Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 | 0.0035 | 0.477 | 0.3812 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.2781 | 0.146 |
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.0025 | 0.2781 | 1 |
Loa Loa (eye worm) | CMGC/MAPK/ERK1 protein kinase | 0.0054 | 0.8371 | 0.8073 |
Trypanosoma cruzi | metacaspase, putative | 0.0019 | 0.1547 | 0.1848 |
Echinococcus granulosus | apoptotic protease activating factor 1 | 0.0044 | 0.6369 | 0.5705 |
Brugia malayi | AMP-binding enzyme family protein | 0.0025 | 0.2781 | 0.146 |
Leishmania major | metacaspase, putative | 0.0019 | 0.1547 | 0.1848 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0054 | 0.8371 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.1551 | 0.0005 |
Trypanosoma cruzi | metacaspase, putative | 0.0019 | 0.1547 | 0.1848 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0028 | 0.3283 | 0.2054 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0025 | 0.2781 | 0.5 |
Giardia lamblia | Kinase, CMGC MAPK | 0.0054 | 0.8371 | 0.5 |
Entamoeba histolytica | peptidyl-prolyl cis-trans isomerase, putative | 0.0034 | 0.4608 | 1 |
Onchocerca volvulus | 0.0044 | 0.6369 | 0.4971 | |
Brugia malayi | AMP-binding enzyme family protein | 0.0025 | 0.2781 | 0.146 |
Trypanosoma cruzi | metacaspase, putative | 0.0019 | 0.1547 | 0.1848 |
Trypanosoma brucei | peptidyl-prolyl cis-trans isomerase/rotamase, putative | 0.0034 | 0.4608 | 0.5505 |
Trypanosoma brucei | metacaspase MCA2 | 0.0019 | 0.1547 | 0.1848 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0025 | 0.2781 | 1 |
Toxoplasma gondii | ICE family protease (caspase) p20 domain-containing protein | 0.0019 | 0.1547 | 0.1848 |
Schistosoma mansoni | rotamase | 0.0035 | 0.477 | 0.3812 |
Echinococcus granulosus | mitogen activated protein kinase | 0.0054 | 0.8371 | 0.8073 |
Schistosoma mansoni | hypothetical protein | 0.0044 | 0.6369 | 0.5705 |
Trypanosoma cruzi | mitogen activated protein kinase 2, putative | 0.0054 | 0.8371 | 1 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0025 | 0.2781 | 1 |
Echinococcus multilocularis | caspase 2 | 0.0062 | 1 | 1 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0025 | 0.2781 | 0.3322 |
Plasmodium vivax | acyl-CoA synthetase, putative | 0.0019 | 0.1551 | 1 |
Trichomonas vaginalis | rotamase, putative | 0.0034 | 0.4608 | 0.4486 |
Mycobacterium ulcerans | hypothetical protein | 0.0025 | 0.2781 | 1 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0025 | 0.2781 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0035 | 0.477 | 0.4722 |
Mycobacterium ulcerans | long-chain-fatty-acid-CoA ligase | 0.0025 | 0.2781 | 1 |
Trypanosoma cruzi | peptidyl-prolyl cis-trans isomerase | 0.0034 | 0.4608 | 0.5505 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0025 | 0.2781 | 1 |
Schistosoma mansoni | caspase-7 (C14 family) | 0.0062 | 1 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0054 | 0.8371 | 1 |
Trypanosoma cruzi | metacaspase 5, putative | 0.0019 | 0.1547 | 0.1848 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0025 | 0.2781 | 0.3322 |
Echinococcus granulosus | mitogen activated protein kinase 3 | 0.0054 | 0.8371 | 0.8073 |
Leishmania major | mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 | 0.0054 | 0.8371 | 1 |
Toxoplasma gondii | ICE family protease (caspase) p20 domain-containing protein | 0.0019 | 0.1547 | 0.1848 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0054 | 0.8371 | 0.8073 |
Echinococcus granulosus | caspase 2 | 0.0062 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.1551 | 0.0005 |
Brugia malayi | hypothetical protein | 0.0044 | 0.6369 | 0.5705 |
Toxoplasma gondii | CMGC kinase, MAPK family (ERK) MAPK-1 | 0.0054 | 0.8371 | 1 |
Echinococcus granulosus | expressed protein | 0.0035 | 0.477 | 0.3812 |
Leishmania major | peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative | 0.0034 | 0.4608 | 0.5505 |
Mycobacterium ulcerans | long-chain fatty-acid CoA ligase | 0.0025 | 0.2781 | 1 |
Toxoplasma gondii | peptidylprolyl isomerase | 0.0034 | 0.4608 | 0.5505 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.1551 | 0.0005 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0054 | 0.8371 | 1 |
Trypanosoma brucei | mitogen activated protein kinase 4, putative | 0.0054 | 0.8371 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.2781 | 0.146 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0025 | 0.2781 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0054 | 0.8371 | 1 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0025 | 0.2781 | 1 |
Onchocerca volvulus | Cell death protein 3 homolog | 0.0062 | 1 | 1 |
Plasmodium falciparum | acyl-CoA synthetase | 0.0019 | 0.1551 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.1551 | 0.0005 |
Echinococcus multilocularis | expressed protein | 0.0035 | 0.477 | 0.3812 |
Leishmania major | mitogen activated protein kinase, putative,map kinase, putative | 0.0054 | 0.8371 | 1 |
Trypanosoma cruzi | peptidyl-prolyl cis-trans isomerase | 0.0034 | 0.4608 | 0.5505 |
Loa Loa (eye worm) | Pin1-type peptidyl-prolyl cis-trans isomerase | 0.0035 | 0.477 | 0.3812 |
Brugia malayi | AMP-binding enzyme family protein | 0.0025 | 0.2781 | 0.146 |
Trypanosoma brucei | protein kinase, putative | 0.0054 | 0.8371 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.6369 | 0.5705 |
Trypanosoma cruzi | metacaspase, putative | 0.0019 | 0.1547 | 0.1848 |
Trypanosoma brucei | metacaspase MCA3 | 0.0019 | 0.1547 | 0.1848 |
Chlamydia trachomatis | acylglycerophosphoethanolamine acyltransferase | 0.0019 | 0.1551 | 0.5 |
Trypanosoma brucei | metacaspase 5, putative | 0.0019 | 0.1547 | 0.1848 |
Wolbachia endosymbiont of Brugia malayi | parvulin-like peptidyl-prolyl isomerase, PPID | 0.0011 | 0 | 0.5 |
Trichomonas vaginalis | rotamase, putative | 0.0035 | 0.477 | 0.4722 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0054 | 0.8371 | 1 |
Echinococcus multilocularis | mitogen activated protein kinase | 0.0054 | 0.8371 | 0.8073 |
Loa Loa (eye worm) | hypothetical protein | 0.0062 | 1 | 1 |
Echinococcus multilocularis | mitogen activated protein kinase 3 | 0.0054 | 0.8371 | 0.8073 |
Trypanosoma cruzi | mitogen activated protein kinase 4, putative | 0.0054 | 0.8371 | 1 |
Brugia malayi | MAP kinase sur-1 | 0.0054 | 0.8371 | 0.8073 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.2781 | 0.146 |
Trypanosoma brucei | metacaspase | 0.0019 | 0.1547 | 0.1848 |
Echinococcus multilocularis | apoptotic protease activating factor 1 | 0.0044 | 0.6369 | 0.5705 |
Trypanosoma brucei | Metacaspase-4 | 0.0019 | 0.1547 | 0.1848 |
Trypanosoma cruzi | metacaspase 5, putative | 0.0019 | 0.1547 | 0.1848 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.1551 | 0.0005 |
Mycobacterium tuberculosis | Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) | 0.0019 | 0.1551 | 0.139 |
Toxoplasma gondii | ICE family protease (caspase) p20 domain-containing protein | 0.0019 | 0.1547 | 0.1848 |
Mycobacterium tuberculosis | Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) | 0.0025 | 0.2781 | 1 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0025 | 0.2781 | 0.3322 |
Brugia malayi | Cytochrome P450 family protein | 0.0028 | 0.3283 | 0.2054 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0054 | 0.8371 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Km (binding) | = 3.2 uM | Induction of human histidine10-tagged MDR1 ATPase activity expressed in BHK cells by apparent Michaelis-Menten constant | ChEMBL. | 19402665 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.