Detailed information for compound 990959

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 272.342 | Formula: C16H20N2O2
  • H donors: 2 H acceptors: 2 LogP: 2.9 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC[C@@H](C(=O)C(=O)NCCc1c[nH]c2c1cccc2)C
  • InChi: 1S/C16H20N2O2/c1-3-11(2)15(19)16(20)17-9-8-12-10-18-14-7-5-4-6-13(12)14/h4-7,10-11,18H,3,8-9H2,1-2H3,(H,17,20)/t11-/m0/s1
  • InChiKey: NIQUZFQMNMNAMD-NSHDSACASA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni sex comb on midleg homolog 0.0047 0.0185 0.0185
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0036 0.012 0.012
Plasmodium falciparum ataxin-2 like protein, putative 0.0029 0.0085 0.0062
Mycobacterium ulcerans dihydrofolate reductase DfrA 0.019 0.0989 0.0694
Loa Loa (eye worm) RNA binding protein 0.013 0.0654 0.0654
Trichomonas vaginalis set domain proteins, putative 0.0256 0.1363 0.1363
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.0023 0.0023
Loa Loa (eye worm) hypothetical protein 0.0015 0.0002 0.0002
Toxoplasma gondii PHD-finger domain-containing protein 0.0031 0.0097 0.0074
Entamoeba histolytica adenosylhomocysteinase, putative 0.1789 1 1
Loa Loa (eye worm) hypothetical protein 0.0031 0.0097 0.0097
Schistosoma mansoni hypothetical protein 0.0042 0.0155 0.0155
Brugia malayi orphan nuclear receptor NR2E1 0.0017 0.0014 0.0014
Loa Loa (eye worm) thymidylate synthase 0.0466 0.2543 0.2543
Echinococcus multilocularis histone acetyltransferase MYST2 0.0054 0.0221 0.0221
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0071 0.0317 0.0317
Echinococcus granulosus histone lysine methyltransferase setb 0.0033 0.0105 0.0105
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0225 0.1188 0.1188
Leishmania major hypothetical protein, conserved 0.0029 0.0085 0.0085
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.0023 0.0023
Schistosoma mansoni nuclear receptor nhr-48 0.0017 0.0014 0.0014
Loa Loa (eye worm) hypothetical protein 0.0036 0.012 0.012
Echinococcus multilocularis adenosylhomocysteinase 0.1789 1 1
Trichomonas vaginalis adenosylhomocysteinase, putative 0.1789 1 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.012 0.012
Echinococcus multilocularis thymidylate synthase 0.0466 0.2543 0.2543
Trypanosoma cruzi S-adenosylhomocysteine hydrolase, putative 0.1789 1 1
Trichomonas vaginalis bromodomain-containing protein, putative 0.0046 0.0178 0.0178
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0036 0.012 0.012
Echinococcus granulosus geminin 0.0573 0.3148 0.3148
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0036 0.012 0.012
Loa Loa (eye worm) isocitrate dehydrogenase 0.0018 0.0023 0.0023
Onchocerca volvulus Protein ultraspiracle homolog 0.0036 0.012 0.0472
Entamoeba histolytica hypothetical protein 0.0042 0.0155 0.0155
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0105 0.0105
Plasmodium vivax SET domain protein, putative 0.0033 0.0105 0.0082
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0019 0.0025 0.0025
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0036 0.012 0.012
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0146 0.074 0.074
Brugia malayi hypothetical protein 0.0017 0.0014 0.0014
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0036 0.012 0.012
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0018 0.0023 0.0023
Echinococcus multilocularis ecdysone induced protein 78C 0.0036 0.012 0.012
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0344 0.1859 0.1859
Brugia malayi mbt repeat family protein 0.0047 0.0185 0.0185
Brugia malayi Isocitrate dehydrogenase 0.0018 0.0023 0.0023
Schistosoma mansoni Smad4 0.0027 0.0069 0.0069
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0036 0.012 0.012
Schistosoma mansoni tar DNA-binding protein 0.013 0.0654 0.0654
Echinococcus granulosus mothers against decapentaplegic 5 0.0027 0.0069 0.0069
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0018 0.0023 0.0023
Onchocerca volvulus Bile acid receptor homolog 0.0036 0.012 0.0472
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase 0.0656 0.3613 0.3613
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0036 0.012 0.012
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0017 0.0014 0.0014
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0018 0.0023 0.0023
Loa Loa (eye worm) hypothetical protein 0.0515 0.282 0.282
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0103 0.05 0.05
Echinococcus granulosus Smad4 0.0027 0.0069 0.0069
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0019 0.0025 0.0025
Brugia malayi ecdysone receptor 0.0017 0.0014 0.0014
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0017 0.0014 0.0055
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0123 0.0611 0.0611
Brugia malayi MH2 domain containing protein 0.039 0.212 0.212
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0036 0.012 0.012
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0123 0.0611 0.0611
Loa Loa (eye worm) MH1 domain-containing protein 0.0027 0.0069 0.0069
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0105 0.0105
Schistosoma mansoni nuclear hormone receptor 0.0036 0.012 0.012
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0027 0.0069 0.0069
Brugia malayi mbt repeat family protein 0.0047 0.0185 0.0185
Echinococcus granulosus thymidylate synthase 0.0466 0.2543 0.2543
Loa Loa (eye worm) jmjC domain-containing protein 0.004 0.0144 0.0144
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0036 0.012 0.012
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase, putative 0.0222 0.1168 0.1168
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0062 0.0267 0.0267
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0036 0.012 0.012
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0017 0.0014 0.0014
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0067 0.0298 0.0298
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0036 0.012 0.012
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0123 0.0611 0.0611
Loa Loa (eye worm) mbt repeat family protein 0.0047 0.0185 0.0185
Echinococcus multilocularis Smad4 0.0027 0.0069 0.0069
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0018 0.0023 0.0023
Schistosoma mansoni nuclear receptor 0.0017 0.0014 0.0014
Schistosoma mansoni RAR-like nuclear receptor 0.0036 0.012 0.012
Brugia malayi hypothetical protein 0.0029 0.0085 0.0085
Brugia malayi Nuclear hormone receptor-like 1 0.0019 0.0025 0.0025
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0018 0.0023 0.0023
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.013 0.0654 0.0654
Brugia malayi ecdysteroid receptor 0.0036 0.012 0.012
Echinococcus granulosus PHD finger protein rhinoceros 0.0031 0.0097 0.0097
Loa Loa (eye worm) hypothetical protein 0.0019 0.0025 0.0025
Brugia malayi MH2 domain containing protein 0.0027 0.0069 0.0069
Loa Loa (eye worm) dihydrofolate reductase 0.019 0.0989 0.0989
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0146 0.074 0.074
Plasmodium falciparum ataxin-2 like protein, putative 0.0029 0.0085 0.0062
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0017 0.0014 0.0014
Trypanosoma cruzi PAB1-binding protein , putative 0.0029 0.0085 0.0085
Brugia malayi thymidylate synthase 0.0466 0.2543 0.2543
Echinococcus granulosus dihydrofolate reductase 0.019 0.0989 0.0989
Schistosoma mansoni smad1 5 8 and 0.0027 0.0069 0.0069
Trypanosoma brucei S-adenosylhomocysteine hydrolase, putative 0.1789 1 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.012 0.012
Loa Loa (eye worm) nuclear factor I 0.0015 0.0002 0.0002
Toxoplasma gondii histone lysine methyltransferase SET1 0.0064 0.028 0.0258
Schistosoma mansoni adenosylhomocysteinase 0.1107 0.6158 0.6158
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0105 0.0511 0.0511
Brugia malayi CXXC zinc finger family protein 0.0031 0.0095 0.0095
Echinococcus granulosus tar DNA binding protein 0.013 0.0654 0.0654
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0036 0.012 0.012
Loa Loa (eye worm) Smad1 0.0027 0.0069 0.0069
Brugia malayi Pre-SET motif family protein 0.0033 0.0105 0.0105
Loa Loa (eye worm) hypothetical protein 0.0017 0.0014 0.0014
Schistosoma mansoni thyroid hormone receptor 0.0036 0.012 0.012
Onchocerca volvulus 0.0047 0.0185 0.0726
Brugia malayi Nuclear hormone receptor-like 1 0.0019 0.0025 0.0025
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0036 0.012 0.012
Brugia malayi nuclear receptor RXR 0.0017 0.0014 0.0014
Brugia malayi isocitrate dehydrogenase 0.0018 0.0023 0.0023
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0036 0.012 0.012
Loa Loa (eye worm) DR-78 0.0017 0.0014 0.0014
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative 0.0656 0.3613 0.3598
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0019 0.0025 0.0025
Onchocerca volvulus 0.0017 0.0014 0.0055
Plasmodium vivax ataxin-2 like protein, putative 0.0029 0.0085 0.0062
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0018 0.0023 0.0023
Echinococcus granulosus histone acetyltransferase KAT2B 0.0152 0.0775 0.0775
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0036 0.012 0.012
Plasmodium falciparum adenosylhomocysteinase 0.1789 1 1
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0017 0.0014 0.0014
Loa Loa (eye worm) MH2 domain-containing protein 0.039 0.212 0.212
Schistosoma mansoni nuclear hormone receptor 0.0017 0.0014 0.0014
Echinococcus granulosus Nuclear hormone receptor HR96 0.0017 0.0014 0.0014
Schistosoma mansoni dihydrofolate reductase 0.019 0.0989 0.0989
Loa Loa (eye worm) hypothetical protein 0.0036 0.012 0.012
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0036 0.012 0.012
Echinococcus granulosus histone acetyltransferase MYST2 0.0054 0.0221 0.0221
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0036 0.012 0.012
Schistosoma mansoni aldehyde dehydrogenase 0.014 0.071 0.071
Brugia malayi Pre-SET motif family protein 0.0225 0.1188 0.1188
Echinococcus granulosus adenosylhomocysteinase 0.1789 1 1
Schistosoma mansoni thyroid hormone receptor 0.0036 0.012 0.012
Onchocerca volvulus 0.0017 0.0014 0.0055
Loa Loa (eye worm) hypothetical protein 0.0017 0.0014 0.0014
Loa Loa (eye worm) hypothetical protein 0.0017 0.0014 0.0014
Schistosoma mansoni protein tyrosine phosphatase non-receptor type nt1 0.0344 0.1859 0.1859
Onchocerca volvulus 0.0256 0.1363 0.5358
Brugia malayi hypothetical protein 0.0042 0.0155 0.0155
Schistosoma mansoni jumonji domain containing protein 0.0082 0.038 0.038
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0156 0.08 0.08
Onchocerca volvulus 0.0031 0.0095 0.0373
Onchocerca volvulus Alhambra homolog 0.0031 0.0097 0.038
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0146 0.074 0.074
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0018 0.0023 0.0023
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0123 0.0611 0.0611
Brugia malayi steroid hormone receptor 0.0036 0.012 0.012
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0054 0.0221 0.0221
Echinococcus multilocularis mothers against decapentaplegic 5 0.0027 0.0069 0.0069
Brugia malayi Nuclear hormone receptor-like 1 0.0036 0.012 0.012
Brugia malayi RNA recognition motif domain containing protein 0.013 0.0654 0.0654
Onchocerca volvulus 0.0105 0.0511 0.2009
Onchocerca volvulus 0.0036 0.012 0.0472
Schistosoma mansoni nuclear receptor 0.0017 0.0014 0.0014
Loa Loa (eye worm) TAR-binding protein 0.013 0.0654 0.0654
Loa Loa (eye worm) hypothetical protein 0.0054 0.0223 0.0223
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0036 0.012 0.012
Plasmodium falciparum phd finger protein, putative 0.0031 0.0097 0.0074
Schistosoma mansoni jumonji/arid domain-containing protein 0.004 0.0144 0.0144
Echinococcus granulosus smad 0.0027 0.0069 0.0069
Brugia malayi MH1 domain containing protein 0.0015 0.0002 0.0002
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0031 0.0097 0.0097
Echinococcus multilocularis FTZ F1 alpha 0.0036 0.012 0.012
Brugia malayi MH1 domain containing protein 0.0027 0.0069 0.0069
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.014 0.071 0.071
Toxoplasma gondii S-Adenosyl homocysteine hydrolase 0.1789 1 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0025 0.0025
Echinococcus multilocularis polycomb protein SCMH1 0.0047 0.0185 0.0185
Echinococcus granulosus SAM and MBT domain containing protein 0.0047 0.0185 0.0185
Loa Loa (eye worm) hypothetical protein 0.0019 0.0025 0.0025
Mycobacterium leprae putative S-adenosyl-L-homocysteine hydrolase SahH 0.1789 1 1
Mycobacterium leprae PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) 0.0466 0.2543 0.1724
Loa Loa (eye worm) hypothetical protein 0.0017 0.0014 0.0014
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0033 0.0105 0.0105
Loa Loa (eye worm) hypothetical protein 0.0033 0.0105 0.0105
Brugia malayi nuclear receptor NHR-88 0.0036 0.012 0.012
Schistosoma mansoni retinoic acid receptor RXR 0.0036 0.012 0.012
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0017 0.0014 0.0055
Mycobacterium ulcerans aldehyde dehydrogenase 0.014 0.071 0.0406
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0156 0.08 0.08
Mycobacterium tuberculosis Probable thymidylate synthase ThyA (ts) (TSASE) 0.0466 0.2543 0.2526
Brugia malayi dihydrofolate reductase family protein 0.019 0.0989 0.0989
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0036 0.012 0.012
Echinococcus granulosus Nuclear hormone receptor HR96 0.0017 0.0014 0.0014
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0017 0.0014 0.0014
Chlamydia trachomatis dihydrofolate reductase 0.019 0.0989 0.5
Giardia lamblia Histone acetyltransferase GCN5 0.0042 0.0157 1
Entamoeba histolytica hypothetical protein 0.0042 0.0155 0.0155
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0017 0.0014 0.0014
Brugia malayi hypothetical protein 0.0019 0.0026 0.0026
Schistosoma mansoni adenosylhomocysteinase 0.1789 1 1
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0071 0.0317 0.0295
Entamoeba histolytica hypothetical protein 0.0042 0.0155 0.0155
Brugia malayi hypothetical protein 0.0017 0.0014 0.0014
Mycobacterium ulcerans aldehyde dehydrogenase 0.014 0.071 0.0406
Loa Loa (eye worm) PHD-finger family protein 0.0031 0.0097 0.0097
Echinococcus granulosus histone acetyltransferase KAT2B 0.0046 0.0178 0.0178
Plasmodium falciparum histone acetyltransferase GCN5 0.0042 0.0157 0.0134
Loa Loa (eye worm) hypothetical protein 0.0017 0.0014 0.0014
Schistosoma mansoni transcription factor LCR-F1 0.0042 0.0155 0.0155
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0036 0.012 0.0472
Loa Loa (eye worm) hypothetical protein 0.0019 0.0025 0.0025
Trypanosoma brucei PAB1-binding protein , putative 0.0029 0.0085 0.0085
Schistosoma mansoni hypothetical protein 0.0573 0.3148 0.3148
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0071 0.0317 0.0317
Schistosoma mansoni survival motor neuron protein 0.0105 0.0511 0.0511
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0071 0.0317 0.0317
Plasmodium vivax hypothetical protein, conserved 0.0031 0.0097 0.0074
Trichomonas vaginalis conserved hypothetical protein 0.0222 0.1168 0.1168
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0033 0.0105 0.0105
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0146 0.074 0.074
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0146 0.074 0.074
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0146 0.074 0.074
Brugia malayi hypothetical protein 0.0019 0.0025 0.0025
Onchocerca volvulus 0.0033 0.0105 0.0411
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0018 0.0023 0.0023
Echinococcus multilocularis survival motor neuron protein 1 0.0515 0.282 0.282
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0103 0.05 0.05
Trichomonas vaginalis adenosylhomocysteinase, putative 0.0562 0.3084 0.3084
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0036 0.012 0.012
Brugia malayi TAR-binding protein 0.013 0.0654 0.0654
Loa Loa (eye worm) hypothetical protein 0.0017 0.0014 0.0014
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0036 0.012 0.012
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0046 0.0178 0.0156
Loa Loa (eye worm) hypothetical protein 0.0047 0.0185 0.0185
Echinococcus granulosus cpg binding protein 0.0033 0.0105 0.0105
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0031 0.0094 0.0094
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.014 0.071 0.071
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.014 0.071 0.071
Schistosoma mansoni tar DNA-binding protein 0.013 0.0654 0.0654
Loa Loa (eye worm) MH2 domain-containing protein 0.0027 0.0069 0.0069
Leishmania major S-adenosylhomocysteine hydrolase 0.1789 1 1
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0036 0.012 0.012
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0186 0.0965 0.0965
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0054 0.0221 0.0221
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0036 0.012 0.012
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0344 0.1859 0.1859
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0036 0.012 0.012
Schistosoma mansoni smad 0.0027 0.0069 0.0069
Mycobacterium tuberculosis Probable adenosylhomocysteinase SahH (S-adenosyl-L-homocysteine hydrolase) (adohcyase) 0.1789 1 1
Loa Loa (eye worm) steroid hormone receptor 0.0036 0.012 0.012
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0017 0.0014 0.0014
Schistosoma mansoni smad1 5 8 and 0.0027 0.0069 0.0069
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0046 0.0178 0.0156
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0036 0.012 0.012
Brugia malayi acetyltransferase, GNAT family protein 0.0156 0.08 0.08
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase 0.0656 0.3613 0.3598
Trichomonas vaginalis adenosylhomocysteinase, putative 0.1789 1 1
Echinococcus multilocularis SAM and MBT domain containing protein 0.0047 0.0185 0.0185
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase 0.0656 0.3613 0.3598
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0036 0.012 0.012
Loa Loa (eye worm) hypothetical protein 0.0017 0.0014 0.0014
Schistosoma mansoni adenosylhomocysteinase 0.1107 0.6158 0.6158
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0036 0.012 0.012
Schistosoma mansoni smad1 5 8 and 0.0027 0.0069 0.0069
Brugia malayi F/Y-rich N-terminus family protein 0.0021 0.0038 0.0038
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0036 0.012 0.012
Loa Loa (eye worm) hypothetical protein 0.0036 0.012 0.012
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0036 0.012 0.012
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0123 0.0611 0.0611
Toxoplasma gondii adenosylhomocysteinase, putative 0.1789 1 1
Brugia malayi nuclear hormone receptor family member odr-7 0.0017 0.0014 0.0014
Brugia malayi conserved hypotetical protein 0.0017 0.0014 0.0014
Loa Loa (eye worm) hypothetical protein 0.0054 0.0221 0.0221
Schistosoma mansoni cpg binding protein 0.0031 0.0095 0.0095
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0036 0.012 0.012
Brugia malayi MH2 domain containing protein 0.0027 0.0069 0.0069
Schistosoma mansoni tar DNA-binding protein 0.013 0.0654 0.0654
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0036 0.012 0.012
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0071 0.0317 0.0317
Schistosoma mansoni hypothetical protein 0.0031 0.0097 0.0097
Loa Loa (eye worm) CXXC zinc finger family protein 0.0031 0.0095 0.0095
Loa Loa (eye worm) hypothetical protein 0.0019 0.0025 0.0025
Schistosoma mansoni coup transcription factor 0.0036 0.012 0.012
Loa Loa (eye worm) hypothetical protein 0.0036 0.012 0.012
Brugia malayi Nuclear hormone receptor E75 0.0017 0.0014 0.0014
Brugia malayi nuclear receptor NHR-67 0.0017 0.0014 0.0014
Toxoplasma gondii LsmAD domain-containing protein 0.0029 0.0085 0.0062
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0036 0.012 0.012
Schistosoma mansoni adenosylhomocysteinase 0.1107 0.6158 0.6158
Schistosoma mansoni hypothetical protein 0.0105 0.0511 0.0511
Schistosoma mansoni tar DNA-binding protein 0.013 0.0654 0.0654
Schistosoma mansoni hypothetical protein 0.0573 0.3148 0.3148
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0071 0.0317 0.0317
Giardia lamblia PHD finger protein 15 0.0031 0.0097 0.6157
Loa Loa (eye worm) nuclear receptor NHR-67 0.0017 0.0014 0.0014
Echinococcus multilocularis dihydrofolate reductase 0.019 0.0989 0.0989
Brugia malayi nuclear hormone receptor family member nhr-6 0.0017 0.0014 0.0014
Mycobacterium tuberculosis Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) 0.019 0.0989 0.0969
Loa Loa (eye worm) jmjC domain-containing protein 0.0065 0.0285 0.0285
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0042 0.0155 0.0155
Loa Loa (eye worm) hypothetical protein 0.0029 0.0085 0.0085
Echinococcus multilocularis tar DNA binding protein 0.013 0.0654 0.0654
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0036 0.012 0.012
Brugia malayi hypothetical protein 0.0515 0.282 0.282
Entamoeba histolytica hypothetical protein 0.0042 0.0155 0.0155
Schistosoma mansoni protein tyrosine phosphatase n11 (shp2) 0.0123 0.0611 0.0611
Brugia malayi jmjC domain containing protein 0.004 0.0144 0.0144
Brugia malayi nuclear receptor NHR-88 0.0017 0.0014 0.0014
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase 0.0656 0.3613 0.3613
Brugia malayi Bromodomain containing protein 0.0035 0.0118 0.0118
Echinococcus multilocularis lysine specific demethylase 5A 0.0038 0.0134 0.0134
Brugia malayi Smad1 0.0027 0.0069 0.0069
Brugia malayi photoreceptor-specific nuclear receptor 0.0036 0.012 0.012
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0033 0.0105 0.0082
Schistosoma mansoni jumonji/arid domain-containing protein 0.004 0.0144 0.0144
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0186 0.0965 0.0965
Trypanosoma cruzi S-adenosylhomocysteine hydrolase, putative 0.1789 1 1
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0017 0.0014 0.0014
Mycobacterium tuberculosis Hypothetical protein 0.0222 0.1168 0.1147
Loa Loa (eye worm) hypothetical protein 0.0017 0.0014 0.0014
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0036 0.012 0.012
Loa Loa (eye worm) hypothetical protein 0.0017 0.0014 0.0014
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0047 0.0185 0.0185
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0146 0.074 0.074
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0019 0.0025 0.0025
Echinococcus granulosus FTZ F1 alpha 0.0036 0.012 0.012
Schistosoma mansoni cpg binding protein 0.0033 0.0105 0.0105
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0019 0.0025 0.0025
Mycobacterium ulcerans thymidylate synthase 0.0466 0.2543 0.2299
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0123 0.0611 0.0611
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0036 0.012 0.012
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0344 0.1859 0.1859
Echinococcus granulosus ecdysone induced protein 78C 0.0036 0.012 0.012
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.0023 0.0023
Echinococcus multilocularis cpg binding protein 0.0033 0.0105 0.0105
Leishmania major dihydrofolate reductase-thymidylate synthase 0.0656 0.3613 0.3613
Echinococcus multilocularis isocitrate dehydrogenase 0.0018 0.0023 0.0023
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0019 0.0028 0.0028
Echinococcus granulosus jumonji domain containing protein 0.0044 0.0166 0.0166
Loa Loa (eye worm) hypothetical protein 0.0017 0.0014 0.0014
Toxoplasma gondii aldehyde dehydrogenase 0.014 0.071 0.0689
Schistosoma mansoni cpg binding protein 0.0033 0.0105 0.0105
Brugia malayi nuclear hormone receptor 0.0017 0.0014 0.0014
Echinococcus multilocularis jumonji domain containing protein 0.0044 0.0166 0.0166
Loa Loa (eye worm) hypothetical protein 0.0036 0.012 0.012
Brugia malayi RNA binding protein 0.013 0.0654 0.0654
Loa Loa (eye worm) adenosylhomocysteinase 0.1789 1 1
Echinococcus granulosus lysine specific demethylase 5A 0.004 0.0144 0.0144
Loa Loa (eye worm) MBCTL1 0.0054 0.0221 0.0221
Schistosoma mansoni sex comb on midleg homolog 0.0047 0.0185 0.0185
Loa Loa (eye worm) hypothetical protein 0.0017 0.0014 0.0014
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0036 0.012 0.012
Brugia malayi Nuclear hormone receptor E75 0.0017 0.0014 0.0014
Loa Loa (eye worm) transcription factor SMAD2 0.039 0.212 0.212
Echinococcus granulosus polycomb protein SCMH1 0.0047 0.0185 0.0185
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0046 0.0178 0.0156
Echinococcus multilocularis PHD finger protein rhinoceros 0.0031 0.0097 0.0097
Brugia malayi hypothetical protein 0.0019 0.0025 0.0025
Echinococcus multilocularis thyroid hormone receptor alpha 0.0036 0.012 0.012
Schistosoma mansoni adenosylhomocysteinase 0.1107 0.6158 0.6158
Mycobacterium ulcerans S-adenosyl-L-homocysteine hydrolase 0.1789 1 1
Echinococcus multilocularis nuclear receptor nhr 48 0.0017 0.0014 0.0014
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0033 0.0105 0.0105
Schistosoma mansoni hypothetical protein 0.0286 0.1532 0.1532
Loa Loa (eye worm) hypothetical protein 0.0036 0.012 0.012
Schistosoma mansoni steroid hormone receptor ad4bp 0.0036 0.012 0.012
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0047 0.0185 0.0726
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0017 0.0014 0.0014
Brugia malayi nuclear receptor RXR 0.0019 0.0025 0.0025
Schistosoma mansoni tar DNA-binding protein 0.013 0.0654 0.0654
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0146 0.074 0.074
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.014 0.071 0.0689
Trypanosoma cruzi PAB1-binding protein , putative 0.0029 0.0085 0.0085
Echinococcus granulosus survival motor neuron protein 1 0.0515 0.282 0.282
Loa Loa (eye worm) nuclear hormone receptor 0.0017 0.0014 0.0014
Brugia malayi nuclear hormone receptor 0.0036 0.012 0.012
Onchocerca volvulus 0.0466 0.2543 1
Brugia malayi Steroid receptor seven-up type 2 0.0036 0.012 0.012
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0054 0.0221 0.0221
Echinococcus granulosus nuclear receptor nhr 48 0.0017 0.0014 0.0014
Echinococcus multilocularis smad 0.0027 0.0069 0.0069
Brugia malayi hypothetical protein 0.0222 0.1168 0.1168
Entamoeba histolytica acetyltransferase, GNAT family 0.0042 0.0157 0.0157
Toxoplasma gondii PHD-finger domain-containing protein 0.0031 0.0097 0.0074
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0017 0.0014 0.0014
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0046 0.0178 0.0178
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0036 0.012 0.012
Schistosoma mansoni zinc finger protein 0.0017 0.0014 0.0014
Schistosoma mansoni myelin transcription factor 1 myt1 0.0054 0.0221 0.0221
Loa Loa (eye worm) acetyltransferase 0.0156 0.08 0.08
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0042 0.0155 0.0155
Echinococcus multilocularis peregrin 0.0035 0.0118 0.0118
Brugia malayi PHD-finger family protein 0.0031 0.0097 0.0097
Loa Loa (eye worm) hypothetical protein 0.0017 0.0014 0.0014
Brugia malayi MH1 domain containing protein 0.0027 0.0069 0.0069
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0344 0.1859 0.1859
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0027 0.0069 0.0069
Echinococcus granulosus thyroid hormone receptor alpha 0.0017 0.0014 0.0014
Brugia malayi tailless protein 0.0017 0.0014 0.0014
Brugia malayi jmjC domain containing protein 0.0103 0.05 0.05
Echinococcus multilocularis geminin 0.0573 0.3148 0.3148
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0036 0.012 0.012
Plasmodium vivax adenosylhomocysteinase(S-adenosyl-L-homocystein e hydrolase), putative 0.1789 1 1
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0036 0.012 0.012
Schistosoma mansoni aldehyde dehydrogenase 0.014 0.071 0.071
Schistosoma mansoni nuclear hormone receptor 0.0017 0.0014 0.0014
Echinococcus granulosus TGF beta signal transducer SmadC 0.0027 0.0069 0.0069
Brugia malayi MH1 domain containing protein 0.0015 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0017 0.0014 0.0014
Mycobacterium ulcerans aldehyde dehydrogenase 0.014 0.071 0.0406
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0105 0.0105
Schistosoma mansoni bifunctional dihydrofolate reductase-thymidylate synthase 0.0466 0.2543 0.2543
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0017 0.0014 0.0014
Brugia malayi Dihydrofolate reductase 0.019 0.0989 0.0989
Echinococcus granulosus peregrin 0.0035 0.0118 0.0118
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0146 0.074 0.074

Activities

Activity type Activity value Assay description Source Reference
Activity (functional) Antibacterial activity against Escherichia coli K12 DSM 489 at 40 ug/mL ChEMBL. 18491867

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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