Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0093 | 0.5997 | 0.8342 |
Leishmania major | trypanothione reductase | 0.0041 | 0.0431 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0066 | 0.3163 | 0.3163 |
Schistosoma mansoni | tar DNA-binding protein | 0.0066 | 0.3163 | 0.3163 |
Brugia malayi | Thioredoxin reductase | 0.0041 | 0.0431 | 0.1362 |
Plasmodium vivax | glutathione reductase, putative | 0.0041 | 0.0431 | 0.5 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0093 | 0.5997 | 0.8342 |
Plasmodium falciparum | glutathione reductase | 0.0041 | 0.0431 | 0.5 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0066 | 0.3163 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0066 | 0.3163 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0066 | 0.3163 | 0.3163 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0103 | 0.7103 | 1 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0093 | 0.5997 | 0.8342 |
Mycobacterium tuberculosis | Probable reductase | 0.0093 | 0.5997 | 0.8342 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0103 | 0.7103 | 1 |
Toxoplasma gondii | thioredoxin reductase | 0.0041 | 0.0431 | 0.5 |
Trypanosoma brucei | trypanothione reductase | 0.0041 | 0.0431 | 0.5 |
Echinococcus multilocularis | tar DNA binding protein | 0.0066 | 0.3163 | 1 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0103 | 0.7103 | 1 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0041 | 0.0431 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.1812 | 0.5727 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0103 | 0.7103 | 1 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0093 | 0.5997 | 0.8342 |
Brugia malayi | glutathione reductase | 0.0041 | 0.0431 | 0.1362 |
Brugia malayi | RNA binding protein | 0.0066 | 0.3163 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0066 | 0.3163 | 0.3163 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0053 | 0.1812 | 0.5727 |
Plasmodium falciparum | thioredoxin reductase | 0.0041 | 0.0431 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0066 | 0.3163 | 0.3163 |
Echinococcus granulosus | tar DNA binding protein | 0.0066 | 0.3163 | 1 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0093 | 0.5997 | 0.8342 |
Loa Loa (eye worm) | glutathione reductase | 0.0041 | 0.0431 | 0.1362 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0066 | 0.3163 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0053 | 0.1812 | 0.5727 |
Loa Loa (eye worm) | TAR-binding protein | 0.0066 | 0.3163 | 1 |
Brugia malayi | TAR-binding protein | 0.0066 | 0.3163 | 1 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0041 | 0.0431 | 0.1362 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0053 | 0.1812 | 0.5727 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0041 | 0.0431 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (binding) | Inhibition of CRM1-mediated nucleocytoplasmic transport of RevM5 mutant in HEK293 cells assessed as RevM5-GFP nuclear localization at 2 ug/ml after 2 hrs by fluorescence microscopy | ChEMBL. | 18835718 | |
Activity (binding) | Inhibition of CRM1-mediated nucleocytoplasmic transport of RevM5 mutant in HEK293 cells assessed as RevM5-GFP nuclear localization at 10 ug/ml after 2 hrs by fluorescence microscopy | ChEMBL. | 18835718 | |
Activity (binding) | Inhibition of CRM1-mediated nucleocytoplasmic transport of RevM5 mutant in HEK293 cells assessed as RevM5-GFP nuclear localization at 0.08 ug/ml after 2 hrs by fluorescence microscopy | ChEMBL. | 18835718 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.