Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | 5-hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Schistosoma mansoni | biogenic amine (5HT) receptor | Get druggable targets OG5_133074 | All targets in OG5_133074 |
Echinococcus granulosus | biogenic amine 5HT receptor | Get druggable targets OG5_133074 | All targets in OG5_133074 |
Echinococcus multilocularis | biogenic amine (5HT) receptor | Get druggable targets OG5_133074 | All targets in OG5_133074 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0347 | 0.5279 | 1 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.019 | 0.1852 | 0.1852 |
Echinococcus granulosus | biogenic amine 5HT receptor | 0.0457 | 0.7681 | 0.7681 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.019 | 0.1852 | 0.1852 |
Echinococcus multilocularis | carbonic anhydrase II | 0.019 | 0.1852 | 0.1852 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0347 | 0.5279 | 1 |
Echinococcus granulosus | dihydrofolate reductase | 0.0564 | 1 | 1 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0347 | 0.5279 | 0.5 |
Schistosoma mansoni | biogenic amine (5HT) receptor | 0.0457 | 0.7681 | 0.7681 |
Onchocerca volvulus | 0.0105 | 0 | 0.5 | |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.0564 | 1 | 1 |
Echinococcus multilocularis | dihydrofolate reductase | 0.0564 | 1 | 1 |
Loa Loa (eye worm) | carbonic anhydrase 3 | 0.019 | 0.1852 | 0.1852 |
Echinococcus multilocularis | biogenic amine (5HT) receptor | 0.0457 | 0.7681 | 0.7681 |
Brugia malayi | Putative carbonic anhydrase 5 precursor | 0.019 | 0.1852 | 0.1852 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0347 | 0.5279 | 0.5 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0347 | 0.5279 | 0.5 |
Echinococcus granulosus | carbonic anhydrase II | 0.019 | 0.1852 | 0.1852 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.019 | 0.1852 | 0.1852 |
Brugia malayi | Dihydrofolate reductase | 0.0564 | 1 | 1 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.0564 | 1 | 1 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0347 | 0.5279 | 1 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.019 | 0.1852 | 0.1852 |
Schistosoma mansoni | dihydrofolate reductase | 0.0564 | 1 | 1 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.0564 | 1 | 1 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.0564 | 1 | 1 |
Chlamydia trachomatis | dihydrofolate reductase | 0.0564 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 949 nM | Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membrane | ChEMBL. | 18456500 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.