Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | isocitrate dehydrogenase | 0.0031 | 0.1354 | 0.5 |
Brugia malayi | TAR-binding protein | 0.0059 | 0.3938 | 0.3938 |
Trypanosoma cruzi | isocitrate dehydrogenase, putative | 0.0031 | 0.1354 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0059 | 0.3938 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0059 | 0.3938 | 1 |
Trypanosoma brucei | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0031 | 0.1354 | 0.5 |
Brugia malayi | RNA binding protein | 0.0059 | 0.3938 | 0.3938 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0059 | 0.3938 | 0.3938 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0031 | 0.1354 | 0.5 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0031 | 0.1354 | 0.2044 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0123 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0059 | 0.3938 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0059 | 0.3938 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.0059 | 0.3938 | 0.3938 |
Schistosoma mansoni | tar DNA-binding protein | 0.0059 | 0.3938 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0059 | 0.3938 | 0.3938 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.069 | 0.069 |
Echinococcus multilocularis | isocitrate dehydrogenase | 0.0031 | 0.1354 | 0.2044 |
Loa Loa (eye worm) | aryl Hydrocarbon receptor Associated protein family member | 0.0024 | 0.069 | 0.069 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0059 | 0.3938 | 0.3938 |
Schistosoma mansoni | NADP-specific isocitrate dehydrogenase | 0.0031 | 0.1354 | 0.3438 |
Echinococcus multilocularis | tar DNA binding protein | 0.0059 | 0.3938 | 1 |
Plasmodium vivax | isocitrate dehydrogenase [NADP], mitochondrial, putative | 0.0031 | 0.1354 | 0.5 |
Mycobacterium tuberculosis | Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) | 0.0031 | 0.1354 | 0.5 |
Brugia malayi | isocitrate dehydrogenase | 0.0031 | 0.1354 | 0.1354 |
Brugia malayi | Isocitrate dehydrogenase | 0.0031 | 0.1354 | 0.1354 |
Leishmania major | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0031 | 0.1354 | 0.5 |
Brugia malayi | hypothetical protein | 0.0024 | 0.069 | 0.069 |
Onchocerca volvulus | 0.0024 | 0.069 | 1 | |
Echinococcus granulosus | NADP dependent isocitrate dehydrogenase | 0.0031 | 0.1354 | 0.2044 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0123 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0059 | 0.3938 | 1 |
Trypanosoma brucei | isocitrate dehydrogenase, putative | 0.0031 | 0.1354 | 0.5 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0031 | 0.1354 | 0.2044 |
Plasmodium falciparum | isocitrate dehydrogenase [NADP], mitochondrial | 0.0031 | 0.1354 | 0.5 |
Loa Loa (eye worm) | isocitrate dehydrogenase | 0.0031 | 0.1354 | 0.1354 |
Echinococcus multilocularis | isocitrate dehydrogenase 2 (NADP+) | 0.0031 | 0.1354 | 0.2044 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0031 | 0.1354 | 0.2044 |
Trypanosoma cruzi | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0031 | 0.1354 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
AUC (ADMET) | = 3.36 ug.hr/ml | AUC (0 to t) in Swiss albino mouse at 10 mg/kg, po | ChEMBL. | 18768315 |
Cmax (ADMET) | = 1.05 ug ml-1 | Cmax in Swiss albino mouse at 10 mg/kg, po | ChEMBL. | 18768315 |
Kel (ADMET) | = 0.79 /hr | Drug elimination in Swiss albino mouse at 10 mg/kg, po | ChEMBL. | 18768315 |
T1/2 (ADMET) | = 0.87 hr | Half life in Swiss albino mouse at 10 mg/kg, po | ChEMBL. | 18768315 |
Tmax (ADMET) | = 0.5 hr | Tmax in Swiss albino mouse at 10 mg/kg, po | ChEMBL. | 18768315 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.