Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (functional) | = 36.2 % | Analgesic activity in Swiss albino mouse assessed as effect on reaction time for tail withdrawal administered at equimolar oral dose relative to 70 mg/kg ibuprofen after 4 hrs by tail immersion method | ChEMBL. | 18023930 |
MIC (functional) | = 200 ug ml-1 | Antibacterial activity against sEscherichia coli ATCC 25922 by cup plate method | ChEMBL. | 18023930 |
MIC (functional) | = 200 ug ml-1 | Antimicrobial activity against Candida albicans ATCC 2091 by cup plate method | ChEMBL. | 18023930 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.