Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0093 | 0.1365 | 0.1299 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0315 | 0.5239 | 0.5239 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0374 | 0.6262 | 0.6262 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.01 | 0.149 | 0.1425 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.01 | 0.149 | 0.1425 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0093 | 0.1365 | 0.1299 |
Mycobacterium tuberculosis | Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) | 0.0018 | 0.0075 | 0.5 |
Echinococcus granulosus | GPCR family 2 | 0.01 | 0.149 | 0.1425 |
Schistosoma mansoni | smad1 5 8 and | 0.0025 | 0.0198 | 0.0124 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0053 | 0.0674 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.01 | 0.149 | 0.149 |
Onchocerca volvulus | Rap guanine nucleotide exchange factor 1 homolog | 0.0209 | 0.3392 | 0.5 |
Brugia malayi | isocitrate dehydrogenase | 0.0018 | 0.0075 | 0.0075 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0374 | 0.6262 | 0.6262 |
Echinococcus multilocularis | smad | 0.0025 | 0.0198 | 0.0124 |
Echinococcus multilocularis | mothers against decapentaplegic 5 | 0.0025 | 0.0198 | 0.0124 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0215 | 0.3504 | 0.3504 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0025 | 0.0198 | 0.0198 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0093 | 0.1365 | 0.1365 |
Echinococcus multilocularis | Smad4 | 0.0025 | 0.0198 | 0.0124 |
Echinococcus granulosus | mothers against decapentaplegic 5 | 0.0025 | 0.0198 | 0.0124 |
Schistosoma mansoni | hypothetical protein | 0.0331 | 0.5514 | 0.548 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.01 | 0.149 | 0.1425 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0093 | 0.1365 | 0.1299 |
Brugia malayi | hypothetical protein | 0.0053 | 0.0674 | 0.0674 |
Brugia malayi | N-terminal motif family protein | 0.0209 | 0.3392 | 0.3392 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0053 | 0.0674 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0053 | 0.0674 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0093 | 0.1365 | 0.1299 |
Schistosoma mansoni | hypothetical protein | 0.01 | 0.149 | 0.1425 |
Echinococcus granulosus | smad | 0.0025 | 0.0198 | 0.0124 |
Schistosoma mansoni | hypothetical protein | 0.01 | 0.149 | 0.1425 |
Echinococcus granulosus | Ataxin 2 N terminaldomain containing protein | 0.0024 | 0.0167 | 0.0092 |
Loa Loa (eye worm) | hypothetical protein | 0.0209 | 0.3392 | 0.3392 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0589 | 1 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0589 | 1 | 1 |
Schistosoma mansoni | smad1 5 8 and | 0.0025 | 0.0198 | 0.0124 |
Brugia malayi | MH2 domain containing protein | 0.0374 | 0.6262 | 0.6262 |
Schistosoma mansoni | hypothetical protein | 0.0215 | 0.3504 | 0.3454 |
Loa Loa (eye worm) | TAR-binding protein | 0.0589 | 1 | 1 |
Echinococcus granulosus | geminin | 0.0331 | 0.5514 | 0.548 |
Brugia malayi | MH1 domain containing protein | 0.0025 | 0.0198 | 0.0198 |
Loa Loa (eye worm) | MH1 domain-containing protein | 0.0025 | 0.0198 | 0.0198 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0053 | 0.0674 | 1 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0053 | 0.0674 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0093 | 0.1365 | 0.1299 |
Schistosoma mansoni | tar DNA-binding protein | 0.0589 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.0674 | 0.0674 |
Brugia malayi | Latrophilin receptor protein 2 | 0.01 | 0.149 | 0.149 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.01 | 0.149 | 0.1425 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0093 | 0.1365 | 0.1299 |
Schistosoma mansoni | smad | 0.0025 | 0.0198 | 0.0124 |
Brugia malayi | MH2 domain containing protein | 0.0025 | 0.0198 | 0.0198 |
Schistosoma mansoni | tar DNA-binding protein | 0.0589 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0024 | 0.0167 | 0.0092 |
Loa Loa (eye worm) | Smad1 | 0.0025 | 0.0198 | 0.0198 |
Loa Loa (eye worm) | hypothetical protein | 0.0215 | 0.3504 | 0.3504 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.01 | 0.149 | 0.149 |
Brugia malayi | Smad1 | 0.0025 | 0.0198 | 0.0198 |
Schistosoma mansoni | hypothetical protein | 0.01 | 0.149 | 0.1425 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0093 | 0.1365 | 0.1365 |
Schistosoma mansoni | hypothetical protein | 0.01 | 0.149 | 0.1425 |
Loa Loa (eye worm) | hypothetical protein | 0.0315 | 0.5239 | 0.5239 |
Schistosoma mansoni | tar DNA-binding protein | 0.0589 | 1 | 1 |
Schistosoma mansoni | TGF-beta signal transducer Smad2 | 0.0025 | 0.0198 | 0.0124 |
Schistosoma mansoni | smad1 5 8 and | 0.0025 | 0.0198 | 0.0124 |
Schistosoma mansoni | hypothetical protein | 0.0331 | 0.5514 | 0.548 |
Brugia malayi | hypothetical protein | 0.0034 | 0.0348 | 0.0348 |
Echinococcus granulosus | Smad4 | 0.0025 | 0.0198 | 0.0124 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0315 | 0.5239 | 0.5239 |
Echinococcus multilocularis | geminin | 0.0331 | 0.5514 | 0.548 |
Brugia malayi | MH2 domain containing protein | 0.0025 | 0.0198 | 0.0198 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0053 | 0.0674 | 1 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0053 | 0.0674 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0093 | 0.1365 | 0.1299 |
Echinococcus multilocularis | tar DNA binding protein | 0.0589 | 1 | 1 |
Schistosoma mansoni | Smad4 | 0.0025 | 0.0198 | 0.0124 |
Echinococcus multilocularis | TGF beta signal transducer SmadC | 0.0025 | 0.0198 | 0.0124 |
Echinococcus multilocularis | Ataxin 2, N terminal,domain containing protein | 0.0024 | 0.0167 | 0.0092 |
Echinococcus granulosus | TGF beta signal transducer SmadC | 0.0025 | 0.0198 | 0.0124 |
Brugia malayi | Isocitrate dehydrogenase | 0.0018 | 0.0075 | 0.0075 |
Loa Loa (eye worm) | isocitrate dehydrogenase | 0.0018 | 0.0075 | 0.0075 |
Echinococcus multilocularis | GPCR, family 2 | 0.01 | 0.149 | 0.1425 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0053 | 0.0674 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0589 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0589 | 1 | 1 |
Brugia malayi | TAR-binding protein | 0.0589 | 1 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0589 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0589 | 1 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0315 | 0.5239 | 0.5239 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.01 | 0.149 | 0.149 |
Brugia malayi | MH1 domain containing protein | 0.0025 | 0.0198 | 0.0198 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GC50 (functional) | = 10 uM | Cytotoxicity against TrxR overexpressing human doxorubicin-resistant MCF7 cells after 48 hrs by MTT assay | ChEMBL. | 18678491 |
GC50 (functional) | = 12.1 uM | Cytotoxicity against TrxR overexpressing human cis-diammine-dichloroplatinum (II)-resistant A549 cells after 48 hrs by MTT assay | ChEMBL. | 18678491 |
GC50 (functional) | > 100 uM | Cytotoxicity against TrxR overexpressing human HepG2 cells after 48 hrs by MTT assay | ChEMBL. | 18678491 |
Ki (binding) | = 74 uM | Inhibition of human recombinant His-tagged glyoxalase 1 expressed in Escherichia coli BL21 (DE3) preincubated for 20 mins by Dixon plot analysis | ChEMBL. | 21237663 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.