Detailed information for compound 990763

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 430.534 | Formula: C25H34O6
  • H donors: 3 H acceptors: 5 LogP: 1.9 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: C/C=C(/C(=O)O[C@@]12C[C@@H](C)[C@]3([C@H]([C@@H]1C2(C)C)C=C(CO)C[C@]1([C@H]3C=C(C1=O)C)O)O)\C
  • InChi: 1S/C25H34O6/c1-7-13(2)21(28)31-24-10-15(4)25(30)17(19(24)22(24,5)6)9-16(12-26)11-23(29)18(25)8-14(3)20(23)27/h7-9,15,17-19,26,29-30H,10-12H2,1-6H3/b13-7+/t15-,17+,18-,19-,23-,24+,25-/m1/s1
  • InChiKey: GFAGCYRBGVCTPP-MDYQULRUSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni amine GPCR 0.0119 0.0303 0.0303
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.002 0.0011 0.004
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0119 0.0303 0.0303
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.002 0.0011 0.0011
Brugia malayi MH2 domain containing protein 0.0016 0.0001 0.0005
Trichomonas vaginalis ferritin, putative 0.0017 0.0005 0.0577
Echinococcus multilocularis rhodopsin orphan GPCR 0.0119 0.0303 0.0303
Brugia malayi Latrophilin receptor protein 2 0.0134 0.0347 0.1081
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0076 0.0178 0.0178
Brugia malayi hypothetical protein 0.0119 0.0303 0.0943
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0136 0.0136
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.002 0.0011 0.109
Echinococcus multilocularis neuropeptides capa receptor 0.0119 0.0303 0.0303
Entamoeba histolytica hypothetical protein 0.0025 0.0027 0.0531
Echinococcus granulosus somatostatin receptor 0.0119 0.0303 0.0303
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0119 0.0303 0.0303
Echinococcus granulosus insulin receptor 0.0153 0.0404 0.0404
Echinococcus granulosus tumor protein p63 0.0987 0.287 0.287
Echinococcus granulosus biogenic amine 5HT receptor 0.0119 0.0303 0.0303
Loa Loa (eye worm) hypothetical protein 0.0031 0.0044 0.0132
Schistosoma mansoni smad1 5 8 and 0.0016 0.0001 0.0001
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0119 0.0303 0.0303
Loa Loa (eye worm) latrophilin receptor protein 2 0.0134 0.0347 0.1077
Schistosoma mansoni neuropeptide receptor 0.0119 0.0303 0.0303
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0043 0.008 0.2725
Loa Loa (eye worm) melatonin receptor type 1A 0.0119 0.0303 0.0939
Schistosoma mansoni eyes absent homolog 0.0088 0.0213 0.0213
Echinococcus granulosus geminin 0.0181 0.0488 0.0488
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0119 0.0303 0.0303
Brugia malayi RE15519p 0.0119 0.0303 0.0943
Toxoplasma gondii exonuclease III APE 0.002 0.0011 0.0369
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0076 0.0178 0.0656
Loa Loa (eye worm) hypothetical protein 0.0119 0.0303 0.0939
Leishmania major 4-coumarate:coa ligase-like protein 0.0047 0.009 0.9117
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0119 0.0303 0.0943
Schistosoma mansoni hypothetical protein 0.0329 0.0925 0.0925
Loa Loa (eye worm) hypothetical protein 0.0134 0.0347 0.1077
Brugia malayi larval opioid receptor 0.0119 0.0303 0.0943
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0018 0.0007 0.0007
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.002 0.0011 0.004
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0076 0.0178 0.0656
Loa Loa (eye worm) hypothetical protein 0.0119 0.0303 0.0939
Schistosoma mansoni neuropeptide receptor 0.0119 0.0303 0.0303
Toxoplasma gondii LsmAD domain-containing protein 0.0049 0.0099 0.3384
Onchocerca volvulus 0.0119 0.0303 0.7345
Schistosoma mansoni cellular tumor antigen P53 0.0145 0.038 0.038
Onchocerca volvulus 0.0119 0.0303 0.7345
Schistosoma mansoni neuropeptide receptor 0.0119 0.0303 0.0303
Echinococcus multilocularis Smad4 0.0016 0.0001 0.0001
Brugia malayi MH1 domain containing protein 0.0016 0.0001 0.0005
Echinococcus granulosus rhodopsin orphan GPCR 0.0119 0.0303 0.0303
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0119 0.0303 0.0303
Schistosoma mansoni ap endonuclease 0.002 0.0011 0.0011
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0119 0.0303 0.0939
Onchocerca volvulus 0.0119 0.0303 0.7345
Schistosoma mansoni tyrosine kinase 0.0068 0.0154 0.0154
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0076 0.0178 0.6083
Schistosoma mansoni smad1 5 8 and 0.0016 0.0001 0.0001
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0119 0.0303 0.0303
Brugia malayi AMP-binding enzyme family protein 0.0047 0.009 0.0281
Echinococcus granulosus allatostatin A receptor 0.0119 0.0303 0.0303
Loa Loa (eye worm) hypothetical protein 0.0119 0.0303 0.0939
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0119 0.0303 0.0939
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0119 0.0303 0.7345
Schistosoma mansoni hypothetical protein 0.0119 0.0303 0.0303
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0119 0.0303 0.0303
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0105 0.0263 0.0968
Echinococcus granulosus g protein coupled receptor 0.0119 0.0303 0.0303
Brugia malayi hypothetical protein 0.0049 0.0099 0.0308
Wolbachia endosymbiont of Brugia malayi 3-oxoacyl-ACP synthase 0.0935 0.2715 1
Schistosoma mansoni biogenic amine receptor 0.0119 0.0303 0.0303
Schistosoma mansoni ferritin 0.0017 0.0005 0.0005
Schistosoma mansoni amine GPCR 0.0119 0.0303 0.0303
Trypanosoma brucei trypanothione reductase 0.0046 0.0089 0.2995
Plasmodium falciparum acyl-CoA synthetase 0.0035 0.0056 0.0205
Brugia malayi Serotonin receptor 0.0119 0.0303 0.0943
Echinococcus granulosus Smad4 0.0016 0.0001 0.0001
Echinococcus multilocularis allatostatin A receptor 0.0119 0.0303 0.0303
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0043 0.008 0.0294
Loa Loa (eye worm) TK/INSR protein kinase 0.0153 0.0404 0.1252
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0026 0.0031 0.0112
Echinococcus granulosus snurportin 1 0.0329 0.0925 0.0925
Onchocerca volvulus 0.0119 0.0303 0.7345
Loa Loa (eye worm) RNA binding protein 0.0062 0.0136 0.0418
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0105 0.0263 0.8819
Brugia malayi hypothetical protein 0.0119 0.0303 0.0943
Schistosoma mansoni hypothetical protein 0.0116 0.0296 0.0296
Echinococcus multilocularis orexin receptor type 2 0.0119 0.0303 0.0303
Schistosoma mansoni growth hormone secretagogue receptor 0.0119 0.0303 0.0303
Echinococcus granulosus serotonin receptor 0.0119 0.0303 0.0303
Brugia malayi ORL1-like opioid receptor 0.0119 0.0303 0.0943
Echinococcus granulosus tm gpcr rhodopsin 0.0119 0.0303 0.0303
Toxoplasma gondii HEAT repeat-containing protein 0.0031 0.0044 0.1502
Loa Loa (eye worm) histone methyltransferase 0.0018 0.0007 0.0016
Echinococcus granulosus sex peptide receptor 0.0119 0.0303 0.0303
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.005 0.0101 0.3279
Brugia malayi Serotonin receptor 0.0119 0.0303 0.0943
Onchocerca volvulus 0.0119 0.0303 0.7345
Brugia malayi hypothetical protein 0.0074 0.0173 0.0537
Echinococcus granulosus histone acetyltransferase KAT2B 0.0043 0.008 0.008
Treponema pallidum bacterioferrin (TpF1) 0.0017 0.0005 0.0259
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0119 0.0303 0.0943
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0134 0.0347 0.1081
Mycobacterium ulcerans acyl-CoA synthetase 0.0047 0.009 0.0333
Mycobacterium ulcerans acyl-CoA synthetase 0.0047 0.009 0.0333
Schistosoma mansoni hypothetical protein 0.0134 0.0347 0.0347
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0023 0.002 0.2013
Loa Loa (eye worm) hypothetical protein 0.0035 0.0056 0.0169
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0011 0.004
Loa Loa (eye worm) TYRA-2 protein 0.0119 0.0303 0.0939
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0119 0.0303 0.0303
Loa Loa (eye worm) hypothetical protein 0.0119 0.0303 0.0939
Schistosoma mansoni tyrosine kinase 0.0068 0.0154 0.0154
Mycobacterium tuberculosis Probable bacterioferritin BfrA 0.0017 0.0005 0.0017
Echinococcus multilocularis mothers against decapentaplegic 5 0.0016 0.0001 0.0001
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0076 0.0178 0.0656
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0047 0.009 0.0333
Echinococcus multilocularis g-protein coupled receptor 0.0119 0.0303 0.0303
Entamoeba histolytica acetyltransferase, GNAT family 0.0039 0.0069 0.1943
Brugia malayi Dopamine receptor 0.0119 0.0303 0.0943
Trypanosoma cruzi Vps23 core domain containing protein, putative 0.0024 0.0023 0.2337
Mycobacterium tuberculosis Probable oxidoreductase 0.0117 0.0297 0.1095
Echinococcus granulosus biogenic amine 5HT receptor 0.0119 0.0303 0.0303
Loa Loa (eye worm) hypothetical protein 0.0119 0.0303 0.0939
Brugia malayi hypothetical protein 0.0088 0.0213 0.0664
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.002 0.0011 0.0029
Plasmodium vivax beta-ketoacyl-acyl carrier protein synthase III precursor, putative 0.0935 0.2715 1
Schistosoma mansoni opsin-like receptor 0.0119 0.0303 0.0303
Echinococcus granulosus neuropeptide Y receptor 0.0119 0.0303 0.0303
Trypanosoma cruzi PAB1-binding protein , putative 0.0049 0.0099 1
Loa Loa (eye worm) hypothetical protein 0.0119 0.0303 0.0939
Brugia malayi AKH receptor 0.0119 0.0303 0.0943
Onchocerca volvulus 0.0119 0.0303 0.7345
Onchocerca volvulus 0.0119 0.0303 0.7345
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0076 0.0178 0.0656
Brugia malayi G protein-coupled receptor F59B2.13 0.0119 0.0303 0.0943
Loa Loa (eye worm) acetyltransferase 0.0146 0.0384 0.1192
Echinococcus granulosus rhodopsin orphan GPCR 0.0119 0.0303 0.0303
Loa Loa (eye worm) hypothetical protein 0.0119 0.0303 0.0939
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0146 0.0384 0.0384
Schistosoma mansoni opsin-like receptor 0.0119 0.0303 0.0303
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0119 0.0303 0.0303
Echinococcus granulosus neuropeptide FF receptor 2 0.0119 0.0303 0.0303
Loa Loa (eye worm) hypothetical protein 0.0119 0.0303 0.0939
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0119 0.0303 0.0303
Echinococcus granulosus tachykinin peptides receptor 99D 0.0119 0.0303 0.0303
Brugia malayi Furin-like cysteine rich region family protein 0.0069 0.0158 0.0492
Echinococcus granulosus neuropeptide receptor 0.0119 0.0303 0.0303
Entamoeba histolytica fatty acid elongase, putative 0.0121 0.0312 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0047 0.009 0.0333
Toxoplasma gondii thioredoxin reductase 0.0046 0.0089 0.303
Brugia malayi Protein kinase domain containing protein 0.0084 0.0202 0.0629
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0119 0.0303 0.0303
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0105 0.0263 0.0968
Schistosoma mansoni neuropeptide receptor 0.0119 0.0303 0.0303
Onchocerca volvulus 0.0119 0.0303 0.7345
Loa Loa (eye worm) hypothetical protein 0.0119 0.0303 0.0939
Echinococcus multilocularis geminin 0.0181 0.0488 0.0488
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0119 0.0303 0.0303
Brugia malayi Protein kinase domain containing protein 0.0153 0.0404 0.1256
Schistosoma mansoni apoferritin-2 0.0017 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0119 0.0303 0.0939
Loa Loa (eye worm) hypothetical protein 0.0119 0.0303 0.0939
Echinococcus multilocularis neuropeptide receptor 0.0119 0.0303 0.0303
Loa Loa (eye worm) MH2 domain-containing protein 0.0241 0.0665 0.2066
Loa Loa (eye worm) hypothetical protein 0.0088 0.0213 0.0659
Loa Loa (eye worm) neuropeptide F receptor 0.0119 0.0303 0.0939
Brugia malayi AMP-binding enzyme family protein 0.0047 0.009 0.0281
Loa Loa (eye worm) G-protein coupled receptor 0.0119 0.0303 0.0939
Loa Loa (eye worm) glutathione reductase 0.0046 0.0089 0.0272
Echinococcus multilocularis neuropeptide Y receptor 0.0119 0.0303 0.0303
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0119 0.0303 0.0303
Echinococcus granulosus rhodopsin orphan GPCR 0.0119 0.0303 0.0303
Echinococcus multilocularis neuropeptide receptor 0.0119 0.0303 0.0303
Loa Loa (eye worm) hypothetical protein 0.0119 0.0303 0.0939
Echinococcus granulosus TGF beta signal transducer SmadC 0.0016 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0289 0.0805 0.2502
Brugia malayi hypothetical protein 0.0119 0.0303 0.0943
Loa Loa (eye worm) TAR-binding protein 0.0062 0.0136 0.0418
Loa Loa (eye worm) hypothetical protein 0.0047 0.009 0.0277
Brugia malayi G-protein coupled receptor 0.0119 0.0303 0.0943
Echinococcus multilocularis G-protein coupled receptor, putative 0.0119 0.0303 0.0303
Echinococcus granulosus 7tm_1 domain containing protein 0.0119 0.0303 0.0303
Echinococcus multilocularis neuropeptide s receptor 0.0119 0.0303 0.0303
Echinococcus granulosus tar DNA binding protein 0.0062 0.0136 0.0136
Brugia malayi GnHR receptor homolog 0.0119 0.0303 0.0943
Echinococcus multilocularis dro:myosuppressin receptor 0.0119 0.0303 0.0303
Brugia malayi Smad1 0.0016 0.0001 0.0005
Brugia malayi Thioredoxin reductase 0.0046 0.0089 0.0276
Brugia malayi hypothetical protein 0.0032 0.0047 0.0147
Echinococcus granulosus fmrfamide receptor 0.0119 0.0303 0.0303
Echinococcus multilocularis thioredoxin glutathione reductase 0.0046 0.0089 0.0089
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0119 0.0303 0.0939
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0815 0.2361 0.2361
Loa Loa (eye worm) TK/EGFR protein kinase 0.0069 0.0158 0.0487
Echinococcus multilocularis rhodopsin orphan GPCR 0.0119 0.0303 0.0303
Mycobacterium ulcerans bacterioferritin BfrA 0.0017 0.0005 0.0017
Brugia malayi neuropeptide F receptor 0.0119 0.0303 0.0943
Brugia malayi Calcitonin receptor-like protein seb-1 0.0422 0.12 0.3733
Brugia malayi RNA recognition motif domain containing protein 0.0062 0.0136 0.0423
Giardia lamblia Histone acetyltransferase GCN5 0.0039 0.0069 1
Echinococcus granulosus smad 0.0016 0.0001 0.0001
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.005 0.0101 0.037
Leishmania major trypanothione reductase 0.0046 0.0089 0.8953
Schistosoma mansoni apoferritin-2 0.0017 0.0005 0.0005
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0119 0.0303 0.0303
Schistosoma mansoni importin beta-1 0.0031 0.0044 0.0044
Schistosoma mansoni ap endonuclease 0.002 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0119 0.0303 0.0939
Brugia malayi Dopamine receptor protein 2 0.0119 0.0303 0.0943
Brugia malayi G protein-coupled receptor 0.0119 0.0303 0.0943
Loa Loa (eye worm) hypothetical protein 0.0119 0.0303 0.0939
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0023 0.002 0.002
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0047 0.009 0.0333
Echinococcus multilocularis sex peptide receptor 0.0119 0.0303 0.0303
Leishmania major 4-coumarate:coa ligase-like protein 0.0047 0.009 0.9117
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0125 0.0322 0.0322
Schistosoma mansoni alpha-1 adrenergic receptor 0.0119 0.0303 0.0303
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.002 0.0011 0.109
Leishmania major importin beta-1 subunit, putative 0.0025 0.0027 0.2701
Echinococcus granulosus tm gpcr rhodopsin 0.0119 0.0303 0.0303
Plasmodium vivax thioredoxin reductase, putative 0.0046 0.0089 0.0327
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0026 0.0031 0.0112
Brugia malayi hypothetical protein 0.0119 0.0303 0.0943
Echinococcus granulosus importin subunit beta 1 0.0031 0.0044 0.0044
Schistosoma mansoni tsg101-related 0.0062 0.0136 0.0136
Echinococcus multilocularis rhodopsin orphan GPCR 0.0119 0.0303 0.0303
Chlamydia trachomatis oxoacyl-ACP synthase III 0.0935 0.2715 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0049 0.0099 0.0365
Schistosoma mansoni hypothetical protein 0.0134 0.0347 0.0347
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0076 0.0178 0.0656
Schistosoma mansoni neuropeptide F-like receptor 0.0119 0.0303 0.0303
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0119 0.0303 0.0303
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0023 0.002 0.0681
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0023 0.002 0.2013
Brugia malayi MH2 domain containing protein 0.0016 0.0001 0.0005
Brugia malayi RNA, U transporter 1 0.0088 0.0212 0.0659
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0076 0.0178 0.593
Brugia malayi MH1 domain containing protein 0.0016 0.0001 0.0005
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0134 0.0347 0.0347
Echinococcus granulosus neuropeptide s receptor 0.0119 0.0303 0.0303
Echinococcus multilocularis epidermal growth factor receptor 0.0069 0.0158 0.0158
Onchocerca volvulus 0.0119 0.0303 0.7345
Loa Loa (eye worm) hypothetical protein 0.0119 0.0303 0.0939
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0023 0.002 0.0673
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.002 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0119 0.0303 0.0939
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0062 0.0136 0.0418
Wolbachia endosymbiont of Brugia malayi bacterioferritin/cytochrome b1 0.0017 0.0005 0.0017
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.002 0.0011 0.109
Schistosoma mansoni tsg101-related 0.0062 0.0136 0.0136
Plasmodium vivax acyl-CoA synthetase, putative 0.0035 0.0056 0.0205
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0422 0.12 0.373
Trypanosoma cruzi importin beta-1 subunit, putative 0.0025 0.0027 0.2701
Loa Loa (eye worm) hypothetical protein 0.0035 0.0056 0.0169
Echinococcus multilocularis GPCR, family 2 0.0134 0.0347 0.0347
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.005 0.0184
Schistosoma mansoni ferritin 0.0017 0.0005 0.0005
Mycobacterium tuberculosis Probable reductase 0.0105 0.0263 0.0968
Schistosoma mansoni hypothetical protein 0.0181 0.0488 0.0488
Schistosoma mansoni tyrosine kinase 0.0069 0.0158 0.0158
Loa Loa (eye worm) hypothetical protein 0.0119 0.0303 0.0939
Echinococcus multilocularis neuropeptides capa receptor 0.0119 0.0303 0.0303
Schistosoma mansoni tyrosine kinase 0.0153 0.0404 0.0404
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.005 0.0184
Echinococcus multilocularis rhodopsin orphan GPCR 0.0119 0.0303 0.0303
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0047 0.009 0.0333
Loa Loa (eye worm) hypothetical protein 0.0119 0.0303 0.0939
Toxoplasma gondii hypothetical protein 0.0026 0.0031 0.1043
Trypanosoma brucei RNA helicase, putative 0.0116 0.0296 1
Plasmodium vivax ataxin-2 like protein, putative 0.0049 0.0099 0.0365
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0026 0.0031 0.1714
Echinococcus granulosus tm gpcr rhodopsin 0.0119 0.0303 0.0303
Echinococcus granulosus g-protein coupled receptor 0.0119 0.0303 0.0303
Schistosoma mansoni amine GPCR 0.0119 0.0303 0.0303
Plasmodium falciparum histone acetyltransferase GCN5 0.0039 0.0069 0.0255
Plasmodium vivax glutathione reductase, putative 0.0046 0.0089 0.0327
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0119 0.0303 0.0303
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0035 0.0056 0.0205
Loa Loa (eye worm) hypothetical protein 0.0119 0.0303 0.0939
Brugia malayi TAR-binding protein 0.0062 0.0136 0.0423
Loa Loa (eye worm) hypothetical protein 0.0145 0.038 0.1178
Plasmodium falciparum glutathione reductase 0.0046 0.0089 0.0327
Schistosoma mansoni biogenic amine receptor 0.0119 0.0303 0.0303
Brugia malayi MH2 domain containing protein 0.0241 0.0665 0.2069
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0136 0.0136
Entamoeba histolytica Ran family GTPase 0.0023 0.002 0.0304
Schistosoma mansoni smad1 5 8 and 0.0016 0.0001 0.0001
Leishmania major hypothetical protein, conserved 0.0024 0.0023 0.2337
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0069 0.0158 0.0158
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0023 0.002 0.2881
Loa Loa (eye worm) hypothetical protein 0.1104 0.3214 1
Schistosoma mansoni hypothetical protein 0.0119 0.0303 0.0303
Schistosoma mansoni hypothetical protein 0.0838 0.2429 0.2429
Echinococcus multilocularis insulin receptor 0.0153 0.0404 0.0404
Brugia malayi CXXC zinc finger family protein 0.0059 0.0127 0.0395
Schistosoma mansoni ferritin 0.0017 0.0005 0.0005
Entamoeba histolytica fatty acid elongase, putative 0.0121 0.0312 1
Onchocerca volvulus 0.0119 0.0303 0.7345
Echinococcus granulosus dro:myosuppressin receptor 0.0119 0.0303 0.0303
Trypanosoma cruzi PAB1-binding protein , putative 0.0049 0.0099 1
Loa Loa (eye worm) hypothetical protein 0.0119 0.0303 0.0939
Trichomonas vaginalis importin beta-1, putative 0.0025 0.0027 0.3353
Leishmania major 4-coumarate:coa ligase-like protein 0.0047 0.009 0.9117
Loa Loa (eye worm) hypothetical protein 0.0083 0.0199 0.0614
Echinococcus multilocularis g protein coupled receptor 0.0119 0.0303 0.0303
Mycobacterium ulcerans 3-oxoacyl-ACP synthase 0.0935 0.2715 1
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0815 0.2361 0.2361
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.002 0.0011 0.156
Echinococcus granulosus peptide allatostatin:somatostatin 0.0119 0.0303 0.0303
Loa Loa (eye worm) hypothetical protein 0.0047 0.009 0.0277
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0018 0.0007 0.0007
Brugia malayi putative neuropeptide receptor 0.0119 0.0303 0.0943
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0119 0.0303 0.0303
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0023 0.002 0.0073
Schistosoma mansoni peptidase Clp (S14 family) 0.0076 0.0178 0.0178
Echinococcus multilocularis expressed protein 0.0017 0.0005 0.0005
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0119 0.0303 0.0303
Onchocerca volvulus 0.0119 0.0303 0.7345
Loa Loa (eye worm) CXXC zinc finger family protein 0.0059 0.0127 0.039
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0119 0.0303 0.0303
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0119 0.0303 0.0303
Brugia malayi putative neuropeptide receptor NPR1 0.0119 0.0303 0.0943
Loa Loa (eye worm) hypothetical protein 0.0076 0.0178 0.055
Schistosoma mansoni cpg binding protein 0.0062 0.0137 0.0137
Toxoplasma gondii histone lysine methyltransferase SET1 0.0115 0.0293 1
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0119 0.0303 0.0303
Brugia malayi F/Y-rich N-terminus family protein 0.0018 0.0006 0.0019
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0153 0.0404 0.0404
Plasmodium vivax importin-beta 2, putative 0.0031 0.0044 0.0162
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0076 0.0178 0.0656
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0076 0.0178 0.6083
Brugia malayi Melatonin receptor type 1A 0.0119 0.0303 0.0943
Echinococcus granulosus 7TM GPCR rhodopsin 0.0119 0.0303 0.0303
Schistosoma mansoni tyrosine kinase 0.0153 0.0404 0.0404
Schistosoma mansoni Smad4 0.0016 0.0001 0.0001
Echinococcus multilocularis serotonin receptor 0.0119 0.0303 0.0303
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0035 0.0056 0.0205
Plasmodium falciparum importin beta, putative 0.0031 0.0044 0.0162
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0119 0.0303 0.0303
Loa Loa (eye worm) hypothetical protein 0.0119 0.0303 0.0939
Loa Loa (eye worm) hypothetical protein 0.0119 0.0303 0.0939
Brugia malayi hypothetical protein 0.0119 0.0303 0.0943
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0023 0.002 0.0058
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0011 0.1354
Schistosoma mansoni hypothetical protein 0.0134 0.0347 0.0347
Brugia malayi follicle stimulating hormone receptor 0.0119 0.0303 0.0943
Echinococcus granulosus ferritin 0.0017 0.0005 0.0005
Echinococcus granulosus thioredoxin glutathione reductase 0.0046 0.0089 0.0089
Onchocerca volvulus 0.0119 0.0303 0.7345
Schistosoma mansoni tyrosine kinase 0.0069 0.0158 0.0158
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0027 0.3353
Loa Loa (eye worm) hypothetical protein 0.0119 0.0303 0.0939
Echinococcus granulosus alpha 1A adrenergic receptor 0.0119 0.0303 0.0303
Leishmania major GTP-binding protein, putative 0.0023 0.002 0.2013
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0105 0.0263 0.0968
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0043 0.008 1
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0076 0.0178 1
Brugia malayi Tachykinin-like peptides receptor 99D 0.0119 0.0303 0.0943
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0119 0.0303 0.0943
Trichomonas vaginalis ran, putative 0.0023 0.002 0.2499
Loa Loa (eye worm) hypothetical protein 0.0119 0.0303 0.0939
Echinococcus multilocularis snurportin 1 0.0329 0.0925 0.0925
Loa Loa (eye worm) hypothetical protein 0.0049 0.0099 0.0304
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0119 0.0303 0.0303
Echinococcus granulosus G protein coupled receptor 139 0.0119 0.0303 0.0303
Schistosoma mansoni ran 0.0023 0.002 0.002
Echinococcus granulosus cpg binding protein 0.0062 0.0137 0.0137
Echinococcus granulosus expressed protein 0.0017 0.0005 0.0005
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0076 0.0178 0.0656
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.002 0.0011 0.004
Brugia malayi hypothetical protein 0.0119 0.0303 0.0943
Echinococcus granulosus mothers against decapentaplegic 5 0.0016 0.0001 0.0001
Schistosoma mansoni cpg binding protein 0.0059 0.0127 0.0127
Schistosoma mansoni ran 0.0023 0.002 0.002
Onchocerca volvulus 0.0119 0.0303 0.7345
Entamoeba histolytica tumor susceptibility gene 101 protein, putative 0.0051 0.0102 0.3042
Schistosoma mansoni ferritin 0.0017 0.0005 0.0005
Schistosoma mansoni tyrosine kinase 0.0069 0.0158 0.0158
Entamoeba histolytica fatty acid elongase, putative 0.0121 0.0312 1
Brugia malayi acetyltransferase, GNAT family protein 0.0146 0.0384 0.1196
Loa Loa (eye worm) hypothetical protein 0.0119 0.0303 0.0939
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0076 0.0178 0.0178
Echinococcus multilocularis tumor susceptibility gene 101 protein 0.0074 0.0173 0.0173
Echinococcus multilocularis dnaJ subfamily B 0.0838 0.2429 0.2429
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0047 0.009 0.0333
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0047 0.009 0.0333
Echinococcus multilocularis cpg binding protein 0.0062 0.0137 0.0137
Schistosoma mansoni hypothetical protein 0.0022 0.0019 0.0019
Echinococcus granulosus GTP binding nuclear protein Ran 0.0023 0.002 0.002
Loa Loa (eye worm) hypothetical protein 0.0074 0.0173 0.0533
Brugia malayi glutathione reductase 0.0046 0.0089 0.0276
Loa Loa (eye worm) hypothetical protein 0.0035 0.0056 0.0169
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0119 0.0303 0.0303
Echinococcus granulosus g protein coupled receptor 0.0119 0.0303 0.0303
Echinococcus multilocularis microtubule associated protein 2 0.3401 1 1
Entamoeba histolytica acyl-CoA synthetase, putative 0.0047 0.009 0.2645
Trypanosoma brucei Vps23 core domain containing protein, putative 0.0024 0.0023 0.0782
Schistosoma mansoni myosin xvIII 0.0119 0.0303 0.0303
Echinococcus granulosus orexin receptor type 2 0.0119 0.0303 0.0303
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0119 0.0303 0.0303
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0023 0.002 0.0062
Echinococcus granulosus neuropeptides capa receptor 0.0119 0.0303 0.0303
Schistosoma mansoni hypothetical protein 0.0134 0.0347 0.0347
Echinococcus multilocularis G protein coupled receptor 139 0.0119 0.0303 0.0303
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0016 0.0001 0.0001
Mycobacterium ulcerans bacterioferritin BfrB 0.0017 0.0005 0.0017
Loa Loa (eye worm) hypothetical protein 0.0119 0.0303 0.0939
Echinococcus multilocularis rhodopsin orphan GPCR 0.0119 0.0303 0.0303
Schistosoma mansoni biogenic amine receptor 0.0119 0.0303 0.0303
Loa Loa (eye worm) hypothetical protein 0.0119 0.0303 0.0939
Echinococcus multilocularis fmrfamide receptor 0.0119 0.0303 0.0303
Mycobacterium ulcerans acyl-CoA synthetase 0.0047 0.009 0.0333
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0119 0.0303 0.0303
Loa Loa (eye worm) thioredoxin reductase 0.0046 0.0089 0.0272
Brugia malayi G-protein coupled receptor 0.0119 0.0303 0.0943
Loa Loa (eye worm) hypothetical protein 0.0119 0.0303 0.0939
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0119 0.0303 0.0303
Schistosoma mansoni hypothetical protein 0.0119 0.0303 0.0303
Entamoeba histolytica acyl-coA synthetase, putative 0.0047 0.009 0.2645
Brugia malayi RNA binding protein 0.0062 0.0136 0.0423
Echinococcus granulosus tumor susceptibility gene 101 protein 0.0074 0.0173 0.0173
Entamoeba histolytica fatty acid elongase, putative 0.0121 0.0312 1
Mycobacterium tuberculosis Bacterioferritin BfrB 0.0017 0.0005 0.0017
Echinococcus multilocularis 0.002 0.0012 0.0012
Mycobacterium ulcerans beta-ketoacyl synthase-like protein 0.0935 0.2715 1
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.005 0.0101 0.037
Echinococcus multilocularis tar DNA binding protein 0.0062 0.0136 0.0136
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0022 0.0019 0.0019
Echinococcus granulosus neuropeptide receptor 0.0119 0.0303 0.0303
Schistosoma mansoni neuropeptide f receptor 76f 0.0119 0.0303 0.0303
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.1104 0.3214 1
Schistosoma mansoni opsin-like receptor 0.0119 0.0303 0.0303
Brugia malayi Importin beta-1 subunit 0.0031 0.0044 0.0137
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0117 0.0297 1
Schistosoma mansoni histamine h1 receptor 0.0119 0.0303 0.0303
Echinococcus multilocularis importin subunit beta 1 0.0031 0.0044 0.0044
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.005 0.0184
Echinococcus granulosus hypothetical protein 0.0119 0.0303 0.0303
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0136 0.0136
Plasmodium falciparum ataxin-2 like protein, putative 0.0049 0.0099 0.0365
Echinococcus multilocularis rhodopsin orphan GPCR 0.0119 0.0303 0.0303
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0011 0.1354
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0119 0.0303 0.0303
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0134 0.0347 0.0347
Echinococcus granulosus neuropeptide receptor A26 0.0119 0.0303 0.0303
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0119 0.0303 0.0303
Loa Loa (eye worm) hypothetical protein 0.0119 0.0303 0.0939
Loa Loa (eye worm) hypothetical protein 0.0047 0.009 0.0277
Loa Loa (eye worm) hypothetical protein 0.0119 0.0303 0.0939
Plasmodium falciparum thioredoxin reductase 0.0046 0.0089 0.0327
Loa Loa (eye worm) G-protein coupled receptor 0.0119 0.0303 0.0939
Mycobacterium tuberculosis 3-oxoacyl-[acyl-carrier-protein] synthase III FabH (beta-ketoacyl-ACP synthase III) (KAS III) 0.0935 0.2715 1
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0046 0.0089 0.0327
Loa Loa (eye worm) hypothetical protein 0.0119 0.0303 0.0939
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0119 0.0303 0.0939
Loa Loa (eye worm) hypothetical protein 0.0035 0.0056 0.0169
Trypanosoma brucei importin beta-1 subunit, putative 0.0031 0.0044 0.1484
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0329 0.0925 0.2875
Echinococcus granulosus rhodopsin orphan GPCR 0.0119 0.0303 0.0303
Echinococcus granulosus histone acetyltransferase KAT2B 0.0142 0.0372 0.0372
Onchocerca volvulus Neuropeptide F receptor homolog 0.0119 0.0303 0.7345
Echinococcus multilocularis tumor protein p63 0.0987 0.287 0.287
Schistosoma mansoni adenoreceptor 0.0119 0.0303 0.0303
Loa Loa (eye worm) hypothetical protein 0.0119 0.0303 0.0939
Plasmodium falciparum beta-ketoacyl-ACP synthase III 0.0935 0.2715 1
Brugia malayi hypothetical protein 0.0119 0.0303 0.0943
Loa Loa (eye worm) hypothetical protein 0.0119 0.0303 0.0939
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0119 0.0303 0.0303
Loa Loa (eye worm) hypothetical protein 0.0119 0.0303 0.0939
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0119 0.0303 0.0303
Brugia malayi Dopamine receptor protein 1 0.0119 0.0303 0.0943
Echinococcus multilocularis fmrfamide receptor 0.0119 0.0303 0.0303
Onchocerca volvulus 0.0119 0.0303 0.7345
Schistosoma mansoni ferritin light chain 0.0017 0.0005 0.0005
Onchocerca volvulus 0.0059 0.0127 0.1259
Schistosoma mansoni amine GPCR 0.0119 0.0303 0.0303
Schistosoma mansoni microtubule-associated protein tau 0.3401 1 1
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0119 0.0303 0.0303
Onchocerca volvulus 0.0119 0.0303 0.7345
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0117 0.0297 0.1095
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0011 0.004
Loa Loa (eye worm) hypothetical protein 0.0119 0.0303 0.0939
Trichomonas vaginalis hypothetical protein 0.0036 0.006 0.7503
Mycobacterium ulcerans hypothetical protein 0.0047 0.009 0.0333
Loa Loa (eye worm) transcription factor SMAD2 0.0241 0.0665 0.2066
Schistosoma mansoni neuropeptide F-like receptor 0.0119 0.0303 0.0303
Schistosoma mansoni biogenic amine (5HT) receptor 0.0119 0.0303 0.0303
Mycobacterium tuberculosis Probable dehydrogenase 0.0105 0.0263 0.0968
Onchocerca volvulus 0.0119 0.0303 0.7345
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0047 0.009 0.293
Schistosoma mansoni smad 0.0016 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0119 0.0303 0.0939
Echinococcus granulosus neuropeptide Y receptor 0.0119 0.0303 0.0303
Schistosoma mansoni cpg binding protein 0.0062 0.0137 0.0137
Echinococcus granulosus epidermal growth factor receptor 0.0069 0.0158 0.0158
Echinococcus granulosus rhodopsin orphan GPCR 0.0119 0.0303 0.0303
Echinococcus multilocularis neuropeptide Y receptor 0.0119 0.0303 0.0303
Brugia malayi latrophilin 2 splice variant baaae 0.0289 0.0805 0.2506
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0136 0.0136
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0035 0.0056 0.0205
Loa Loa (eye worm) hypothetical protein 0.0035 0.0056 0.0169
Echinococcus granulosus neuropeptides capa receptor 0.0119 0.0303 0.0303
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0119 0.0303 0.0303
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0119 0.0303 0.0943
Loa Loa (eye worm) hypothetical protein 0.0119 0.0303 0.0939
Schistosoma mansoni hypothetical protein 0.0181 0.0488 0.0488
Trichomonas vaginalis bromodomain-containing protein, putative 0.0043 0.008 1
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0119 0.0303 0.0939
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.002 0.0011 0.0365
Loa Loa (eye worm) hypothetical protein 0.0119 0.0303 0.0939
Schistosoma mansoni ferritin light chain 0.0017 0.0005 0.0005
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0105 0.0263 0.0968
Schistosoma mansoni biogenic amine (5HT) receptor 0.0119 0.0303 0.0303
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0022 0.0019 0.0019
Schistosoma mansoni hypothetical protein 0.0119 0.0303 0.0303
Treponema pallidum exodeoxyribonuclease (exoA) 0.002 0.0011 0.0606
Echinococcus granulosus g protein coupled receptor 0.0119 0.0303 0.0303
Echinococcus multilocularis g protein coupled receptor 0.0119 0.0303 0.0303
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0136 0.0136
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0016 0.0001 0.0001
Schistosoma mansoni hypothetical protein 0.0289 0.0805 0.0805
Loa Loa (eye worm) hypothetical protein 0.0088 0.0213 0.0659
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0043 0.008 0.2725
Brugia malayi hypothetical protein 0.0119 0.0303 0.0943
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0146 0.0384 0.0384
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0119 0.0303 0.0303
Echinococcus multilocularis neuropeptide receptor A26 0.0119 0.0303 0.0303
Echinococcus multilocularis ferritin 0.0017 0.0005 0.0005
Brugia malayi hypothetical protein 0.0119 0.0303 0.0943
Echinococcus granulosus rhodopsin orphan GPCR 0.0119 0.0303 0.0303
Echinococcus granulosus dnaJ subfamily B 0.0838 0.2429 0.2429
Trypanosoma cruzi trypanothione reductase, putative 0.0046 0.0089 0.8953
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0119 0.0303 0.0303
Echinococcus granulosus epidermal growth factor receptor 0.0069 0.0158 0.0158
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.005 0.0184
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0119 0.0303 0.0303
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0047 0.009 0.293
Loa Loa (eye worm) hypothetical protein 0.0119 0.0303 0.0939
Echinococcus granulosus peptidase Clp S14 family 0.005 0.0101 0.0101
Echinococcus multilocularis rhodopsin orphan GPCR 0.0119 0.0303 0.0303
Brugia malayi AMP-binding enzyme family protein 0.0047 0.009 0.0281
Mycobacterium ulcerans 3-oxoacyl-ACP synthase 0.0935 0.2715 1
Loa Loa (eye worm) hypothetical protein 0.0119 0.0303 0.0939
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0119 0.0303 0.0303
Loa Loa (eye worm) hypothetical protein 0.0119 0.0303 0.0939
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0119 0.0303 0.0303
Onchocerca volvulus 0.0145 0.038 1
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0119 0.0303 0.0943
Echinococcus multilocularis peptidase Clp (S14 family) 0.005 0.0101 0.0101
Brugia malayi sulfakinin receptor protein 0.0119 0.0303 0.0943
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0027 0.3353
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0119 0.0303 0.0303
Trypanosoma brucei importin beta-1 subunit, putative 0.0031 0.0044 0.1484
Loa Loa (eye worm) hypothetical protein 0.0119 0.0303 0.0939
Brugia malayi hypothetical protein 0.0119 0.0303 0.0943
Schistosoma mansoni amine GPCR 0.0119 0.0303 0.0303
Echinococcus granulosus rhodopsin orphan GPCR 0.0119 0.0303 0.0303
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0119 0.0303 0.0303
Brugia malayi exodeoxyribonuclease III family protein 0.002 0.0011 0.0034
Schistosoma mansoni tyrosine kinase 0.0068 0.0154 0.0154
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0026 0.0031 0.0886
Echinococcus granulosus GPCR family 2 0.0134 0.0347 0.0347
Echinococcus multilocularis serotonin receptor 0.0119 0.0303 0.0303
Loa Loa (eye worm) hypothetical protein 0.0119 0.0303 0.0939
Echinococcus multilocularis somatostatin receptor 0.0119 0.0303 0.0303
Schistosoma mansoni tsg101-related 0.0051 0.0102 0.0102
Loa Loa (eye worm) hypothetical protein 0.0119 0.0303 0.0939
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0117 0.0297 0.1095
Brugia malayi Probable ClpP-like protease 0.0076 0.0178 0.0554
Echinococcus multilocularis smad 0.0016 0.0001 0.0001
Echinococcus multilocularis rhodopsin orphan GPCR 0.0119 0.0303 0.0303
Entamoeba histolytica acyl-CoA synthetase, putative 0.0047 0.009 0.2645
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0023 0.002 0.0073
Entamoeba histolytica fatty acid elongase, putative 0.0121 0.0312 1
Echinococcus multilocularis epidermal growth factor receptor 0.0069 0.0158 0.0158
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0153 0.0404 0.0404
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0119 0.0303 0.0303
Loa Loa (eye worm) hypothetical protein 0.0119 0.0303 0.0939
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0119 0.0303 0.0303
Echinococcus multilocularis neuropeptide FF receptor 2 0.0119 0.0303 0.0303
Loa Loa (eye worm) neuropeptide F receptor 0.0119 0.0303 0.0939
Echinococcus multilocularis g protein coupled receptor 0.0119 0.0303 0.0303
Onchocerca volvulus 0.0119 0.0303 0.7345
Brugia malayi neuropeptide F receptor 0.0119 0.0303 0.0943
Trypanosoma brucei PAB1-binding protein , putative 0.0049 0.0099 0.3345
Leishmania major hypothetical protein, conserved 0.0049 0.0099 1

Activities

Activity type Activity value Assay description Source Reference
Activity (ADMET) = 3.6 /nmol Skin irritant activity in NMRI mouse ear assessed as irritancy 50 after 24 hrs ChEMBL. 3236005
Activity (ADMET) = 0.28 nmol Skin irritant activity in NMRI mouse ear assessed as irritant dose 50 per ear after 24 hrs ChEMBL. 3236005

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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