Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | hypothetical protein, conserved | 0.0036 | 0.1006 | 1 |
Trichomonas vaginalis | esterase, putative | 0.0036 | 0.1006 | 0.1073 |
Schistosoma mansoni | ferritin | 0.0018 | 0.0175 | 0.0067 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0036 | 0.1006 | 1 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0036 | 0.1006 | 0.1073 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.1006 | 0.1133 |
Echinococcus granulosus | 3-phosphoinositide-dependent protein kinase 1 | 0.0185 | 0.7912 | 1 |
Echinococcus granulosus | ferritin | 0.0018 | 0.0175 | 0.0067 |
Onchocerca volvulus | 0.0036 | 0.1006 | 0.5 | |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0036 | 0.1006 | 0.1133 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0036 | 0.1006 | 0.1073 |
Mycobacterium tuberculosis | Probable esterase/lipase LipP | 0.0036 | 0.1006 | 0.0845 |
Brugia malayi | beta-lactamase family protein | 0.0036 | 0.1006 | 0.1133 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0141 | 0.5867 | 0.7375 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0021 | 0.0299 | 0.2969 |
Echinococcus granulosus | terminal deoxycytidyl transferase rev1 | 0.0021 | 0.0299 | 0.0226 |
Brugia malayi | phosphoinositide-dependent protein kinase I | 0.0185 | 0.7912 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0185 | 0.7912 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0185 | 0.7912 | 1 |
Loa Loa (eye worm) | AGC/PDK1 protein kinase | 0.0185 | 0.7912 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.1004 | 0.0927 |
Schistosoma mansoni | tar DNA-binding protein | 0.013 | 0.5345 | 0.6705 |
Echinococcus granulosus | dna polymerase eta | 0.0021 | 0.0299 | 0.0226 |
Brugia malayi | TAR-binding protein | 0.013 | 0.5345 | 0.6705 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0036 | 0.1006 | 0.1133 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0036 | 0.1004 | 0.1132 |
Echinococcus multilocularis | ferritin | 0.0018 | 0.0175 | 0.0067 |
Schistosoma mansoni | tar DNA-binding protein | 0.013 | 0.5345 | 0.6705 |
Schistosoma mansoni | ferritin | 0.0018 | 0.0175 | 0.0067 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0021 | 0.0299 | 0.2969 |
Mycobacterium tuberculosis | Possible conserved lipoprotein LpqK | 0.0036 | 0.1006 | 0.0845 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.1004 | 0.0927 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0046 | 0.1457 | 0.1713 |
Brugia malayi | RNA binding protein | 0.013 | 0.5345 | 0.6705 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0021 | 0.0299 | 0.2969 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0021 | 0.0299 | 0.2969 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0021 | 0.0299 | 0.2969 |
Mycobacterium tuberculosis | Conserved protein | 0.0036 | 0.1006 | 0.0845 |
Echinococcus multilocularis | dna polymerase eta | 0.0021 | 0.0299 | 0.0226 |
Schistosoma mansoni | gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 | 0.0145 | 0.6056 | 0.7617 |
Schistosoma mansoni | hypothetical protein | 0.0183 | 0.7783 | 0.9835 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0021 | 0.0299 | 0.1486 |
Schistosoma mansoni | terminal deoxycytidyl transferase | 0.0021 | 0.0299 | 0.0226 |
Schistosoma mansoni | hypothetical protein | 0.0183 | 0.7783 | 0.9835 |
Entamoeba histolytica | protein kinase, putative | 0.0185 | 0.7912 | 1 |
Echinococcus multilocularis | tar DNA binding protein | 0.013 | 0.5345 | 0.6705 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0036 | 0.1006 | 0.1073 |
Schistosoma mansoni | apoferritin-2 | 0.0018 | 0.0175 | 0.0067 |
Trichomonas vaginalis | AGC family protein kinase | 0.0185 | 0.7912 | 1 |
Mycobacterium ulcerans | beta-lactamase | 0.0036 | 0.1006 | 1 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0036 | 0.1006 | 0.1073 |
Schistosoma mansoni | tar DNA-binding protein | 0.013 | 0.5345 | 0.6705 |
Trichomonas vaginalis | AGC family protein kinase | 0.0185 | 0.7912 | 1 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-B | 0.0043 | 0.1312 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0021 | 0.0299 | 0.2969 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0046 | 0.1457 | 0.1713 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0046 | 0.1457 | 0.1713 |
Plasmodium falciparum | histone acetyltransferase GCN5 | 0.0039 | 0.1148 | 0.5 |
Schistosoma mansoni | apoferritin-2 | 0.0018 | 0.0175 | 0.0067 |
Giardia lamblia | Histone acetyltransferase GCN5 | 0.0039 | 0.1148 | 1 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0021 | 0.0299 | 0.2969 |
Loa Loa (eye worm) | beta-lactamase | 0.0036 | 0.1006 | 0.1133 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0036 | 0.1006 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0046 | 0.1457 | 0.1713 |
Schistosoma mansoni | ferritin | 0.0018 | 0.0175 | 0.0067 |
Echinococcus granulosus | expressed protein | 0.0018 | 0.0175 | 0.0067 |
Echinococcus multilocularis | expressed protein | 0.0018 | 0.0175 | 0.0067 |
Echinococcus multilocularis | geminin | 0.0183 | 0.7783 | 0.9835 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-A | 0.0043 | 0.1312 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.013 | 0.5345 | 0.6705 |
Brugia malayi | acetyltransferase, GNAT family protein | 0.0145 | 0.6056 | 0.7617 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.1006 | 0.1133 |
Mycobacterium tuberculosis | Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) | 0.0021 | 0.0299 | 0.0126 |
Schistosoma mansoni | hypothetical protein | 0.0037 | 0.1035 | 0.1171 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0043 | 0.1312 | 0.1527 |
Mycobacterium tuberculosis | Probable hydrolase | 0.0036 | 0.1006 | 0.0845 |
Mycobacterium tuberculosis | Probable lipase LipD | 0.0036 | 0.1006 | 0.0845 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0036 | 0.1006 | 1 |
Treponema pallidum | bacterioferrin (TpF1) | 0.0018 | 0.0175 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.1004 | 0.0927 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0046 | 0.1457 | 0.1713 |
Loa Loa (eye worm) | RNA binding protein | 0.013 | 0.5345 | 0.6705 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0036 | 0.1006 | 0.1133 |
Trichomonas vaginalis | DNA polymerase eta, putative | 0.0021 | 0.0299 | 0.016 |
Mycobacterium tuberculosis | Conserved protein | 0.0036 | 0.1006 | 0.0845 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0021 | 0.0299 | 0.2969 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.1006 | 0.1133 |
Schistosoma mansoni | tar DNA-binding protein | 0.013 | 0.5345 | 0.6705 |
Mycobacterium ulcerans | hypothetical protein | 0.0036 | 0.1006 | 1 |
Mycobacterium leprae | conserved hypothetical protein | 0.0036 | 0.1006 | 1 |
Trichomonas vaginalis | cat eye syndrome critical region protein 2, cscr2, putative | 0.0043 | 0.1312 | 0.147 |
Schistosoma mansoni | DNA polymerase eta | 0.0021 | 0.0299 | 0.0226 |
Entamoeba histolytica | acetyltransferase, GNAT family | 0.0039 | 0.1148 | 0.1116 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0054 | 0.1822 | 0.2181 |
Schistosoma mansoni | ferritin light chain | 0.0018 | 0.0175 | 0.0067 |
Echinococcus multilocularis | terminal deoxycytidyl transferase rev1 | 0.0021 | 0.0299 | 0.0226 |
Loa Loa (eye worm) | AGC/PDK1 protein kinase | 0.0185 | 0.7912 | 1 |
Trypanosoma brucei | DNA polymerase eta, putative | 0.0021 | 0.0299 | 0.2969 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0037 | 0.1035 | 0.1171 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0021 | 0.0299 | 0.2969 |
Mycobacterium tuberculosis | Probable conserved lipoprotein | 0.0036 | 0.1006 | 0.0845 |
Schistosoma mansoni | ferritin light chain | 0.0018 | 0.0175 | 0.0067 |
Brugia malayi | beta-lactamase family protein | 0.0036 | 0.1006 | 0.1133 |
Schistosoma mansoni | hypothetical protein | 0.0036 | 0.1004 | 0.1132 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0299 | 0.0226 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0036 | 0.1006 | 0.1133 |
Onchocerca volvulus | 0.0036 | 0.1006 | 0.5 | |
Mycobacterium tuberculosis | Conserved protein | 0.0036 | 0.1006 | 0.0845 |
Brugia malayi | beta-lactamase | 0.0036 | 0.1006 | 0.1133 |
Onchocerca volvulus | 0.0036 | 0.1006 | 0.5 | |
Loa Loa (eye worm) | acetyltransferase | 0.0145 | 0.6056 | 0.7617 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.1004 | 0.0927 |
Echinococcus multilocularis | gcn5proteinral control of amino acid synthesis | 0.0145 | 0.6056 | 0.7617 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.1006 | 0.1133 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0021 | 0.0299 | 0.1486 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0036 | 0.1006 | 1 |
Echinococcus multilocularis | 3 phosphoinositide dependent protein kinase 1 | 0.0185 | 0.7912 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0046 | 0.1457 | 0.1713 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0021 | 0.0299 | 0.2969 |
Loa Loa (eye worm) | ImpB/MucB/SamB family protein | 0.0021 | 0.0299 | 0.0226 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.1822 | 0.2181 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.1006 | 0.1133 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.1006 | 0.1133 |
Echinococcus granulosus | dna polymerase kappa | 0.0021 | 0.0299 | 0.0226 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.013 | 0.5345 | 0.6705 |
Brugia malayi | hypothetical protein | 0.0036 | 0.1004 | 0.1132 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0046 | 0.1457 | 0.1713 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0046 | 0.1457 | 0.1713 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0036 | 0.1006 | 1 |
Mycobacterium ulcerans | lipase LipD | 0.0036 | 0.1006 | 1 |
Mycobacterium tuberculosis | Probable esterase LipL | 0.0036 | 0.1006 | 0.0845 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0036 | 0.1004 | 0.1132 |
Brugia malayi | Protein kinase domain containing protein | 0.0185 | 0.7912 | 1 |
Mycobacterium leprae | Probable lipase LipE | 0.0036 | 0.1006 | 1 |
Mycobacterium tuberculosis | Probable lipase LipE | 0.0036 | 0.1006 | 0.0845 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0021 | 0.0299 | 0.2969 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0036 | 0.1006 | 0.1133 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0046 | 0.1457 | 0.1713 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.0043 | 0.1312 | 0.147 |
Trypanosoma brucei | unspecified product | 0.0021 | 0.0299 | 0.2969 |
Schistosoma mansoni | tar DNA-binding protein | 0.013 | 0.5345 | 0.6705 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0021 | 0.0299 | 0.0226 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0054 | 0.1822 | 0.2181 |
Echinococcus multilocularis | dna polymerase kappa | 0.0021 | 0.0299 | 0.0226 |
Wolbachia endosymbiont of Brugia malayi | bacterioferritin/cytochrome b1 | 0.0018 | 0.0175 | 0.5 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0021 | 0.0299 | 0.0226 |
Brugia malayi | RNA recognition motif domain containing protein | 0.013 | 0.5345 | 0.6705 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.1035 | 0.1171 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0054 | 0.1822 | 0.2181 |
Plasmodium vivax | histone acetyltransferase GCN5, putative | 0.0043 | 0.1312 | 1 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0036 | 0.1006 | 0.1133 |
Loa Loa (eye worm) | TAR-binding protein | 0.013 | 0.5345 | 0.6705 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0021 | 0.0299 | 0.2969 |
Echinococcus granulosus | geminin | 0.0183 | 0.7783 | 0.9835 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0021 | 0.0299 | 0.0126 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0036 | 0.1006 | 0.1073 |
Schistosoma mansoni | rab geranylgeranyl transferase alpha subunit | 0.0021 | 0.0299 | 0.0226 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0021 | 0.0299 | 0.2969 |
Schistosoma mansoni | ferritin | 0.0018 | 0.0175 | 0.0067 |
Trichomonas vaginalis | DNA polymerase IV / kappa, putative | 0.0021 | 0.0299 | 0.016 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0036 | 0.1004 | 0.1132 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC (functional) | > 100 uM | Antibacterial activity against Escherichia coli ATCC 49696 after 20 hrs by microdilution assay | ChEMBL. | 18031869 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.