Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.00132533 | 0 | 0.5 | |
Echinococcus granulosus | transient receptor potential cation channel | 0.00132533 | 0.000000207854 | 0.000000207854 |
Loa Loa (eye worm) | hypothetical protein | 0.00132533 | 0.000000207854 | 0.000000207854 |
Trichomonas vaginalis | CMGC family protein kinase | 0.00520976 | 1 | 1 |
Trypanosoma brucei | protein kinase, putative | 0.00520976 | 1 | 1 |
Brugia malayi | olfactory channel protein osm-9 | 0.00132533 | 0.000000207854 | 0.000000207854 |
Schistosoma mansoni | serine/threonine protein kinase | 0.00520976 | 1 | 1 |
Schistosoma mansoni | transient receptor potential channel | 0.00132533 | 0.000000207854 | 0.000000207854 |
Leishmania major | mitogen activated protein kinase, putative,map kinase, putative | 0.00520976 | 1 | 1 |
Loa Loa (eye worm) | CMGC/MAPK/ERK1 protein kinase | 0.00520976 | 1 | 1 |
Echinococcus granulosus | calcium activated potassium channel | 0.00137246 | 0.0121348 | 0.0121348 |
Onchocerca volvulus | Transient receptor potential cation channel trpm homolog | 0.00132533 | 0 | 0.5 |
Schistosoma mansoni | transient receptor potential channel | 0.00132533 | 0.000000207854 | 0.000000207854 |
Trichomonas vaginalis | CMGC family protein kinase | 0.00520976 | 1 | 1 |
Trypanosoma brucei | mitogen activated protein kinase 4, putative | 0.00520976 | 1 | 1 |
Onchocerca volvulus | Transient receptor potential cation channel trpm homolog | 0.00132533 | 0 | 0.5 |
Leishmania major | mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 | 0.00520976 | 1 | 1 |
Echinococcus granulosus | mitogen activated protein kinase 3 | 0.00520976 | 1 | 1 |
Echinococcus multilocularis | transient receptor potential cation channel | 0.00132533 | 0.000000207854 | 0.000000207854 |
Trichomonas vaginalis | CMGC family protein kinase | 0.00520976 | 1 | 1 |
Echinococcus granulosus | transient receptor potential cation channel | 0.00132533 | 0.000000207854 | 0.000000207854 |
Brugia malayi | MAP kinase sur-1 | 0.00520976 | 1 | 1 |
Trypanosoma cruzi | mitogen activated protein kinase 4, putative | 0.00520976 | 1 | 1 |
Echinococcus multilocularis | transient receptor potential cation channel | 0.00132533 | 0.000000207854 | 0.000000207854 |
Trypanosoma cruzi | mitogen activated protein kinase 2, putative | 0.00520976 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.00132533 | 0.000000207854 | 0.000000207854 |
Trichomonas vaginalis | CMGC family protein kinase | 0.00520976 | 1 | 1 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.00520976 | 1 | 1 |
Echinococcus granulosus | transient receptor potential cation channel | 0.00132533 | 0.000000207854 | 0.000000207854 |
Giardia lamblia | Kinase, CMGC MAPK | 0.00520976 | 1 | 0.5 |
Echinococcus multilocularis | mitogen activated protein kinase 3 | 0.00520976 | 1 | 1 |
Echinococcus multilocularis | mitogen activated protein kinase | 0.00520976 | 1 | 1 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.00520976 | 1 | 1 |
Toxoplasma gondii | CMGC kinase, MAPK family (ERK) MAPK-1 | 0.00520976 | 1 | 1 |
Echinococcus multilocularis | transient receptor potential cation channel | 0.00132533 | 0.000000207854 | 0.000000207854 |
Loa Loa (eye worm) | hypothetical protein | 0.00132533 | 0.000000207854 | 0.000000207854 |
Echinococcus granulosus | mitogen activated protein kinase | 0.00520976 | 1 | 1 |
Echinococcus multilocularis | calcium activated potassium channel | 0.00137246 | 0.0121348 | 0.0121348 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 3.79 uM | Antimalarial activity against chloroquine-sensitive Plasmodium falciparum D6 in erythrocytes after 72 hrs by LDH activity | ChEMBL. | 19231182 |
IC50 (functional) | = 6.01 uM | Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2 in erythrocytes after 72 hrs by LDH activity | ChEMBL. | 19231182 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 | 19231182 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.