Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0925 | 1 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0632 | 0.6675 | 0.6675 |
Schistosoma mansoni | NADP-specific isocitrate dehydrogenase | 0.0096 | 0.0583 | 0.0873 |
Plasmodium falciparum | isocitrate dehydrogenase [NADP], mitochondrial | 0.0096 | 0.0583 | 0.8859 |
Loa Loa (eye worm) | isocitrate dehydrogenase | 0.0096 | 0.0583 | 0.0583 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0102 | 0.0655 | 1 |
Loa Loa (eye worm) | MH1 domain-containing protein | 0.005 | 0.0065 | 0.0065 |
Echinococcus multilocularis | 3 hydroxyacyl coenzyme A dehydrogenase type 2 | 0.0061 | 0.0183 | 0.0216 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0096 | 0.0583 | 0.0686 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0102 | 0.0655 | 1 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0229 | 0.209 | 1 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0336 | 0.3314 | 0.3314 |
Brugia malayi | RNA binding protein | 0.0336 | 0.3314 | 0.3314 |
Schistosoma mansoni | smad1 5 8 and | 0.005 | 0.0065 | 0.0097 |
Echinococcus multilocularis | geminin | 0.0169 | 0.1406 | 0.1654 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0047 | 0.0026 | 0.0026 |
Mycobacterium tuberculosis | Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) | 0.0096 | 0.0583 | 0.2697 |
Brugia malayi | TAR-binding protein | 0.0336 | 0.3314 | 0.3314 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0047 | 0.0026 | 0.0031 |
Schistosoma mansoni | hypothetical protein | 0.0293 | 0.2817 | 0.422 |
Brugia malayi | MH2 domain containing protein | 0.005 | 0.0065 | 0.0065 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0119 | 0.0846 | 0.3974 |
Brugia malayi | Isocitrate dehydrogenase | 0.0096 | 0.0583 | 0.0583 |
Trypanosoma brucei | isocitrate dehydrogenase, putative | 0.0096 | 0.0583 | 0.8859 |
Loa Loa (eye worm) | hypothetical protein | 0.0102 | 0.0655 | 0.0655 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0107 | 0.071 | 0.3315 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0102 | 0.0655 | 1 |
Echinococcus granulosus | GPCR family 2 | 0.0293 | 0.2817 | 0.8499 |
Trypanosoma brucei | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0096 | 0.0583 | 0.8859 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0293 | 0.2817 | 0.8499 |
Echinococcus granulosus | mothers against decapentaplegic 5 | 0.005 | 0.0065 | 0.0195 |
Schistosoma mansoni | hypothetical protein | 0.0046 | 0.0013 | 0.002 |
Echinococcus granulosus | geminin | 0.0169 | 0.1406 | 0.4243 |
Schistosoma mansoni | hypothetical protein | 0.0293 | 0.2817 | 0.422 |
Schistosoma mansoni | tar DNA-binding protein | 0.0336 | 0.3314 | 0.4965 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.074 | 0.7901 | 0.7901 |
Echinococcus multilocularis | GPCR, family 2 | 0.0293 | 0.2817 | 0.3313 |
Schistosoma mansoni | tar DNA-binding protein | 0.0336 | 0.3314 | 0.4965 |
Leishmania major | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0096 | 0.0583 | 0.8859 |
Schistosoma mansoni | hypothetical protein | 0.0293 | 0.2817 | 0.422 |
Mycobacterium tuberculosis | Probable short-chain type dehydrogenase/reductase | 0.0061 | 0.0183 | 0.0763 |
Schistosoma mansoni | tar DNA-binding protein | 0.0336 | 0.3314 | 0.4965 |
Brugia malayi | MH2 domain containing protein | 0.005 | 0.0065 | 0.0065 |
Echinococcus multilocularis | tar DNA binding protein | 0.0336 | 0.3314 | 0.3898 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0096 | 0.0583 | 0.0686 |
Brugia malayi | 3-hydroxyacyl-CoA dehydrogenase type II | 0.0061 | 0.0183 | 0.0183 |
Echinococcus granulosus | Smad4 | 0.005 | 0.0065 | 0.0195 |
Brugia malayi | MH1 domain containing protein | 0.005 | 0.0065 | 0.0065 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0119 | 0.0846 | 1 |
Mycobacterium tuberculosis | Probable reductase | 0.0107 | 0.071 | 0.3315 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0107 | 0.071 | 0.3315 |
Brugia malayi | hypothetical protein | 0.0066 | 0.0242 | 0.0242 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0061 | 0.0183 | 0.5 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0119 | 0.0846 | 0.3974 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.074 | 0.7901 | 0.7901 |
Echinococcus multilocularis | isocitrate dehydrogenase 2 (NADP+) | 0.0096 | 0.0583 | 0.0686 |
Loa Loa (eye worm) | hypothetical protein | 0.0925 | 1 | 1 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0102 | 0.0655 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0336 | 0.3314 | 0.3314 |
Loa Loa (eye worm) | RNA binding protein | 0.0336 | 0.3314 | 0.3314 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0293 | 0.2817 | 0.3313 |
Trypanosoma cruzi | isocitrate dehydrogenase, putative | 0.0096 | 0.0583 | 0.8859 |
Brugia malayi | MH2 domain containing protein | 0.074 | 0.7901 | 0.7901 |
Schistosoma mansoni | smad1 5 8 and | 0.005 | 0.0065 | 0.0097 |
Schistosoma mansoni | tar DNA-binding protein | 0.0336 | 0.3314 | 0.4965 |
Loa Loa (eye worm) | hypothetical protein | 0.0293 | 0.2817 | 0.2817 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0107 | 0.071 | 0.3315 |
Loa Loa (eye worm) | TAR-binding protein | 0.0336 | 0.3314 | 0.3314 |
Leishmania major | hypothetical protein, conserved | 0.0102 | 0.0655 | 1 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0293 | 0.2817 | 0.8499 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0107 | 0.071 | 0.3315 |
Schistosoma mansoni | tar DNA-binding protein | 0.0336 | 0.3314 | 0.4965 |
Brugia malayi | MH1 domain containing protein | 0.005 | 0.0065 | 0.0065 |
Trypanosoma cruzi | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0096 | 0.0583 | 0.8859 |
Brugia malayi | Thioredoxin reductase | 0.0047 | 0.0026 | 0.0026 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0925 | 1 | 1 |
Echinococcus multilocularis | TGF beta signal transducer SmadC | 0.005 | 0.0065 | 0.0076 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0293 | 0.2817 | 0.3313 |
Schistosoma mansoni | smad1 5 8 and | 0.005 | 0.0065 | 0.0097 |
Loa Loa (eye worm) | 3-hydroxyacyl-CoA dehydrogenase type II | 0.0053 | 0.0096 | 0.0096 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0096 | 0.0583 | 0.8859 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0047 | 0.0026 | 0.0078 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0119 | 0.0846 | 0.3974 |
Schistosoma mansoni | smad | 0.005 | 0.0065 | 0.0097 |
Schistosoma mansoni | hypothetical protein | 0.0169 | 0.1406 | 0.2106 |
Echinococcus granulosus | Ataxin 2 N terminaldomain containing protein | 0.0046 | 0.0013 | 0.004 |
Schistosoma mansoni | 3-hydroxyacyl-CoA dehydrogenase | 0.0061 | 0.0183 | 0.0275 |
Brugia malayi | hypothetical protein | 0.0102 | 0.0655 | 0.0655 |
Loa Loa (eye worm) | Smad1 | 0.005 | 0.0065 | 0.0065 |
Echinococcus granulosus | tar DNA binding protein | 0.0336 | 0.3314 | 1 |
Echinococcus multilocularis | smad | 0.005 | 0.0065 | 0.0076 |
Plasmodium vivax | isocitrate dehydrogenase [NADP], mitochondrial, putative | 0.0096 | 0.0583 | 0.8859 |
Schistosoma mansoni | hypothetical protein | 0.0169 | 0.1406 | 0.2106 |
Echinococcus granulosus | smad | 0.005 | 0.0065 | 0.0195 |
Schistosoma mansoni | hypothetical protein | 0.0293 | 0.2817 | 0.422 |
Schistosoma mansoni | TGF-beta signal transducer Smad2 | 0.005 | 0.0065 | 0.0097 |
Loa Loa (eye worm) | glutathione reductase | 0.0047 | 0.0026 | 0.0026 |
Brugia malayi | glutathione reductase | 0.0047 | 0.0026 | 0.0026 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0096 | 0.0583 | 0.0686 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0102 | 0.0655 | 1 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0102 | 0.0655 | 1 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0107 | 0.071 | 0.3315 |
Schistosoma mansoni | Smad4 | 0.005 | 0.0065 | 0.0097 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0293 | 0.2817 | 0.2817 |
Echinococcus multilocularis | Ataxin 2, N terminal,domain containing protein | 0.0046 | 0.0013 | 0.0016 |
Loa Loa (eye worm) | hypothetical protein | 0.0632 | 0.6675 | 0.6675 |
Echinococcus granulosus | TGF beta signal transducer SmadC | 0.005 | 0.0065 | 0.0195 |
Leishmania major | 3-oxoacyl-(acyl-carrier protein) reductase, putative | 0.0061 | 0.0183 | 0.2506 |
Echinococcus granulosus | 3 hydroxyacyl coenzyme A dehydrogenase type 2 | 0.0061 | 0.0183 | 0.0554 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0293 | 0.2817 | 0.2817 |
Onchocerca volvulus | 0.0168 | 0.1403 | 0.5 | |
Echinococcus multilocularis | atpase aaa+ type core atpase aaa type core | 0.0793 | 0.8501 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0632 | 0.6675 | 1 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.005 | 0.0065 | 0.0065 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0293 | 0.2817 | 0.2817 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0102 | 0.0655 | 1 |
Brugia malayi | hypothetical protein | 0.0168 | 0.1403 | 0.1403 |
Echinococcus multilocularis | Smad4 | 0.005 | 0.0065 | 0.0076 |
Echinococcus multilocularis | mothers against decapentaplegic 5 | 0.005 | 0.0065 | 0.0076 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0061 | 0.0183 | 0.5 |
Echinococcus multilocularis | isocitrate dehydrogenase | 0.0096 | 0.0583 | 0.0686 |
Loa Loa (eye worm) | hypothetical protein | 0.0168 | 0.1403 | 0.1403 |
Echinococcus granulosus | NADP dependent isocitrate dehydrogenase | 0.0096 | 0.0583 | 0.1759 |
Brugia malayi | isocitrate dehydrogenase | 0.0096 | 0.0583 | 0.0583 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0096 | 0.0583 | 0.8859 |
Brugia malayi | Smad1 | 0.005 | 0.0065 | 0.0065 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.