Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0079 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0079 | 1 | 1 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0079 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0079 | 1 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0079 | 1 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.0079 | 1 | 0.5 |
Echinococcus granulosus | carboxylesterase 5A | 0.0079 | 1 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0079 | 1 | 0.5 |
Loa Loa (eye worm) | carboxylesterase | 0.0079 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0079 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0079 | 1 | 1 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0079 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | = 1.19 10'-5M | Growth inhibition of human MDA-MB-231 cells after 48 hrs by MTT assay | ChEMBL. | 18799316 |
GI50 (functional) | = 3.67 10'-6M | Growth inhibition of human HT-29 cells after 48 hrs by MTT assay | ChEMBL. | 18799316 |
GI50 (functional) | > 100 mM | Growth inhibition of human A549 cells after 48 hrs by MTT assay | ChEMBL. | 18799316 |
LC50 (functional) | > 100 mM | Cytotoxicity against human HT-29 cells after 48 hrs by MTT assay | ChEMBL. | 18799316 |
LC50 (functional) | > 100 mM | Cytotoxicity against human A549 cells after 48 hrs by MTT assay | ChEMBL. | 18799316 |
LC50 (functional) | > 100 mM | Cytotoxicity against human MDA-MB-231 cells after 48 hrs by MTT assay | ChEMBL. | 18799316 |
TGI (functional) | > 100 mM | Growth inhibition of human HT-29 cells after 48 hrs by MTT assay | ChEMBL. | 18799316 |
TGI (functional) | > 100 mM | Growth inhibition of human A549 cells after 48 hrs by MTT assay | ChEMBL. | 18799316 |
TGI (functional) | > 100 mM | Growth inhibition of human MDA-MB-231 cells after 48 hrs by MTT assay | ChEMBL. | 18799316 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.