Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | hypothetical protein | 0.0116 | 0.1676 | 0.3854 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0116 | 0.1676 | 0.3952 |
Schistosoma mansoni | tar DNA-binding protein | 0.0269 | 0.4242 | 0.9751 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0019 | 0.0055 | 0.0055 |
Schistosoma mansoni | hypothetical protein | 0.0116 | 0.1676 | 0.3854 |
Echinococcus multilocularis | mothers against decapentaplegic 5 | 0.0042 | 0.0442 | 0.1042 |
Loa Loa (eye worm) | RNA binding protein | 0.0269 | 0.4242 | 0.4242 |
Echinococcus multilocularis | smad | 0.0042 | 0.0442 | 0.1042 |
Brugia malayi | MH2 domain containing protein | 0.0019 | 0.0055 | 0.0055 |
Echinococcus multilocularis | Smad4 | 0.0042 | 0.0442 | 0.1042 |
Trypanosoma brucei | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0015 | 0 | 0.5 |
Schistosoma mansoni | Smad4 | 0.0019 | 0.0055 | 0.0128 |
Echinococcus granulosus | tar DNA binding protein | 0.0269 | 0.4242 | 1 |
Schistosoma mansoni | smad | 0.0042 | 0.0442 | 0.1016 |
Schistosoma mansoni | hypothetical protein | 0.0116 | 0.1676 | 0.3854 |
Echinococcus granulosus | mothers against decapentaplegic 2 | 0.0019 | 0.0055 | 0.0131 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0116 | 0.1676 | 0.1676 |
Schistosoma mansoni | tar DNA-binding protein | 0.0269 | 0.4242 | 0.9751 |
Schistosoma mansoni | Smad4 | 0.0042 | 0.0442 | 0.1016 |
Brugia malayi | MH2 domain containing protein | 0.0042 | 0.0442 | 0.0442 |
Trypanosoma cruzi | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0015 | 0 | 0.5 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0116 | 0.1676 | 0.3952 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.025 | 0.392 | 0.392 |
Schistosoma mansoni | smad1 5 8 and | 0.0042 | 0.0442 | 0.1016 |
Loa Loa (eye worm) | MH1 domain-containing protein | 0.0042 | 0.0442 | 0.0442 |
Schistosoma mansoni | tar DNA-binding protein | 0.0269 | 0.4242 | 0.9751 |
Mycobacterium ulcerans | glutaminase | 0.0275 | 0.435 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0269 | 0.4242 | 0.9751 |
Loa Loa (eye worm) | hypothetical protein | 0.025 | 0.392 | 0.392 |
Onchocerca volvulus | Mothers against decapentaplegic homolog | 0.0019 | 0.0055 | 0.5 |
Schistosoma mansoni | Smad4 | 0.0019 | 0.0055 | 0.0128 |
Brugia malayi | MH1 domain containing protein | 0.0023 | 0.013 | 0.013 |
Brugia malayi | TAR-binding protein | 0.0269 | 0.4242 | 0.4242 |
Schistosoma mansoni | smad1 5 8 and | 0.0042 | 0.0442 | 0.1016 |
Leishmania major | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0015 | 0 | 0.5 |
Echinococcus granulosus | GPCR family 2 | 0.0116 | 0.1676 | 0.3952 |
Schistosoma mansoni | TGF-beta signal transducer Smad2 | 0.0042 | 0.0442 | 0.1016 |
Brugia malayi | MH1 domain containing protein | 0.0042 | 0.0442 | 0.0442 |
Schistosoma mansoni | glutaminase | 0.0275 | 0.435 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0365 | 0.5853 | 0.5853 |
Schistosoma mansoni | hypothetical protein | 0.025 | 0.392 | 0.9011 |
Trypanosoma cruzi | isocitrate dehydrogenase, putative | 0.0015 | 0 | 0.5 |
Echinococcus multilocularis | TGF beta signal transducer SmadC | 0.0042 | 0.0442 | 0.1042 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0116 | 0.1676 | 0.1676 |
Trypanosoma brucei | isocitrate dehydrogenase, putative | 0.0015 | 0 | 0.5 |
Brugia malayi | MH1 domain containing protein | 0.0023 | 0.013 | 0.013 |
Loa Loa (eye worm) | hypothetical protein | 0.0365 | 0.5853 | 0.5853 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0613 | 1 | 1 |
Brugia malayi | MH2 domain containing protein | 0.0042 | 0.0442 | 0.0442 |
Loa Loa (eye worm) | Smad1 | 0.0042 | 0.0442 | 0.0442 |
Echinococcus granulosus | smad | 0.0042 | 0.0442 | 0.1042 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0116 | 0.1676 | 0.1676 |
Echinococcus granulosus | Smad4 | 0.0042 | 0.0442 | 0.1042 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0116 | 0.1676 | 0.3952 |
Brugia malayi | RNA binding protein | 0.0269 | 0.4242 | 0.4242 |
Loa Loa (eye worm) | nuclear factor I | 0.0023 | 0.013 | 0.013 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0015 | 0 | 0.5 |
Schistosoma mansoni | smad | 0.0019 | 0.0055 | 0.0128 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0055 | 0.0055 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0042 | 0.0442 | 0.0442 |
Schistosoma mansoni | tar DNA-binding protein | 0.0269 | 0.4242 | 0.9751 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.013 | 0.013 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0269 | 0.4242 | 0.4242 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0269 | 0.4242 | 0.4242 |
Brugia malayi | Smad1 | 0.0042 | 0.0442 | 0.0442 |
Loa Loa (eye worm) | TAR-binding protein | 0.0269 | 0.4242 | 0.4242 |
Loa Loa (eye worm) | hypothetical protein | 0.0116 | 0.1676 | 0.1676 |
Echinococcus multilocularis | GPCR, family 2 | 0.0116 | 0.1676 | 0.3952 |
Mycobacterium tuberculosis | Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) | 0.0015 | 0 | 0.5 |
Echinococcus multilocularis | mothers against decapentaplegic 2 | 0.0019 | 0.0055 | 0.0131 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0613 | 1 | 1 |
Loa Loa (eye worm) | MH1 domain-containing protein | 0.0019 | 0.0055 | 0.0055 |
Plasmodium falciparum | isocitrate dehydrogenase [NADP], mitochondrial | 0.0015 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0116 | 0.1676 | 0.3854 |
Plasmodium vivax | isocitrate dehydrogenase [NADP], mitochondrial, putative | 0.0015 | 0 | 0.5 |
Schistosoma mansoni | smad1 5 8 and | 0.0042 | 0.0442 | 0.1016 |
Loa Loa (eye worm) | glutaminase 2 | 0.0275 | 0.435 | 0.435 |
Echinococcus granulosus | mothers against decapentaplegic 5 | 0.0042 | 0.0442 | 0.1042 |
Echinococcus granulosus | TGF beta signal transducer SmadC | 0.0042 | 0.0442 | 0.1042 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0015 | 0 | 0.5 |
Echinococcus granulosus | mothers against decapentaplegic 6 | 0.0019 | 0.0055 | 0.0131 |
Brugia malayi | mothers against decapentaplegic homolog 3 | 0.0019 | 0.0055 | 0.0055 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0116 | 0.1676 | 0.3952 |
Echinococcus multilocularis | tar DNA binding protein | 0.0269 | 0.4242 | 1 |
Echinococcus multilocularis | mothers against decapentaplegic 6 | 0.0019 | 0.0055 | 0.0131 |
Brugia malayi | MH1 domain containing protein | 0.0042 | 0.0442 | 0.0442 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0365 | 0.5853 | 0.5853 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0365 | 0.5853 | 0.5853 |
Loa Loa (eye worm) | glutaminase | 0.0275 | 0.435 | 0.435 |
Brugia malayi | glutaminase DH11.1 | 0.0275 | 0.435 | 0.435 |
Trichomonas vaginalis | glutaminase, putative | 0.0275 | 0.435 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.