Detailed information for compound 990930

Basic information

Technical information
  • TDR Targets ID: 990930
  • Name: N-[2-(7-methoxy-3-phenyl-1,2,3,4-tetrahydrona phthalen-1-yl)ethyl]cyclobutanecarboxamide
  • MW: 363.493 | Formula: C24H29NO2
  • H donors: 1 H acceptors: 1 LogP: 4.94 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc2c(c1)C(CCNC(=O)C1CCC1)CC(C2)c1ccccc1
  • InChi: 1S/C24H29NO2/c1-27-22-11-10-19-14-21(17-6-3-2-4-7-17)15-20(23(19)16-22)12-13-25-24(26)18-8-5-9-18/h2-4,6-7,10-11,16,18,20-21H,5,8-9,12-15H2,1H3,(H,25,26)
  • InChiKey: CHNMYFQAXCNAFN-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-[2-(7-methoxy-3-phenyl-tetralin-1-yl)ethyl]cyclobutanecarboxamide
  • N-[2-(7-methoxy-3-phenyl-1-tetralinyl)ethyl]cyclobutanecarboxamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0181 0.0121 1
Echinococcus multilocularis dna polymerase eta 0.0045 0.0015 0.0015
Echinococcus granulosus TGF beta signal transducer SmadC 0.0102 0.0059 0.0059
Brugia malayi MH2 domain containing protein 0.0102 0.0059 0.0329
Echinococcus multilocularis serotonin transporter 0.0152 0.0099 0.0099
Onchocerca volvulus 0.0026 0 0.0001
Loa Loa (eye worm) hypothetical protein 0.0099 0.0057 0.0316
Mycobacterium leprae Probable glycosyltransferase 0.0037 0.0008 0.002
Schistosoma mansoni lamin 0.0139 0.0088 0.0088
Loa Loa (eye worm) hypothetical protein 0.0046 0.0015 0.0085
Brugia malayi Pre-SET motif family protein 0.0336 0.0242 0.1339
Schistosoma mansoni smad1 5 8 and 0.0102 0.0059 0.0059
Trypanosoma cruzi UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase, putative 0.0031 0.0004 0.0333
Loa Loa (eye worm) hypothetical protein 0.0027 0.0001 0.0003
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0028 0.0065
Echinococcus granulosus thioredoxin glutathione reductase 0.0048 0.0017 0.0017
Trypanosoma cruzi UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase, putative 0.0031 0.0004 0.0333
Giardia lamblia Cysteinyl-tRNA synthetase 0.008 0.0042 0.3446
Echinococcus granulosus serotonin transporter 0.0152 0.0099 0.0099
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0323 0.0232 0.0232
Trichomonas vaginalis bromodomain-containing protein, putative 0.005 0.0019 0.0089
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.005 0.0019 0.0773
Mycobacterium tuberculosis Conserved protein 0.0113 0.0068 0.016
Mycobacterium leprae Probable phospho-N-acetylmuramoyl-pentappeptidetransferase MurX 0.0749 0.0563 0.1329
Schistosoma mansoni hypothetical protein 0.0229 0.0158 0.0158
Echinococcus granulosus histone acetyltransferase KAT2B 0.005 0.0019 0.0019
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0232 0.016 0.016
Toxoplasma gondii ABC1 family protein 0.0113 0.0068 0.281
Leishmania major DNA polymerase eta, putative 0.0032 0.0005 0.0401
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0189 0.0127 0.0127
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0181 0.0121 1
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0152 0.0099 0.0547
Brugia malayi MH1 domain containing protein 0.0056 0.0024 0.0132
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0189 0.0127 0.0127
Trichomonas vaginalis PIKK family atypical protein kinase 0.0135 0.0085 0.0411
Onchocerca volvulus 0.0113 0.0068 0.0331
Schistosoma mansoni tar DNA-binding protein 0.0201 0.0137 0.0136
Schistosoma mansoni Smad4 0.0102 0.0059 0.0059
Plasmodium vivax N-acetylglucosamine-1-phosphate transferase, putative 0.0031 0.0004 0.0179
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0113 0.0068 0.0068
Trichomonas vaginalis PIKK family atypical protein kinase 0.0049 0.0018 0.0085
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0074 0.0038 0.0211
Toxoplasma gondii FATC domain-containing protein 0.0034 0.0007 0.0271
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0035 0.0007 0.0007
Trichomonas vaginalis PIKK family atypical protein kinase 0.0098 0.0056 0.0271
Brugia malayi Bromodomain containing protein 0.008 0.0042 0.0235
Brugia malayi jmjC domain containing protein 0.0072 0.0036 0.0199
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.005 0.0019 0.0089
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative 0.0153 0.0099 0.4089
Schistosoma mansoni jumonji domain containing protein 0.015 0.0097 0.0097
Echinococcus multilocularis jumonji domain containing protein 0.008 0.0042 0.0042
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0102 0.0059 0.0059
Giardia lamblia UDP-N-acetylglucosamine-dolichyl-phosphateN-acetylglucosaminephosphotransferase 0.0031 0.0004 0.0333
Toxoplasma gondii PHD-finger domain-containing protein 0.0058 0.0025 0.1025
Loa Loa (eye worm) serotonin transporter b 0.0152 0.0099 0.0547
Loa Loa (eye worm) MH2 domain-containing protein 0.0046 0.0015 0.0085
Trichomonas vaginalis PIKK family atypical protein kinase 0.0144 0.0092 0.0447
Schistosoma mansoni dihydrofolate reductase 0.0044 0.0014 0.0014
Echinococcus granulosus thymidylate synthase 0.0108 0.0064 0.0064
Echinococcus multilocularis thymidylate synthase 0.0108 0.0064 0.0064
Schistosoma mansoni cysteinyl-tRNA synthetase 0.008 0.0042 0.0042
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0181 0.0121 0.7553
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0113 0.0068 0.016
Trichomonas vaginalis PIKK family atypical protein kinase 0.0135 0.0085 0.0411
Trichomonas vaginalis PIKK family atypical protein kinase 0.0144 0.0092 0.0447
Leishmania major cysteinyl-tRNA synthetase, putative 0.008 0.0042 0.3469
Echinococcus granulosus mothers against decapentaplegic 5 0.0102 0.0059 0.0059
Echinococcus granulosus smad 0.0102 0.0059 0.0059
Plasmodium falciparum histone acetyltransferase GCN5 0.0043 0.0014 0.1389
Loa Loa (eye worm) hypothetical protein 0.0324 0.0233 0.129
Echinococcus multilocularis mothers against decapentaplegic 5 0.0102 0.0059 0.0059
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0181 0.0121 1
Onchocerca volvulus Mothers against decapentaplegic homolog 0.0046 0.0015 0.0075
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0034 0.0007 0.0517
Trichomonas vaginalis PIKK family atypical protein kinase 0.0135 0.0085 0.0411
Onchocerca volvulus 0.0139 0.0088 0.0429
Mycobacterium tuberculosis Cysteine:1D-myo-inosityl 2-amino-2-deoxy--D-glucopyranoside ligase MshC 0.5464 0.4237 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0181 0.0121 0.0588
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0244 0.017 0.017
Onchocerca volvulus 0.0113 0.0068 0.0331
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0061 0.0028 0.0065
Mycobacterium ulcerans cysteinyl-tRNA synthetase 0.5464 0.4237 1
Trypanosoma cruzi DNA polymerase eta, putative 0.0045 0.0015 0.124
Brugia malayi beta-lactamase family protein 0.0113 0.0068 0.0377
Trichomonas vaginalis PIKK family atypical protein kinase 0.0144 0.0092 0.0447
Schistosoma mansoni apoferritin-2 0.0062 0.0028 0.0028
Trichomonas vaginalis PIKK family atypical protein kinase 0.0061 0.0027 0.0131
Loa Loa (eye worm) hypothetical protein 0.0139 0.0088 0.0489
Loa Loa (eye worm) nuclear factor I 0.0056 0.0024 0.0132
Onchocerca volvulus 0.0324 0.0233 0.1132
Loa Loa (eye worm) norepinephrine transporter 0.0152 0.0099 0.0547
Echinococcus multilocularis serine protein kinase ATM 0.0034 0.0007 0.0007
Echinococcus granulosus GPCR family 2 0.0229 0.0158 0.0158
Onchocerca volvulus Alhambra homolog 0.0058 0.0025 0.0121
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0061 0.0027 0.2227
Loa Loa (eye worm) hypothetical protein 0.0045 0.0015 0.0085
Chlamydia trachomatis cysteine--tRNA ligase 0.008 0.0042 0.208
Loa Loa (eye worm) hypothetical protein 0.0026 0 0.0001
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0061 0.0027 0.0027
Plasmodium vivax flap endonuclease 1, putative 0.0026 0 0.0013
Loa Loa (eye worm) MH1 domain-containing protein 0.0046 0.0015 0.0085
Schistosoma mansoni tar DNA-binding protein 0.0201 0.0137 0.0136
Giardia lamblia GTOR 0.0181 0.0121 1
Plasmodium vivax SET domain protein, putative 0.0336 0.0242 1
Brugia malayi MH1 domain containing protein 0.0102 0.0059 0.0329
Brugia malayi ImpB/MucB/SamB family protein 0.0045 0.0015 0.0085
Brugia malayi cysteinyl tRNA synthetase protein 1 0.008 0.0042 0.0233
Brugia malayi RNA recognition motif domain containing protein 0.0201 0.0137 0.0757
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0229 0.0158 0.0877
Trypanosoma cruzi cysteinyl-tRNA synthetase, putative 0.008 0.0042 0.3446
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0058 0.0025 0.0025
Loa Loa (eye worm) glutathione reductase 0.0048 0.0017 0.0095
Echinococcus multilocularis cysteinyl tRNA synthetase 0.008 0.0042 0.0042
Mycobacterium leprae PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) 0.0108 0.0064 0.0152
Echinococcus multilocularis musashi 0.0139 0.0088 0.0088
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase 0.0153 0.0099 0.8151
Echinococcus granulosus lamin dm0 0.0139 0.0088 0.0088
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase 0.0153 0.0099 0.4089
Echinococcus multilocularis lamin dm0 0.0139 0.0088 0.0088
Trichomonas vaginalis PIKK family atypical protein kinase 0.0098 0.0056 0.0271
Brugia malayi Pre-SET motif family protein 0.2341 0.1804 1
Brugia malayi beta-lactamase family protein 0.0113 0.0068 0.0377
Echinococcus multilocularis UDP N acetylglucosamine dolichyl phosphate 0.0031 0.0004 0.0004
Schistosoma mansoni bifunctional dihydrofolate reductase-thymidylate synthase 0.0108 0.0064 0.0064
Loa Loa (eye worm) hypothetical protein 0.0026 0 0.0001
Echinococcus granulosus tar DNA binding protein 0.0201 0.0137 0.0136
Trichomonas vaginalis PIKK family atypical protein kinase 0.0098 0.0056 0.0271
Treponema pallidum sodium- and chloride- dependent transporter 0.0152 0.0099 0.4067
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0034 0.0007 0.0517
Mycobacterium ulcerans phospho-N-acetylmuramoyl-pentapeptide-transferase 0.0749 0.0563 0.1329
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0034 0.0007 0.0007
Mycobacterium ulcerans beta-lactamase 0.0113 0.0068 0.016
Echinococcus granulosus tumor protein p63 0.4166 0.3226 0.3225
Trichomonas vaginalis PIKK family atypical protein kinase 0.0098 0.0056 0.0271
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0061 0.0028 0.2284
Loa Loa (eye worm) hypothetical protein 0.0065 0.003 0.0168
Leishmania major dihydrofolate reductase-thymidylate synthase 0.0153 0.0099 0.8157
Brugia malayi PHD-finger family protein 0.0058 0.0025 0.0138
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase 0.0153 0.0099 0.8151
Loa Loa (eye worm) hypothetical protein 0.061 0.0455 0.2523
Mycobacterium tuberculosis Bacterioferritin BfrB 0.0062 0.0028 0.0066
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0026 0 0.0001
Plasmodium vivax histone acetyltransferase GCN5, putative 0.005 0.0019 0.0773
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0109 0.0065 0.0153
Mycobacterium tuberculosis Probable bacterioferritin BfrA 0.0062 0.0028 0.0066
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0336 0.0242 0.0241
Onchocerca volvulus 0.0139 0.0088 0.0429
Loa Loa (eye worm) hypothetical protein 0.0113 0.0068 0.0377
Trichomonas vaginalis PIKK family atypical protein kinase 0.0135 0.0085 0.0411
Schistosoma mansoni ferritin 0.0062 0.0028 0.0028
Mycobacterium leprae Probable lipase LipE 0.0113 0.0068 0.016
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0229 0.0158 0.0158
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0121 0.0074 0.0175
Mycobacterium leprae PROBABLE BACTERIOFERRITIN BFRA 0.0062 0.0028 0.0066
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0113 0.0068 0.0377
Loa Loa (eye worm) hypothetical protein 0.0056 0.0024 0.0132
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0181 0.0121 1
Plasmodium falciparum phd finger protein, putative 0.0058 0.0025 0.2507
Wolbachia endosymbiont of Brugia malayi cysteinyl-tRNA synthetase 0.008 0.0042 0.0259
Trypanosoma brucei cysteinyl-tRNA synthetase, putative 0.008 0.0042 0.3446
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0181 0.0121 0.0672
Brugia malayi Thioredoxin reductase 0.0048 0.0017 0.0095
Loa Loa (eye worm) phosphatidylinositol 3 0.0061 0.0027 0.0151
Plasmodium vivax thioredoxin reductase, putative 0.0048 0.0017 0.0704
Loa Loa (eye worm) hypothetical protein 0.0058 0.0025 0.0138
Loa Loa (eye worm) hypothetical protein 0.0065 0.003 0.0168
Loa Loa (eye worm) hypothetical protein 0.0723 0.0543 0.3013
Loa Loa (eye worm) hypothetical protein 0.0077 0.004 0.0222
Loa Loa (eye worm) solute carrier family 6 member 4 0.0152 0.0099 0.0547
Schistosoma mansoni UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase 0.0031 0.0004 0.0004
Mycobacterium leprae conserved hypothetical protein 0.0113 0.0068 0.016
Toxoplasma gondii cysteine-tRNA synthetase (CysRS) 0.008 0.0042 0.1736
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0113 0.0068 0.016
Loa Loa (eye worm) hypothetical protein 0.0113 0.0068 0.0377
Echinococcus multilocularis PHD finger protein rhinoceros 0.0058 0.0025 0.0025
Mycobacterium ulcerans lipase LipD 0.0113 0.0068 0.016
Trichomonas vaginalis PIKK family atypical protein kinase 0.0155 0.0101 0.0487
Trichomonas vaginalis conserved hypothetical protein 0.0052 0.002 0.0096
Trichomonas vaginalis PIKK family atypical protein kinase 0.0144 0.0092 0.0447
Wolbachia endosymbiont of Brugia malayi UDP-N-acetylglucosamine:LPS N-acetylglucosamine transferase 0.0173 0.0115 0.1615
Schistosoma mansoni DNA polymerase eta 0.0045 0.0015 0.0015
Trichomonas vaginalis PIKK family atypical protein kinase 0.0181 0.0121 0.0588
Trichomonas vaginalis penicillin-binding protein, putative 0.0113 0.0068 0.0329
Trichomonas vaginalis PIKK family atypical protein kinase 0.0135 0.0085 0.0411
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0032 0.0005 0.0196
Plasmodium vivax hypothetical protein, conserved 0.0058 0.0025 0.1025
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0164 0.0107 0.0107
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0109 0.0065 0.0153
Schistosoma mansoni hypothetical protein 0.0232 0.016 0.016
Schistosoma mansoni tar DNA-binding protein 0.0201 0.0137 0.0136
Echinococcus granulosus histone lysine methyltransferase setb 0.0353 0.0255 0.0255
Trypanosoma cruzi PAB1-binding protein , putative 0.0077 0.004 0.3285
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0037 0.0008 0.0008
Loa Loa (eye worm) hypothetical protein 0.0047 0.0017 0.0093
Brugia malayi Intermediate filament tail domain containing protein 0.0139 0.0088 0.0489
Mycobacterium tuberculosis Probable lipase LipD 0.0113 0.0068 0.016
Onchocerca volvulus 0.0026 0 0.0001
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0028 0.0065
Trichomonas vaginalis esterase, putative 0.0113 0.0068 0.0329
Trichomonas vaginalis PIKK family atypical protein kinase 0.0107 0.0063 0.0307
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0067 0.0032 0.0032
Schistosoma mansoni Smad4 0.0046 0.0015 0.0015
Trypanosoma cruzi cysteinyl-tRNA synthetase, putative 0.008 0.0042 0.3446
Brugia malayi hypothetical protein 0.005 0.0019 0.0104
Trichomonas vaginalis ferritin, putative 0.0062 0.0028 0.0135
Brugia malayi PHD-finger family protein 0.0029 0.0003 0.0015
Mycobacterium ulcerans thymidylate synthase 0.0108 0.0064 0.0152
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0035 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.008 0.0042 0.0233
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0026 0 0.0001
Toxoplasma gondii thioredoxin reductase 0.0048 0.0017 0.0704
Loa Loa (eye worm) latrophilin receptor protein 2 0.0229 0.0158 0.0877
Onchocerca volvulus 0.0026 0 0.0001
Loa Loa (eye worm) Smad1 0.0102 0.0059 0.0329
Loa Loa (eye worm) TAR-binding protein 0.0201 0.0137 0.0757
Plasmodium vivax ataxin-2 like protein, putative 0.0077 0.004 0.1656
Treponema pallidum undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase 0.0173 0.0115 0.4981
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0181 0.0121 1
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0139 0.0088 0.0489
Toxoplasma gondii aldehyde dehydrogenase 0.0061 0.0028 0.1142
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0102 0.0059 0.0059
Brugia malayi Latrophilin receptor protein 2 0.0229 0.0158 0.0877
Schistosoma mansoni microtubule-associated protein tau 1.2863 1 1
Leishmania major trypanothione reductase 0.0048 0.0017 0.1413
Brugia malayi jmjC domain containing protein 0.0189 0.0127 0.0704
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0201 0.0137 0.0757
Brugia malayi Bromodomain containing protein 0.0043 0.0013 0.0074
Loa Loa (eye worm) thioredoxin reductase 0.0048 0.0017 0.0095
Brugia malayi acetyltransferase, GNAT family protein 0.0164 0.0107 0.0596
Brugia malayi MH1 domain containing protein 0.0102 0.0059 0.0329
Schistosoma mansoni smad 0.0102 0.0059 0.0059
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0065 0.003 0.003
Schistosoma mansoni hypothetical protein 0.0494 0.0365 0.0365
Echinococcus multilocularis mothers against decapentaplegic 6 0.0046 0.0015 0.0015
Mycobacterium tuberculosis Probable glycosyltransferase 0.0037 0.0008 0.002
Echinococcus granulosus jumonji domain containing protein 0.008 0.0042 0.0042
Trypanosoma brucei hypothetical protein, conserved 0.0113 0.0068 0.5593
Mycobacterium ulcerans undecapaprenyl-phosphate alpha-N-acetylglucosaminyltransferase Rfe 0.0031 0.0004 0.001
Entamoeba histolytica hypothetical protein 0.0034 0.0007 0.0416
Mycobacterium tuberculosis Probable dehydrogenase 0.0109 0.0065 0.0153
Loa Loa (eye worm) hypothetical protein 0.0152 0.0099 0.0547
Treponema pallidum phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) 0.0285 0.0202 1
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0067 0.0032 0.0032
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0232 0.016 0.016
Schistosoma mansoni hypothetical protein 0.0244 0.017 0.017
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0061 0.0027 0.0027
Schistosoma mansoni hypothetical protein 0.0229 0.0158 0.0158
Brugia malayi MH2 domain containing protein 0.0046 0.0015 0.0085
Trichomonas vaginalis D-aminoacylase, putative 0.0113 0.0068 0.0329
Plasmodium vivax cysteine--tRNA ligase, putative 0.008 0.0042 0.1736
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0109 0.0065 0.0153
Leishmania major DNA polymerase eta, putative 0.0045 0.0015 0.127
Loa Loa (eye worm) hypothetical protein 0.0494 0.0365 0.2025
Brugia malayi FAT domain containing protein 0.0027 0.0001 0.0003
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0181 0.0121 0.0121
Schistosoma mansoni cysteinyl-tRNA synthetase 0.008 0.0042 0.0042
Onchocerca volvulus 0.0113 0.0068 0.0331
Loa Loa (eye worm) hypothetical protein 0.0113 0.0068 0.0377
Echinococcus granulosus PHD finger protein rhinoceros 0.0058 0.0025 0.0025
Entamoeba histolytica Flap nuclease, putative 0.0026 0 0.0026
Trypanosoma brucei UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase, putative 0.0031 0.0004 0.0333
Trichomonas vaginalis glucosaminephosphotransferase, putative 0.0031 0.0004 0.002
Trichomonas vaginalis D-aminoacylase, putative 0.0113 0.0068 0.0329
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0061 0.0027 0.2254
Brugia malayi beta-lactamase 0.0113 0.0068 0.0377
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0113 0.0068 0.016
Trypanosoma cruzi target of rapamycin kinase 3 0.0144 0.0092 0.7617
Trypanosoma brucei PAB1-binding protein , putative 0.0077 0.004 0.3285
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0061 0.0028 0.0028
Brugia malayi MH1 domain containing protein 0.0056 0.0024 0.0132
Trichomonas vaginalis PIKK family atypical protein kinase 0.0122 0.0075 0.0361
Echinococcus multilocularis GPCR, family 2 0.0229 0.0158 0.0158
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0113 0.0068 0.0068
Mycobacterium tuberculosis Probable thymidylate synthase ThyA (ts) (TSASE) 0.0108 0.0064 0.0152
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0026 0 0.0001
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0061 0.0027 0.0151
Trypanosoma cruzi hypothetical protein, conserved 0.0113 0.0068 0.5593
Loa Loa (eye worm) PHD-finger family protein 0.0058 0.0025 0.0138
Loa Loa (eye worm) hypothetical protein 0.0034 0.0007 0.0037
Schistosoma mansoni ferritin light chain 0.0062 0.0028 0.0028
Echinococcus multilocularis lamin 0.0139 0.0088 0.0088
Schistosoma mansoni sodium/chloride dependent transporter 0.0152 0.0099 0.0099
Trypanosoma cruzi PAB1-binding protein , putative 0.0077 0.004 0.3285
Mycobacterium leprae ProbableUPD-N-acetylglucosamine-N-acetylmuramyl-(pentapeptide)pyrophosphoryl-undecaprenol-N-acetylglucosamine transferase MurG 0.0127 0.0079 0.0185
Mycobacterium ulcerans bacterioferritin BfrA 0.0062 0.0028 0.0066
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase 0.0153 0.0099 1
Loa Loa (eye worm) hypothetical protein 0.0152 0.0099 0.0547
Leishmania major phosphatidylinositol 3-kinase, putative 0.0061 0.0027 0.2254
Onchocerca volvulus 0.061 0.0455 0.2214
Plasmodium falciparum cysteine--tRNA ligase 0.008 0.0042 0.4245
Schistosoma mansoni intermediate filament proteins 0.0139 0.0088 0.0088
Trichomonas vaginalis PIKK family atypical protein kinase 0.0108 0.0064 0.0311
Giardia lamblia PHD finger protein 15 0.0058 0.0025 0.2024
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0061 0.0027 0.0027
Trichomonas vaginalis PIKK family atypical protein kinase 0.0061 0.0027 0.0131
Entamoeba histolytica hypothetical protein 0.0232 0.016 1
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0164 0.0107 0.0107
Brugia malayi cytoplasmic intermediate filament protein 0.0074 0.0038 0.0211
Trypanosoma brucei trypanothione reductase 0.0048 0.0017 0.1383
Trichomonas vaginalis PIKK family atypical protein kinase 0.0144 0.0092 0.0447
Echinococcus granulosus cysteinyl tRNA synthetase 0.008 0.0042 0.0042
Trichomonas vaginalis PIKK family atypical protein kinase 0.0107 0.0063 0.0307
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0353 0.0255 0.0255
Wolbachia endosymbiont of Brugia malayi phospho-N-acetylmuramoyl-pentapeptide-transferase 0.0749 0.0563 1
Brugia malayi hypothetical protein 0.0077 0.004 0.0222
Loa Loa (eye worm) jmjC domain-containing protein 0.0072 0.0036 0.0199
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0109 0.0065 0.0153
Brugia malayi hypothetical protein 0.0324 0.0233 0.129
Brugia malayi RNA binding protein 0.0201 0.0137 0.0757
Schistosoma mansoni ferritin 0.0062 0.0028 0.0028
Schistosoma mansoni hypothetical protein 0.0058 0.0025 0.0025
Echinococcus multilocularis thyroid hormone receptor alpha 0.0264 0.0185 0.0185
Entamoeba histolytica hypothetical protein 0.0232 0.016 1
Mycobacterium ulcerans cysteinyl-tRNA synthetase 0.008 0.0042 0.0099
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0007 0.003
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0152 0.0099 0.0099
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0031 0.0004 0.0004
Echinococcus multilocularis Smad4 0.0102 0.0059 0.0059
Entamoeba histolytica hypothetical protein 0.0232 0.016 1
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0109 0.0065 0.0153
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0353 0.0255 0.0255
Brugia malayi TAR-binding protein 0.0201 0.0137 0.0757
Loa Loa (eye worm) intermediate filament protein 0.0139 0.0088 0.0489
Entamoeba histolytica UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase, putative 0.0031 0.0004 0.0277
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0113 0.0068 0.0377
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0181 0.0121 0.0121
Echinococcus granulosus mothers against decapentaplegic 6 0.0046 0.0015 0.0015
Leishmania major hypothetical protein, conserved 0.0113 0.0068 0.5609
Schistosoma mansoni thyroid hormone receptor 0.0264 0.0185 0.0185
Loa Loa (eye worm) hypothetical protein 0.0026 0 0.0001
Trichomonas vaginalis PIKK family atypical protein kinase 0.0108 0.0064 0.0311
Brugia malayi glutathione reductase 0.0048 0.0017 0.0095
Brugia malayi hypothetical protein 0.0026 0 0.0001
Schistosoma mansoni Smad4 0.0046 0.0015 0.0015
Echinococcus granulosus expressed protein 0.0062 0.0028 0.0028
Mycobacterium ulcerans esterase/lipase LipP 0.0113 0.0068 0.016
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.001 0.0045
Mycobacterium tuberculosis Probable UPD-N-acetylglucosamine-N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol-N-acetylglucosamine transferase MurG 0.0127 0.0079 0.0185
Echinococcus multilocularis mothers against decapentaplegic 2 0.0046 0.0015 0.0015
Loa Loa (eye worm) hypothetical protein 0.0026 0 0.0001
Trichomonas vaginalis cysteinyl-tRNA synthetase, putative 0.008 0.0042 0.0202
Trypanosoma brucei DNA polymerase eta, putative 0.0045 0.0015 0.124
Schistosoma mansoni fkbp-rapamycin associated protein 0.0034 0.0007 0.0007
Onchocerca volvulus 0.0336 0.0242 0.1175
Echinococcus granulosus serine protein kinase ATM 0.0034 0.0007 0.0007
Brugia malayi Bromodomain containing protein 0.0064 0.003 0.0165
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.0028 0.0028
Toxoplasma gondii glycosyl transferase, group 4 family protein 0.0031 0.0004 0.0179
Brugia malayi Dihydrofolate reductase 0.0044 0.0014 0.008
Loa Loa (eye worm) MH1 domain-containing protein 0.0102 0.0059 0.0329
Echinococcus multilocularis expressed protein 0.0062 0.0028 0.0028
Schistosoma mansoni ferritin 0.0062 0.0028 0.0028
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0026 0 0.0001
Mycobacterium ulcerans dihydrofolate reductase DfrA 0.0044 0.0014 0.0034
Echinococcus multilocularis thioredoxin glutathione reductase 0.0048 0.0017 0.0017
Schistosoma mansoni hypothetical protein 0.0229 0.0158 0.0158
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0121 0.0074 0.0175
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0034 0.0007 0.0037
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0181 0.0121 0.0121
Toxoplasma gondii target of rapamycin (TOR), putative 0.0135 0.0085 0.3515
Loa Loa (eye worm) cysteinyl tRNA synthetase 1 0.008 0.0042 0.0233
Mycobacterium tuberculosis Probable hydrolase 0.0113 0.0068 0.016
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0336 0.0242 0.0241
Trypanosoma cruzi trypanothione reductase, putative 0.0048 0.0017 0.1383
Loa Loa (eye worm) jmjC domain-containing protein 0.0119 0.0073 0.0403
Plasmodium vivax hypothetical protein, conserved 0.0113 0.0068 0.281
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0026 0 0.0001
Schistosoma mansoni smad1 5 8 and 0.0102 0.0059 0.0059
Brugia malayi hypothetical protein 0.0052 0.002 0.0112
Loa Loa (eye worm) hypothetical protein 0.0045 0.0015 0.0085
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0001 0.0001
Trichomonas vaginalis PIKK family atypical protein kinase 0.0108 0.0064 0.0311
Loa Loa (eye worm) flap endonuclease-1 0.0026 0 0.0002
Echinococcus multilocularis lysine specific demethylase 5A 0.007 0.0034 0.0034
Echinococcus granulosus intermediate filament protein 0.0139 0.0088 0.0088
Mycobacterium tuberculosis Hypothetical protein 0.0052 0.002 0.0048
Entamoeba histolytica cysteinyl-tRNA synthetase, putative 0.008 0.0042 0.262
Mycobacterium tuberculosis Conserved protein 0.0113 0.0068 0.016
Schistosoma mansoni thyroid hormone receptor 0.0264 0.0185 0.0185
Trichomonas vaginalis PIKK family atypical protein kinase 0.0118 0.0072 0.0346
Schistosoma mansoni smad 0.0046 0.0015 0.0015
Plasmodium vivax glutathione reductase, putative 0.0048 0.0017 0.0704
Echinococcus granulosus dihydrofolate reductase 0.0044 0.0014 0.0014
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.005 0.0019 0.0773
Echinococcus multilocularis smad 0.0102 0.0059 0.0059
Echinococcus multilocularis microtubule associated protein 2 1.2863 1 1
Loa Loa (eye worm) thymidylate synthase 0.0108 0.0064 0.0357
Onchocerca volvulus 0.008 0.0042 0.0204
Schistosoma mansoni hypothetical protein 0.0035 0.0007 0.0007
Brugia malayi F/Y-rich N-terminus family protein 0.0033 0.0006 0.0032
Mycobacterium ulcerans hypothetical protein 0.0113 0.0068 0.016
Leishmania major UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase, putative 0.0031 0.0004 0.0367
Loa Loa (eye worm) hypothetical protein 0.0152 0.0099 0.0547
Echinococcus granulosus leucyl tRNA synthetase 0.008 0.0042 0.0042
Schistosoma mansoni apoferritin-2 0.0062 0.0028 0.0028
Trichomonas vaginalis PIKK family atypical protein kinase 0.0098 0.0056 0.0271
Mycobacterium ulcerans undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase 0.0173 0.0115 0.027
Loa Loa (eye worm) hypothetical protein 0.0026 0 0.0001
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.2341 0.1804 1
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0229 0.0158 0.0158
Brugia malayi hypothetical protein 0.0232 0.016 0.0889
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0026 0 0.0035
Echinococcus granulosus histone acetyltransferase KAT2B 0.0157 0.0102 0.0102
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0336 0.0242 0.0241
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0229 0.0158 0.0158
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.0028 0.0028
Mycobacterium tuberculosis Probable oxidoreductase 0.0121 0.0074 0.0175
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0723 0.0543 0.3013
Trichomonas vaginalis PIKK family atypical protein kinase 0.0098 0.0056 0.0271
Echinococcus multilocularis tar DNA binding protein 0.0201 0.0137 0.0136
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0086 0.0047 0.3836
Echinococcus granulosus beta LACTamase domain containing family member 0.0113 0.0068 0.0068
Loa Loa (eye worm) hypothetical protein 0.0037 0.0009 0.0048
Entamoeba histolytica protein kinase rad3, putative 0.0034 0.0007 0.0416
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0075 0.0039 0.3162
Mycobacterium tuberculosis Probable reductase 0.0109 0.0065 0.0153
Trichomonas vaginalis PIKK family atypical protein kinase 0.0061 0.0027 0.0131
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0113 0.0068 0.016
Mycobacterium tuberculosis Probable lipase LipE 0.0113 0.0068 0.016
Loa Loa (eye worm) dihydrofolate reductase 0.0044 0.0014 0.008
Loa Loa (eye worm) hypothetical protein 0.0067 0.0032 0.0179
Schistosoma mansoni transcription factor LCR-F1 0.0232 0.016 0.016
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0121 0.0074 0.0175
Leishmania major hypothetical protein, conserved 0.0077 0.004 0.3309
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0034 0.0007 0.0517
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0722 0.0542 0.128
Schistosoma mansoni hypothetical protein 0.0229 0.0158 0.0158
Brugia malayi latrophilin 2 splice variant baaae 0.0494 0.0365 0.2025
Schistosoma mansoni jumonji/arid domain-containing protein 0.0072 0.0036 0.0036
Brugia malayi Smad1 0.0102 0.0059 0.0329
Plasmodium falciparum thioredoxin reductase 0.0048 0.0017 0.1722
Trichomonas vaginalis penicillin-binding protein, putative 0.0113 0.0068 0.0329
Trypanosoma cruzi hypothetical protein, conserved 0.0113 0.0068 0.5593
Mycobacterium tuberculosis Probable phospho-N-acetylmuramoyl-pentappeptidetransferase MurX 0.0749 0.0563 0.1329
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0034 0.0007 0.0007
Mycobacterium tuberculosis Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) 0.0044 0.0014 0.0034
Mycobacterium ulcerans glycosyltransferase 0.0037 0.0008 0.002
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0229 0.0158 0.0158
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0038 0.001 0.0398
Loa Loa (eye worm) beta-lactamase 0.0113 0.0068 0.0377
Echinococcus granulosus Smad4 0.0102 0.0059 0.0059
Brugia malayi thymidylate synthase 0.0108 0.0064 0.0357
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0144 0.0092 0.7625
Loa Loa (eye worm) hypothetical protein 0.0072 0.0036 0.0199
Plasmodium falciparum ataxin-2 like protein, putative 0.0077 0.004 0.4049
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0007 0.003
Trichomonas vaginalis PIKK family atypical protein kinase 0.0181 0.0121 0.0588
Plasmodium falciparum glutathione reductase 0.0048 0.0017 0.1722
Echinococcus granulosus ferritin 0.0062 0.0028 0.0028
Schistosoma mansoni jumonji/arid domain-containing protein 0.0072 0.0036 0.0036
Entamoeba histolytica acetyltransferase, GNAT family 0.0043 0.0014 0.0862
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0026 0 0.0013
Chlamydia trachomatis UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase 0.0173 0.0115 0.5679
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0181 0.0121 0.7553
Echinococcus granulosus dna polymerase eta 0.0045 0.0015 0.0015
Plasmodium falciparum cysteine--tRNA ligase 0.008 0.0042 0.4245
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0061 0.0028 0.0028
Loa Loa (eye worm) hypothetical protein 0.0113 0.0068 0.0377
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0061 0.0027 0.2227
Loa Loa (eye worm) hypothetical protein 0.0026 0 0.0001
Loa Loa (eye worm) hypothetical protein 0.0113 0.0068 0.0377
Brugia malayi MH2 domain containing protein 0.1494 0.1144 0.6343
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0723 0.0543 0.3013
Loa Loa (eye worm) transcription factor SMAD2 0.1494 0.1144 0.6343
Schistosoma mansoni tar DNA-binding protein 0.0201 0.0137 0.0136
Mycobacterium leprae DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) 0.0044 0.0014 0.0034
Mycobacterium leprae Probable cysteine:1D-myo-inosityl 2-amino-2-deoxy--D-glucopyranoside ligase MshC 0.5464 0.4237 1
Schistosoma mansoni lamin 0.0139 0.0088 0.0088
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0353 0.0255 0.0255
Echinococcus multilocularis peregrin 0.0064 0.003 0.003
Trichomonas vaginalis PIKK family atypical protein kinase 0.0098 0.0056 0.0271
Loa Loa (eye worm) hypothetical protein 0.0026 0 0.0001
Brugia malayi dihydrofolate reductase family protein 0.0044 0.0014 0.008
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0336 0.0242 1
Echinococcus multilocularis dihydrofolate reductase 0.0044 0.0014 0.0014
Echinococcus granulosus UDP N acetylglucosamine dolichyl phosphate 0.0031 0.0004 0.0004
Schistosoma mansoni UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase 0.0031 0.0004 0.0004
Schistosoma mansoni bromodomain containing protein 0.0068 0.0033 0.0033
Mycobacterium ulcerans bacterioferritin BfrB 0.0062 0.0028 0.0066
Echinococcus granulosus lysine specific demethylase 5A 0.0072 0.0036 0.0036
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0034 0.0007 0.0007
Chlamydia trachomatis dihydrofolate reductase 0.0044 0.0014 0.0708
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0028 0.0065
Plasmodium falciparum flap endonuclease 1 0.0026 0 0.0031
Loa Loa (eye worm) hypothetical protein 0.0031 0.0004 0.0025
Toxoplasma gondii LsmAD domain-containing protein 0.0077 0.004 0.1656
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0144 0.0092 0.7617
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0048 0.0017 0.004
Giardia lamblia Histone acetyltransferase GCN5 0.0043 0.0014 0.111
Loa Loa (eye worm) MH2 domain-containing protein 0.0102 0.0059 0.0329
Echinococcus granulosus mothers against decapentaplegic 2 0.0046 0.0015 0.0015
Trichomonas vaginalis set domain proteins, putative 0.2664 0.2056 1
Loa Loa (eye worm) hypothetical protein 0.0137 0.0086 0.0478
Loa Loa (eye worm) phosphatidylinositol 3 0.0181 0.0121 0.0672
Loa Loa (eye worm) hypothetical protein 0.0039 0.001 0.0057
Onchocerca volvulus 0.0152 0.0099 0.048
Echinococcus multilocularis beta LACTamase domain containing family member 0.0113 0.0068 0.0068
Loa Loa (eye worm) MH2 domain-containing protein 0.1494 0.1144 0.6343
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase, putative 0.0052 0.002 0.1632
Trichomonas vaginalis PIKK family atypical protein kinase 0.0135 0.0085 0.0411
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.0026 0 0.0001
Treponema pallidum cysteinyl-tRNA synthetase 0.008 0.0042 0.0799
Plasmodium falciparum ataxin-2 like protein, putative 0.0077 0.004 0.4049
Trypanosoma cruzi DNA polymerase eta, putative 0.0032 0.0005 0.0367
Loa Loa (eye worm) hypothetical protein 0.0229 0.0158 0.0877
Onchocerca volvulus 0.0031 0.0004 0.0022
Echinococcus multilocularis ferritin 0.0062 0.0028 0.0028
Schistosoma mansoni ferritin light chain 0.0062 0.0028 0.0028
Toxoplasma gondii PHD-finger domain-containing protein 0.0058 0.0025 0.1025
Echinococcus granulosus peregrin 0.0064 0.003 0.003
Plasmodium falciparum UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase, putative 0.0031 0.0004 0.0438
Loa Loa (eye worm) hypothetical protein 0.0038 0.001 0.0054
Trichomonas vaginalis PIKK family atypical protein kinase 0.0061 0.0027 0.0131
Trichomonas vaginalis PIKK family atypical protein kinase 0.0061 0.0027 0.0131
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0034 0.0007 0.0416
Loa Loa (eye worm) RNA binding protein 0.0201 0.0137 0.0757
Onchocerca volvulus 0.0108 0.0064 0.0313
Chlamydia trachomatis phospho-N-acetylmuramoyl-pentapeptide-transferase 0.0285 0.0202 1
Loa Loa (eye worm) hypothetical protein 0.0353 0.0255 0.1414
Mycobacterium tuberculosis Conserved protein 0.0113 0.0068 0.016
Schistosoma mansoni smad1 5 8 and 0.0102 0.0059 0.0059
Loa Loa (eye worm) hypothetical protein 0.0113 0.0068 0.0377
Brugia malayi mothers against decapentaplegic homolog 3 0.0046 0.0015 0.0085
Echinococcus multilocularis tumor protein p63 0.4166 0.3226 0.3225
Trichomonas vaginalis D-aminoacylase, putative 0.0113 0.0068 0.0329
Echinococcus granulosus lamin 0.0139 0.0088 0.0088
Mycobacterium tuberculosis Probable esterase LipL 0.0113 0.0068 0.016
Loa Loa (eye worm) acetyltransferase 0.0164 0.0107 0.0596
Brugia malayi Flap endonuclease-1 0.0026 0 0.0002
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0181 0.0121 1
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0037 0.0008 0.0008
Trichomonas vaginalis PIKK family atypical protein kinase 0.0135 0.0085 0.0411
Brugia malayi Calcitonin receptor-like protein seb-1 0.0723 0.0543 0.3013
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0061 0.0027 0.2227
Brugia malayi UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase 0.0031 0.0004 0.0025
Mycobacterium tuberculosis Probable glycosyltransferase 0.0037 0.0008 0.002
Onchocerca volvulus 0.2664 0.2056 1
Schistosoma mansoni cellular tumor antigen P53 0.061 0.0455 0.0455
Brugia malayi MH2 domain containing protein 0.0102 0.0059 0.0329
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0007 0.003
Brugia malayi intermediate filament protein 0.0139 0.0088 0.0489
Schistosoma mansoni tar DNA-binding protein 0.0201 0.0137 0.0136
Schistosoma mansoni ferritin 0.0062 0.0028 0.0028
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0061 0.0027 0.2227
Entamoeba histolytica hypothetical protein 0.0232 0.016 1
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0065 0.003 0.003
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0244 0.017 0.017
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0034 0.0007 0.0037

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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