Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | polycystin 1-related | 0.0042 | 0.063 | 0.0608 |
Brugia malayi | Peroxidasin | 0.0084 | 0.2518 | 0.7239 |
Brugia malayi | hypothetical protein | 0.0042 | 0.063 | 0.176 |
Brugia malayi | Animal haem peroxidase family protein | 0.0084 | 0.2518 | 0.7239 |
Brugia malayi | Heterochromatin protein 1 | 0.0073 | 0.2041 | 0.5856 |
Echinococcus multilocularis | GPCR, family 2 | 0.0033 | 0.0242 | 0.022 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0076 | 0.2184 | 0.2166 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0084 | 0.2518 | 0.7258 |
Schistosoma mansoni | hypothetical protein | 0.0042 | 0.063 | 0.0608 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0033 | 0.0242 | 0.0636 |
Echinococcus granulosus | ATP dependent Clp protease proteolytic subunit | 0.0082 | 0.2458 | 0.244 |
Onchocerca volvulus | 0.0084 | 0.2518 | 1 | |
Schistosoma mansoni | lipoxygenase | 0.0249 | 1 | 1 |
Trichomonas vaginalis | chromobox protein, putative | 0.0044 | 0.0735 | 0.3419 |
Echinococcus granulosus | chromobox protein 1 | 0.0073 | 0.2041 | 0.2023 |
Toxoplasma gondii | ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein | 0.0082 | 0.2458 | 1 |
Echinococcus multilocularis | lipoxygenase domain containing protein | 0.0042 | 0.063 | 0.0608 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0041 | 0.0594 | 0.2714 |
Loa Loa (eye worm) | hypothetical protein | 0.0084 | 0.2518 | 0.7258 |
Loa Loa (eye worm) | hypothetical protein | 0.0084 | 0.2518 | 0.7258 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0028 | 0.0023 | 0.0067 |
Brugia malayi | Animal haem peroxidase family protein | 0.0084 | 0.2518 | 0.7239 |
Loa Loa (eye worm) | hypothetical protein | 0.0084 | 0.2518 | 0.7258 |
Onchocerca volvulus | 0.0032 | 0.0196 | 0.0691 | |
Onchocerca volvulus | Dual oxidase homolog | 0.0084 | 0.2518 | 1 |
Chlamydia trachomatis | ATP-dependent Clp protease proteolytic subunit | 0.0082 | 0.2458 | 0.5 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0033 | 0.0242 | 0.022 |
Loa Loa (eye worm) | hypothetical protein | 0.0072 | 0.1976 | 0.5695 |
Schistosoma mansoni | hypothetical protein | 0.0033 | 0.0242 | 0.022 |
Schistosoma mansoni | hypothetical protein | 0.0033 | 0.0242 | 0.022 |
Onchocerca volvulus | 0.0042 | 0.063 | 0.2432 | |
Onchocerca volvulus | 0.0084 | 0.2518 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0084 | 0.2518 | 0.7258 |
Echinococcus multilocularis | ATP dependent Clp protease proteolytic subunit | 0.0082 | 0.2458 | 0.244 |
Trichomonas vaginalis | chromobox protein, putative | 0.0044 | 0.0735 | 0.3419 |
Loa Loa (eye worm) | hypothetical protein | 0.0084 | 0.2518 | 0.7258 |
Brugia malayi | Doublecortin family protein | 0.0042 | 0.063 | 0.176 |
Schistosoma mansoni | hypothetical protein | 0.0072 | 0.1976 | 0.1957 |
Echinococcus multilocularis | lipoxygenase domain containing protein | 0.0042 | 0.063 | 0.0608 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0023 | 0.0067 |
Wolbachia endosymbiont of Brugia malayi | ATP-dependent Clp protease proteolytic subunit | 0.0082 | 0.2458 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0084 | 0.2518 | 0.7258 |
Echinococcus granulosus | peptidase Clp S14 family | 0.0054 | 0.118 | 0.116 |
Schistosoma mansoni | hypothetical protein | 0.0033 | 0.0242 | 0.022 |
Echinococcus granulosus | Polycystic kidney disease protein | 0.0042 | 0.063 | 0.0608 |
Onchocerca volvulus | 0.0084 | 0.2518 | 1 | |
Schistosoma mansoni | loxhd1 | 0.0042 | 0.063 | 0.0608 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0033 | 0.0242 | 0.022 |
Brugia malayi | hypothetical protein | 0.0042 | 0.063 | 0.176 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0105 | 0.3469 | 1 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0033 | 0.0242 | 0.0636 |
Schistosoma mansoni | peptidase Clp (S14 family) | 0.0082 | 0.2458 | 0.244 |
Brugia malayi | Animal haem peroxidase family protein | 0.0084 | 0.2518 | 0.7239 |
Echinococcus granulosus | RUN | 0.0042 | 0.063 | 0.0608 |
Echinococcus granulosus | lipoxygenase domain containing protein | 0.0042 | 0.063 | 0.0608 |
Echinococcus multilocularis | peptidase Clp (S14 family) | 0.0054 | 0.118 | 0.116 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0072 | 0.1976 | 0.5666 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.063 | 0.1816 |
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.0044 | 0.0735 | 0.2851 |
Loa Loa (eye worm) | doublecortin family protein | 0.0042 | 0.063 | 0.1816 |
Loa Loa (eye worm) | intermediate filament protein | 0.0028 | 0.0023 | 0.0067 |
Echinococcus multilocularis | Polycystic kidney disease protein | 0.0042 | 0.063 | 0.0608 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.0249 | 1 | 1 |
Echinococcus granulosus | GPCR family 2 | 0.0033 | 0.0242 | 0.022 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0076 | 0.2184 | 0.2166 |
Schistosoma mansoni | chromobox protein | 0.0073 | 0.2041 | 0.2023 |
Onchocerca volvulus | Peroxidase homolog | 0.0084 | 0.2518 | 1 |
Onchocerca volvulus | Peroxidase homolog | 0.0084 | 0.2518 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0242 | 0.0699 |
Loa Loa (eye worm) | hypothetical protein | 0.0084 | 0.2518 | 0.7258 |
Brugia malayi | Probable ClpP-like protease | 0.0082 | 0.2458 | 0.7066 |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.0084 | 0.2518 | 0.7258 |
Entamoeba histolytica | hypothetical protein | 0.0076 | 0.2184 | 0.5 |
Schistosoma mansoni | peroxidasin | 0.0084 | 0.2518 | 0.25 |
Echinococcus multilocularis | chromobox protein 1 | 0.0073 | 0.2041 | 0.2023 |
Schistosoma mansoni | hypothetical protein | 0.0181 | 0.6923 | 0.6916 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0105 | 0.3469 | 1 |
Plasmodium vivax | ATP-dependent Clp protease proteolytic subunit, putative | 0.0082 | 0.2458 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0084 | 0.2518 | 0.7239 |
Trichomonas vaginalis | chromobox protein, putative | 0.0073 | 0.2041 | 1 |
Echinococcus multilocularis | peroxidasin | 0.0084 | 0.2518 | 0.25 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0041 | 0.0594 | 0.2714 |
Chlamydia trachomatis | ATP-dependent Clp protease proteolytic subunit | 0.0082 | 0.2458 | 0.5 |
Plasmodium vivax | multidomain scavenger receptor, putative | 0.0042 | 0.063 | 0.248 |
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.0041 | 0.0594 | 0.229 |
Loa Loa (eye worm) | hypothetical protein | 0.0084 | 0.2518 | 0.7258 |
Schistosoma mansoni | peroxidasin | 0.0084 | 0.2518 | 0.25 |
Loa Loa (eye worm) | hypothetical protein | 0.0082 | 0.2458 | 0.7086 |
Brugia malayi | Blistered cuticle protein 3 | 0.0084 | 0.2518 | 0.7239 |
Treponema pallidum | ATP-dependent Clp protease proteolytic subunit | 0.0082 | 0.2458 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0181 | 0.6923 | 0.6916 |
Onchocerca volvulus | Peroxidasin homolog | 0.0084 | 0.2518 | 1 |
Plasmodium falciparum | ATP-dependent Clp protease proteolytic subunit | 0.0082 | 0.2458 | 1 |
Schistosoma mansoni | rab6-interacting | 0.0042 | 0.063 | 0.0608 |
Onchocerca volvulus | Chorion peroxidase homolog | 0.0084 | 0.2518 | 1 |
Mycobacterium tuberculosis | Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) | 0.0054 | 0.118 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0084 | 0.2518 | 0.7258 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0033 | 0.0242 | 0.022 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0076 | 0.2184 | 0.2166 |
Loa Loa (eye worm) | hypothetical protein | 0.0084 | 0.2518 | 0.7258 |
Mycobacterium leprae | PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) | 0.0082 | 0.2458 | 1 |
Brugia malayi | hypothetical protein | 0.0084 | 0.2518 | 0.7239 |
Loa Loa (eye worm) | hypothetical protein | 0.0084 | 0.2518 | 0.7258 |
Mycobacterium ulcerans | ATP-dependent Clp protease proteolytic subunit | 0.0082 | 0.2458 | 0.5 |
Onchocerca volvulus | 0.0042 | 0.063 | 0.2432 | |
Loa Loa (eye worm) | hypothetical protein | 0.0084 | 0.2518 | 0.7258 |
Schistosoma mansoni | chromobox protein | 0.0073 | 0.2041 | 0.2023 |
Loa Loa (eye worm) | hypothetical protein | 0.0084 | 0.2518 | 0.7258 |
Brugia malayi | hypothetical protein | 0.0076 | 0.2184 | 0.6272 |
Loa Loa (eye worm) | heterochromatin protein 1 | 0.0073 | 0.2041 | 0.5884 |
Onchocerca volvulus | Peroxidasin homolog | 0.0084 | 0.2518 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0076 | 0.2184 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0076 | 0.2184 | 0.5 |
Echinococcus multilocularis | chromobox protein 1 | 0.0073 | 0.2041 | 0.2023 |
Echinococcus multilocularis | RUN | 0.0042 | 0.063 | 0.0608 |
Toxoplasma gondii | ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein | 0.0082 | 0.2458 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0105 | 0.3469 | 1 |
Mycobacterium tuberculosis | Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) | 0.0054 | 0.118 | 0.5 |
Trichomonas vaginalis | chromobox protein, putative | 0.0073 | 0.2041 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0105 | 0.3469 | 1 |
Schistosoma mansoni | lipoxygenase | 0.0174 | 0.6614 | 0.6607 |
Echinococcus granulosus | geminin | 0.0181 | 0.6923 | 0.6916 |
Echinococcus multilocularis | geminin | 0.0181 | 0.6923 | 0.6916 |
Schistosoma mansoni | hypothetical protein | 0.0076 | 0.2184 | 0.2166 |
Schistosoma mansoni | rab6-interacting | 0.0042 | 0.063 | 0.0608 |
Mycobacterium leprae | PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) | 0.0054 | 0.118 | 0.4744 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0084 | 0.2518 | 0.7258 |
Plasmodium falciparum | LCCL domain-containing protein | 0.0042 | 0.063 | 0.248 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0033 | 0.0242 | 0.0699 |
Schistosoma mansoni | hypothetical protein | 0.0033 | 0.0242 | 0.022 |
Echinococcus granulosus | chromobox protein 1 | 0.0073 | 0.2041 | 0.2023 |
Echinococcus granulosus | lipoxygenase domain containing protein | 0.0042 | 0.063 | 0.0608 |
Entamoeba histolytica | hypothetical protein | 0.0076 | 0.2184 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0084 | 0.2518 | 0.7258 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0033 | 0.0242 | 0.022 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0084 | 0.2518 | 0.7258 |
Loa Loa (eye worm) | hypothetical protein | 0.0084 | 0.2518 | 0.7258 |
Brugia malayi | Animal haem peroxidase family protein | 0.0084 | 0.2518 | 0.7239 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0594 | 0.1714 |
Brugia malayi | chromobox protein homolog 3 | 0.0041 | 0.0594 | 0.1658 |
Echinococcus granulosus | peroxidasin | 0.0084 | 0.2518 | 0.25 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.063 | 0.1816 |
Mycobacterium ulcerans | ATP-dependent Clp protease proteolytic subunit | 0.0082 | 0.2458 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0196 | 0.0564 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (functional) | = 3.96 % | Analgesic activity in albino mouse assessed as inhibition of acetic acid-induced writhing at 10 mg/kg, po | ChEMBL. | 17959273 |
Inhibition (functional) | = 27 % | Antibacterial activity against Escherichia coli at 25 ug/mL after 48 hrs by cup-plate method | ChEMBL. | 17959273 |
Inhibition (functional) | = 46 % | Antibacterial activity against Escherichia coli at 50 ug/mL after 48 hrs by cup-plate method | ChEMBL. | 17959273 |
Inhibition (functional) | = 73 % | Antibacterial activity against Escherichia coli at 100 ug/mL after 48 hrs by cup-plate method | ChEMBL. | 17959273 |
IZ (functional) | = 58 mm | Antibacterial activity against Escherichia coli at 25 ug/mL after 48 hrs by cup-plate method | ChEMBL. | 17959273 |
IZ (functional) | = 108 mm | Antibacterial activity against Escherichia coli at 50 ug/mL after 48 hrs by cup-plate method | ChEMBL. | 17959273 |
IZ (functional) | = 188 mm | Antibacterial activity against Escherichia coli at 100 ug/mL after 48 hrs by cup-plate method | ChEMBL. | 17959273 |
LD50 (ADMET) | > 800 mg kg-1 | Acute toxicity in ip dosed albino mouse after 24 hrs | ChEMBL. | 17959273 |
LD50 (ADMET) | > 1000 mg kg-1 | Acute toxicity in po dosed albino mouse after 24 hrs | ChEMBL. | 17959273 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.