Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Carboxylesterase family protein | 0.0066 | 0.4313 | 1 |
Trypanosoma brucei | dihydrolipoamide dehydrogenase, point mutation | 0.0021 | 0.0483 | 0.0254 |
Plasmodium falciparum | thioredoxin reductase | 0.0061 | 0.3918 | 1 |
Loa Loa (eye worm) | glutathione reductase | 0.0061 | 0.3918 | 0.9028 |
Leishmania major | dihydrolipoamide dehydrogenase, putative | 0.0021 | 0.0483 | 0.0254 |
Brugia malayi | Amidohydrolase family protein | 0.0019 | 0.0249 | 0.0577 |
Schistosoma mansoni | thyroid hormone receptor | 0.0132 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0021 | 0.0483 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0066 | 0.4313 | 0.4562 |
Schistosoma mansoni | dihydrolipoamide dehydrogenase | 0.0021 | 0.0483 | 0.0241 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0021 | 0.0483 | 0.0254 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0066 | 0.4313 | 0.4168 |
Echinococcus granulosus | carboxylesterase 5A | 0.0066 | 0.4313 | 0.4562 |
Brugia malayi | dihydrolipoyl dehydrogenase, mitochondrial precursor, putative | 0.0021 | 0.0483 | 0.1121 |
Brugia malayi | Thioredoxin reductase | 0.0061 | 0.3918 | 0.9084 |
Echinococcus multilocularis | acetylcholinesterase | 0.0066 | 0.4313 | 0.4168 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0021 | 0.0483 | 0.0254 |
Echinococcus multilocularis | dihydrolipoamide dehydrogenase | 0.0021 | 0.0483 | 0.0241 |
Entamoeba histolytica | guanine deaminase, putative | 0.0126 | 0.9487 | 1 |
Trypanosoma cruzi | guanine deaminase, putative | 0.0126 | 0.9487 | 1 |
Trichomonas vaginalis | protein ssnA, putative | 0.0126 | 0.9487 | 1 |
Trichomonas vaginalis | guanine deaminase, putative | 0.0126 | 0.9487 | 1 |
Trypanosoma cruzi | guanine deaminase, putative | 0.0126 | 0.9487 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0066 | 0.4313 | 0.4168 |
Brugia malayi | glutathione reductase | 0.0061 | 0.3918 | 0.9084 |
Trichomonas vaginalis | glutathione reductase, putative | 0.0021 | 0.0483 | 0.0254 |
Trypanosoma brucei | guanine deaminase, putative | 0.0126 | 0.9487 | 1 |
Treponema pallidum | NADH oxidase | 0.0021 | 0.0483 | 0.5 |
Leishmania major | dihydrolipoamide dehydrogenase, putative | 0.0021 | 0.0483 | 0.0254 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0021 | 0.0483 | 0.064 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0021 | 0.0483 | 0.0254 |
Echinococcus granulosus | dihydrolipoamide dehydrogenase | 0.0021 | 0.0483 | 0.0263 |
Trypanosoma cruzi | dihydrolipoyl dehydrogenase, putative | 0.0021 | 0.0483 | 0.0254 |
Plasmodium vivax | glutathione reductase, putative | 0.0061 | 0.3918 | 1 |
Trypanosoma brucei | dihydrolipoyl dehydrogenase | 0.0021 | 0.0483 | 0.0254 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0061 | 0.3918 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0066 | 0.4313 | 1 |
Echinococcus multilocularis | Mitotic checkpoint protein PRCC, C terminal | 0.0123 | 0.9157 | 0.9136 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0021 | 0.0483 | 0.0254 |
Leishmania major | 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein | 0.0021 | 0.0483 | 0.0254 |
Trypanosoma cruzi | dihydrolipoyl dehydrogenase, putative | 0.0021 | 0.0483 | 0.0254 |
Plasmodium vivax | dihydrolipoyl dehydrogenase, apicoplast, putative | 0.0021 | 0.0483 | 0.064 |
Loa Loa (eye worm) | hypothetical protein | 0.0066 | 0.4313 | 1 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase, LpdB | 0.0021 | 0.0483 | 0.0254 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0061 | 0.3918 | 0.3763 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0021 | 0.0483 | 1 |
Mycobacterium ulcerans | flavoprotein disulfide reductase | 0.0021 | 0.0483 | 0.0254 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase | 0.0021 | 0.0483 | 0.0254 |
Echinococcus multilocularis | acetylcholinesterase | 0.0066 | 0.4313 | 0.4168 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0061 | 0.3918 | 0.4119 |
Chlamydia trachomatis | dihydrolipoyl dehydrogenase | 0.0021 | 0.0483 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0066 | 0.4313 | 0.4562 |
Toxoplasma gondii | thioredoxin reductase | 0.0061 | 0.3918 | 1 |
Echinococcus granulosus | Mitotic checkpoint protein PRCC C terminal | 0.0123 | 0.9157 | 1 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0061 | 0.3918 | 0.9028 |
Giardia lamblia | NADH oxidase lateral transfer candidate | 0.0021 | 0.0483 | 0.5 |
Trypanosoma brucei | dihydrolipoamide dehydrogenase | 0.0021 | 0.0483 | 0.0254 |
Leishmania major | trypanothione reductase | 0.0061 | 0.3918 | 0.3972 |
Schistosoma mansoni | thyroid hormone receptor | 0.0132 | 1 | 1 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0021 | 0.0483 | 1 |
Trichomonas vaginalis | mercuric reductase, putative | 0.0021 | 0.0483 | 0.0254 |
Trypanosoma brucei | dihydrolipoamide dehydrogenase | 0.0021 | 0.0483 | 0.0254 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0061 | 0.3918 | 0.3972 |
Mycobacterium tuberculosis | Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot | 0.0021 | 0.0483 | 0.064 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0021 | 0.0483 | 0.064 |
Plasmodium falciparum | glutathione reductase | 0.0061 | 0.3918 | 1 |
Leishmania major | guanine deaminase, putative | 0.0126 | 0.9487 | 1 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0021 | 0.0483 | 0.0254 |
Trypanosoma brucei | trypanothione reductase | 0.0061 | 0.3918 | 0.3972 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0021 | 0.0483 | 0.064 |
Leishmania major | acetoin dehydrogenase e3 component-like protein | 0.0021 | 0.0483 | 0.0254 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0061 | 0.3918 | 1 |
Trichomonas vaginalis | protein ssnA, putative | 0.0126 | 0.9487 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0066 | 0.4313 | 1 |
Trypanosoma brucei | guanine deaminase, putative | 0.0126 | 0.9487 | 1 |
Mycobacterium ulcerans | hydroxydechloroatrazine ethylaminohydrolase | 0.0126 | 0.9487 | 1 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0021 | 0.0483 | 0.0254 |
Schistosoma mansoni | hypothetical protein | 0.0123 | 0.9157 | 0.9136 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0066 | 0.4313 | 1 |
Plasmodium vivax | dihydrolipoyl dehydrogenase, mitochondrial, putative | 0.0021 | 0.0483 | 0.064 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0021 | 0.0483 | 0.0254 |
Brugia malayi | Carboxylesterase family protein | 0.0066 | 0.4313 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (binding) | Effect on HDAC in human HaCaT cells assessed as downregulation of miR-106b# at 10 uM after 1 hr by RT-PCR analysis | ChEMBL. | 24900596 | |
Activity (binding) | Effect on HDAC in human HaCaT cells assessed as upregulation of miR-1227 at 10 uM after 1 hr by RT-PCR analysis | ChEMBL. | 24900596 | |
Activity (binding) | Effect on HDAC in human HaCaT cells assessed as upregulation of miR-126# at 10 uM after 1 hr by RT-PCR analysis | ChEMBL. | 24900596 | |
Activity (binding) | Effect on HDAC in human HaCaT cells assessed as downregulation of miR-505# at 10 uM after 1 hr by RT-PCR analysis | ChEMBL. | 24900596 | |
Activity (binding) | Effect on HDAC in human HaCaT cells assessed as downregulation of miR-378 at 10 uM after 1 hr by RT-PCR analysis | ChEMBL. | 24900596 | |
Activity (binding) | Effect on HDAC in human HaCaT cells assessed as upregulation of miR-661 at 10 uM after 1 hr by RT-PCR analysis | ChEMBL. | 24900596 | |
Activity (binding) | Effect on HDAC in human HaCaT cells assessed as upregulation of miR-1296 at 10 uM after 1 hr by RT-PCR analysis | ChEMBL. | 24900596 | |
Activity (binding) | Effect on HDAC in human HaCaT cells assessed as downregulation of miR-744# at 10 uM after 1 hr by RT-PCR analysis | ChEMBL. | 24900596 | |
Activity (binding) | Effect on HDAC in human HaCaT cells assessed as downregulation of miR-941 at 10 uM after 1 hr by RT-PCR analysis | ChEMBL. | 24900596 | |
Activity (binding) | Effect on HDAC in human HaCaT cells assessed as upregulation of miR-30d# at 10 uM after 1 hr by RT-PCR analysis | ChEMBL. | 24900596 | |
Activity (binding) | Effect on HDAC in human HaCaT cells assessed as upregulation of miR-16-1# at 10 uM after 1 hr by RT-PCR analysis | ChEMBL. | 24900596 | |
GI (functional) | = 5 % | Antitrypanosomal activity against Trypanosoma cruzi Tulahuen 2 assessed as inhibition of growth of epimastigotes at 25 uM after 5 days by MTT assay relative to control | ChEMBL. | 18706821 |
Inhibition (binding) | Inhibition of HDAC activity in human HaCaT cell lysate at 50 uM after 1 hr by colorimetry | ChEMBL. | 24900596 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.