Detailed information for compound 990695

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 241.284 | Formula: C12H19NO4
  • H donors: 3 H acceptors: 4 LogP: -0.81 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC(=O)[C@H]([C@@H]1[C@H]([C@@H]1C1CCCCC1)C(=O)O)N
  • InChi: 1S/C12H19NO4/c13-10(12(16)17)8-7(9(8)11(14)15)6-4-2-1-3-5-6/h6-10H,1-5,13H2,(H,14,15)(H,16,17)/t7-,8+,9+,10+/m1/s1
  • InChiKey: PKIAMLDRUKFNIH-KATARQTJSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni cell polarity protein 0.0133 0.0686 0.1541
Loa Loa (eye worm) hypothetical protein 0.0039 0.0148 0.0199
Onchocerca volvulus 0.0016 0.0017 0.0067
Echinococcus granulosus Protein kinase C brain isozyme 0.0021 0.0044 0.0054
Schistosoma mansoni hypothetical protein 0.0133 0.0686 0.1541
Schistosoma mansoni patched 1 0.0048 0.0202 0.0446
Onchocerca volvulus 0.0039 0.0148 0.0754
Schistosoma mansoni cercarial elastase (S01 family) 0.0064 0.0292 0.0652
Echinococcus granulosus mitogen activated protein kinase 11 0.1324 0.7469 1
Brugia malayi Niemann-Pick C1 protein precursor 0.0113 0.0568 0.0756
Echinococcus granulosus unc 13 munc13 0.0016 0.0017 0.0017
Echinococcus multilocularis g protein coupled receptor 0.0039 0.0148 0.0144
Schistosoma mansoni hypothetical protein 0.0016 0.0017 0.0029
Echinococcus granulosus microtubule associated protein 2 0.079 0.443 0.5929
Echinococcus multilocularis rhodopsin orphan GPCR 0.0039 0.0148 0.0144
Onchocerca volvulus 0.0064 0.0292 0.1506
Brugia malayi GCC2 and GCC3 family protein 0.0133 0.0686 0.0914
Schistosoma mansoni notch 0.0133 0.0686 0.1541
Brugia malayi jmjC domain containing protein 0.0034 0.0122 0.0158
Echinococcus granulosus 7TM GPCR rhodopsin 0.0039 0.0148 0.0193
Plasmodium vivax stearoyl-CoA desaturase (acyl-CoA desaturase, faty acid desaturase), putative 0.0101 0.05 1
Schistosoma mansoni hypothetical protein 0.0039 0.0148 0.0326
Onchocerca volvulus 0.0015 0.0012 0.0043
Trypanosoma cruzi fatty acid desaturase, putative 0.011 0.0551 0.0722
Brugia malayi Cadherin domain containing protein 0.0133 0.0686 0.0914
Schistosoma mansoni hypothetical protein 0.0047 0.0192 0.0424
Echinococcus granulosus survival motor neuron protein 1 0.0271 0.1469 0.1963
Onchocerca volvulus 0.0108 0.054 0.2801
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0196 0.0433
Echinococcus granulosus neurogenic locus notch protein 0.0133 0.0686 0.0914
Toxoplasma gondii PHD-finger domain-containing protein 0.0028 0.0088 0.0457
Echinococcus granulosus rhodopsin orphan GPCR 0.0039 0.0148 0.0193
Trichomonas vaginalis modulator of drug activity B, putative 0.0119 0.0603 0.2287
Loa Loa (eye worm) hypothetical protein 0.0133 0.0686 0.0919
Echinococcus granulosus neuropeptide FF receptor 2 0.0039 0.0148 0.0193
Echinococcus multilocularis raf serine:threonine protein kinase 0.0458 0.2535 0.2532
Schistosoma mansoni hypothetical protein 0.0047 0.0192 0.0424
Echinococcus granulosus expressed conserved protein 0.0106 0.0529 0.0704
Onchocerca volvulus Neuropeptide F receptor homolog 0.0039 0.0148 0.0754
Echinococcus granulosus g protein coupled receptor 0.0039 0.0148 0.0193
Toxoplasma gondii target of rapamycin (TOR), putative 0.0021 0.0044 0.0229
Loa Loa (eye worm) hypothetical protein 0.0029 0.0092 0.0123
Schistosoma mansoni hypothetical protein 0.0047 0.0192 0.0424
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0021 0.0044 0.004
Trichomonas vaginalis conserved hypothetical protein 0.0475 0.2635 1
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0015 0.0012 0.0064
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0015 0.0012 0.0546
Echinococcus granulosus peptide allatostatin:somatostatin 0.0039 0.0148 0.0193
Trichomonas vaginalis conserved hypothetical protein 0.0119 0.0603 0.2287
Onchocerca volvulus 0.0015 0.0012 0.0043
Brugia malayi Dopamine receptor protein 2 0.0039 0.0148 0.0193
Onchocerca volvulus 0.0133 0.0686 0.3563
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0039 0.0148 0.0326
Giardia lamblia NADPH oxidoreductase, putative 0.0475 0.2635 1
Brugia malayi AMP-binding enzyme family protein 0.0052 0.022 0.029
Echinococcus granulosus dro:myosuppressin receptor 0.0039 0.0148 0.0193
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0048 0.0202 0.027
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0039 0.0148 0.0144
Loa Loa (eye worm) hypothetical protein 0.002 0.0039 0.0052
Loa Loa (eye worm) hypothetical protein 0.0039 0.0146 0.0195
Entamoeba histolytica hypothetical protein 0.0041 0.0161 0.2513
Loa Loa (eye worm) hypothetical protein 0.0039 0.0148 0.0199
Schistosoma mansoni hypothetical protein 0.0133 0.0686 0.1541
Schistosoma mansoni cercarial elastase (S01 family) 0.0064 0.0292 0.0652
Schistosoma mansoni serine/threonine protein kinase 0.0021 0.0044 0.0091
Onchocerca volvulus Alhambra homolog 0.0028 0.0088 0.0437
Onchocerca volvulus 0.0016 0.0017 0.0067
Brugia malayi Trypsin family protein 0.0064 0.0292 0.0386
Echinococcus granulosus slit 2 protein 0.0133 0.0686 0.0914
Echinococcus multilocularis rhodopsin orphan GPCR 0.0039 0.0148 0.0144
Loa Loa (eye worm) hypothetical protein 0.0039 0.0148 0.0199
Echinococcus multilocularis notch 0.0133 0.0686 0.0682
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0039 0.0148 0.0193
Echinococcus multilocularis neuropeptide receptor A26 0.0039 0.0148 0.0144
Brugia malayi GnHR receptor homolog 0.0039 0.0148 0.0193
Loa Loa (eye worm) RasGEF domain-containing protein 0.0016 0.0017 0.0023
Echinococcus multilocularis neurogenic locus notch protein 0.0133 0.0686 0.0682
Brugia malayi hypothetical protein 0.0039 0.0148 0.0193
Trichomonas vaginalis modulator of drug activity B, putative 0.0119 0.0603 0.2287
Schistosoma mansoni hypothetical protein 0.0133 0.0686 0.1541
Loa Loa (eye worm) neuropeptide F receptor 0.0039 0.0148 0.0199
Schistosoma mansoni notch 0.0133 0.0686 0.1541
Brugia malayi Muscle positioning protein 4 0.0133 0.0686 0.0914
Loa Loa (eye worm) hypothetical protein 0.0039 0.0146 0.0195
Echinococcus multilocularis neural cadherin 0.0133 0.0686 0.0682
Loa Loa (eye worm) Ras association domain family 1 isoform A 0.0016 0.0017 0.0023
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0029 0.0092 0.0478
Echinococcus granulosus C2 calcium dependent membrane targeting 0.0016 0.0017 0.0017
Schistosoma mansoni biogenic amine (5HT) receptor 0.0039 0.0148 0.0326
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0021 0.0044 0.009
Trypanosoma brucei fatty acid desaturase, putative 0.011 0.0551 0.0737
Brugia malayi protein kinase C II. 0.0021 0.0044 0.0054
Schistosoma mansoni acetyl-CoA synthetase 0.0015 0.0012 0.0019
Schistosoma mansoni serine/threonine protein kinase 0.0021 0.0044 0.0091
Echinococcus multilocularis neuropeptide FF receptor 2 0.0039 0.0148 0.0144
Trichomonas vaginalis NAD(P)H dehydrogenase, putative 0.0119 0.0603 0.2287
Loa Loa (eye worm) hypothetical protein 0.0016 0.0017 0.0023
Schistosoma mansoni cercarial elastase (S01 family) 0.0064 0.0292 0.0652
Trichomonas vaginalis FMN-dependent NADH-azoreductase, putative 0.0119 0.0603 0.2287
Loa Loa (eye worm) jmjC domain-containing protein 0.0059 0.026 0.0348
Echinococcus multilocularis neuropeptide Y receptor 0.0039 0.0148 0.0144
Brugia malayi jmjC domain containing protein 0.0093 0.0456 0.0606
Loa Loa (eye worm) TYRA-2 protein 0.0039 0.0148 0.0199
Brugia malayi neuropeptide F receptor 0.0039 0.0148 0.0193
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0047 0.0196 0.0256
Brugia malayi hypothetical protein 0.0039 0.0148 0.0193
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0064 0.0292 0.0652
Echinococcus multilocularis rhodopsin orphan GPCR 0.0039 0.0148 0.0144
Schistosoma mansoni hypothetical protein 0.0039 0.0148 0.0326
Entamoeba histolytica acyl-coA synthetase, putative 0.0052 0.022 0.3525
Loa Loa (eye worm) hypothetical protein 0.0113 0.0568 0.0761
Schistosoma mansoni cercarial elastase (S01 family) 0.0064 0.0292 0.0652
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0041 0.0161 0.021
Brugia malayi hypothetical protein 0.0039 0.0148 0.0193
Trichomonas vaginalis modulator of drug activity B, putative 0.0119 0.0603 0.2287
Echinococcus multilocularis g protein coupled receptor 0.0039 0.0148 0.0144
Brugia malayi EGF-like domain containing protein 0.0133 0.0686 0.0914
Loa Loa (eye worm) hypothetical protein 0.0039 0.0148 0.0199
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0052 0.022 0.7427
Echinococcus multilocularis laminin 0.035 0.1919 0.1915
Echinococcus multilocularis metabotropic glutamate receptor 5 0.015 0.0783 0.078
Trichomonas vaginalis conserved hypothetical protein 0.0475 0.2635 1
Echinococcus multilocularis metabotropic glutamate receptor 2 0.0102 0.0509 0.0506
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0039 0.0148 0.0326
Loa Loa (eye worm) hypothetical protein 0.0133 0.0686 0.0919
Schistosoma mansoni hypothetical protein 0.002 0.0039 0.0079
Brugia malayi EGF-like domain containing protein 0.0133 0.0686 0.0914
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0039 0.0148 0.0144
Echinococcus granulosus mitogen activated protein kinase 14 0.1324 0.7469 1
Echinococcus granulosus Niemann Pick C1 protein 0.0161 0.0844 0.1125
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family 0.0064 0.0292 0.0386
Echinococcus multilocularis protein kinase c iota type 0.0021 0.0044 0.004
Echinococcus multilocularis jumonji domain containing protein 0.004 0.0151 0.0147
Onchocerca volvulus 0.0133 0.0686 0.3563
Echinococcus multilocularis neurogenic locus protein delta 0.0133 0.0686 0.0682
Loa Loa (eye worm) hypothetical protein 0.0133 0.0686 0.0919
Mycobacterium ulcerans hypothetical protein 0.0052 0.022 0.7427
Loa Loa (eye worm) hypothetical protein 0.0015 0.0012 0.0016
Schistosoma mansoni septate junction protein 0.0133 0.0686 0.1541
Onchocerca volvulus 0.0064 0.0292 0.1506
Schistosoma mansoni biogenic amine receptor 0.0039 0.0148 0.0326
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0021 0.0044 0.0043
Brugia malayi follicle stimulating hormone receptor 0.0303 0.165 0.2205
Onchocerca volvulus 0.0039 0.0148 0.0754
Entamoeba histolytica hypothetical protein 0.0016 0.0017 0.0077
Echinococcus granulosus rhodopsin orphan GPCR 0.0039 0.0148 0.0193
Plasmodium vivax SET domain protein, putative 0.0029 0.0092 0.1626
Entamoeba histolytica hypothetical protein 0.0041 0.0161 0.2513
Trichomonas vaginalis set domain proteins, putative 0.0231 0.1241 0.4712
Loa Loa (eye worm) bone morphogenetic protein 1b 0.035 0.1919 0.2569
Loa Loa (eye worm) hypothetical protein 0.035 0.1919 0.2569
Schistosoma mansoni diacylglycerol kinase theta 0.0016 0.0017 0.0029
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0052 0.022 1
Loa Loa (eye worm) multiple epidermal growth factor-like domains 6 0.035 0.1919 0.2569
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0044 0.0167
Echinococcus granulosus protein jagged 2 0.0133 0.0686 0.0914
Echinococcus multilocularis expressed conserved protein 0.0106 0.0529 0.0526
Loa Loa (eye worm) hypothetical protein 0.0039 0.0148 0.0199
Trichomonas vaginalis conserved hypothetical protein 0.0119 0.0603 0.2287
Schistosoma mansoni adenoreceptor 0.0039 0.0148 0.0326
Onchocerca volvulus 0.0064 0.0292 0.1506
Loa Loa (eye worm) hypothetical protein 0.0039 0.0148 0.0199
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0037 0.0134 0.6071
Loa Loa (eye worm) hypothetical protein 0.0039 0.0148 0.0199
Trichomonas vaginalis NAD(P)H dehydrogenase, putative 0.0475 0.2635 1
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0028 0.0088 0.0118
Leishmania major 4-coumarate:coa ligase-like protein 0.0052 0.022 0.0279
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0088 0.0334
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0064 0.0292 0.0652
Schistosoma mansoni hypothetical protein 0.0064 0.0292 0.0652
Schistosoma mansoni hypothetical protein 0.0133 0.0686 0.1541
Brugia malayi metabotropic GABA-B receptor subtype 2 0.002 0.0039 0.0047
Brugia malayi AMP-binding enzyme family protein 0.0015 0.0012 0.0011
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0039 0.0148 0.0144
Loa Loa (eye worm) hypothetical protein 0.0039 0.0148 0.0199
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0039 0.0148 0.0326
Echinococcus granulosus g protein coupled receptor 0.0039 0.0148 0.0193
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0039 0.0148 0.0326
Onchocerca volvulus 0.0039 0.0148 0.0754
Onchocerca volvulus 0.011 0.0551 0.2856
Trichomonas vaginalis modulator of drug activity B, putative 0.0119 0.0603 0.2287
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0064 0.0292 0.0652
Loa Loa (eye worm) hypothetical protein 0.0133 0.0686 0.0919
Entamoeba histolytica hypothetical protein 0.0028 0.0088 0.1282
Brugia malayi larval opioid receptor 0.0039 0.0148 0.0193
Loa Loa (eye worm) jmjC domain-containing protein 0.0034 0.0122 0.0163
Trichomonas vaginalis NAD(P)H dehydrogenase, putative 0.0475 0.2635 1
Loa Loa (eye worm) hypothetical protein 0.0039 0.0146 0.0195
Schistosoma mansoni rac gtpase activating protein 0.0016 0.0017 0.0029
Loa Loa (eye worm) hypothetical protein 0.0016 0.0017 0.0023
Echinococcus granulosus metabotropic glutamate receptor 2 0.0102 0.0509 0.0677
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0055 0.0241 0.0317
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0044 0.0167
Echinococcus granulosus serine protein kinase ATM 0.0028 0.0088 0.0112
Brugia malayi AMP-binding enzyme family protein 0.0015 0.0012 0.0011
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0021 0.0044 0.0053
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0021 0.0044 0.0059
Trichomonas vaginalis modulator of drug activity B, putative 0.0119 0.0603 0.2287
Loa Loa (eye worm) hypothetical protein 0.0039 0.0148 0.0199
Echinococcus granulosus enteropeptidase 0.0064 0.0292 0.0386
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0016 0.0017 0.0023
Brugia malayi Raf kinase 0.0442 0.2444 0.3269
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.0016 0.0017 0.0013
Loa Loa (eye worm) hypothetical protein 0.0039 0.0148 0.0199
Loa Loa (eye worm) hypothetical protein 0.0016 0.0017 0.0023
Onchocerca volvulus Neurogenic locus notch protein homolog 0.0133 0.0686 0.3563
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0039 0.0148 0.0144
Echinococcus multilocularis enteropeptidase 0.0064 0.0292 0.0288
Echinococcus granulosus fmrfamide receptor 0.0039 0.0148 0.0193
Loa Loa (eye worm) metabotropic GABA-B receptor subtype 2 0.0031 0.0104 0.014
Echinococcus granulosus neuropeptide receptor A26 0.0039 0.0148 0.0193
Brugia malayi Cadherin domain containing protein 0.0133 0.0686 0.0914
Loa Loa (eye worm) hypothetical protein 0.0064 0.0292 0.0392
Echinococcus granulosus Peptidase S1 S6 chymotrypsin Hap 0.0064 0.0292 0.0386
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0044 0.0167
Loa Loa (eye worm) hypothetical protein 0.0016 0.0017 0.0023
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0039 0.0148 0.0144
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0028 0.0088 0.0189
Onchocerca volvulus 0.0029 0.0092 0.0457
Schistosoma mansoni serine/threonine protein kinase 0.0021 0.0044 0.0091
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.0133 0.0686 0.0914
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0037 0.0134 0.6071
Brugia malayi Dopamine receptor protein 1 0.0039 0.0148 0.0193
Echinococcus multilocularis Niemann Pick C1 protein 0.0113 0.0568 0.0565
Loa Loa (eye worm) hypothetical protein 0.035 0.1919 0.2569
Onchocerca volvulus 0.0039 0.0148 0.0754
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0015 0.0012 0.0011
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0044 0.0167
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0029 0.0092 0.0198
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0303 0.165 0.2209
Trichomonas vaginalis conserved hypothetical protein 0.0475 0.2635 1
Brugia malayi Protein kinase c protein 2 0.0021 0.0044 0.0054
Trichomonas vaginalis modulator of drug activity B, putative 0.0119 0.0603 0.2287
Onchocerca volvulus 0.0039 0.0148 0.0754
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0039 0.0148 0.0144
Brugia malayi AMP-binding enzyme family protein 0.0015 0.0012 0.0011
Toxoplasma gondii calcium binding egf domain-containing protein 0.035 0.1919 1
Toxoplasma gondii EGF family domain-containing protein 0.0133 0.0686 0.3576
Schistosoma mansoni myosin xvIII 0.0039 0.0148 0.0326
Mycobacterium ulcerans hypothetical protein 0.0064 0.0292 1
Loa Loa (eye worm) RGC/RGC protein kinase 0.0014 0.0004 0.0005
Schistosoma mansoni amine GPCR 0.0039 0.0148 0.0326
Echinococcus multilocularis fmrfamide receptor 0.0039 0.0148 0.0144
Schistosoma mansoni hypothetical protein 0.0041 0.0161 0.0354
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0039 0.0148 0.0193
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0039 0.0148 0.0193
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0039 0.0148 0.0326
Schistosoma mansoni amine GPCR 0.0039 0.0148 0.0326
Loa Loa (eye worm) trypsin family protein 0.0064 0.0292 0.0392
Echinococcus multilocularis dro:myosuppressin receptor 0.0039 0.0148 0.0144
Loa Loa (eye worm) hypothetical protein 0.0039 0.0148 0.0199
Echinococcus multilocularis myotubularin protein 13 0.0016 0.0017 0.0013
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0044 0.0167
Schistosoma mansoni neuropeptide receptor 0.0039 0.0148 0.0326
Leishmania major 4-coumarate:coa ligase-like protein 0.0052 0.022 0.0279
Onchocerca volvulus 0.0039 0.0148 0.0754
Echinococcus multilocularis serine protein kinase ATM 0.0028 0.0088 0.0084
Brugia malayi metabotropic glutamate receptor subtype 5a (mGluR5a), putative 0.0111 0.0557 0.0741
Echinococcus granulosus sex peptide receptor 0.0039 0.0148 0.0193
Toxoplasma gondii propionate-CoA ligase 0.0015 0.0012 0.0064
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0064 0.0292 0.0652
Loa Loa (eye worm) hypothetical protein 0.0133 0.0686 0.0919
Brugia malayi Serotonin receptor 0.0039 0.0148 0.0193
Trichomonas vaginalis modulator of drug activity B, putative 0.0119 0.0603 0.2287
Echinococcus granulosus neurogenic locus protein delta 0.0133 0.0686 0.0914
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0021 0.0044 0.0042
Onchocerca volvulus 0.0039 0.0148 0.0754
Echinococcus granulosus protein jagged 1 0.0133 0.0686 0.0914
Loa Loa (eye worm) AGC/PKC/IOTA protein kinase 0.0021 0.0044 0.0059
Loa Loa (eye worm) hypothetical protein 0.0133 0.0686 0.0919
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0015 0.0012 0.0016
Brugia malayi Calcium binding EGF domain containing protein 0.0133 0.0686 0.0914
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0015 0.0012 0.0011
Echinococcus multilocularis fat cadherin tumor suppressor 0.0133 0.0686 0.0682
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0015 0.0012 0.0546
Loa Loa (eye worm) hypothetical protein 0.0133 0.0686 0.0919
Echinococcus granulosus myotubularin protein 13 0.0016 0.0017 0.0017
Echinococcus granulosus orexin receptor type 2 0.0039 0.0148 0.0193
Echinococcus multilocularis Rac GTPase activating protein 1 0.0016 0.0017 0.0013
Schistosoma mansoni metabotropic glutamate receptor 0.006 0.0265 0.059
Schistosoma mansoni jumonji domain containing protein 0.0074 0.0347 0.0775
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0093 0.0456 0.0606
Loa Loa (eye worm) hypothetical protein 0.0039 0.0146 0.0195
Loa Loa (eye worm) hypothetical protein 0.0133 0.0686 0.0919
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0039 0.0148 0.0144
Brugia malayi EGF-like domain containing protein 0.0133 0.0686 0.0914
Loa Loa (eye worm) hypothetical protein 0.0039 0.0148 0.0199
Schistosoma mansoni serine/threonine protein kinase 0.0021 0.0044 0.0091
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0021 0.0044 0.0535
Schistosoma mansoni opsin-like receptor 0.0039 0.0148 0.0326
Loa Loa (eye worm) hypothetical protein 0.0031 0.0104 0.014
Brugia malayi Trypsin family protein 0.0064 0.0292 0.0386
Loa Loa (eye worm) phosphatidylinositol 3 0.0021 0.0044 0.0059
Schistosoma mansoni cercarial elastase (S01 family) 0.0064 0.0292 0.0652
Echinococcus granulosus g-protein coupled receptor 0.0039 0.0148 0.0193
Loa Loa (eye worm) hypothetical protein 0.0133 0.0686 0.0919
Schistosoma mansoni hypothetical protein 0.0133 0.0686 0.1541
Loa Loa (eye worm) hypothetical protein 0.0039 0.0148 0.0199
Onchocerca volvulus 0.0052 0.022 0.113
Brugia malayi RE15519p 0.0039 0.0148 0.0193
Brugia malayi Phorbol esters/diacylglycerol binding domain 0.0021 0.0044 0.0054
Schistosoma mansoni cercarial elastase (S01 family) 0.0064 0.0292 0.0652
Echinococcus granulosus neurogenic locus notch protein 0.0133 0.0686 0.0914
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0039 0.0148 0.0144
Plasmodium vivax hypothetical protein, conserved 0.0028 0.0088 0.1546
Brugia malayi Pleckstrin Homology Domain 0.0016 0.0017 0.0017
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0039 0.0148 0.0326
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0044 0.0167
Echinococcus multilocularis rhodopsin orphan GPCR 0.0039 0.0148 0.0144
Schistosoma mansoni notch 0.0133 0.0686 0.1541
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0044 0.0167
Schistosoma mansoni cercarial elastase (S01 family) 0.0064 0.0292 0.0652
Loa Loa (eye worm) oxidoreductase 0.0015 0.0012 0.0016
Echinococcus granulosus laminin 0.035 0.1919 0.2565
Echinococcus multilocularis somatostatin receptor 0.0039 0.0148 0.0144
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) 0.0064 0.0292 0.0288
Loa Loa (eye worm) hypothetical protein 0.0064 0.0292 0.0392
Schistosoma mansoni hypothetical protein 0.0055 0.0241 0.0535
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0021 0.0044 0.0059
Schistosoma mansoni hypothetical protein 0.0039 0.0148 0.0326
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0044 0.0167
Brugia malayi Calcium binding EGF domain containing protein 0.0133 0.0686 0.0914
Echinococcus multilocularis neurogenic locus notch protein 0.0133 0.0686 0.0682
Echinococcus granulosus rhodopsin orphan GPCR 0.0039 0.0148 0.0193
Echinococcus granulosus protein kinase c iota type 0.0021 0.0044 0.0054
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.0016 0.0017 0.0017
Trichomonas vaginalis modulator of drug activity B, putative 0.0119 0.0603 0.2287
Brugia malayi hypothetical protein 0.0039 0.0148 0.0193
Loa Loa (eye worm) phosphatidylinositol 3 0.0021 0.0044 0.0059
Schistosoma mansoni jumonji/arid domain-containing protein 0.0034 0.0122 0.0266
Echinococcus granulosus rhodopsin orphan GPCR 0.0039 0.0148 0.0193
Loa Loa (eye worm) hypothetical protein 0.0039 0.0148 0.0199
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0039 0.0148 0.0326
Echinococcus multilocularis survival motor neuron protein 1 0.0271 0.1469 0.1466
Loa Loa (eye worm) hypothetical protein 0.0039 0.0148 0.0199
Echinococcus granulosus neural cadherin 0.0133 0.0686 0.0914
Plasmodium vivax acyl-CoA synthetase, putative 0.0039 0.0146 0.2738
Loa Loa (eye worm) hypothetical protein 0.035 0.1919 0.2569
Onchocerca volvulus 0.0039 0.0148 0.0754
Onchocerca volvulus 0.0133 0.0686 0.3563
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0039 0.0148 0.0326
Loa Loa (eye worm) hypothetical protein 0.0039 0.0148 0.0199
Schistosoma mansoni hypothetical protein 0.0047 0.0192 0.0424
Onchocerca volvulus 0.0133 0.0686 0.3563
Leishmania major stearic acid desaturase, putative 0.011 0.0551 0.0722
Echinococcus multilocularis neuropeptide s receptor 0.0039 0.0148 0.0144
Brugia malayi PHD-finger family protein 0.0028 0.0088 0.0112
Schistosoma mansoni protein kinase C mu 0.0016 0.0017 0.0029
Echinococcus granulosus protein kinase c eta type 0.0016 0.0017 0.0017
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.1324 0.7469 1
Giardia lamblia PHD finger protein 15 0.0028 0.0088 0.0169
Echinococcus granulosus jumonji domain containing protein 0.004 0.0151 0.0197
Leishmania major phosphatidylinositol kinase related protein, putative 0.0021 0.0044 0.0043
Echinococcus granulosus Tolloid protein 1 0.035 0.1919 0.2565
Loa Loa (eye worm) hypothetical protein 0.0108 0.054 0.0723
Loa Loa (eye worm) hypothetical protein 0.0133 0.0686 0.0919
Loa Loa (eye worm) CMGC/MAPK/P38 protein kinase 0.1324 0.7469 1
Loa Loa (eye worm) hypothetical protein 0.0133 0.0686 0.0919
Loa Loa (eye worm) hypothetical protein 0.0016 0.0017 0.0023
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0044 0.0167
Echinococcus multilocularis protein dispatched 1 0.0055 0.0241 0.0237
Loa Loa (eye worm) TKL/RAF/RAF protein kinase 0.026 0.1405 0.1881
Echinococcus multilocularis protein jagged 1 0.0133 0.0686 0.0682
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0064 0.0292 0.0652
Echinococcus multilocularis rhodopsin orphan GPCR 0.0039 0.0148 0.0144
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0092 0.0198
Schistosoma mansoni cercarial elastase (S01 family) 0.0064 0.0292 0.0652
Trichomonas vaginalis conserved hypothetical protein 0.0475 0.2635 1
Brugia malayi sulfakinin receptor protein 0.0039 0.0148 0.0193
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0021 0.0044 0.0059
Loa Loa (eye worm) hypothetical protein 0.0133 0.0686 0.0919
Loa Loa (eye worm) hypothetical protein 0.015 0.0783 0.1049
Loa Loa (eye worm) hypothetical protein 0.0039 0.0148 0.0199
Brugia malayi hypothetical protein 0.0039 0.0148 0.0193
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0039 0.0146 0.5
Loa Loa (eye worm) hypothetical protein 0.0059 0.0264 0.0353
Plasmodium falciparum acyl-CoA synthetase 0.0039 0.0146 0.2738
Loa Loa (eye worm) hypothetical protein 0.0039 0.0148 0.0199
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0015 0.0012 0.0546
Loa Loa (eye worm) hypothetical protein 0.0015 0.0012 0.0016
Loa Loa (eye worm) hypothetical protein 0.0039 0.0148 0.0199
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0028 0.0088 0.0112
Loa Loa (eye worm) hypothetical protein 0.0016 0.0017 0.0023
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0039 0.0148 0.0326
Trichomonas vaginalis modulator of drug activity B, putative 0.0119 0.0603 0.2287
Echinococcus granulosus protein kinase c epsilon type 0.0021 0.0044 0.0054
Echinococcus multilocularis mitogen activated protein kinase 14 0.1324 0.7469 0.7468
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0021 0.0044 0.009
Brugia malayi hypothetical protein 0.0064 0.0292 0.0386
Brugia malayi EGF-like domain containing protein 0.0133 0.0686 0.0914
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0015 0.0012 0.0008
Loa Loa (eye worm) hypothetical protein 0.0133 0.0686 0.0919
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0044 0.0167
Loa Loa (eye worm) notch protein 0.0133 0.0686 0.0919
Onchocerca volvulus 0.0133 0.0686 0.3563
Brugia malayi EGF-like domain containing protein 0.0133 0.0686 0.0914
Schistosoma mansoni vav2 0.0016 0.0017 0.0029
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0015 0.0012 0.0546
Brugia malayi acyl-CoA desaturase 0.0101 0.05 0.0665
Onchocerca volvulus 0.0055 0.0241 0.1236
Onchocerca volvulus 0.0039 0.0148 0.0754
Echinococcus multilocularis neuropeptide Y receptor 0.0039 0.0148 0.0144
Schistosoma mansoni cercarial elastase (S01 family) 0.0064 0.0292 0.0652
Giardia lamblia NADPH oxidoreductase, putative 0.0475 0.2635 1
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0039 0.0148 0.0193
Loa Loa (eye worm) glutamate receptor 0.0122 0.0622 0.0833
Brugia malayi G protein-coupled receptor F59B2.13 0.0039 0.0148 0.0193
Loa Loa (eye worm) hypothetical protein 0.0039 0.0148 0.0199
Brugia malayi G-protein coupled receptor 0.0039 0.0148 0.0193
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0015 0.0012 0.0016
Echinococcus granulosus hypothetical protein 0.0039 0.0148 0.0193
Loa Loa (eye worm) raf kinase 0.0456 0.2522 0.3377
Loa Loa (eye worm) hypothetical protein 0.0271 0.1469 0.1967
Loa Loa (eye worm) hypothetical protein 0.0133 0.0686 0.0919
Leishmania major phosphatidylinositol 3-kinase, putative 0.0021 0.0044 0.0042
Schistosoma mansoni alpha-1 adrenergic receptor 0.0039 0.0148 0.0326
Brugia malayi putative neuropeptide receptor NPR1 0.0039 0.0148 0.0193
Schistosoma mansoni serine/threonine protein kinase 0.0021 0.0044 0.0091
Schistosoma mansoni opsin-like receptor 0.0039 0.0148 0.0326
Echinococcus granulosus G protein coupled receptor 139 0.0039 0.0148 0.0193
Loa Loa (eye worm) hypothetical protein 0.0028 0.0088 0.0117
Brugia malayi ORL1-like opioid receptor 0.0039 0.0148 0.0193
Schistosoma mansoni protein kinase C mu 0.0021 0.0044 0.0091
Echinococcus multilocularis fibrillin 1 0.035 0.1919 0.1915
Brugia malayi Pre-SET motif family protein 0.0203 0.1082 0.1444
Plasmodium falciparum phd finger protein, putative 0.0028 0.0088 0.1546
Brugia malayi P38 map kinase family protein 2 0.1324 0.7469 1
Echinococcus granulosus Rac GTPase activating protein 1 0.0016 0.0017 0.0017
Loa Loa (eye worm) hypothetical protein 0.0039 0.0148 0.0199
Mycobacterium ulcerans acyl-CoA synthetase 0.0052 0.022 0.7427
Loa Loa (eye worm) hypothetical protein 0.0016 0.0017 0.0023
Echinococcus granulosus rhodopsin orphan GPCR 0.0039 0.0148 0.0193
Onchocerca volvulus Arrow homolog 0.035 0.1919 1
Brugia malayi Metabotropic glutamate receptor precursor. 0.0122 0.0622 0.0828
Loa Loa (eye worm) hypothetical protein 0.0052 0.022 0.0295
Schistosoma mansoni cellular tumor antigen P53 0.0108 0.054 0.1211
Loa Loa (eye worm) hypothetical protein 0.0039 0.0148 0.0199
Leishmania major fatty-acid desaturase, putative 0.011 0.0551 0.0722
Loa Loa (eye worm) hypothetical protein 0.0016 0.0017 0.0023
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0029 0.0092 0.0088
Onchocerca volvulus 0.0039 0.0148 0.0754
Trypanosoma cruzi fatty acid desaturase, putative 0.0101 0.05 0.0654
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0044 0.0167
Brugia malayi AMP-binding enzyme family protein 0.0052 0.022 0.029
Loa Loa (eye worm) hypothetical protein 0.0039 0.0148 0.0199
Loa Loa (eye worm) hypothetical protein 0.0039 0.0148 0.0199
Entamoeba histolytica hypothetical protein 0.0119 0.0603 1
Onchocerca volvulus 0.0064 0.0292 0.1506
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0092 0.0198
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0021 0.0044 0.0053
Brugia malayi Pre-SET motif family protein 0.0029 0.0092 0.0117
Echinococcus granulosus protein jagged 2 0.0133 0.0686 0.0914
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0052 0.022 1
Schistosoma mansoni jumonji/arid domain-containing protein 0.0034 0.0122 0.0266
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0044 0.0167
Loa Loa (eye worm) acyl-CoA desaturase 0.0101 0.05 0.067
Loa Loa (eye worm) hypothetical protein 0.0133 0.0686 0.0919
Brugia malayi Chymotrypsin-like protease CTRL-1 precursor 0.0064 0.0292 0.0386
Trichomonas vaginalis conserved hypothetical protein 0.0119 0.0603 0.2287
Echinococcus multilocularis sex peptide receptor 0.0039 0.0148 0.0144
Brugia malayi Receptor family ligand binding region containing protein 0.0031 0.0104 0.0134
Schistosoma mansoni subfamily M12A unassigned peptidase (M12 family) 0.035 0.1919 0.4325
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0039 0.0148 0.0144
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0021 0.0044 0.0042
Loa Loa (eye worm) hypothetical protein 0.0039 0.0148 0.0199
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0039 0.0148 0.0144
Echinococcus multilocularis PHD finger protein rhinoceros 0.0028 0.0088 0.0084
Echinococcus multilocularis tumor protein p63 0.0737 0.4124 0.4121
Trichomonas vaginalis modulator of drug activity B, putative 0.0119 0.0603 0.2287
Trypanosoma cruzi target of rapamycin kinase 3 0.0021 0.0044 0.0042
Loa Loa (eye worm) hypothetical protein 0.0016 0.0017 0.0023
Trichomonas vaginalis modulator of drug activity B, putative 0.0119 0.0603 0.2287
Brugia malayi diacylglycerol kinase 0.0016 0.0017 0.0017
Onchocerca volvulus 0.0039 0.0148 0.0754
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0015 0.0012 0.0016
Loa Loa (eye worm) hypothetical protein 0.0064 0.0292 0.0392
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0052 0.022 1
Trichomonas vaginalis conserved hypothetical protein 0.0475 0.2635 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0044 0.0167
Onchocerca volvulus 0.0231 0.1241 0.6463
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0029 0.0092 0.0088
Trichomonas vaginalis conserved hypothetical protein 0.0475 0.2635 1
Leishmania major mitogen-activated protein kinase 3, putative,map kinase 3, putative 0.1324 0.7469 1
Brugia malayi Tachykinin-like peptides receptor 99D 0.0039 0.0148 0.0193
Entamoeba histolytica iron-sulfur flavoprotein, putative 0.0119 0.0603 1
Entamoeba histolytica hypothetical protein 0.0041 0.0161 0.2513
Trichomonas vaginalis modulator of drug activity B, putative 0.0119 0.0603 0.2287
Onchocerca volvulus Metabotropic glutamate receptor homolog 0.002 0.0039 0.0182
Echinococcus granulosus alpha 1A adrenergic receptor 0.0039 0.0148 0.0193
Echinococcus multilocularis N chimaerin 0.0016 0.0017 0.0013
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0039 0.0148 0.0199
Schistosoma mansoni cercarial elastase (S01 family) 0.0064 0.0292 0.0652
Brugia malayi C1-like domain containing protein 0.0021 0.0044 0.0054
Loa Loa (eye worm) G-protein coupled receptor 0.0039 0.0148 0.0199
Echinococcus granulosus neuropeptide Y receptor 0.0039 0.0148 0.0193
Echinococcus granulosus protein jagged 1 0.0133 0.0686 0.0914
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0044 0.0167
Schistosoma mansoni hypothetical protein 0.0133 0.0686 0.1541
Loa Loa (eye worm) melatonin receptor type 1A 0.0039 0.0148 0.0199
Echinococcus granulosus tm gpcr rhodopsin 0.0039 0.0148 0.0193
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0039 0.0148 0.0193
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0196 0.0192
Entamoeba histolytica acyl-CoA synthetase, putative 0.0052 0.022 0.3525
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0015 0.0012 0.0546
Loa Loa (eye worm) hypothetical protein 0.0039 0.0148 0.0199
Onchocerca volvulus 0.0016 0.0017 0.0067
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0086 0.0109
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0039 0.0148 0.0326
Loa Loa (eye worm) Notch2 0.0133 0.0686 0.0919
Echinococcus multilocularis neuropeptides capa receptor 0.0039 0.0148 0.0144
Mycobacterium ulcerans acyl-CoA synthetase 0.0052 0.022 0.7427
Loa Loa (eye worm) hypothetical protein 0.0039 0.0148 0.0199
Loa Loa (eye worm) hypothetical protein 0.0052 0.022 0.0295
Loa Loa (eye worm) hypothetical protein 0.0039 0.0148 0.0199
Echinococcus multilocularis peregrin 0.0028 0.0088 0.0084
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0196 0.0256
Loa Loa (eye worm) hypothetical protein 0.0052 0.022 0.0295
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0021 0.0044 0.0059
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0039 0.0148 0.0326
Loa Loa (eye worm) RGC/RGC protein kinase 0.0014 0.0004 0.0005
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0039 0.0148 0.0326
Echinococcus multilocularis g protein coupled receptor 0.0039 0.0148 0.0144
Echinococcus granulosus raf serine:threonine protein kinase 0.0458 0.2535 0.339
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0044 0.0167
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0039 0.0148 0.0144
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0016 0.0017 0.0029
Schistosoma mansoni neuropeptide F-like receptor 0.0039 0.0148 0.0326
Brugia malayi hypothetical protein 0.0039 0.0148 0.0193
Toxoplasma gondii FATC domain-containing protein 0.0028 0.0088 0.0458
Echinococcus multilocularis transmembrane protease serine 3 0.0064 0.0292 0.0288
Brugia malayi CHE-14 protein 0.0048 0.0202 0.0265
Trichomonas vaginalis conserved hypothetical protein 0.0475 0.2635 1
Onchocerca volvulus Slit protein homolog 0.0133 0.0686 0.3563
Trypanosoma brucei mitogen-activated protein kinase 3, putative 0.1324 0.7469 1
Echinococcus multilocularis G-protein coupled receptor, putative 0.0039 0.0148 0.0144
Loa Loa (eye worm) hypothetical protein 0.0133 0.0686 0.0919
Schistosoma mansoni unc-13 (munc13) 0.0016 0.0017 0.0029
Echinococcus multilocularis microtubule associated protein 2 0.079 0.443 0.4428
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0039 0.0148 0.0326
Giardia lamblia NADPH oxidoreductase, putative 0.0475 0.2635 1
Loa Loa (eye worm) glutamate receptor 0.0048 0.02 0.0268
Echinococcus multilocularis neuropeptide receptor 0.0039 0.0148 0.0144
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0028 0.0088 0.0101
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0196 0.0256
Schistosoma mansoni neuropeptide f receptor 76f 0.0039 0.0148 0.0326
Schistosoma mansoni biogenic amine (5HT) receptor 0.0039 0.0148 0.0326
Schistosoma mansoni amine GPCR 0.0039 0.0148 0.0326
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0203 0.1082 0.1448
Echinococcus granulosus PHD finger protein rhinoceros 0.0028 0.0088 0.0112
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0052 0.022 0.7427
Schistosoma mansoni hypothetical protein 0.0039 0.0148 0.0326
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0039 0.0148 0.0193
Onchocerca volvulus 0.0064 0.0292 0.1506
Brugia malayi neuropeptide F receptor 0.0039 0.0148 0.0193
Loa Loa (eye worm) hypothetical protein 0.0133 0.0686 0.0919
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0039 0.0148 0.0326
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0021 0.0044 0.0535
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0039 0.0148 0.0326
Trichomonas vaginalis conserved hypothetical protein 0.0119 0.0603 0.2287
Schistosoma mansoni microtubule-associated protein tau 0.079 0.443 1
Onchocerca volvulus 0.0039 0.0148 0.0754
Schistosoma mansoni laminin gamma-3 chain 0.0133 0.0686 0.1541
Loa Loa (eye worm) hypothetical protein 0.0039 0.0148 0.0199
Echinococcus multilocularis protein jagged 2 0.0133 0.0686 0.0682
Loa Loa (eye worm) hypothetical protein 0.0133 0.0686 0.0919
Echinococcus granulosus peregrin 0.0028 0.0088 0.0112
Echinococcus granulosus neuropeptide Y receptor 0.0039 0.0148 0.0193
Loa Loa (eye worm) hypothetical protein 0.0039 0.0148 0.0199
Echinococcus multilocularis Peptidase S1 S6, chymotrypsin Hap 0.0064 0.0292 0.0288
Loa Loa (eye worm) hypothetical protein 0.0039 0.0148 0.0199
Schistosoma mansoni diacylglycerol kinase theta 0.0016 0.0017 0.0029
Echinococcus multilocularis mitogen activated protein kinase 14 0.1324 0.7469 0.7468
Echinococcus granulosus fibropellin Ia 0.0133 0.0686 0.0914
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0039 0.0146 0.4769
Loa Loa (eye worm) hypothetical protein 0.0014 0.0004 0.0005
Trichomonas vaginalis antibiotic synthetase, putative 0.0015 0.0012 0.0047
Mycobacterium ulcerans acyl-CoA synthetase 0.0052 0.022 0.7427
Brugia malayi hypothetical protein 0.0039 0.0148 0.0193
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0041 0.0161 0.0157
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0021 0.0044 0.004
Echinococcus granulosus neuropeptide s receptor 0.0039 0.0148 0.0193
Echinococcus multilocularis Diacylglycerol kinase theta 0.0016 0.0017 0.0013
Loa Loa (eye worm) hypothetical protein 0.0133 0.0686 0.0919
Echinococcus granulosus neuropeptide receptor 0.0039 0.0148 0.0193
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0044 0.0167
Trichomonas vaginalis conserved hypothetical protein 0.0119 0.0603 0.2287
Brugia malayi EGF-like domain containing protein 0.0133 0.0686 0.0914
Trichomonas vaginalis modulator of drug activity B, putative 0.0119 0.0603 0.2287
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0015 0.0012 0.0011
Echinococcus granulosus allatostatin A receptor 0.0039 0.0148 0.0193
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.1324 0.7469 1
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0039 0.0148 0.0326
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0044 0.0167
Echinococcus multilocularis serotonin receptor 0.0039 0.0148 0.0144
Echinococcus granulosus tm gpcr rhodopsin 0.0039 0.0148 0.0193
Trichomonas vaginalis modulator of drug activity B, putative 0.0119 0.0603 0.2287
Loa Loa (eye worm) hypothetical protein 0.0064 0.0292 0.0392
Trichomonas vaginalis conserved hypothetical protein 0.0119 0.0603 0.2287
Trichomonas vaginalis conserved hypothetical protein 0.0475 0.2635 1
Echinococcus multilocularis Tolloid protein 1 0.035 0.1919 0.1915
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0039 0.0148 0.0193
Echinococcus granulosus glycoprotein Antigen 5 0.0064 0.0292 0.0386
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0039 0.0148 0.0144
Loa Loa (eye worm) hypothetical protein 0.0039 0.0148 0.0199
Brugia malayi EGF-like domain containing protein 0.0133 0.0686 0.0914
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0039 0.0148 0.0144
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0039 0.0148 0.0144
Brugia malayi AKH receptor 0.0039 0.0148 0.0193
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0021 0.0044 0.0053
Echinococcus granulosus biogenic amine 5HT receptor 0.0039 0.0148 0.0193
Brugia malayi protein kinase C3,putative 0.0021 0.0044 0.0054
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0044 0.0167
Loa Loa (eye worm) hypothetical protein 0.0048 0.0202 0.027
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0015 0.0012 0.0546
Loa Loa (eye worm) hypothetical protein 0.0039 0.0148 0.0199
Brugia malayi Calcium binding EGF domain containing protein 0.035 0.1919 0.2565
Loa Loa (eye worm) hypothetical protein 0.0049 0.0203 0.0272
Schistosoma mansoni egf-like domain protein 0.035 0.1919 0.4325
Schistosoma mansoni transcription factor LCR-F1 0.0041 0.0161 0.0354
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0039 0.0148 0.0193
Echinococcus multilocularis sterol regulatory element binding protein 0.0048 0.0202 0.0198
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0028 0.0088 0.019
Schistosoma mansoni atypical protein kinase C 0.0021 0.0044 0.0091
Schistosoma mansoni metabotropic glutamate receptor 2 3 (mglur group 2) 0.0139 0.0718 0.1613
Echinococcus granulosus notch 0.0133 0.0686 0.0914
Echinococcus granulosus Mastin 0.0064 0.0292 0.0386
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0021 0.0044 0.0059
Loa Loa (eye worm) hypothetical protein 0.0039 0.0148 0.0199
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0021 0.0044 0.0042
Trichomonas vaginalis conserved hypothetical protein 0.0475 0.2635 1
Echinococcus multilocularis mitogen activated protein kinase 11 0.1324 0.7469 0.7468
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0044 0.0167
Brugia malayi Ras association domain family 1 isoform A 0.0016 0.0017 0.0017
Loa Loa (eye worm) hypothetical protein 0.0039 0.0148 0.0199
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0039 0.0146 0.6617
Brugia malayi hypothetical protein 0.0039 0.0148 0.0193
Entamoeba histolytica diacylglycerol kinase, putative 0.0016 0.0017 0.0077
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0044 0.0167
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0039 0.0148 0.0326
Schistosoma mansoni biogenic amine receptor 0.0039 0.0148 0.0326
Echinococcus multilocularis rhodopsin orphan GPCR 0.0039 0.0148 0.0144
Trichomonas vaginalis conserved hypothetical protein 0.0475 0.2635 1
Schistosoma mansoni hypothetical protein 0.0028 0.0088 0.0189
Brugia malayi hypothetical protein 0.0039 0.0148 0.0193
Loa Loa (eye worm) PHD-finger family protein 0.0028 0.0088 0.0117
Echinococcus granulosus GPCR family 3 C terminal 0.002 0.0039 0.0047
Schistosoma mansoni slit 0.0133 0.0686 0.1541
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0039 0.0148 0.0199
Schistosoma mansoni hypothetical protein 0.0133 0.0686 0.1541
Trypanosoma cruzi fatty acid desaturase, putative 0.0101 0.05 0.0654
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0021 0.0044 0.0042
Toxoplasma gondii diacylglycerol kinase, putative 0.0016 0.0017 0.0088
Brugia malayi Serotonin receptor 0.0039 0.0148 0.0193
Trichomonas vaginalis modulator of drug activity B, putative 0.0119 0.0603 0.2287
Brugia malayi AMP-binding enzyme family protein 0.0015 0.0012 0.0011
Echinococcus multilocularis lysine specific demethylase 5A 0.0034 0.0122 0.0118
Echinococcus multilocularis C2 calcium dependent membrane targeting 0.0016 0.0017 0.0013
Echinococcus multilocularis Niemann Pick C1 protein 0.0161 0.0844 0.0841
Echinococcus multilocularis neurogenic locus protein delta 0.0133 0.0686 0.0682
Onchocerca volvulus 0.0039 0.0148 0.0754
Loa Loa (eye worm) hypothetical protein 0.0039 0.0148 0.0199
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0052 0.022 0.7427
Brugia malayi Bromodomain containing protein 0.0028 0.0088 0.0112
Echinococcus multilocularis protein kinase c eta type 0.0016 0.0017 0.0013
Echinococcus multilocularis GPCR, family 3, C terminal 0.002 0.0039 0.0035
Onchocerca volvulus Neurogenic locus notch homolog 0.0133 0.0686 0.3563
Echinococcus granulosus Niemann Pick C1 protein 0.0113 0.0568 0.0756
Echinococcus granulosus neuropeptides capa receptor 0.0039 0.0148 0.0193
Trichomonas vaginalis NAD(P)H dehydrogenase, putative 0.0119 0.0603 0.2287
Onchocerca volvulus 0.0015 0.0012 0.0043
Loa Loa (eye worm) hypothetical protein 0.0039 0.0148 0.0199
Trichomonas vaginalis modulator of drug activity B, putative 0.0119 0.0603 0.2287
Brugia malayi putative neuropeptide receptor 0.0039 0.0148 0.0193
Brugia malayi Melatonin receptor type 1A 0.0039 0.0148 0.0193
Loa Loa (eye worm) hypothetical protein 0.0133 0.0686 0.0919
Loa Loa (eye worm) G-protein coupled receptor 0.0039 0.0148 0.0199
Loa Loa (eye worm) low-density lipoprotein receptor repeat class B containing protein 0.035 0.1919 0.2569
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0015 0.0012 0.0546
Loa Loa (eye worm) hypothetical protein 0.0039 0.0148 0.0199
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0037 0.0134 0.6071
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0064 0.0292 0.0652
Onchocerca volvulus Putative cubilin 0.0133 0.0686 0.3563
Echinococcus multilocularis fmrfamide receptor 0.0039 0.0148 0.0144
Brugia malayi RhoGAP domain containing protein 0.0016 0.0017 0.0017
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0044 0.0167
Loa Loa (eye worm) hypothetical protein 0.0064 0.0292 0.0392
Trichomonas vaginalis conserved hypothetical protein 0.0475 0.2635 1
Schistosoma mansoni opsin-like receptor 0.0039 0.0148 0.0326
Entamoeba histolytica hypothetical protein 0.0041 0.0161 0.2513
Echinococcus multilocularis protein jagged 1 0.0133 0.0686 0.0682
Schistosoma mansoni notch 0.0133 0.0686 0.1541
Echinococcus multilocularis unc 13 (munc13) 0.0016 0.0017 0.0013
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0039 0.0148 0.0326
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0196 0.0433
Brugia malayi RhoGEF domain containing protein 0.0016 0.0017 0.0017
Brugia malayi notch-like transmembrane receptor 0.0133 0.0686 0.0914
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0021 0.0044 0.0059
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0052 0.022 0.7427
Echinococcus multilocularis fibropellin Ia 0.0133 0.0686 0.0682
Echinococcus granulosus g protein coupled receptor 0.0039 0.0148 0.0193
Brugia malayi Calcium binding EGF domain containing protein 0.0133 0.0686 0.0914
Echinococcus granulosus sterol regulatory element binding protein 0.0048 0.0202 0.0265
Echinococcus multilocularis g-protein coupled receptor 0.0039 0.0148 0.0144
Brugia malayi G protein-coupled receptor 0.0039 0.0148 0.0193
Trichomonas vaginalis conserved hypothetical protein 0.0119 0.0603 0.2287
Schistosoma mansoni neuropeptide F-like receptor 0.0039 0.0148 0.0326
Brugia malayi hypothetical protein 0.0041 0.0161 0.021
Toxoplasma gondii PHD-finger domain-containing protein 0.0028 0.0088 0.0457
Loa Loa (eye worm) hypothetical protein 0.0024 0.0065 0.0087
Echinococcus granulosus transmembrane protease serine 3 0.0064 0.0292 0.0386
Schistosoma mansoni amine GPCR 0.0039 0.0148 0.0326
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0021 0.0044 0.0053
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0015 0.0012 0.0016
Echinococcus granulosus Serine/threonine-protein kinase Genghis Khan 0.0021 0.0044 0.0054
Schistosoma mansoni notch 0.0133 0.0686 0.1541
Schistosoma mansoni amine GPCR 0.0039 0.0148 0.0326
Brugia malayi Trypsin family protein 0.0064 0.0292 0.0386
Loa Loa (eye worm) hypothetical protein 0.035 0.1919 0.2569
Brugia malayi Low-density lipoprotein receptor repeat class B containing protein 0.035 0.1919 0.2565
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0039 0.0148 0.0199
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0196 0.0192
Echinococcus granulosus metabotropic glutamate receptor 5 0.015 0.0783 0.1044
Trichomonas vaginalis conserved hypothetical protein 0.0357 0.1958 0.7431
Plasmodium falciparum stearoyl-CoA desaturase 0.0101 0.05 1
Entamoeba histolytica acyl-CoA synthetase, putative 0.0052 0.022 0.3525
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0016 0.0017 0.0029
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0044 0.0167
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0052 0.022 1
Echinococcus granulosus tumor protein p63 0.0737 0.4124 0.5518
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0024 0.0065 0.0071
Schistosoma mansoni hypothetical protein 0.0064 0.0292 0.0652
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0044 0.0167
Trichomonas vaginalis NAD(P)H dehydrogenase, putative 0.0475 0.2635 1
Brugia malayi Trypsin family protein 0.0064 0.0292 0.0386
Brugia malayi hypothetical protein 0.0039 0.0148 0.0193
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0039 0.0148 0.0193
Onchocerca volvulus Poor gastrulation protein homolog 0.002 0.0039 0.0182
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0037 0.0134 0.6071
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0021 0.0044 0.0042
Echinococcus granulosus neurogenic locus notch protein 4 0.0133 0.0686 0.0914
Echinococcus multilocularis allatostatin A receptor 0.0039 0.0148 0.0144
Leishmania major 4-coumarate:coa ligase-like protein 0.0052 0.022 0.0279
Brugia malayi G-protein coupled receptor 0.0039 0.0148 0.0193
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0015 0.0012 0.0546
Loa Loa (eye worm) hypothetical protein 0.0039 0.0148 0.0199
Schistosoma mansoni biogenic amine receptor 0.0039 0.0148 0.0326
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0039 0.0148 0.0754
Echinococcus multilocularis glycoprotein Antigen 5 0.0064 0.0292 0.0288
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0021 0.0044 0.0042
Echinococcus granulosus rhodopsin orphan GPCR 0.0039 0.0148 0.0193
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0021 0.0044 0.0042
Brugia malayi Fibulin-1 precursor 0.035 0.1919 0.2565
Trichomonas vaginalis modulator of drug activity B, putative 0.0119 0.0603 0.2287
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0044 0.0167
Loa Loa (eye worm) RGC/RGC protein kinase 0.0014 0.0004 0.0005
Loa Loa (eye worm) hypothetical protein 0.0039 0.0148 0.0199
Schistosoma mansoni notch 0.0133 0.0686 0.1541
Trichomonas vaginalis conserved hypothetical protein 0.0119 0.0603 0.2287
Echinococcus granulosus neuropeptides capa receptor 0.0039 0.0148 0.0193
Brugia malayi Delta serrate ligand family protein 0.0133 0.0686 0.0914
Schistosoma mansoni Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)] 0.0133 0.0686 0.1541
Trichomonas vaginalis conserved hypothetical protein 0.0475 0.2635 1
Schistosoma mansoni metabotropic glutamate receptor 0.0102 0.0509 0.1142
Toxoplasma gondii calcium binding egf domain-containing protein 0.035 0.1919 1
Entamoeba histolytica diacylglycerol kinase, putative 0.0016 0.0017 0.0077
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0044 0.0167
Echinococcus multilocularis protein patched 0.0048 0.0202 0.0198
Echinococcus granulosus histone lysine methyltransferase setb 0.0029 0.0092 0.0117
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0021 0.0044 0.0042
Echinococcus multilocularis neuropeptide receptor 0.0039 0.0148 0.0144
Trichomonas vaginalis conserved hypothetical protein 0.0475 0.2635 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0044 0.0167
Loa Loa (eye worm) RhoGAP domain-containing protein 0.0016 0.0017 0.0023
Echinococcus multilocularis orexin receptor type 2 0.0039 0.0148 0.0144
Loa Loa (eye worm) hypothetical protein 0.0039 0.0148 0.0199
Trichomonas vaginalis antibiotic synthetase, putative 0.0015 0.0012 0.0047
Onchocerca volvulus 0.0064 0.0292 0.1506
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0015 0.0012 0.0546
Echinococcus granulosus N chimaerin 0.0016 0.0017 0.0017
Loa Loa (eye worm) hypothetical protein 0.0016 0.0017 0.0023
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0039 0.0148 0.0326
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0044 0.0167
Loa Loa (eye worm) hypothetical protein 0.0039 0.0146 0.0195
Echinococcus multilocularis neurogenic locus notch protein 4 0.0133 0.0686 0.0682
Entamoeba histolytica modulator of drug activity B homolog, putative 0.0119 0.0603 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0039 0.0148 0.0144
Schistosoma mansoni protein kinase C 0.0016 0.0017 0.0029
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0092 0.0198
Echinococcus multilocularis protein kinase c epsilon type 0.0021 0.0044 0.004
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0196 0.0433
Echinococcus granulosus Diacylglycerol kinase theta 0.0016 0.0017 0.0017
Onchocerca volvulus 0.011 0.0551 0.2856
Trichomonas vaginalis conserved hypothetical protein 0.0119 0.0603 0.2287
Schistosoma mansoni serine/threonine protein kinase 0.0458 0.2535 0.5718
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0044 0.0167
Loa Loa (eye worm) hypothetical protein 0.0039 0.0148 0.0199
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0021 0.0044 0.0059
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0015 0.0012 0.0064
Trichomonas vaginalis modulator of drug activity B, putative 0.0119 0.0603 0.2287
Echinococcus granulosus delta-like protein 1 0.0133 0.0686 0.0914
Brugia malayi metabotropic glutamate receptor type 2 0.006 0.0265 0.035
Echinococcus multilocularis slit 2 protein 0.0133 0.0686 0.0682
Brugia malayi diacylglycerol kinase 0.0016 0.0017 0.0017
Loa Loa (eye worm) hypothetical protein 0.0039 0.0148 0.0199
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0015 0.0012 0.0546
Trichomonas vaginalis modulator of drug activity B, putative 0.0119 0.0603 0.2287
Echinococcus granulosus lysine specific demethylase 5A 0.0034 0.0122 0.0158
Echinococcus granulosus tm gpcr rhodopsin 0.0039 0.0148 0.0193
Brugia malayi hypothetical protein 0.0271 0.1469 0.1963
Schistosoma mansoni neuropeptide receptor 0.0039 0.0148 0.0326
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0039 0.0148 0.0199
Onchocerca volvulus 0.0039 0.0148 0.0754
Schistosoma mansoni neuropeptide receptor 0.0039 0.0148 0.0326
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0039 0.0148 0.0193
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0047 0.0196 0.0262
Echinococcus granulosus Protein patched homolog 1 0.0048 0.0202 0.0265
Loa Loa (eye worm) hypothetical protein 0.0064 0.0292 0.0392
Echinococcus multilocularis G protein coupled receptor 139 0.0039 0.0148 0.0144
Echinococcus granulosus 7tm_1 domain containing protein 0.0039 0.0148 0.0193
Onchocerca volvulus 0.0039 0.0148 0.0754
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0039 0.0148 0.0193
Echinococcus multilocularis mitogen activated protein kinase 11 0.1324 0.7469 0.7468
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0039 0.0148 0.0326
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0044 0.0167
Echinococcus multilocularis Mastin 0.0064 0.0292 0.0288
Onchocerca volvulus 0.0039 0.0148 0.0754
Echinococcus multilocularis rhodopsin orphan GPCR 0.0039 0.0148 0.0144
Echinococcus multilocularis neuropeptides capa receptor 0.0039 0.0148 0.0144
Trichomonas vaginalis modulator of drug activity B, putative 0.0119 0.0603 0.2287
Echinococcus multilocularis serotonin receptor 0.0039 0.0148 0.0144
Loa Loa (eye worm) hypothetical protein 0.035 0.1919 0.2569
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0115 0.0578 0.1298
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0064 0.0292 0.0652
Onchocerca volvulus 0.0039 0.0148 0.0754
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0015 0.0012 0.0546
Giardia lamblia High cysteine protein 0.0133 0.0686 0.2479
Brugia malayi AMP-binding enzyme family protein 0.0052 0.022 0.029
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0039 0.0148 0.0326
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0093 0.0456 0.0452
Echinococcus granulosus neuropeptide receptor 0.0039 0.0148 0.0193
Echinococcus granulosus tachykinin peptides receptor 99D 0.0039 0.0148 0.0193
Loa Loa (eye worm) hypothetical protein 0.0039 0.0148 0.0199
Loa Loa (eye worm) neuropeptide F receptor 0.0039 0.0148 0.0199
Brugia malayi Variant SH3 domain containing protein 0.0016 0.0017 0.0017
Loa Loa (eye worm) hypothetical protein 0.0064 0.0292 0.0392
Schistosoma mansoni growth hormone secretagogue receptor 0.0039 0.0148 0.0326
Brugia malayi RhoGAP domain containing protein 0.0016 0.0017 0.0017
Echinococcus multilocularis serine:threonine protein kinase MRCK beta 0.0021 0.0044 0.004
Echinococcus granulosus serotonin receptor 0.0039 0.0148 0.0193
Brugia malayi Protein kinase domain containing protein 0.0021 0.0044 0.0054
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0039 0.0148 0.0326
Loa Loa (eye worm) hypothetical protein 0.0133 0.0686 0.0919
Brugia malayi Trypsin-like protease protein 5 0.0064 0.0292 0.0386
Trichomonas vaginalis conserved hypothetical protein 0.0048 0.0202 0.0765
Schistosoma mansoni survival motor neuron protein 0.0055 0.0241 0.0535
Loa Loa (eye worm) hypothetical protein 0.0133 0.0686 0.0919
Onchocerca volvulus 0.0015 0.0012 0.0043
Echinococcus granulosus biogenic amine 5HT receptor 0.0039 0.0148 0.0193
Brugia malayi Dopamine receptor 0.0039 0.0148 0.0193
Loa Loa (eye worm) receptor family ligand binding region containing protein 0.0031 0.0104 0.014
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0113 0.0568 0.9422
Schistosoma mansoni unc-13 (munc13) 0.0016 0.0017 0.0029
Loa Loa (eye worm) hypothetical protein 0.0039 0.0148 0.0199
Schistosoma mansoni histamine h1 receptor 0.0039 0.0148 0.0326
Schistosoma mansoni cercarial elastase (S01 family) 0.0064 0.0292 0.0652
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0064 0.0292 0.0652
Loa Loa (eye worm) hypothetical protein 0.0016 0.0017 0.0023
Loa Loa (eye worm) hypothetical protein 0.0016 0.0017 0.0023
Schistosoma mansoni neuropeptide receptor 0.0039 0.0148 0.0326
Echinococcus granulosus somatostatin receptor 0.0039 0.0148 0.0193
Echinococcus granulosus rhodopsin orphan GPCR 0.0039 0.0148 0.0193
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0021 0.0044 0.004

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) > 100 uM Agonist activity at mGlu1 receptor expressed in CHO cells assessed as myo-[2-3H]Inositol turnover by scintillation counting ChEMBL. 20638290
EC50 (functional) > 100 uM Agonist activity at mGlu4 receptor expressed in CHO cells assessed as inhibition of forskolin-induced increase of cAMP level ChEMBL. 20638290
IC50 (functional) = 62 uM Antagonist activity at mGlu2 receptor expressed in CHO cells assessed as increase of cAMP level ChEMBL. 20638290
IC50 (binding) > 100 uM Displacement of [3H]CGP39653 from NMDA receptor in Sprague-Dawley rat brain synaptic membranes after 60 mins ChEMBL. 20638290

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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