Detailed information for compound 992684

Basic information

Technical information
  • TDR Targets ID: 992684
  • Name: (2Z)-2-[(3,4-dihydroxyphenyl)methylidene]-6-[ (2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxym ethyl)oxan-2-yl]oxy-1-benzofuran-3-one
  • MW: 432.378 | Formula: C21H20O10
  • H donors: 6 H acceptors: 7 LogP: 0.73 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 2
  • SMILES: OC[C@H]1O[C@@H](Oc2ccc3c(c2)O/C(=C\c2ccc(c(c2)O)O)/C3=O)[C@@H]([C@H]([C@@H]1O)O)O
  • InChi: 1S/C21H20O10/c22-8-16-18(26)19(27)20(28)21(31-16)29-10-2-3-11-14(7-10)30-15(17(11)25)6-9-1-4-12(23)13(24)5-9/h1-7,16,18-24,26-28H,8H2/b15-6-/t16-,18-,19+,20-,21-/m1/s1
  • InChiKey: MEHCTOVFPFJFEW-LTEMJKMTSA-N  

Network

Hover on a compound node to display the structore

Synonyms

  • (2Z)-2-[(3,4-dihydroxyphenyl)methylene]-6-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydropyran-2-yl]oxy-benzofuran-3-one
  • (2Z)-2-[(3,4-dihydroxyphenyl)methylene]-6-[[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)-2-tetrahydropyranyl]oxy]-3-benzofuranone
  • (2Z)-2-(3,4-dihydroxybenzylidene)-6-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-methylol-tetrahydropyran-2-yl]oxy-benzofuran-3-one

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Trypanosoma brucei trypanothione reductase 0.0044 0.0252 1
Brugia malayi Pre-SET motif family protein 0.0035 0.0188 0.1047
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0021 0.0084 0.0441
Wolbachia endosymbiont of Brugia malayi UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.1326 1 1
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0111 0.0761 0.013
Plasmodium falciparum thioredoxin reductase 0.0044 0.0252 1
Schistosoma mansoni hypothetical protein 0.0016 0.0041 0.0093
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0084 0.0451
Loa Loa (eye worm) hypothetical protein 0.0021 0.0084 0.0441
Schistosoma mansoni hypothetical protein 0.0034 0.0181 0.0471
Plasmodium vivax glutathione reductase, putative 0.0044 0.0252 1
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0021 0.0084 0.0451
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0021 0.0084 0.0208
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0021 0.0084 0.0441
Loa Loa (eye worm) hypothetical protein 0.0021 0.0084 0.0441
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0013 0.002 0.0035
Echinococcus multilocularis peroxidasin 0.0026 0.0118 0.03
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0084 0.0451
Mycobacterium ulcerans 3-phosphoshikimate 1-carboxyvinyltransferase 0.0374 0.2762 0.2736
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0021 0.0084 0.0451
Giardia lamblia NADH oxidase lateral transfer candidate 0.0015 0.0036 1
Chlamydia trachomatis phosphoshikimate 1-carboxyl vinyltransferase 0.0374 0.2762 0.2736
Brugia malayi Animal haem peroxidase family protein 0.0026 0.0118 0.0646
Trypanosoma cruzi PAB1-binding protein , putative 0.0029 0.0142 0.4894
Brugia malayi Animal haem peroxidase family protein 0.0026 0.0118 0.0646
Echinococcus multilocularis thioredoxin glutathione reductase 0.0044 0.0257 0.0674
Onchocerca volvulus 0.0146 0.1034 0.4956
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0035 0.0188 0.0489
Plasmodium vivax ataxin-2 like protein, putative 0.0029 0.0142 0.4894
Loa Loa (eye worm) hypothetical protein 0.0026 0.0118 0.0637
Brugia malayi steroid hormone receptor 0.0021 0.0084 0.0451
Loa Loa (eye worm) hypothetical protein 0.0026 0.0118 0.0637
Loa Loa (eye worm) glutathione reductase 0.0044 0.0252 0.1408
Brugia malayi nuclear receptor NHR-88 0.0021 0.0084 0.0451
Loa Loa (eye worm) hypothetical protein 0.0026 0.0118 0.0637
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0099 0.0677 0.09
Toxoplasma gondii histone lysine methyltransferase SET1 0.0064 0.0407 0.1472
Mycobacterium tuberculosis Probable oxidoreductase 0.0111 0.0761 0.1018
Trichomonas vaginalis glutathione reductase, putative 0.0015 0.0036 0.0178
Loa Loa (eye worm) hypothetical protein 0.0021 0.0084 0.0441
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0084 0.0208
Trypanosoma cruzi PAB1-binding protein , putative 0.0029 0.0142 0.4894
Schistosoma mansoni hypothetical protein 0.0016 0.0041 0.0093
Onchocerca volvulus Peroxidase homolog 0.0026 0.0118 0.0178
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0084 0.0451
Loa Loa (eye worm) hypothetical protein 0.0146 0.1034 0.5895
Schistosoma mansoni thyroid hormone receptor 0.0021 0.0084 0.0208
Leishmania major trypanothione reductase 0.0044 0.0252 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0084 0.0451
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0084 0.0208
Mycobacterium tuberculosis Probable dehydrogenase 0.0099 0.0677 0.09
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0021 0.0084 0.0208
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0007 0.001
Schistosoma mansoni RAR-like nuclear receptor 0.0021 0.0084 0.0208
Onchocerca volvulus 0.0274 0.2001 1
Trichomonas vaginalis mercuric reductase, putative 0.0015 0.0036 0.0178
Loa Loa (eye worm) hypothetical protein 0.0026 0.0118 0.0637
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0007 0.001
Loa Loa (eye worm) hypothetical protein 0.0026 0.0118 0.0637
Loa Loa (eye worm) hypothetical protein 0.005 0.0302 0.1694
Toxoplasma gondii LsmAD domain-containing protein 0.0029 0.0142 0.0511
Schistosoma mansoni cpg binding protein 0.0035 0.0187 0.0486
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0041 0.0093
Onchocerca volvulus Peroxidase homolog 0.0026 0.0118 0.0178
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0015 0.0036 0.0175
Echinococcus granulosus ecdysone induced protein 78C 0.0021 0.0084 0.0208
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.001 0 0.5
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0015 0.0036 0.0078
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0035 0.0188 0.0489
Loa Loa (eye worm) hypothetical protein 0.0021 0.0084 0.0441
Brugia malayi photoreceptor-specific nuclear receptor 0.0021 0.0084 0.0451
Loa Loa (eye worm) animal heme peroxidase 0.0026 0.0118 0.0637
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0021 0.0084 0.0208
Loa Loa (eye worm) steroid hormone receptor 0.0021 0.0084 0.0441
Onchocerca volvulus 0.0026 0.0118 0.0178
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0241 0.1749 1
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0021 0.0084 0.0208
Echinococcus granulosus GPCR family 2 0.0016 0.0041 0.0093
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0035 0.0188 0.0679
Brugia malayi nuclear receptor RXR 0.0011 0.0007 0.001
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.001 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0026 0.0118 0.0637
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0084 0.0451
Trichomonas vaginalis MYB, putative 0.001 0 0.0002
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0021 0.0084 0.0208
Echinococcus multilocularis FTZ F1 alpha 0.0021 0.0084 0.0208
Echinococcus multilocularis ecdysone induced protein 78C 0.0021 0.0084 0.0208
Brugia malayi Calcitonin receptor-like protein seb-1 0.005 0.0302 0.1702
Loa Loa (eye worm) CXXC zinc finger family protein 0.0033 0.0172 0.095
Schistosoma mansoni hypothetical protein 0.0013 0.002 0.0035
Trypanosoma brucei PAB1-binding protein , putative 0.0029 0.0142 0.4894
Echinococcus multilocularis thyroid hormone receptor alpha 0.0021 0.0084 0.0208
Loa Loa (eye worm) animal heme peroxidase 0.0026 0.0118 0.0637
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0084 0.0451
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0021 0.0084 0.0208
Trypanosoma cruzi trypanothione reductase, putative 0.0044 0.0252 1
Schistosoma mansoni hypothetical protein 0.0499 0.3709 1
Brugia malayi hypothetical protein 0.0146 0.1034 0.5899
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0111 0.0761 0.1018
Onchocerca volvulus Peroxidasin homolog 0.0026 0.0118 0.0178
Plasmodium falciparum ataxin-2 like protein, putative 0.0029 0.0142 0.4894
Brugia malayi Steroid receptor seven-up type 2 0.0021 0.0084 0.0451
Echinococcus multilocularis cpg binding protein 0.0035 0.0187 0.0486
Onchocerca volvulus 0.0026 0.0118 0.0178
Brugia malayi nuclear hormone receptor 0.0021 0.0084 0.0451
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0021 0.0084 0.0441
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0033 0.0173 0.0448
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0041 0.0198
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.001 0 0.5
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.001 0 0.0002
Loa Loa (eye worm) histone methyltransferase 0.0012 0.0008 0.0008
Loa Loa (eye worm) hypothetical protein 0.0021 0.0084 0.0441
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0021 0.0084 0.0451
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0021 0.0084 0.0208
Brugia malayi hypothetical protein 0.0026 0.0118 0.0646
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0041 0.0208
Toxoplasma gondii thioredoxin reductase 0.0044 0.0252 0.0912
Schistosoma mansoni hypothetical protein 0.0016 0.0041 0.0093
Loa Loa (eye worm) animal heme peroxidase 0.0026 0.0118 0.0637
Toxoplasma gondii shikimate dehydrogenase substrate binding domain-containing protein 0.0374 0.2762 1
Schistosoma mansoni hypothetical protein 0.0499 0.3709 1
Mycobacterium ulcerans UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.1326 1 1
Schistosoma mansoni peroxidasin 0.0026 0.0118 0.03
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0099 0.0677 0.09
Schistosoma mansoni nuclear hormone receptor 0.0021 0.0084 0.0208
Loa Loa (eye worm) hypothetical protein 0.0029 0.0142 0.0773
Loa Loa (eye worm) hypothetical protein 0.0021 0.0084 0.0441
Brugia malayi Animal haem peroxidase family protein 0.0026 0.0118 0.0646
Treponema pallidum UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.1326 1 1
Onchocerca volvulus 0.0033 0.0172 0.0462
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0044 0.0252 0.0304
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0021 0.0084 0.0451
Loa Loa (eye worm) pigment dispersing factor receptor c 0.005 0.0302 0.1694
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0015 0.0036 0.0078
Onchocerca volvulus Peroxidasin homolog 0.0026 0.0118 0.0178
Brugia malayi ecdysteroid receptor 0.0021 0.0084 0.0451
Onchocerca volvulus 0.0026 0.0118 0.0178
Trichomonas vaginalis set domain proteins, putative 0.0274 0.2001 1
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0012 0.0008 0.0004
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0041 0.0093
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.005 0.0302 0.1702
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0084 0.0208
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0041 0.0093
Loa Loa (eye worm) hypothetical protein 0.0026 0.0118 0.0637
Schistosoma mansoni peroxidasin 0.0026 0.0118 0.03
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0021 0.0084 0.0441
Echinococcus granulosus cpg binding protein 0.0035 0.0187 0.0486
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0041 0.0208
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0084 0.0208
Brugia malayi Thioredoxin reductase 0.0044 0.0252 0.1416
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0021 0.0084 0.0208
Plasmodium falciparum ataxin-2 like protein, putative 0.0029 0.0142 0.4894
Brugia malayi Blistered cuticle protein 3 0.0026 0.0118 0.0646
Loa Loa (eye worm) hypothetical protein 0.0026 0.0118 0.0637
Loa Loa (eye worm) hypothetical protein 0.0026 0.0118 0.0637
Plasmodium vivax thioredoxin reductase, putative 0.0044 0.0252 1
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0021 0.0084 0.0208
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0021 0.0084 0.0208
Echinococcus multilocularis GPCR, family 2 0.0016 0.0041 0.0093
Plasmodium vivax SET domain protein, putative 0.0035 0.0188 0.7027
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0035 0.0188 0.0489
Schistosoma mansoni cpg binding protein 0.0033 0.0172 0.0447
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0021 0.0084 0.0208
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0021 0.0084 0.0441
Loa Loa (eye worm) animal heme peroxidase 0.0026 0.0118 0.0637
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0021 0.0084 0.0441
Brugia malayi Peroxidasin 0.0026 0.0118 0.0646
Brugia malayi hypothetical protein 0.0029 0.0142 0.0782
Brugia malayi Nuclear hormone receptor-like 1 0.0021 0.0084 0.0451
Brugia malayi glutathione reductase 0.0044 0.0252 0.1416
Loa Loa (eye worm) hypothetical protein 0.0016 0.0041 0.0198
Schistosoma mansoni thyroid hormone receptor 0.0021 0.0084 0.0208
Loa Loa (eye worm) hypothetical protein 0.0026 0.0118 0.0637
Echinococcus granulosus histone lysine methyltransferase setb 0.0035 0.0188 0.0489
Brugia malayi Pre-SET motif family protein 0.0241 0.1749 1
Mycobacterium leprae PROBABLE UDP-N-ACETYLGLUCOSAMINE 1-CARBOXYVINYLTRANSFERASE MURA 0.0952 0.7159 1
Onchocerca volvulus 0.0035 0.0188 0.0542
Mycobacterium tuberculosis Probable reductase 0.0099 0.0677 0.09
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0111 0.0761 0.1018
Echinococcus granulosus thioredoxin glutathione reductase 0.0044 0.0257 0.0674
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0021 0.0084 0.0208
Echinococcus granulosus peroxidasin 0.0026 0.0118 0.03
Echinococcus granulosus FTZ F1 alpha 0.0021 0.0084 0.0208
Schistosoma mansoni steroid hormone receptor ad4bp 0.0021 0.0084 0.0208
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0181 0.1011
Loa Loa (eye worm) hypothetical protein 0.0035 0.0188 0.1038
Brugia malayi Animal haem peroxidase family protein 0.0026 0.0118 0.0646
Mycobacterium leprae probable 3-phosphoshikimate 1-carboxyvinyl transferase AroA (5-ENOLPYRUVYLSHIKIMATE-3-PHOSPHATE SYNTHASE) (EPSP SYNTHASE) (EPSPS 0.0374 0.2762 0.3218
Onchocerca volvulus Dual oxidase homolog 0.0026 0.0118 0.0178
Loa Loa (eye worm) hypothetical protein 0.0026 0.0118 0.0637
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0021 0.0084 0.0451
Echinococcus multilocularis geminin 0.0499 0.3709 1
Mycobacterium tuberculosis Probable UDP-N-acetylglucosamine 1-carboxyvinyltransferase MurA 0.0952 0.7159 1
Echinococcus granulosus geminin 0.0499 0.3709 1
Brugia malayi hypothetical protein 0.0011 0.0007 0.001
Brugia malayi hypothetical protein 0.0011 0.0007 0.001
Brugia malayi Animal haem peroxidase family protein 0.0026 0.0118 0.0646
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0041 0.0093
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0021 0.0084 0.0208
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0035 0.0188 0.0489
Loa Loa (eye worm) hypothetical protein 0.0026 0.0118 0.0637
Schistosoma mansoni retinoic acid receptor RXR 0.0021 0.0084 0.0208
Leishmania major hypothetical protein, conserved 0.0029 0.0142 0.4894
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0099 0.0677 0.09
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.001 0 0.5
Schistosoma mansoni hypothetical protein 0.0016 0.0041 0.0093
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0021 0.0084 0.0451
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0021 0.0084 0.0208
Schistosoma mansoni coup transcription factor 0.0021 0.0084 0.0208
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0035 0.0188 0.0489
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0099 0.0677 0.09
Loa Loa (eye worm) hypothetical protein 0.0034 0.0181 0.1001
Loa Loa (eye worm) hypothetical protein 0.0026 0.0118 0.0637
Loa Loa (eye worm) thioredoxin reductase 0.0044 0.0252 0.1408
Loa Loa (eye worm) hypothetical protein 0.0021 0.0084 0.0441
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0015 0.0036 0.0078
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0021 0.0084 0.0451
Brugia malayi hypothetical protein 0.0019 0.0063 0.0334
Loa Loa (eye worm) hypothetical protein 0.0026 0.0118 0.0637
Brugia malayi F/Y-rich N-terminus family protein 0.0011 0.0007 0.0012
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0021 0.0084 0.0441
Loa Loa (eye worm) blistered cuticle protein 3 0.0026 0.0118 0.0637
Brugia malayi CXXC zinc finger family protein 0.0033 0.0172 0.0959
Toxoplasma gondii NADPH-glutathione reductase 0.0015 0.0036 0.0128
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.001 0 0.0002
Plasmodium falciparum glutathione reductase 0.0044 0.0252 1
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0021 0.0084 0.0208
Loa Loa (eye worm) hypothetical protein 0.0021 0.0084 0.0441
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.001 0 0.5
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0013 0.002 0.0035
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0035 0.0188 0.0489
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0012 0.0008 0.0004
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0015 0.0036 0.0128
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0071 0.0464 0.1235
Onchocerca volvulus Chorion peroxidase homolog 0.0026 0.0118 0.0178
Schistosoma mansoni cpg binding protein 0.0035 0.0187 0.0486

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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