Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | nitric oxide synthase 2, inducible | Starlite/ChEMBL | References |
Homo sapiens | nitric oxide synthase 3 (endothelial cell) | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0065 | 1 | 0.5 |
Brugia malayi | FAD binding domain containing protein | 0.0065 | 1 | 1 |
Trypanosoma cruzi | p450 reductase, putative | 0.0065 | 1 | 0.5 |
Giardia lamblia | Hypothetical protein | 0.0057 | 0.7709 | 0.5 |
Trypanosoma brucei | NADPH-dependent diflavin oxidoreductase 1 | 0.0065 | 1 | 0.5 |
Schistosoma mansoni | 5-methyl tetrahydrofolate-homocysteine methyltransferase reductase | 0.004 | 0.2291 | 0.2291 |
Echinococcus multilocularis | NADPH dependent diflavin oxidoreductase 1 | 0.0065 | 1 | 1 |
Schistosoma mansoni | cytochrome P450 reductase | 0.0065 | 1 | 1 |
Plasmodium vivax | NADPH-cytochrome p450 reductase, putative | 0.0065 | 1 | 1 |
Giardia lamblia | Nitric oxide synthase, inducible | 0.0057 | 0.7709 | 0.5 |
Echinococcus granulosus | NADPH dependent diflavin oxidoreductase 1 | 0.0065 | 1 | 1 |
Trypanosoma cruzi | NADPH-dependent FMN/FAD containing oxidoreductase, putative | 0.0065 | 1 | 0.5 |
Leishmania major | p450 reductase, putative | 0.0065 | 1 | 1 |
Leishmania major | NADPH-cytochrome p450 reductase-like protein | 0.0065 | 1 | 1 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0065 | 1 | 0.5 |
Chlamydia trachomatis | sulfite reductase | 0.004 | 0.2291 | 0.5 |
Trypanosoma brucei | NADPH-cytochrome p450 reductase, putative | 0.0065 | 1 | 0.5 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.0065 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0065 | 1 | 1 |
Trichomonas vaginalis | sulfite reductase, putative | 0.0065 | 1 | 1 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0065 | 1 | 0.5 |
Echinococcus granulosus | NADPH cytochrome P450 reductase | 0.0065 | 1 | 1 |
Mycobacterium ulcerans | formate dehydrogenase H FdhF | 0.0065 | 1 | 0.5 |
Plasmodium falciparum | nitric oxide synthase, putative | 0.0065 | 1 | 0.5 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0065 | 1 | 0.5 |
Echinococcus multilocularis | NADPH cytochrome P450 reductase | 0.0065 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (binding) | = 0.062 uM | Inhibition of human iNOS expressed in HEK293 cells assessed as NO production by transient transfection assay | ChEMBL. | 19374401 |
EC50 (binding) | = 15 uM | Inhibition of human eNOS expressed in HEK293 cells assessed as NO production by transient transfection assay | ChEMBL. | 19374401 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.