Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0372 | 0.1071 | 0.1071 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0705 | 1 | 1 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0705 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0705 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0705 | 1 | 1 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0705 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0705 | 1 | 1 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0705 | 1 | 1 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0705 | 1 | 1 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0705 | 1 | 1 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0705 | 1 | 1 |
Brugia malayi | nuclear hormone receptor | 0.0705 | 1 | 1 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0705 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0372 | 0.1071 | 0.1071 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0705 | 1 | 1 |
Brugia malayi | nuclear receptor RXR | 0.0372 | 0.1071 | 0.1071 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0705 | 1 | 1 |
Echinococcus granulosus | FTZ F1 alpha | 0.0705 | 1 | 1 |
Echinococcus granulosus | nuclear receptor subfamily 1 group D | 0.0372 | 0.1071 | 0.1071 |
Onchocerca volvulus | 0.0705 | 1 | 1 | |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0705 | 1 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0705 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0705 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0705 | 1 | 1 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0705 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0372 | 0.1071 | 0.1071 |
Schistosoma mansoni | thyroid hormone receptor | 0.0705 | 1 | 1 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0705 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0705 | 1 | 1 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0705 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0705 | 1 | 1 |
Schistosoma mansoni | ecdysone-induced protein 78c (dr-78) | 0.0372 | 0.1071 | 0.1071 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0705 | 1 | 1 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0705 | 1 | 1 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0705 | 1 | 1 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0705 | 1 | 1 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0705 | 1 | 1 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0705 | 1 | 1 |
Echinococcus multilocularis | nuclear receptor subfamily 1 group D | 0.0372 | 0.1071 | 0.1071 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0705 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0705 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0705 | 1 | 1 |
Brugia malayi | nuclear receptor NHR-88 | 0.0705 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0705 | 1 | 1 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0705 | 1 | 1 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0705 | 1 | 1 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0705 | 1 | 1 |
Schistosoma mansoni | nuclear hormone receptor | 0.0705 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0705 | 1 | 1 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0372 | 0.1071 | 0.1071 |
Loa Loa (eye worm) | hypothetical protein | 0.0705 | 1 | 1 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0705 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0705 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.0372 | 0.1071 | 0.1071 |
Schistosoma mansoni | coup transcription factor | 0.0705 | 1 | 1 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0705 | 1 | 1 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0705 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0705 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0705 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0705 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0372 | 0.1071 | 0.1071 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0705 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0705 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0705 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0705 | 1 | 1 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0705 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0372 | 0.1071 | 0.1071 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0705 | 1 | 1 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0705 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0705 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0372 | 0.1071 | 0.1071 |
Brugia malayi | hypothetical protein | 0.0372 | 0.1071 | 0.1071 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0372 | 0.1071 | 0.1071 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0705 | 1 | 1 |
Brugia malayi | steroid hormone receptor | 0.0705 | 1 | 1 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0705 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0705 | 1 | 1 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0705 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0705 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0705 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0705 | 1 | 1 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0705 | 1 | 1 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0705 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0372 | 0.1071 | 0.1071 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0705 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (ADMET) | Toxicity in BS1 mouse at 125 mg/kg, ip | ChEMBL. | 7119809 | |
Activity (ADMET) | Toxicity in BS1 mouse at 63 mg/kg, ip | ChEMBL. | 7119809 | |
Activity (ADMET) | Toxicity in BS1 mouse assessed as occurrence of liver lesions at 250 mg/kg, ip | ChEMBL. | 7119809 | |
Activity (ADMET) | Toxicity in BS1 mouse assessed as death at 500 mg/kg, ip within 4 mins | ChEMBL. | 7119809 | |
Activity (ADMET) | Toxicity in BS1 mouse assessed as ataxia at 250 mg/kg, ip | ChEMBL. | 7119809 | |
Activity (ADMET) | Toxicity in BS1 mouse assessed as lethargy, ataxia, gasping and clonic convulsion at 500 mg/kg, ip within 4 mins | ChEMBL. | 7119809 | |
Activity (ADMET) | Toxicity in BS1 mouse assessed as lethargy at 250 mg/kg, ip | ChEMBL. | 7119809 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.