrix metalloproteinase 0.0849 0.1063 0.1063
Echinococcus multilocularis cathepsin d (lysosomal aspartyl protease) 0.0035 0.0012 0.0015
Echinococcus granulosus rhodopsin orphan GPCR 0.0046 0.0027 0.0027
Mycobacterium tuberculosis Possible arabinofuranosyltransferase AftD 0.0032 0.0008 0.0056
Echinococcus multilocularis g protein coupled receptor 0.0046 0.0027 0.0034
Trypanosoma cruzi subtilisin-like serine peptidase, putative 0.0371 0.0446 0.5194
Brugia malayi Tachykinin-like peptides receptor 99D 0.0046 0.0027 0.0027
Loa Loa (eye worm) hypothetical protein 0.0069 0.0056 0.0056
Brugia malayi Integrin alpha pat-2 precursor 0.1142 0.1441 0.1441
Schistosoma mansoni hypothetical protein 0.0069 0.0056 0.0056
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0035 0.0012 0.0015
Onchocerca volvulus 0.0032 0.0008 0.003
Loa Loa (eye worm) matrixin family protein 0.2266 0.2892 0.2892
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0046 0.0027 0.0027
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0046 0.0027 0.0027
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0046 0.0027 0.0034
Plasmodium falciparum plasmepsin IV 0.0035 0.0012 0.0093
Brugia malayi ADAMTS-like protease 0.0136 0.0143 0.0143
Brugia malayi EGF-like domain containing protein 0.0162 0.0176 0.0176
Toxoplasma gondii aspartyl protease ASP3 0.0035 0.0012 0.0093
Echinococcus granulosus 7tm_1 domain containing protein 0.0046 0.0027 0.0027
Schistosoma mansoni ADAMTS14 peptidase (M12 family) 0.0064 0.005 0.005
Echinococcus granulosus epidermal growth factor receptor 0.0086 0.0078 0.0078
Echinococcus multilocularis protein arginine methyltransferase 0.003 0.0006 0.0007
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0041 0.002 0.0025
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0352 0.0421 0.0682
Brugia malayi amine oxidase, flavin-containing family protein 0.0146 0.0156 0.0156
Trichomonas vaginalis conserved hypothetical protein 0.1537 0.1951 0.3192
Mycobacterium ulcerans fatty acid synthase Fas 0.0027 0.0001 0.0006
Giardia lamblia Furin precursor putative serine protease 0.1537 0.1951 0.5301
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB 0.0065 0.0051 0.0383
Loa Loa (eye worm) hypothetical protein 0.0103 0.01 0.01
Echinococcus multilocularis neuropeptide s receptor 0.0046 0.0027 0.0034
Trichomonas vaginalis alpha-L-fucosidase, putative 0.0032 0.0008 0.0004
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0352 0.0421 0.0682
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0035 0.0012 0.0012
Echinococcus multilocularis MAM 0.0069 0.0056 0.007
Loa Loa (eye worm) hypothetical protein 0.0046 0.0027 0.0027
Toxoplasma gondii subtilisin SUB8 0.0352 0.0421 0.6622
Brugia malayi Glutamate receptor 1 precursor 0.0035 0.0012 0.0012
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0008 0.0004
Echinococcus multilocularis fibrillin 2 0.0162 0.0176 0.022
Schistosoma mansoni biogenic amine receptor 0.0046 0.0027 0.0027
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0099 0.0095 0.0146
Loa Loa (eye worm) hypothetical protein 0.1062 0.1339 0.1339
Brugia malayi ORL1-like opioid receptor 0.0046 0.0027 0.0027
Schistosoma mansoni adam (A disintegrin and metalloprotease 0.0304 0.036 0.036
Toxoplasma gondii PA14 domain-containing protein 0.0032 0.0008 0.0034
Loa Loa (eye worm) hypothetical protein 0.0139 0.0147 0.0147
Onchocerca volvulus 0.0046 0.0027 0.0101
Trichomonas vaginalis alpha-L-fucosidase, putative 0.0032 0.0008 0.0004
Mycobacterium leprae PROBABLE THIOESTERASE TESA 0.0071 0.0058 0.0436
Loa Loa (eye worm) melatonin receptor type 1A 0.0046 0.0027 0.0027
Brugia malayi Dopamine receptor 0.0046 0.0027 0.0027
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0041 0.002 0.0025
Trichomonas vaginalis beta-hexosaminidase B, putative 0.0032 0.0008 0.0004
Schistosoma mansoni Protoporphyrinogen oxidase chloroplast/mitochondrial precursor 0.0103 0.01 0.01
Echinococcus granulosus allatostatin A receptor 0.0046 0.0027 0.0027
Mycobacterium ulcerans NAD-dependent deacetylase 0.0099 0.0095 0.0723
Echinococcus multilocularis disintegrin and metalloproteinase 0.0096 0.0092 0.0114
Echinococcus granulosus c-Jun N-terminal kinases 0.026 0.0303 0.0303
Plasmodium falciparum plasmepsin VIII, putative 0.0035 0.0012 0.0093
Loa Loa (eye worm) TK/ALK protein kinase 0.0071 0.0059 0.0059
Schistosoma mansoni chromatin regulatory protein sir2 0.0099 0.0095 0.0095
Plasmodium falciparum plasmepsin V 0.0388 0.0469 0.7371
Plasmodium vivax hypothetical protein, conserved 0.0099 0.0095 0.1416
Echinococcus multilocularis integrin beta 2 0.558 0.717 0.8945
Brugia malayi hypothetical protein 0.0046 0.0027 0.0027
Echinococcus multilocularis serotonin receptor 0.0046 0.0027 0.0034
Schistosoma mansoni tyrosine kinase 0.0084 0.0075 0.0075
Brugia malayi hypothetical protein 0.0035 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.0046 0.0027 0.0027
Schistosoma mansoni dock 0.0032 0.0008 0.0008
Schistosoma mansoni tyrosine kinase 0.0041 0.002 0.002
Schistosoma mansoni protein kinase 0.0131 0.0136 0.0136
Plasmodium vivax subtilisin-like protease 2, putative 0.0352 0.0421 0.6622
Echinococcus granulosus serotonin receptor 0.0046 0.0027 0.0027
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0046 0.0027 0.0027
Schistosoma mansoni hypothetical protein 0.0069 0.0056 0.0056
Echinococcus multilocularis glutamate receptor ionotropic kainate 0.0035 0.0012 0.0015
Schistosoma mansoni discoidin domain receptor 0.0032 0.0008 0.0008
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0046 0.0027 0.0027
Mycobacterium tuberculosis Polyketide synthetase MbtC (polyketide synthase) 0.0026 0.0001 0.0002
Brugia malayi Membrane-bound transcription factor site-1 protease precursor 0.0352 0.0421 0.0421
Loa Loa (eye worm) hypothetical protein 0.0064 0.005 0.005
Onchocerca volvulus 0.0035 0.0012 0.0044
Loa Loa (eye worm) hypothetical protein 0.0046 0.0027 0.0027
Echinococcus granulosus Ribosomal protein S1 RNA binding domain 0.0035 0.0012 0.0012
Trypanosoma brucei serine peptidase, clan SB, family S8-like protein 0.0371 0.0446 0.5194
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0046 0.0027 0.0027
Echinococcus granulosus glutamate receptor ionotropic kainate 0.0035 0.0012 0.0012
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0046 0.0027 0.0027
Loa Loa (eye worm) hypothetical protein 0.0046 0.0027 0.0027
Echinococcus multilocularis Peptidase S8 S53, subtilisin kexin sedolisin 0.0352 0.0421 0.0526
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.067 0.0832 1
Echinococcus granulosus protein arginine N methyltransferase 8 0.003 0.0006 0.0006
Schistosoma mansoni integrin beta subunit 0.4419 0.5671 0.5671
Brugia malayi Serotonin receptor 0.0046 0.0027 0.0027
Giardia lamblia High cysteine protein 0.0162 0.0176 0.0423
Echinococcus multilocularis nuclear receptor 2C2 associated protein 0.0032 0.0008 0.001
Echinococcus granulosus neuropeptide Y receptor 0.0046 0.0027 0.0027
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0046 0.0027 0.0027
Schistosoma mansoni amine oxidase 0.0103 0.01 0.01
Schistosoma mansoni neuropeptide F-like receptor 0.0046 0.0027 0.0027
Loa Loa (eye worm) neuropeptide F receptor 0.0046 0.0027 0.0027
Schistosoma mansoni tyrosine kinase 0.0041 0.002 0.002
Brugia malayi transcriptional regulator, Sir2 family protein 0.0099 0.0095 0.0095
Loa Loa (eye worm) matrixin family protein 0.1883 0.2398 0.2398
Loa Loa (eye worm) SRC-1 0.0041 0.002 0.002
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0046 0.0027 0.0027
Toxoplasma gondii type I fatty acid synthase, putative 0.0087 0.0079 0.1171
Brugia malayi hypothetical protein 0.0103 0.01 0.01
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0352 0.0421 0.0682
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0046 0.0027 0.0027
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.0352 0.0421 0.0421
Brugia malayi NAD-dependent deacetylase SIRT1 0.0099 0.0095 0.0095
Giardia lamblia Tenascin-X 0.0162 0.0176 0.0423
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0046 0.0027 0.0034
Brugia malayi Dopamine receptor protein 1 0.0046 0.0027 0.0027
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0099 0.0095 0.0146
Schistosoma mansoni chromatin regulatory protein sir2 0.0099 0.0095 0.0095
Mycobacterium leprae Possible secreted protease 0.0352 0.0421 0.323
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0046 0.0027 0.0034
Onchocerca volvulus Fatty acid synthase homolog 0.0153 0.0164 0.0614
Schistosoma mansoni tyrosine kinase 0.0084 0.0075 0.0075
Loa Loa (eye worm) TK/EGFR protein kinase 0.0562 0.0693 0.0693
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0352 0.0421 0.0682
Brugia malayi Apoptosis regulator proteins, Bcl-2 family protein 0.006 0.0045 0.0045
Echinococcus granulosus neuropeptide receptor 0.0046 0.0027 0.0027
Toxoplasma gondii subtilisin SUB6 0.0352 0.0421 0.6622
Schistosoma mansoni opsin-like receptor 0.0046 0.0027 0.0027
Brugia malayi hypothetical protein 0.0046 0.0027 0.0027
Trichomonas vaginalis conserved hypothetical protein 0.0352 0.0421 0.0682
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0079 0.0069 0.0526
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.1889 0.2406 0.3938
Plasmodium falciparum LCCL domain-containing protein 0.0032 0.0008 0.0034
Echinococcus multilocularis discoidin domain containing receptor 2 0.0032 0.0008 0.001
Echinococcus granulosus orexin receptor type 2 0.0046 0.0027 0.0027
Brugia malayi GnHR receptor homolog 0.0046 0.0027 0.0027
Plasmodium vivax hypothetical protein, conserved 0.0103 0.01 0.1504
Loa Loa (eye worm) hypothetical protein 0.0162 0.0176 0.0176
Echinococcus granulosus Coagulation factor 5 8 type C terminal 0.0032 0.0008 0.0008
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0099 0.0095 0.0146
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0008 0.0004
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0352 0.0421 0.0682
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0079 0.0069 0.0069
Giardia lamblia Hypothetical protein 0.067 0.0832 0.2226
Loa Loa (eye worm) hypothetical protein 0.0035 0.0012 0.0012
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0046 0.0027 0.0027
Loa Loa (eye worm) hypothetical protein 0.0046 0.0027 0.0027
Toxoplasma gondii F5/8 type C domain-containing protein 0.0032 0.0008 0.0034
Echinococcus multilocularis serine:threonine protein kinase N2 0.0079 0.007 0.0087
Mycobacterium ulcerans polyketide synthase 0.0087 0.0079 0.0605
Mycobacterium tuberculosis Polyketide synthase Pks12 0.0087 0.0079 0.0605
Mycobacterium ulcerans dehydrogenase 0.0103 0.01 0.0765
Echinococcus multilocularis G-protein coupled receptor, putative 0.0046 0.0027 0.0034
Echinococcus granulosus tm gpcr rhodopsin 0.0046 0.0027 0.0027
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0099 0.0095 0.0146
Onchocerca volvulus 0.0046 0.0027 0.0101
Schistosoma mansoni glutamate receptor kainate 0.0035 0.0012 0.0012
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0041 0.002 0.0025
Mycobacterium leprae Probable polyketide synthase Pks1 0.0087 0.0079 0.06
Onchocerca volvulus 0.0046 0.0027 0.0101
Schistosoma mansoni ATP-binding cassette transporter 0.0036 0.0013 0.0013
Echinococcus granulosus tyrosine protein kinase Src42A 0.0041 0.002 0.002
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0046 0.0027 0.0101
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0008 0.0004
Echinococcus granulosus Furin 1 0.1889 0.2406 0.2406
Loa Loa (eye worm) hypothetical protein 0.0046 0.0027 0.0027
Toxoplasma gondii subtilisin SUB11 0.0352 0.0421 0.6622
Brugia malayi Serotonin receptor 0.0046 0.0027 0.0027
Mycobacterium ulcerans thioesterase 0.0071 0.0058 0.0441
Plasmodium vivax subtilisin-like serine protease, putative 0.0352 0.0421 0.6622
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase subunit type II alpha 0.0114 0.0114 0.0114
Loa Loa (eye worm) hypothetical protein 0.0046 0.0027 0.0027
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0082 0.0073 0.0553
Echinococcus multilocularis lysine specific histone demethylase 1A 0.0508 0.0622 0.0776
Echinococcus granulosus neuropeptide Y receptor 0.0046 0.0027 0.0027
Echinococcus granulosus 7TM GPCR rhodopsin 0.0046 0.0027 0.0027
Echinococcus granulosus tyrosine protein kinase Blk 0.0037 0.0015 0.0015
Loa Loa (eye worm) hypothetical protein 0.0072 0.006 0.006
Entamoeba histolytica hypothetical protein, conserved 0.0099 0.0095 0.1036
Brugia malayi neuropeptide F receptor 0.0046 0.0027 0.0027
Brugia malayi transcriptional regulator, Sir2 family protein 0.067 0.0832 0.0832
Mycobacterium tuberculosis Probable membrane-anchored mycosin MycP3 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-3) 0.0352 0.0421 0.3234
Brugia malayi Metabotropic glutamate receptor precursor. 0.0033 0.001 0.001
Echinococcus granulosus cathepsin d lysosomal aspartyl protease 0.0035 0.0012 0.0012
Echinococcus granulosus chromatin regulatory protein sir2 0.067 0.0832 0.0832
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.1889 0.2406 0.3938
Echinococcus multilocularis neuropeptide Y receptor 0.0046 0.0027 0.0034
Echinococcus multilocularis epidermal growth factor receptor 0.0562 0.0693 0.0864
Loa Loa (eye worm) CMGC/MAPK/JNK protein kinase 0.026 0.0303 0.0303
Echinococcus granulosus lysine specific histone demethylase 1A 0.0508 0.0622 0.0622
Echinococcus granulosus tyrosine protein kinase Fyn 0.0041 0.002 0.002
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0058 0.0042 0.0042
Brugia malayi ADAM-TS Spacer 1 family protein 0.0136 0.0143 0.0143
Schistosoma mansoni hypothetical protein 0.0046 0.0027 0.0027
Echinococcus granulosus peptide allatostatin:somatostatin 0.0046 0.0027 0.0027
Plasmodium vivax subtilisin-like protease 1 0.0516 0.0634 1
Schistosoma mansoni serine/threonine protein kinase 0.0087 0.0079 0.0079
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.1889 0.2406 0.3938
Trichomonas vaginalis conserved hypothetical protein 0.1537 0.1951 0.3192
Brugia malayi Matrixin family protein 0.0849 0.1063 0.1063
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0046 0.0027 0.0027
Onchocerca volvulus 0.0046 0.0027 0.0101
Echinococcus multilocularis 0.0103 0.01 0.0125
Mycobacterium tuberculosis Probable polyketide synthase Pks1 0.0061 0.0046 0.0345
Trichomonas vaginalis hypothetical protein 0.1537 0.1951 0.3192
Brugia malayi EGF-like domain containing protein 0.0162 0.0176 0.0176
Loa Loa (eye worm) hypothetical protein 0.0035 0.0012 0.0012
Echinococcus multilocularis fmrfamide receptor 0.0046 0.0027 0.0034
Chlamydia trachomatis protoporphyrinogen oxidase 0.0103 0.01 1
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0058 0.0042 0.0042
Onchocerca volvulus 0.0849 0.1063 0.3976
Leishmania major UDP-galactopyranose mutase 0.0103 0.01 0.1142
Loa Loa (eye worm) reprolysin 0.0233 0.0267 0.0267
Plasmodium falciparum plasmepsin III 0.0035 0.0012 0.0093
Loa Loa (eye worm) hypothetical protein 0.0103 0.01 0.01
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0046 0.0027 0.0027
Schistosoma mansoni tyrosine kinase 0.0086 0.0078 0.0078
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0087 0.0079 0.0079
Mycobacterium tuberculosis Possible oxidoreductase 0.0103 0.01 0.0765
Mycobacterium leprae PROBABLE CONSERVED TRANSMEMBRANE PROTEIN 0.0032 0.0008 0.0051
Plasmodium vivax LCCL domain-containing protein 0.0032 0.0008 0.0034
Loa Loa (eye worm) hypothetical protein 0.0099 0.0095 0.0095
Onchocerca volvulus 0.0046 0.0027 0.0101
Schistosoma mansoni protein arginine N-methyltransferase 1 0.003 0.0006 0.0006
Trichomonas vaginalis Clan AA, family A1, cathepsin D-like aspartic peptidase 0.0035 0.0012 0.001
Loa Loa (eye worm) hypothetical protein 0.0046 0.0027 0.0027
Brugia malayi G-protein coupled receptor 0.0046 0.0027 0.0027
Brugia malayi hypothetical protein 0.0047 0.0028 0.0028
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0035 0.0012 0.0012
Loa Loa (eye worm) aspartic protease BmAsp-1 0.0035 0.0012 0.0012
Trichomonas vaginalis WD repeat domain, putative 0.0071 0.0059 0.0087
Brugia malayi hypothetical protein 0.0046 0.0027 0.0027
Onchocerca volvulus 0.0069 0.0056 0.0211
Brugia malayi transcriptional regulator, Sir2 family protein 0.0099 0.0095 0.0095
Brugia malayi EGF-like domain containing protein 0.0162 0.0176 0.0176
Schistosoma mansoni tyrosine kinase 0.0086 0.0078 0.0078
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0058 0.0042 0.0042
Onchocerca volvulus 0.0071 0.0059 0.022
Echinococcus multilocularis rhodopsin orphan GPCR 0.0046 0.0027 0.0034
Trichomonas vaginalis hypothetical protein 0.0162 0.0176 0.028
Mycobacterium tuberculosis Probable proline rich membrane-anchored mycosin MycP5 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-5) 0.0352 0.0421 0.3234
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0099 0.0095 0.0146
Mycobacterium ulcerans membrane-anchored serine protease (mycosin), MycP4 0.0352 0.0421 0.3234
Loa Loa (eye worm) angiogenesis inhibito 0.0064 0.005 0.005
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0352 0.0421 0.0682
Echinococcus multilocularis discoidin domain containing receptor 2 0.0032 0.0008 0.001
Giardia lamblia Tenascin precursor 0.0162 0.0176 0.0423
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA 0.0082 0.0073 0.0548
Echinococcus granulosus protein arginine methyltransferase 0.003 0.0006 0.0006
Brugia malayi hypothetical protein 0.0046 0.0027 0.0027
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD 0.0082 0.0073 0.0548
Schistosoma mansoni amine GPCR 0.0046 0.0027 0.0027
Brugia malayi hypothetical protein 0.0046 0.0027 0.0027
Schistosoma mansoni hypothetical protein 0.006 0.0045 0.0045
Echinococcus multilocularis tyrosine protein kinase HCK 0.0033 0.001 0.0012
Schistosoma mansoni cathepsin D (A01 family) 0.0035 0.0012 0.0012
Echinococcus granulosus discoidin domain containing receptor 2 0.0032 0.0008 0.0008
Schistosoma mansoni subfamily M12B unassigned peptidase (M12 family) 0.0233 0.0267 0.0267
Toxoplasma gondii beta-ketoacyl synthase, N-terminal domain-containing protein 0.0055 0.0038 0.0511
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0058 0.0042 0.0052
Echinococcus granulosus discoidin domain containing receptor 2 0.0032 0.0008 0.0008
Loa Loa (eye worm) hypothetical protein 0.0046 0.0027 0.0027
Schistosoma mansoni septate junction protein 0.0036 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0046 0.0027 0.0027
Trichomonas vaginalis conserved hypothetical protein 0.0352 0.0421 0.0682
Schistosoma mansoni memapsin-2 (A01 family) 0.0035 0.0012 0.0012
Echinococcus multilocularis dro:myosuppressin receptor 0.0046 0.0027 0.0034
Loa Loa (eye worm) transcriptional regulator 0.0099 0.0095 0.0095
Echinococcus multilocularis matrix metallopeptidase 7 (M10 family) 0.33 0.4227 0.5273
Loa Loa (eye worm) aspartic protease BmAsp-2 0.0035 0.0012 0.0012
Leishmania major subtilisin-like serine peptidase 0.0352 0.0421 0.5028
Echinococcus multilocularis Bcl 2 ous antagonist:killer 0.006 0.0045 0.0056
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0352 0.0421 0.0682
Entamoeba histolytica PH domain containing protein kinase, putative 0.0071 0.0059 0.0597
Giardia lamblia Neurogenic locus Notch protein precursor 0.0162 0.0176 0.0423
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0099 0.0095 0.1036
Echinococcus granulosus fibrillin 1 0.0164 0.0178 0.0178
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0352 0.0421 0.0682
Schistosoma mansoni growth hormone secretagogue receptor 0.0046 0.0027 0.0027
Onchocerca volvulus 0.0046 0.0027 0.0101
Schistosoma mansoni biogenic amine (5HT) receptor 0.0046 0.0027 0.0027
Trypanosoma brucei Silent information regulator 2 related protein 1 0.067 0.0832 1
Loa Loa (eye worm) hypothetical protein 0.0162 0.0176 0.0176
Schistosoma mansoni matrix metallopeptidase-7 (M10 family) 0.1062 0.1339 0.1339
Mycobacterium leprae PROBABLE PROLINE RICH MEMBRANE-ANCHORED MYCOSIN MYCP5 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-5) 0.0352 0.0421 0.323
Loa Loa (eye worm) apoptosis regulator protein 0.006 0.0045 0.0045
Mycobacterium tuberculosis Probable multifunctional mycocerosic acid synthase membrane-associated Mas 0.0087 0.0079 0.0605
Echinococcus multilocularis neuropeptide receptor A26 0.0046 0.0027 0.0034
Echinococcus granulosus dro:myosuppressin receptor 0.0046 0.0027 0.0027
Mycobacterium tuberculosis Probable polyketide synthase Pks7 0.0087 0.0079 0.0605
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0046 0.0027 0.0027
Entamoeba histolytica SWIRM domain protein 0.0043 0.0023 0.0158
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0041 0.002 0.0025
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0352 0.0421 0.0682
Schistosoma mansoni chromatin regulatory protein sir2 0.067 0.0832 0.0832
Mycobacterium tuberculosis Probable polyketide synthase Pks9 0.0048 0.0029 0.0219
Loa Loa (eye worm) hypothetical protein 0.0069 0.0056 0.0056
Echinococcus multilocularis membrane bound transcription factor site 1 0.0352 0.0421 0.0526
Loa Loa (eye worm) hypothetical protein 0.0046 0.0027 0.0027
Mycobacterium tuberculosis Polyketide synthase Pks2 0.0082 0.0073 0.0556
Loa Loa (eye worm) metalloprotease 0.0064 0.005 0.005
Schistosoma mansoni cathepsin D (A01 family) 0.0035 0.0012 0.0012
Schistosoma mansoni furin-1 (S08 family) 0.3373 0.4321 0.4321
Loa Loa (eye worm) hypothetical protein 0.0047 0.0028 0.0028
Echinococcus multilocularis Blood coagulation inhibitor, Disintegrin 0.0096 0.0092 0.0114
Brugia malayi Disintegrin family protein 0.0096 0.0092 0.0092
Brugia malayi putative neuropeptide receptor NPR1 0.0046 0.0027 0.0027
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0035 0.0012 0.0012
Echinococcus granulosus NAD dependent deacetylase sirtuin 1 0.0099 0.0095 0.0095
Brugia malayi hypothetical protein 0.0046 0.0027 0.0027
Brugia malayi Hypothetical subtilase-type proteinase F21H12.6 in chromosome II 0.0352 0.0421 0.0421
Plasmodium falciparum subtilisin-like protease 2 0.0352 0.0421 0.6622
Loa Loa (eye worm) hypothetical protein 0.035 0.0419 0.0419
Loa Loa (eye worm) hypothetical protein 0.0046 0.0027 0.0027
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0046 0.0027 0.0027
Loa Loa (eye worm) hypothetical protein 0.0046 0.0027 0.0027
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0046 0.0027 0.0027
Schistosoma mansoni tyrosine kinase 0.0084 0.0075 0.0075
Toxoplasma gondii eukaryotic aspartyl protease superfamily protein 0.0035 0.0012 0.0093
Schistosoma mansoni discoidin domain receptor 0.0032 0.0008 0.0008
Echinococcus granulosus adam 0.0466 0.0569 0.0569
Echinococcus multilocularis G protein coupled receptor 139 0.0046 0.0027 0.0034
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0352 0.0421 0.0682
Plasmodium vivax aspartyl protease, putative 0.0035 0.0012 0.0093
Toxoplasma gondii subtilisin SUB1 0.0516 0.0634 1
Echinococcus multilocularis protein kinase c epsilon type 0.0087 0.0079 0.0099
Trichomonas vaginalis conserved hypothetical protein 0.1537 0.1951 0.3192
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0008 0.0004
Brugia malayi Melatonin receptor type 1A 0.0046 0.0027 0.0027
Toxoplasma gondii subtilisin SUB2 0.0352 0.0421 0.6622
Echinococcus granulosus glutamate NMDA receptor subunit 0.0291 0.0343 0.0343
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0046 0.0027 0.0034
Brugia malayi Subtilase family protein 0.0352 0.0421 0.0421
Echinococcus multilocularis fibrillin 1 0.0164 0.0178 0.0223
Echinococcus multilocularis protein jagged 2 0.0162 0.0176 0.022
Brugia malayi putative neuropeptide receptor 0.0046 0.0027 0.0027
Echinococcus multilocularis neuropeptide FF receptor 2 0.0046 0.0027 0.0034
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0052 0.0034 0.0034
Loa Loa (eye worm) hypothetical protein 0.0375 0.0451 0.0451
Trypanosoma cruzi Silent information regulator 2 related protein 1 0.067 0.0832 1
Echinococcus granulosus fibrillin 2 0.0162 0.0176 0.0176
Echinococcus multilocularis adam 0.0466 0.0569 0.071
Loa Loa (eye worm) hypothetical protein 0.0046 0.0027 0.0027
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0046 0.0027 0.0027
Echinococcus multilocularis NMDA receptor 0.0035 0.0012 0.0015
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0041 0.002 0.0025
Brugia malayi Glutamate receptor 2 precursor 0.0035 0.0012 0.0012
Toxoplasma gondii aspartyl protease 0.0035 0.0012 0.0093
Echinococcus granulosus NAD dependent deacetylase sirtuin 3 0.067 0.0832 0.0832
Mycobacterium ulcerans polyketide synthase Pks13 0.0124 0.0127 0.0968
Onchocerca volvulus 0.0046 0.0027 0.0101
Echinococcus granulosus tachykinin peptides receptor 99D 0.0046 0.0027 0.0027
Plasmodium vivax hypothetical protein, conserved 0.0103 0.01 0.1504
Trichomonas vaginalis conserved hypothetical protein 0.0352 0.0421 0.0682
Trypanosoma cruzi Silent information regulator 2 related protein 3 0.0099 0.0095 0.0833
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0058 0.0042 0.0052
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0046 0.0027 0.0027
Loa Loa (eye worm) hypothetical protein 0.0046 0.0027 0.0027
Echinococcus multilocularis protein arginine N methyltransferase 8 0.003 0.0006 0.0007
Echinococcus granulosus metabotropic glutamate receptor 5 0.0048 0.0028 0.0028
Plasmodium falciparum protoporphyrinogen oxidase 0.0103 0.01 0.1504
Schistosoma mansoni integrin alpha-ps 0.0375 0.0451 0.0451
Echinococcus multilocularis Coagulation factor 5 8 type, C terminal 0.0032 0.0008 0.001
Brugia malayi hypothetical protein 0.0069 0.0056 0.0056
Loa Loa (eye worm) hypothetical protein 0.0146 0.0156 0.0156
Plasmodium falciparum plasmepsin VII 0.0035 0.0012 0.0093
Onchocerca volvulus 0.0046 0.0027 0.0101
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0046 0.0027 0.0027
Trichomonas vaginalis neuroendocrine convertase 2 precursor, putative 0.1537 0.1951 0.3192
Loa Loa (eye worm) hypothetical protein 0.0035 0.0012 0.0012
Schistosoma mansoni neuropeptide f receptor 76f 0.0046 0.0027 0.0027
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0046 0.0027 0.0027
Echinococcus multilocularis integrin alpha 3 0.083 0.1039 0.1296
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0099 0.0095 0.0146
Schistosoma mansoni hypothetical protein 0.0287 0.0338 0.0338
Toxoplasma gondii histone deacetylase SIR2-like 0.0099 0.0095 0.1416
Entamoeba histolytica SWIRM domain protein 0.0043 0.0023 0.0158
Toxoplasma gondii histone lysine-specific demethylase LSD1/BHC110/KDMA1A 0.0103 0.01 0.1504
Loa Loa (eye worm) glutamate receptor 2 0.0035 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.0046 0.0027 0.0027
Loa Loa (eye worm) fatty acid synthase 0.0083 0.0075 0.0075
Echinococcus granulosus EGFP:Bcl2 fusion protein 0.0756 0.0943 0.0943
Schistosoma mansoni hypothetical protein 0.0071 0.0059 0.0059
Schistosoma mansoni protein arginine N-methyltransferase 1 0.003 0.0006 0.0006
Loa Loa (eye worm) transcriptional regulator 0.067 0.0832 0.0832
Schistosoma mansoni myosin xvIII 0.0046 0.0027 0.0027
Echinococcus multilocularis glutamate receptor 2 0.0058 0.0042 0.0052
Schistosoma mansoni hypothetical protein 0.006 0.0045 0.0045
Schistosoma mansoni biogenic amine receptor 0.0046 0.0027 0.0027
Brugia malayi metabotropic glutamate receptor type 2 0.0048 0.0028 0.0028
Echinococcus granulosus tyrosine kinase 0.0037 0.0015 0.0015
Schistosoma mansoni amine GPCR 0.0046 0.0027 0.0027
Echinococcus multilocularis neuropeptide receptor 0.0046 0.0027 0.0034
Schistosoma mansoni protein kinase 0.0131 0.0136 0.0136
Schistosoma mansoni neuropeptide receptor 0.0046 0.0027 0.0027
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0352 0.0421 0.0682
Loa Loa (eye worm) endoprotease bli-4 0.7773 1 1
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.1889 0.2406 0.3938
Onchocerca volvulus 0.1204 0.1521 0.5689
Onchocerca volvulus 0.0035 0.0012 0.0044
Loa Loa (eye worm) hypothetical protein 0.0136 0.0143 0.0143
Echinococcus multilocularis Furin 1 0.1889 0.2406 0.3001
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0131 0.0136 0.0169
Trichomonas vaginalis conserved hypothetical protein 0.1537 0.1951 0.3192
Mycobacterium tuberculosis Probable fatty acid synthase Fas (fatty acid synthetase) 0.0027 0.0001 0.0006
Schistosoma mansoni serine/threonine protein kinase 0.026 0.0303 0.0303
Plasmodium falciparum lysine-specific histone demethylase 1, putative 0.0103 0.01 0.1504
Loa Loa (eye worm) hypothetical protein 0.1162 0.1467 0.1467
Echinococcus multilocularis neuroendocrine convertase 2 0.491 0.6306 0.7867
Loa Loa (eye worm) acyl carrier protein 0.0039 0.0017 0.0017
Onchocerca volvulus 0.0079 0.0069 0.0259
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0099 0.0095 0.0146
Mycobacterium ulcerans proline rich membrane-anchored mycosin MycP5 0.0352 0.0421 0.3234
Echinococcus multilocularis insulin receptor 0.0052 0.0034 0.0042
Schistosoma mansoni neuropeptide receptor 0.0046 0.0027 0.0027
Loa Loa (eye worm) hypothetical protein 0.0046 0.0027 0.0027
Entamoeba histolytica hypothetical protein 0.0047 0.0028 0.0221
Echinococcus granulosus g-protein coupled receptor 0.0046 0.0027 0.0027
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0041 0.002 0.0025
Schistosoma mansoni apoptosis regulator bax 0.006 0.0045 0.0045
Echinococcus granulosus Bcl 2 ous antagonist:killer 0.006 0.0045 0.0045
Brugia malayi metalloprotease 0.0064 0.005 0.005
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0082 0.0073 0.0553
Giardia lamblia Sirtuin type 2 0.0099 0.0095 0.0199
Toxoplasma gondii type I fatty acid synthase, putative 0.006 0.0045 0.0621
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC 0.0087 0.0079 0.06
Brugia malayi Protein kinase domain containing protein 0.0034 0.0011 0.0011
Schistosoma mansoni chromatin regulatory protein sir2 0.067 0.0832 0.0832
Trypanosoma brucei subtilisin peptidase 0.0352 0.0421 0.4893
Echinococcus granulosus rhodopsin orphan GPCR 0.0046 0.0027 0.0027
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0352 0.0421 0.0682
Loa Loa (eye worm) hypothetical protein 0.0352 0.0421 0.0421
Loa Loa (eye worm) hypothetical protein 0.0046 0.0027 0.0027
Echinococcus granulosus somatostatin receptor 0.0046 0.0027 0.0027
Schistosoma mansoni glutamate receptor kainate 0.0035 0.0012 0.0012
Echinococcus granulosus alpha 1A adrenergic receptor 0.0046 0.0027 0.0027
Loa Loa (eye worm) glutamate receptor 1 0.0035 0.0012 0.0012
Onchocerca volvulus 0.0109 0.0108 0.0403
Echinococcus multilocularis metabotropic glutamate receptor 5 0.0048 0.0028 0.0035
Mycobacterium ulcerans hydrolase 0.1034 0.1302 1
Schistosoma mansoni hypothetical protein 0.0046 0.0027 0.0027
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0352 0.0421 0.0682
Echinococcus granulosus nmda type glutamate receptor 0.0123 0.0126 0.0126
Loa Loa (eye worm) G-protein coupled receptor 0.0046 0.0027 0.0027
Brugia malayi larval opioid receptor 0.0046 0.0027 0.0027
Echinococcus granulosus G protein coupled receptor 139 0.0046 0.0027 0.0027
Onchocerca volvulus 0.0046 0.0027 0.0101
Brugia malayi celfurPC protein 0.6235 0.8016 0.8016
Echinococcus multilocularis NAD dependent deacetylase sirtuin 1 0.0099 0.0095 0.0118
Echinococcus granulosus NAD dependent deacetylase sirtuin 6 0.0099 0.0095 0.0095
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0046 0.0027 0.0027
Echinococcus multilocularis NAD dependent deacetylase sirtuin 3 0.067 0.0832 0.1039
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0046 0.0027 0.0027
Echinococcus granulosus neuropeptides capa receptor 0.0245 0.0284 0.0284
Echinococcus multilocularis glutamate receptor subunit protein glur 0.0035 0.0012 0.0015
Loa Loa (eye worm) hypothetical protein 0.0046 0.0027 0.0027
Mycobacterium ulcerans Type I modular polyketide synthase 0.0082 0.0073 0.0553
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0023 0.0027
Echinococcus multilocularis tyrosine protein kinase Blk 0.0037 0.0015 0.0018
Echinococcus multilocularis protoporphyrinogen oxidase 0.0103 0.01 0.0125
Echinococcus multilocularis Ribosomal protein S1, RNA binding domain 0.0035 0.0012 0.0015
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0052 0.0034 0.0042
Loa Loa (eye worm) hypothetical protein 0.0046 0.0027 0.0027
Trypanosoma cruzi subtilisin-like serine peptidase, putative 0.0371 0.0446 0.5194
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0046 0.0027 0.0027
Schistosoma mansoni chromatin regulatory protein sir2 0.067 0.0832 0.0832
Echinococcus granulosus epidermal growth factor receptor 0.0562 0.0693 0.0693
Schistosoma mansoni histamine h1 receptor 0.0046 0.0027 0.0027
Brugia malayi neuropeptide F receptor 0.0046 0.0027 0.0027
Toxoplasma gondii F5/8 type C domain-containing protein 0.0032 0.0008 0.0034
Schistosoma mansoni opsin-like receptor 0.0046 0.0027 0.0027
Schistosoma mansoni chromatin regulatory protein sir2 0.0099 0.0095 0.0095
Echinococcus granulosus tm gpcr rhodopsin 0.0046 0.0027 0.0027
Trichomonas vaginalis proprotein convertase subtilisin/kexin type, putative 0.1537 0.1951 0.3192
Trichomonas vaginalis conserved hypothetical protein 0.1537 0.1951 0.3192
Echinococcus granulosus peptidase s8 s53 subtilisin kexin sedolisin 0.0352 0.0421 0.0421
Brugia malayi RE15519p 0.0046 0.0027 0.0027
Toxoplasma gondii subtilisin SUB10 0.0352 0.0421 0.6622
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0035 0.0012 0.0012
Schistosoma mansoni hypothetical protein 0.1204 0.1521 0.1521
Onchocerca volvulus Neuropeptide F receptor homolog 0.0046 0.0027 0.0101
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0046 0.0027 0.0027
Echinococcus granulosus insulin receptor 0.0052 0.0034 0.0034
Loa Loa (eye worm) hypothetical protein 0.0046 0.0027 0.0027
Schistosoma mansoni family A2 unassigned peptidase (A02 family) 0.0461 0.0563 0.0563
Echinococcus granulosus biogenic amine 5HT receptor 0.0046 0.0027 0.0027
Echinococcus granulosus serine:threonine protein kinase N2 0.0071 0.0059 0.0059
Brugia malayi hypothetical protein 0.0046 0.0027 0.0027
Echinococcus multilocularis proprotein convertase subtilisin:kexin type 5 0.4751 0.61 0.761
Onchocerca volvulus 0.0046 0.0027 0.0101
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0352 0.0421 0.0682
Schistosoma mansoni neuropeptide receptor 0.0046 0.0027 0.0027
Brugia malayi hypothetical protein 0.0046 0.0027 0.0027
Echinococcus multilocularis 0.0049 0.003 0.0038
Loa Loa (eye worm) hypothetical protein 0.0046 0.0027 0.0027
Plasmodium vivax LCCL domain-containing protein 0.0032 0.0008 0.0034
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0041 0.002 0.0025
Loa Loa (eye worm) hypothetical protein 0.0046 0.0027 0.0027
Echinococcus granulosus sex peptide receptor 0.0046 0.0027 0.0027
Echinococcus multilocularis rhodopsin orphan GPCR 0.0046 0.0027 0.0034
Brugia malayi Dopamine receptor protein 2 0.0046 0.0027 0.0027
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0046 0.0027 0.0027
Mycobacterium ulcerans membrane-anchored mycosin MycP3 0.0352 0.0421 0.3234
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0086 0.0078 0.0078
Loa Loa (eye worm) hypothetical protein 0.0048 0.0028 0.0028
Echinococcus granulosus tyrosine protein kinase Src42A 0.0035 0.0012 0.0012
Plasmodium vivax aspartyl protease, putative 0.0035 0.0012 0.0093
Echinococcus multilocularis nmda type glutamate receptor 0.0123 0.0126 0.0157
Schistosoma mansoni amine GPCR 0.0046 0.0027 0.0027
Mycobacterium tuberculosis Polyketide synthase Pks13 0.0124 0.0127 0.0968
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0046 0.0027 0.0027
Loa Loa (eye worm) hypothetical protein 0.1034 0.1302 0.1302
Echinococcus granulosus glutamate receptor subunit protein glur 0.0035 0.0012 0.0012
Brugia malayi Matrixin family protein 0.2266 0.2892 0.2892
Echinococcus granulosus discoidin domain receptor 0.0032 0.0008 0.0008
Onchocerca volvulus 0.0046 0.0027 0.0101
Schistosoma mansoni hypothetical protein 0.006 0.0045 0.0045
Brugia malayi Protein kinase domain containing protein 0.0071 0.0059 0.0059
Loa Loa (eye worm) hypothetical protein 0.0046 0.0027 0.0027
Brugia malayi G-protein coupled receptor 0.0046 0.0027 0.0027
Schistosoma mansoni amine GPCR 0.0046 0.0027 0.0027
Loa Loa (eye worm) hypothetical protein 0.0045 0.0025 0.0025
Trichomonas vaginalis conserved hypothetical protein 0.1537 0.1951 0.3192
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0046 0.0027 0.0034
Echinococcus multilocularis orexin receptor type 2 0.0046 0.0027 0.0034
Trypanosoma brucei SIR2-like protein 4, putative 0.0099 0.0095 0.0833
Giardia lamblia High cysteine protein 0.0162 0.0176 0.0423
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.1889 0.2406 0.3938
Loa Loa (eye worm) hypothetical protein 0.0046 0.0027 0.0027
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0008 0.0004
Echinococcus granulosus disintegrin and metalloproteinase 0.0096 0.0092 0.0092
Toxoplasma gondii subtilisin SUB9 0.0352 0.0421 0.6622
Trichomonas vaginalis conserved hypothetical protein 0.0352 0.0421 0.0682
Loa Loa (eye worm) hypothetical protein 0.0063 0.0048 0.0048
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0082 0.0073 0.0553
Loa Loa (eye worm) hypothetical protein 0.0774 0.0966 0.0966
Plasmodium falciparum plasmepsin I 0.0035 0.0012 0.0093
Schistosoma mansoni opsin-like receptor 0.0046 0.0027 0.0027
Schistosoma mansoni amine GPCR 0.0046 0.0027 0.0027
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0352 0.0421 0.0682
Echinococcus multilocularis c Jun NH2 terminal kinase 0.026 0.0303 0.0378
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0037 0.0015 0.0018
Giardia lamblia NAD-dependent histone deacetylase Sir2 0.0099 0.0095 0.0199
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE 0.0053 0.0036 0.0263
Mycobacterium tuberculosis Probable membrane-anchored mycosin MycP4 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-4) 0.0352 0.0421 0.3234
Loa Loa (eye worm) hypothetical protein 0.0069 0.0056 0.0056
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.7773 1 1
Brugia malayi Stress-activated protein kinase jnk-1 0.026 0.0303 0.0303
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0035 0.0012 0.0012
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.0058 0.0042 0.0052
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0035 0.0012 0.0012
Brugia malayi Integrin beta pat-3 precursor 0.7563 0.9729 0.9729
Echinococcus multilocularis somatostatin receptor 0.0046 0.0027 0.0034
Loa Loa (eye worm) hypothetical protein 0.0508 0.0622 0.0622
Schistosoma mansoni biogenic amine (5HT) receptor 0.0046 0.0027 0.0027
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0046 0.0027 0.0034
Mycobacterium ulcerans thioesterase TesA 0.0071 0.0058 0.0441
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0046 0.0027 0.0027
Loa Loa (eye worm) hypothetical protein 0.0046 0.0027 0.0027
Trichomonas vaginalis conserved hypothetical protein 0.1537 0.1951 0.3192
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0099 0.0095 0.0146
Brugia malayi Furin-like cysteine rich region family protein 0.0562 0.0693 0.0693
Giardia lamblia Transcriptional regulator, Sir2 family 0.0099 0.0095 0.0199
Echinococcus granulosus tyrosine protein kinase HCK 0.0033 0.001 0.001
Plasmodium vivax plasmepsin IV, putative 0.0035 0.0012 0.0093
Mycobacterium ulcerans polyketide synthase 0.0082 0.0073 0.0553
Onchocerca volvulus 0.0046 0.0027 0.0101
Echinococcus granulosus protein will die slowly 0.0071 0.0059 0.0059
Schistosoma mansoni subfamily S8B non-peptidase homologue (S08 family) 0.1889 0.2406 0.2406
Echinococcus granulosus neuropeptide s receptor 0.0046 0.0027 0.0027
Brugia malayi Protein kinase domain containing protein 0.0052 0.0034 0.0034
Schistosoma mansoni biogenic amine receptor 0.0046 0.0027 0.0027
Echinococcus multilocularis fmrfamide receptor 0.0046 0.0027 0.0034
Echinococcus granulosus hypothetical protein 0.0046 0.0027 0.0027
Schistosoma mansoni intracisternal A-particle retropepsin (A02 family) 0.2537 0.3242 0.3242
Trypanosoma cruzi subtilisin peptidase 0.0352 0.0421 0.4893
Schistosoma mansoni integrin alpha 0.1142 0.1441 0.1441
Echinococcus granulosus MAM 0.0069 0.0056 0.0056
Schistosoma mansoni protein arginine N-methyltransferase 1 0.003 0.0006 0.0006
Echinococcus granulosus matrix metallopeptidase 7 M10 family 0.33 0.4227 0.4227
Mycobacterium leprae Polyketide synthase Pks13 0.0124 0.0127 0.0963
Echinococcus granulosus integrin alpha ps 0.0662 0.0822 0.0822
Schistosoma mansoni amine oxidase 0.0103 0.01 0.01
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.067 0.0832 0.1356
Treponema pallidum amino acid ABC transporter, periplasmic binding protein (hisJ) 0.0089 0.0081 0.5
Loa Loa (eye worm) hypothetical protein 0.005 0.0032 0.0032
Brugia malayi Hemopexin family protein 0.1204 0.1521 0.1521
Leishmania major sir2-family protein-like protein 0.0099 0.0095 0.1076
Echinococcus multilocularis rhodopsin orphan GPCR 0.0046 0.0027 0.0034
Toxoplasma gondii aspartyl protease ASP1 0.0035 0.0012 0.0093
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0008 0.0004
Echinococcus multilocularis SWI:SNF complex subunit SMARCC2 0.0043 0.0023 0.0028
Echinococcus multilocularis protein will die slowly 0.0071 0.0059 0.0074
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0046 0.0027 0.0027
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0103 0.01 0.0765
Echinococcus multilocularis NAD dependent deacetylase sirtuin 7 0.0099 0.0095 0.0118
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0008 0.0004
Schistosoma mansoni neuropeptide F-like receptor 0.0046 0.0027 0.0027
Leishmania major NAD dependent deacetylase, putative,transcriptional regulator, Sir2 family protein, nicotinic acid mononucleotide 5,6-dimethylbe 0.0099 0.0095 0.1076
Loa Loa (eye worm) integrin beta-2 0.7563 0.9729 0.9729
Mycobacterium tuberculosis Probable thioesterase TesA 0.0071 0.0058 0.0441
Brugia malayi Matrixin family protein 0.0849 0.1063 0.1063
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0035 0.0012 0.0012
Onchocerca volvulus 0.0162 0.0176 0.066
Loa Loa (eye worm) hypothetical protein 0.0046 0.0027 0.0027
Schistosoma mansoni bcl-2 homologous antagonist/killer (bak) 0.006 0.0045 0.0045
Onchocerca volvulus 0.0046 0.0027 0.0101
Onchocerca volvulus 0.0046 0.0027 0.0101
Echinococcus multilocularis epidermal growth factor receptor 0.0086 0.0078 0.0097
Echinococcus granulosus subfamily M12B unassigned peptidase 0.0233 0.0267 0.0267
Brugia malayi hypothetical protein 0.0046 0.0027 0.0027
Schistosoma mansoni glutamate receptor AMPA 0.0035 0.0012 0.0012
Brugia malayi AKH receptor 0.0046 0.0027 0.0027
Echinococcus granulosus Blood coagulation inhibitor Disintegrin 0.0096 0.0092 0.0092
Brugia malayi Will die slowly protein 0.0071 0.0059 0.0059
Entamoeba histolytica arginine N-methyltransferase protein, putative 0.0047 0.0028 0.0221
Brugia malayi SRC-1 0.0041 0.002 0.002
Toxoplasma gondii aspartyl protease ASP5 0.0354 0.0424 0.666
Echinococcus granulosus g protein coupled receptor 0.0046 0.0027 0.0027
Loa Loa (eye worm) glutamate receptor 0.0033 0.001 0.001
Echinococcus granulosus neuroendocrine convertase 2 0.491 0.6306 0.6306
Schistosoma mansoni adenoreceptor 0.0046 0.0027 0.0027
Echinococcus granulosus biogenic amine 5HT receptor 0.0046 0.0027 0.0027
Loa Loa (eye worm) hypothetical protein 0.0046 0.0027 0.0027
Echinococcus multilocularis glutamate receptor 2 0.0035 0.0012 0.0015
Brugia malayi protein-tyrosine kinase 0.0037 0.0015 0.0015
Schistosoma mansoni hypothetical protein 0.0046 0.0027 0.0027
Loa Loa (eye worm) hypothetical protein 0.0046 0.0027 0.0027
Toxoplasma gondii F5/8 type C domain-containing protein 0.0032 0.0008 0.0034
Brugia malayi Kelch motif family protein 0.1181 0.1491 0.1491
Brugia malayi aspartic protease BmAsp-2, identical 0.0035 0.0012 0.0012
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0352 0.0421 0.0682
Trichomonas vaginalis leucine-rich repeat protein, BspA family 0.1537 0.1951 0.3192
Loa Loa (eye worm) hypothetical protein 0.0033 0.001 0.001
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0352 0.0421 0.0682
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0046 0.0027 0.0034
Onchocerca volvulus 0.0069 0.0056 0.0211
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0046 0.0027 0.0034
Toxoplasma gondii histone deacetylase SIR2 0.0099 0.0095 0.1416
Schistosoma mansoni glutamate receptor kainate 0.0035 0.0012 0.0012
Echinococcus granulosus neuropeptide receptor A26 0.0046 0.0027 0.0027
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0082 0.0073 0.0553
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0008 0.0004
Loa Loa (eye worm) G-protein coupled receptor 0.0046 0.0027 0.0027
Schistosoma mansoni site-1 peptidase (S08 family) 0.0352 0.0421 0.0421
Mycobacterium leprae Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas 0.0087 0.0079 0.06
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0046 0.0027 0.0027
Toxoplasma gondii subtilisin SUB7 0.0352 0.0421 0.6622
Plasmodium falciparum plasmepsin X 0.0035 0.0012 0.0093
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0103 0.01 0.1504
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0046 0.0027 0.0027
Brugia malayi Matrix metalloprotease, N-terminal domain containing protein 0.1034 0.1302 0.1302
Brugia malayi hypothetical protein 0.0035 0.0012 0.0012
Plasmodium vivax protoporphyrinogen oxidase, putative 0.0103 0.01 0.1504
Plasmodium falciparum plasmepsin II 0.0035 0.0012 0.0093
Loa Loa (eye worm) hypothetical protein 0.3021 0.3867 0.3867
Onchocerca volvulus Matrilysin homolog 0.0849 0.1063 0.3976
Brugia malayi angiogenesis inhibito 0.0136 0.0143 0.0143
Brugia malayi neuroendocrine convertase 1 precursor 0.491 0.6306 0.6306
Loa Loa (eye worm) transcriptional regulator 0.0099 0.0095 0.0095
Echinococcus granulosus glutamate receptor ionotropic kainate 3 0.0035 0.0012 0.0012
Plasmodium vivax NAD-dependent deacetylase, putative 0.0099 0.0095 0.1416
Schistosoma mansoni matrix metallopeptidase-9 (M10 family) 0.0876 0.1098 0.1098
Echinococcus granulosus SWI:SNF complex subunit SMARCC2 0.0043 0.0023 0.0023
Giardia lamblia hypothetical protein 0.0162 0.0176 0.0423
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0023 0.0027
Loa Loa (eye worm) hypothetical protein 0.0551 0.0678 0.0678
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0008 0.0004
Trypanosoma cruzi UDP-galactopyranose mutase 0.0103 0.01 0.0902
Brugia malayi Matrixin family protein 0.0849 0.1063 0.1063
Toxoplasma gondii subtilisin SUB5 0.0352 0.0421 0.6622
Echinococcus granulosus g protein coupled receptor 0.0046 0.0027 0.0027
Schistosoma mansoni tripeptidyl-peptidase II (S08 family) 0.0352 0.0421 0.0421
Loa Loa (eye worm) WD40 repeat protein 0.0071 0.0059 0.0059
Trichomonas vaginalis conserved hypothetical protein 0.1537 0.1951 0.3192
Loa Loa (eye worm) hypothetical protein 0.0849 0.1063 0.1063
Echinococcus multilocularis g-protein coupled receptor 0.0046 0.0027 0.0034
Echinococcus multilocularis neuropeptide Y receptor 0.0046 0.0027 0.0034
Brugia malayi SWIRM domain containing protein 0.0551 0.0678 0.0678
Mycobacterium ulcerans monoamine oxidase 0.0103 0.01 0.0765
Mycobacterium tuberculosis Probable alanine and proline rich membrane-anchored mycosin MycP2 (serine protease) (subtilisin-like protease) (subtilase-like) 0.0352 0.0421 0.3234
Trypanosoma brucei Silent information regulator 2 related protein 3 0.0099 0.0095 0.0833
Echinococcus granulosus tm gpcr rhodopsin 0.0046 0.0027 0.0027
Echinococcus multilocularis subfamily M12B unassigned peptidase 0.0233 0.0267 0.0334
Loa Loa (eye worm) hypothetical protein 0.0233 0.0267 0.0267
Schistosoma mansoni hypothetical protein 0.0032 0.0008 0.0008
Toxoplasma gondii subtilisin SUB4 0.0352 0.0421 0.6622
Trichomonas vaginalis conserved hypothetical protein 0.0352 0.0421 0.0682
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0046 0.0027 0.0027
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0046 0.0027 0.0027
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0352 0.0421 0.0682
Echinococcus granulosus lysine specific histone demethylase 1A 0.0103 0.01 0.01
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0008 0.0004
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0352 0.0421 0.0682
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0046 0.0027 0.0027
Loa Loa (eye worm) hypothetical protein 0.0849 0.1063 0.1063
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0046 0.0027 0.0034
Loa Loa (eye worm) hypothetical protein 0.0162 0.0176 0.0176
Loa Loa (eye worm) TYRA-2 protein 0.0046 0.0027 0.0027
Brugia malayi hypothetical protein 0.0046 0.0027 0.0027
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.067 0.0832 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0046 0.0027 0.0034
Onchocerca volvulus 0.0046 0.0027 0.0101
Schistosoma mansoni tyrosine kinase 0.0562 0.0693 0.0693
Mycobacterium ulcerans oxidoreductase 0.0103 0.01 0.0765
Mycobacterium leprae PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) 0.0103 0.01 0.076
Schistosoma mansoni neuropeptide receptor 0.0046 0.0027 0.0027
Echinococcus multilocularis rhodopsin orphan GPCR 0.0046 0.0027 0.0034
Schistosoma mansoni hypothetical protein 0.0046 0.0027 0.0027
Loa Loa (eye worm) hypothetical protein 0.0508 0.0622 0.0622
Echinococcus granulosus tyrosine protein kinase Src64B 0.0041 0.002 0.002
Schistosoma mansoni integrin alpha-ps 0.0599 0.0741 0.0741
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0008 0.0004
Echinococcus multilocularis g protein coupled receptor 0.0046 0.0027 0.0034
Trypanosoma cruzi serine peptidase, clan SB, family S8-like protein 0.0352 0.0421 0.4893
Plasmodium falciparum transcriptional regulatory protein sir2a 0.0099 0.0095 0.1416
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0008 0.0004
Loa Loa (eye worm) hypothetical protein 0.006 0.0045 0.0045
Toxoplasma gondii subtilisin SUB12 0.0352 0.0421 0.6622
Trichomonas vaginalis teneurin and N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase, putative 0.0162 0.0176 0.028
Toxoplasma gondii aspartyl proteinase (eimepsin), putative 0.0035 0.0012 0.0093
Toxoplasma gondii SWIRM domain-containing protein 0.0043 0.0023 0.0266
Loa Loa (eye worm) kelch domain-containing protein family protein 0.1181 0.1491 0.1491
Onchocerca volvulus 0.0046 0.0027 0.0101
Mycobacterium leprae PROBABLE MEMBRANE-ANCHORED MYCOSIN MYCP3 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-3) 0.0352 0.0421 0.323
Toxoplasma gondii hypothetical protein 0.0162 0.0176 0.2716
Entamoeba histolytica hypothetical protein 0.0043 0.0023 0.0158
Loa Loa (eye worm) subtilase 0.0352 0.0421 0.0421
Toxoplasma gondii histone lysine-specific demethylase 0.0103 0.01 0.1504
Echinococcus granulosus tyrosine protein kinase Fyn 0.0041 0.002 0.002
Mycobacterium leprae PROBABLE HYDROLASE 0.1034 0.1302 1
Loa Loa (eye worm) integrin alpha pat-2 0.1566 0.1988 0.1988
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0352 0.0421 0.0682
Brugia malayi Matrixin family protein 0.0849 0.1063 0.1063
Loa Loa (eye worm) aspartyl protease 6 0.0035 0.0012 0.0012
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0046 0.0027 0.0034
Echinococcus granulosus rhodopsin orphan GPCR 0.0046 0.0027 0.0027
Echinococcus multilocularis chromatin regulatory protein sir2 0.067 0.0832 0.1039
Echinococcus granulosus integrin alpha 3 0.083 0.1039 0.1039
Echinococcus granulosus integrin beta 2 0.558 0.717 0.717
Plasmodium vivax aspartyl proteinase, putative 0.0035 0.0012 0.0093
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.4751 0.61 1
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0065 0.0051 0.0389
Brugia malayi Eukaryotic aspartyl protease family protein 0.0035 0.0012 0.0012
Entamoeba histolytica NAD-dependent deacetylase 1, putative 0.0099 0.0095 0.1036
Loa Loa (eye worm) proprotein convertase 2 0.1889 0.2406 0.2406
Leishmania major silent information regulator 2, putative 0.067 0.0832 1
Treponema pallidum amino acid ABC transporter, periplasmic binding protein 0.0089 0.0081 0.5
Plasmodium vivax plasmepsin V, putative 0.0388 0.0469 0.7371
Mycobacterium tuberculosis Conserved hypothetical protein 0.0103 0.01 0.0765
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0352 0.0421 0.0682
Onchocerca volvulus Matrix metalloproteinase homolog 0.1883 0.2398 0.8969
Schistosoma mansoni metabotropic glutamate receptor 0.0218 0.0248 0.0248
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0041 0.002 0.0025
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0352 0.0421 0.0682
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0114 0.0114 0.0114
Loa Loa (eye worm) TK/INSR protein kinase 0.0052 0.0034 0.0034
Loa Loa (eye worm) hypothetical protein 0.0543 0.0668 0.0668
Loa Loa (eye worm) neuropeptide F receptor 0.0046 0.0027 0.0027
Echinococcus granulosus rhodopsin orphan GPCR 0.0046 0.0027 0.0027
Loa Loa (eye worm) hypothetical protein 0.0046 0.0027 0.0027
Loa Loa (eye worm) hypothetical protein 0.0046 0.0027 0.0027
Echinococcus multilocularis discoidin domain receptor 0.0032 0.0008 0.001
Trichomonas vaginalis conserved hypothetical protein 0.1537 0.1951 0.3192
Plasmodium falciparum transcriptional regulatory protein sir2b 0.0099 0.0095 0.1416
Plasmodium falciparum plasmepsin VI 0.0035 0.0012 0.0093
Loa Loa (eye worm) hypothetical protein 0.0855 0.1071 0.1071
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0058 0.0042 0.0052
Brugia malayi SWIRM domain containing protein 0.0043 0.0023 0.0023
Echinococcus granulosus neuropeptide receptor 0.0046 0.0027 0.0027
Mycobacterium tuberculosis Probable polyketide synthase Pks5 0.0082 0.0073 0.0556
Onchocerca volvulus 0.0352 0.0421 0.1577
Brugia malayi protein kinase C II. 0.0087 0.0079 0.0079
Echinococcus multilocularis sex peptide receptor 0.0046 0.0027 0.0034
Echinococcus granulosus furin 0.7773 1 1
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0046 0.0027 0.0034
Trichomonas vaginalis hypothetical protein 0.0032 0.0008 0.0004
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0041 0.002 0.0025
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0103 0.01 0.0765
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0352 0.0421 0.0682
Mycobacterium ulcerans glutamine-binding lipoprotein GlnH 0.0089 0.0081 0.062
Echinococcus multilocularis neuropeptides capa receptor 0.0245 0.0284 0.0354
Loa Loa (eye worm) hypothetical protein 0.0046 0.0027 0.0027
Schistosoma mansoni dihydroceramide desaturase 0.0096 0.0092 0.0092
Brugia malayi G protein-coupled receptor 0.0046 0.0027 0.0027
Giardia lamblia High cysteine membrane protein Group 2 0.2862 0.3662 1
Echinococcus granulosus glutamate receptor 2 0.0058 0.0042 0.0042
Giardia lamblia Neurogenic locus notch-like protein 0.0162 0.0176 0.0423
Mycobacterium tuberculosis Probable polyketide synthase Pks15 0.0034 0.0011 0.0081
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0041 0.002 0.002
Echinococcus multilocularis integrin alpha ps 0.0599 0.0741 0.0924
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0131 0.0136 0.0136
Schistosoma mansoni tyrosine kinase 0.0052 0.0034 0.0034
Echinococcus multilocularis discoidin domain containing receptor 2 0.0032 0.0008 0.001
Plasmodium falciparum subtilisin-like protease 3 0.0352 0.0421 0.6622
Brugia malayi follicle stimulating hormone receptor 0.0046 0.0027 0.0027
Loa Loa (eye worm) hypothetical protein 0.0136 0.0143 0.0143
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0008 0.0004
Loa Loa (eye worm) hypothetical protein 0.0162 0.0176 0.0176
Brugia malayi hypothetical protein 0.0304 0.036 0.036
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0046 0.0027 0.0034
Brugia malayi Pepsin A precursor 0.0035 0.0012 0.0012
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsB 0.0065 0.0051 0.0389
Schistosoma mansoni hypothetical protein 0.0035 0.0012 0.0012
Schistosoma mansoni Lysine-specific histone demethylase 1 0.0508 0.0622 0.0622
Echinococcus granulosus neuropeptide FF receptor 2 0.0046 0.0027 0.0027
Loa Loa (eye worm) hypothetical protein 0.0046 0.0027 0.0027
Onchocerca volvulus 0.0046 0.0027 0.0101
Onchocerca volvulus Matrilysin homolog 0.2096 0.2673 1
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0046 0.0027 0.0027
Echinococcus granulosus tyrosine protein kinase Fyn 0.0041 0.002 0.002
Mycobacterium ulcerans protoporphyrinogen oxidase 0.0103 0.01 0.0765
Onchocerca volvulus 0.0147 0.0157 0.0588
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0046 0.0027 0.0034
Echinococcus multilocularis rhodopsin orphan GPCR 0.0046 0.0027 0.0034
Echinococcus multilocularis 0.6235 0.8016 1
Loa Loa (eye worm) hypothetical protein 0.0043 0.0023 0.0023
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0037 0.0015 0.0015
Echinococcus multilocularis glutamate (NMDA) receptor subunit 0.0291 0.0343 0.0428
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0008 0.0004
Plasmodium vivax aspartyl proteinase, putative 0.0035 0.0012 0.0093
Echinococcus multilocularis allatostatin A receptor 0.0046 0.0027 0.0034
Echinococcus granulosus membrane bound transcription factor site 1 0.0352 0.0421 0.0421
Schistosoma mansoni alpha-1 adrenergic receptor 0.0046 0.0027 0.0027
Echinococcus granulosus integrin alpha ps 0.0287 0.0338 0.0338
Loa Loa (eye worm) hypothetical protein 0.0046 0.0027 0.0027
Plasmodium vivax aspartyl protease, putative 0.0035 0.0012 0.0093
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.0123 0.0126 0.0157
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0035 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.0046 0.0027 0.0027
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0046 0.0027 0.0027
Echinococcus granulosus neuropeptides capa receptor 0.0046 0.0027 0.0027
Brugia malayi sulfakinin receptor protein 0.0046 0.0027 0.0027
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0008 0.0004
Echinococcus multilocularis neuropeptide receptor 0.0046 0.0027 0.0034
Loa Loa (eye worm) hypothetical protein 0.0046 0.0027 0.0027
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0046 0.0027 0.0027
Loa Loa (eye worm) hypothetical protein 0.0046 0.0027 0.0027
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0035 0.0012 0.0012
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0046 0.0027 0.0027
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0046 0.0027 0.0027
Trypanosoma cruzi Silent information regulator 2 related protein 3 0.0099 0.0095 0.0833
Echinococcus multilocularis NAD dependent deacetylase sirtuin 6 0.0099 0.0095 0.0118
Mycobacterium tuberculosis Probable membrane bound polyketide synthase Pks6 0.0124 0.0127 0.0968
Brugia malayi Reprolysin 0.0136 0.0143 0.0143
Echinococcus multilocularis rhodopsin orphan GPCR 0.0046 0.0027 0.0034
Mycobacterium tuberculosis Probable glutamine-binding lipoprotein GlnH (GLNBP) 0.0089 0.0081 0.062
Loa Loa (eye worm) TK protein kinase 0.0033 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0096 0.0092 0.0092
Echinococcus multilocularis serotonin receptor 0.0046 0.0027 0.0034
Brugia malayi Receptor family ligand binding region containing protein 0.0033 0.001 0.001
Brugia malayi aspartic protease BmAsp-1, identical 0.0035 0.0012 0.0012
Mycobacterium ulcerans multifunctional mycocerosic acid synthase membrane-associated Mas 0.0087 0.0079 0.0605
Mycobacterium ulcerans polyketide synthase Pks9 0.0053 0.0036 0.0268
Schistosoma mansoni glutamate receptor NMDA 0.0291 0.0343 0.0343
Loa Loa (eye worm) hypothetical protein 0.0046 0.0027 0.0027
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsE 0.0053 0.0036 0.0268
Mycobacterium ulcerans Type I modular polyketide synthase 0.0082 0.0073 0.0553
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.1889 0.2406 0.3938
Schistosoma mansoni hypothetical protein 0.1537 0.1951 0.1951
Loa Loa (eye worm) hypothetical protein 0.0046 0.0027 0.0027
Echinococcus granulosus discoidin domain containing receptor 2 0.0032 0.0008 0.0008
Echinococcus granulosus NAD dependent deacetylase sirtuin 7 0.0099 0.0095 0.0095
Echinococcus granulosus tyrosine protein kinase Lyn 0.0042 0.0021 0.0021
Brugia malayi Integrin alpha cytoplasmic region family protein 0.0774 0.0966 0.0966
Echinococcus multilocularis integrin alpha ps 0.0662 0.0822 0.1025
Echinococcus multilocularis EGFP:Bcl2 fusion protein 0.0756 0.0943 0.1176
Loa Loa (eye worm) receptor family ligand binding region containing protein 0.0033 0.001 0.001
Plasmodium falciparum subtilisin-like protease 1 0.0516 0.0634 1
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0041 0.002 0.002
Loa Loa (eye worm) hypothetical protein 0.0046 0.0027 0.0027
Echinococcus multilocularis rhodopsin orphan GPCR 0.0046 0.0027 0.0034
Loa Loa (eye worm) hypothetical protein 0.0032 0.0008 0.0008
Loa Loa (eye worm) hypothetical protein 0.0032 0.0008 0.0008
Loa Loa (eye worm) TK protein kinase 0.0037 0.0015 0.0015
Echinococcus multilocularis g protein coupled receptor 0.0046 0.0027 0.0034
Brugia malayi hypothetical protein 0.1162 0.1467 0.1467
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0087 0.0079 0.0605
Echinococcus granulosus protein kinase c epsilon type 0.0087 0.0079 0.0079
Loa Loa (eye worm) hypothetical protein 0.0046 0.0027 0.0027
Onchocerca volvulus 0.0034 0.0011 0.004
Echinococcus granulosus adam 17 protease 0.0096 0.0092 0.0092
Echinococcus granulosus rhodopsin orphan GPCR 0.0046 0.0027 0.0027
Echinococcus multilocularis neuropeptides capa receptor 0.0046 0.0027 0.0034
Mycobacterium tuberculosis Probable peptidoglycan hydrolase 0.1034 0.1302 1
Brugia malayi AMP-binding enzyme family protein 0.0079 0.0069 0.0069
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.0058 0.0042 0.0042
Mycobacterium tuberculosis Transcriptional regulatory protein 0.0099 0.0095 0.0723
Trichomonas vaginalis conserved hypothetical protein 0.1537 0.1951 0.3192
Echinococcus granulosus fmrfamide receptor 0.0046 0.0027 0.0027
Loa Loa (eye worm) hypothetical protein 0.7773 1 1
Giardia lamblia Tenascin-like 0.0162 0.0176 0.0423
Schistosoma mansoni protein kinase 0.0131 0.0136 0.0136
Plasmodium falciparum LCCL domain-containing protein 0.0032 0.0008 0.0034
Mycobacterium ulcerans Type I modular polyketide synthase 0.0082 0.0073 0.0553
Echinococcus granulosus rhodopsin orphan GPCR 0.0046 0.0027 0.0027
Trypanosoma cruzi UDP-galactopyranose mutase 0.0103 0.01 0.0902
Brugia malayi G protein-coupled receptor F59B2.13 0.0046 0.0027 0.0027
Echinococcus multilocularis integrin alpha ps 0.0287 0.0338 0.0422
Schistosoma mansoni site-1 peptidase (S08 family) 0.0352 0.0421 0.0421
Mycobacterium ulcerans Sir2-like regulatory protein 0.0099 0.0095 0.0723
Schistosoma mansoni subfamily M12B unassigned peptidase (M12 family) 0.0233 0.0267 0.0267
Brugia malayi proprotein convertase 2 0.491 0.6306 0.6306
Schistosoma mansoni glutamate receptor AMPA 0.0035 0.0012 0.0012
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0043 0.0022 0.0262
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.0082 0.0073 0.0073
Echinococcus granulosus rhodopsin orphan GPCR 0.0046 0.0027 0.0027
Echinococcus granulosus g protein coupled receptor 0.0046 0.0027 0.0027
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0046 0.0027 0.0034
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.4751 0.61 1
Mycobacterium tuberculosis Probable polyketide synthase Pks8 0.0066 0.0053 0.04
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0046 0.0027 0.0027
Loa Loa (eye worm) hypothetical protein 0.0046 0.0027 0.0027
Trichomonas vaginalis conserved hypothetical protein 0.1537 0.1951 0.3192
Giardia lamblia Tenascin-37 0.0162 0.0176 0.0423
Echinococcus multilocularis tyrosine protein kinase Srms 0.0037 0.0015 0.0018
Echinococcus granulosus proprotein convertase subtilisin:kexin type 5 0.4751 0.61 0.61
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.067 0.0832 0.1356
Schistosoma mansoni btb and poz domain-containing protein 0.0032 0.0008 0.0008
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0158 0.017 0.017
Schistosoma mansoni glutamate receptor NMDA 0.0058 0.0042 0.0042
Loa Loa (eye worm) hypothetical protein 0.0046 0.0027 0.0027
Plasmodium vivax lysine-specific histone demethylase 1, putative 0.0103 0.01 0.1504
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0099 0.0095 0.0146
Loa Loa (eye worm) hypothetical protein 0.0046 0.0027 0.0027
Schistosoma mansoni chromatin regulatory protein sir2 0.0099 0.0095 0.0095
Loa Loa (eye worm) sirtuin 4 0.0099 0.0095 0.0095
Loa Loa (eye worm) metabotropic GABA-B receptor subtype 2 0.0033 0.001 0.001
Onchocerca volvulus 0.0551 0.0678 0.2535
Loa Loa (eye worm) hypothetical protein 0.0046 0.0027 0.0027
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0001 0.0001
Trypanosoma cruzi Silent information regulator 2 related protein 1 0.067 0.0832 1
Plasmodium falciparum plasmepsin IX 0.0035 0.0012 0.0093

Activities

Activity type Activity value Assay description Source Reference
EC50 (binding) Binding affinity to beta3 adrenoceptor ChEMBL. 19492813
IC50 (binding) = 0.068 uM Binding affinity to human parathyroid calcium receptor 1 expressed in HEK293 4.0-7 cells by radioligand binding assay ChEMBL. 19492813
IC50 (binding) = 0.3 uM Binding affinity to beta2 adrenoceptor ChEMBL. 19492813

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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