Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | histamine receptor H3 | Starlite/ChEMBL | References |
Rattus norvegicus | Histamine H3 receptor | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus granulosus | biogenic amine 5HT receptor | Histamine H3 receptor | 445 aa | 405 aa | 25.2 % |
Loa Loa (eye worm) | hypothetical protein | Histamine H3 receptor | 445 aa | 384 aa | 22.4 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | tar DNA binding protein | 0.0067 | 0.9255 | 0.9255 |
Brugia malayi | Inositol-1 | 0.0039 | 0.3147 | 0.3147 |
Echinococcus granulosus | tyrosyl DNA phosphodiesterase 1 | 0.007 | 1 | 1 |
Onchocerca volvulus | 0.0025 | 0 | 0.5 | |
Onchocerca volvulus | 0.0025 | 0 | 0.5 | |
Loa Loa (eye worm) | TAR-binding protein | 0.0067 | 0.9255 | 0.9255 |
Onchocerca volvulus | 0.0025 | 0 | 0.5 | |
Trichomonas vaginalis | inositol monophosphatase, putative | 0.0039 | 0.3147 | 0.5 |
Onchocerca volvulus | 0.0025 | 0 | 0.5 | |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0039 | 0.3147 | 0.5 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0067 | 0.9255 | 0.9255 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0067 | 0.9255 | 0.9255 |
Echinococcus multilocularis | inositol monophosphatase 1 | 0.0039 | 0.3147 | 0.3147 |
Loa Loa (eye worm) | RNA binding protein | 0.0067 | 0.9255 | 0.9255 |
Trypanosoma brucei | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.007 | 1 | 1 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.007 | 1 | 1 |
Echinococcus multilocularis | tyrosyl DNA phosphodiesterase 1 | 0.007 | 1 | 1 |
Loa Loa (eye worm) | tyrosyl-DNA phosphodiesterase | 0.007 | 1 | 1 |
Mycobacterium leprae | possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). | 0.0035 | 0.2235 | 0.5 |
Onchocerca volvulus | 0.0025 | 0 | 0.5 | |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.007 | 1 | 1 |
Entamoeba histolytica | tyrosyl-DNA phosphodiesterase, putative | 0.007 | 1 | 1 |
Onchocerca volvulus | 0.0025 | 0 | 0.5 | |
Onchocerca volvulus | 0.0025 | 0 | 0.5 | |
Onchocerca volvulus | 0.0025 | 0 | 0.5 | |
Schistosoma mansoni | tyrosyl-DNA phosphodiesterase | 0.007 | 1 | 1 |
Onchocerca volvulus | 0.0025 | 0 | 0.5 | |
Schistosoma mansoni | tar DNA-binding protein | 0.0067 | 0.9255 | 0.9255 |
Mycobacterium tuberculosis | Inositol-1-monophosphatase SuhB | 0.0035 | 0.2235 | 0.5 |
Onchocerca volvulus | 0.0025 | 0 | 0.5 | |
Onchocerca volvulus | 0.0025 | 0 | 0.5 | |
Echinococcus multilocularis | transcription factor Dp 1 | 0.0041 | 0.3448 | 0.3448 |
Onchocerca volvulus | 0.0025 | 0 | 0.5 | |
Onchocerca volvulus | 0.0025 | 0 | 0.5 | |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0039 | 0.3147 | 0.5 |
Toxoplasma gondii | inositol(myo)-1(or 4)-monophosphatase 2, putative | 0.0039 | 0.3147 | 0.5 |
Echinococcus multilocularis | tar DNA binding protein | 0.0067 | 0.9255 | 0.9255 |
Schistosoma mansoni | inositol monophosphatase | 0.0039 | 0.3147 | 0.3147 |
Echinococcus granulosus | transcription factor Dp 1 | 0.0041 | 0.3448 | 0.3448 |
Schistosoma mansoni | tar DNA-binding protein | 0.0067 | 0.9255 | 0.9255 |
Leishmania major | tyrosyl-DNA phosphodiesterase 1 | 0.007 | 1 | 1 |
Onchocerca volvulus | 0.0025 | 0 | 0.5 | |
Onchocerca volvulus | 0.0025 | 0 | 0.5 | |
Schistosoma mansoni | tar DNA-binding protein | 0.0067 | 0.9255 | 0.9255 |
Schistosoma mansoni | inositol monophosphatase | 0.0039 | 0.3147 | 0.3147 |
Mycobacterium ulcerans | extragenic suppressor protein SuhB | 0.0039 | 0.3147 | 0.5 |
Onchocerca volvulus | 0.0025 | 0 | 0.5 | |
Loa Loa (eye worm) | inositol-1 | 0.0039 | 0.3147 | 0.3147 |
Schistosoma mansoni | tar DNA-binding protein | 0.0067 | 0.9255 | 0.9255 |
Schistosoma mansoni | tar DNA-binding protein | 0.0067 | 0.9255 | 0.9255 |
Onchocerca volvulus | 0.0025 | 0 | 0.5 | |
Echinococcus granulosus | inositol monophosphatase 1 | 0.0039 | 0.3147 | 0.3147 |
Onchocerca volvulus | Neuropeptide F receptor homolog | 0.0025 | 0 | 0.5 |
Brugia malayi | RNA binding protein | 0.0067 | 0.9255 | 0.9255 |
Onchocerca volvulus | Dopamine\/Ecdysteroid receptor homolog | 0.0025 | 0 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | fructose-1,6-bisphosphatase | 0.0039 | 0.3147 | 0.5 |
Brugia malayi | TAR-binding protein | 0.0067 | 0.9255 | 0.9255 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 7.91 nM | Displacement of [3H]NAMH from rat full length histamine H3 receptor expressed in rat C6 cells | ChEMBL. | 18683917 |
Ki (binding) | = 7.91 nM | Displacement of [3H]N-alpha methyl histamine from rat cortical membrane histamine H3 receptor | ChEMBL. | 19588934 |
Ki (binding) | = 19.7 nM | Displacement of [3H]NAMH from human full length histamine H3 receptor expressed in rat C6 cells | ChEMBL. | 18683917 |
Ki (binding) | = 19.7 nM | Displacement of [3H]N-alpha methyl histamine from human cloned histamine H3 receptor expressed in C6 cells | ChEMBL. | 19588934 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.