Detailed information for compound 993266

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 300.399 | Formula: C17H24N4O
  • H donors: 1 H acceptors: 2 LogP: 4.16 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: N#CN1CCCCN1C(=O)C(C(C)C)Nc1cccc(c1)C
  • InChi: 1S/C17H24N4O/c1-13(2)16(19-15-8-6-7-14(3)11-15)17(22)21-10-5-4-9-20(21)12-18/h6-8,11,13,16,19H,4-5,9-10H2,1-3H3
  • InChiKey: OCNRYIRRTPOMKW-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens cathepsin K Starlite/ChEMBL References
Homo sapiens cathepsin B Starlite/ChEMBL References
Homo sapiens cathepsin L Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trypanosoma cruzi cysteine peptidase C (CPC), putative Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Plasmodium falciparum cysteine proteinase falcipain 3 Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Plasmodium falciparum cysteine proteinase falcipain 2b Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Toxoplasma gondii cathepsin B Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium berghei berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase C (CPC), putative,CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like, putative Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin b Get druggable targets OG5_127800 All targets in OG5_127800
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-4 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin B-like peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-3 Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania donovani cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum expressed protein Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) ctsf protein Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania donovani cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni SmCB2 peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania infantum cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K01363 cathepsin B [EC3.4.22.1], putative Get druggable targets OG5_127800 All targets in OG5_127800
Echinococcus granulosus cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Neospora caninum Cathepsin B-like protease (Precursor), related Get druggable targets OG5_127800 All targets in OG5_127800
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) fibroinase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi cathepsin B-like cysteine proteinase Get druggable targets OG5_127800 All targets in OG5_127800
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Giardia lamblia Cathepsin B precursor Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Toxoplasma gondii cathepsin CPL Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 2a Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Schistosoma japonicum ko:K01373 cathepsin F [EC3.4.22.41], putative Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Giardia lamblia Cathepsin B precursor Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin b Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania major cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin L-like proteinase precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin L cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Giardia lamblia Cathepsin B precursor Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium yoelii berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase C (CPC), putative Get druggable targets OG5_127800 All targets in OG5_127800
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Neospora caninum Cathepsin L, related Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like Get druggable targets OG5_127800 All targets in OG5_127800
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania braziliensis cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin B-like peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Onchocerca volvulus Cathepsin F homolog Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin B-like peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium parvum cryptopain - cysteine proteinase secreted, possible transmembrane domain near N-terminus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin b Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma cruzi cruzipain precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) cathepsin B Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin b Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin B-like peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
Loa Loa (eye worm) cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium hominis cryptopain precursor Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Plasmodium falciparum cysteine proteinase falcipain 1 cathepsin K 329 aa 349 aa 33.2 %
Plasmodium falciparum cysteine proteinase falcipain 1 cathepsin L 333 aa 359 aa 30.1 %
Plasmodium falciparum dipeptidyl aminopeptidase 1 cathepsin B 339 aa 368 aa 26.9 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0078 0.1327 0.1327
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0121 0.0495
Schistosoma mansoni hypothetical protein 0.0307 0.638 1
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0053 0.0772 0.2217
Echinococcus granulosus peptidase Clp S14 family 0.0051 0.0735 0.1048
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0121 0.0495
Brugia malayi cathepsin B-like cysteine proteinase 0.0176 0.3484 0.3484
Schistosoma mansoni importin beta-1 0.0029 0.0241 0.0378
Loa Loa (eye worm) hypothetical protein 0.0041 0.0513 0.0513
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0059 0.0906 0.8671
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0059 0.0919 0.8807
Trypanosoma cruzi cysteine peptidase, putative 0.0059 0.0906 0.26
Giardia lamblia Kinase, CMGC MAPK 0.0053 0.0772 0.7279
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0033 0.0329 0.0516
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.0772 0.7279
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0059 0.0906 0.8671
Brugia malayi Cathepsin L-like precursor 0.0059 0.0906 0.0906
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0033 0.0329 0.0516
Echinococcus multilocularis peptidase Clp (S14 family) 0.0051 0.0735 0.1048
Brugia malayi Probable ClpP-like protease 0.0078 0.1327 0.1327
Entamoeba histolytica cysteine proteinase 1, putative 0.0033 0.0329 0.307
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0033 0.0329 0.2662
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0074 0.0212
Echinococcus granulosus cathepsin b 0.0176 0.3484 0.5408
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.0772 0.7279
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0053 0.0772 0.2217
Trichomonas vaginalis maltase-glucoamylase, putative 0.0036 0.0402 0.3424
Echinococcus multilocularis cysteine protease 0.0059 0.0906 0.1319
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0059 0.0919 1
Brugia malayi cathepsin L-like precursor 0.0041 0.0513 0.0513
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0059 0.0906 0.8671
Echinococcus multilocularis cathepsin L cysteine protease 0.0059 0.0906 0.1319
Giardia lamblia Cathepsin B precursor 0.0065 0.1033 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0402 0.3424
Brugia malayi Cathepsin L-like precursor 0.0059 0.0906 0.0906
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0176 0.3484 0.5461
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0078 0.1327 1
Brugia malayi Glycosyl hydrolases family 31 protein 0.0163 0.3192 0.3192
Leishmania major cathepsin L-like protease 0.0059 0.0906 0.8671
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0059 0.0906 0.8671
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0078 0.1327 1
Brugia malayi Cathepsin L-like cysteine proteinase 0.0041 0.0513 0.0513
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0402 0.1155
Echinococcus granulosus mitogen activated protein kinase 3 0.0053 0.0772 0.1108
Echinococcus multilocularis neutral alpha glucosidase AB 0.0036 0.0402 0.0521
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0036 0.0402 0.3424
Entamoeba histolytica cysteine protease, putative 0.0033 0.0329 0.307
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0027 0.02 0.1504
Toxoplasma gondii hypothetical protein 0.0027 0.02 0.1004
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0402 0.3424
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0078 0.1327 1
Brugia malayi Cathepsin L-like precursor 0.0059 0.0906 0.0906
Trypanosoma cruzi cysteine peptidase, putative 0.0059 0.0906 0.26
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0059 0.0906 0.8671
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0059 0.0906 0.8671
Loa Loa (eye worm) hypothetical protein 0.0041 0.0513 0.0513
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0074 0.0212
Plasmodium falciparum cysteine proteinase falcipain 1 0.0033 0.0329 0.2037
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0053 0.0772 0.0772
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0033 0.0329 0.2662
Plasmodium falciparum cysteine proteinase falcipain 3 0.0059 0.0906 0.6637
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0059 0.0906 0.8671
Echinococcus multilocularis cathepsin L 0.0033 0.0329 0.0405
Schistosoma mansoni alpha-glucosidase 0.014 0.2692 0.422
Leishmania major alpha glucosidase II subunit, putative 0.0036 0.0402 0.3424
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0059 0.0919 0.134
Trypanosoma brucei glucosidase, putative 0.0036 0.0402 0.3424
Brugia malayi RNA, U transporter 1 0.0082 0.1411 0.1411
Echinococcus granulosus lysosomal alpha glucosidase 0.0163 0.3192 0.4944
Leishmania major cathepsin L-like protease 0.0059 0.0906 0.8671
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0059 0.0906 0.8671
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0059 0.0906 0.0906
Brugia malayi Cathepsin L-like precursor 0.0041 0.0513 0.0513
Onchocerca volvulus Cathepsin F homolog 0.0059 0.0906 0.3367
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0053 0.0772 0.2217
Loa Loa (eye worm) hypothetical protein 0.0029 0.0241 0.0241
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0065 0.1033 0.162
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0078 0.1327 1
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0059 0.0906 0.6637
Schistosoma mansoni serine/threonine protein kinase 0.0053 0.0772 0.121
Onchocerca volvulus 0.0059 0.0906 0.3367
Echinococcus granulosus cathepsin L cysteine protease 0.0033 0.0329 0.0405
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0059 0.0919 0.134
Plasmodium vivax vivapain-2 0.0059 0.0906 0.6824
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0059 0.0906 0.8671
Entamoeba histolytica cysteine proteinase, putative 0.0033 0.0329 0.307
Onchocerca volvulus 0.0059 0.0906 0.3367
Echinococcus granulosus cathepsin b 0.0176 0.3484 0.5408
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0033 0.0329 0.2662
Entamoeba histolytica cysteine protease, putative 0.0033 0.0329 0.307
Loa Loa (eye worm) MH2 domain-containing protein 0.0119 0.2234 0.2234
Plasmodium vivax vivapain-2 0.0059 0.0906 0.6824
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0176 0.3484 1
Entamoeba histolytica cysteine proteinase, putative 0.0041 0.0513 0.5275
Onchocerca volvulus 0.0059 0.0906 0.3367
Trypanosoma cruzi cysteine peptidase, putative 0.0059 0.0906 0.26
Loa Loa (eye worm) transcription factor SMAD2 0.0119 0.2234 0.2234
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0059 0.0906 0.8671
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0078 0.1327 0.5
Echinococcus granulosus cathepsin l1 0.0059 0.0906 0.1319
Entamoeba histolytica cysteine protease, putative 0.0033 0.0329 0.307
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0065 0.1033 1
Echinococcus multilocularis importin subunit beta 1 0.0029 0.0241 0.0266
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0059 0.0906 0.8671
Trypanosoma cruzi cysteine proteinase, putative 0.0033 0.0329 0.0945
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0402 0.3424
Schistosoma mansoni ran 0.0021 0.0074 0.0116
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0059 0.0906 0.8671
Schistosoma mansoni peptidase Clp (S14 family) 0.0078 0.1327 0.2081
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0307 0.638 0.638
Leishmania major cathepsin L-like protease 0.0059 0.0906 0.8671
Leishmania major cathepsin L-like protease 0.0059 0.0906 0.8671
Entamoeba histolytica cysteine proteinase, putative 0.0059 0.0906 1
Entamoeba histolytica cysteine proteinase, putative 0.0059 0.0906 1
Echinococcus multilocularis snurportin 1 0.0307 0.638 1
Leishmania major cysteine peptidase A (CPA) 0.0059 0.0906 0.8671
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0059 0.0906 0.8671
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0241 0.1746
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0059 0.0906 0.8671
Loa Loa (eye worm) ctsf protein 0.0059 0.0906 0.0906
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0065 0.1033 1
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0033 0.0329 0.0945
Loa Loa (eye worm) hypothetical protein 0.0041 0.0513 0.0513
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0059 0.0906 0.1319
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0078 0.1327 1
Echinococcus multilocularis cathepsin L cysteine protease 0.0059 0.0906 0.1319
Trypanosoma cruzi cruzipain precursor, putative 0.0059 0.0906 0.26
Onchocerca volvulus Cathepsin L homolog 0.0059 0.0906 0.3367
Trypanosoma cruzi cysteine peptidase, putative 0.0033 0.0329 0.0945
Echinococcus multilocularis cysteine protease 0.0059 0.0906 0.1319
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0041 0.0513 0.1471
Entamoeba histolytica cysteine protease, putative 0.0033 0.0329 0.307
Schistosoma mansoni cathepsin F (C01 family) 0.0041 0.0513 0.0804
Brugia malayi Cathepsin L-like precursor 0.0059 0.0906 0.0906
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0059 0.0906 0.6637
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0059 0.0906 0.8671
Echinococcus granulosus cathepsin L 0.0033 0.0329 0.0405
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0059 0.0906 0.8671
Schistosoma mansoni ran 0.0021 0.0074 0.0116
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0059 0.0906 0.8671
Echinococcus granulosus snurportin 1 0.0307 0.638 1
Schistosoma mansoni alpha-glucosidase 0.014 0.2692 0.422
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0033 0.0329 0.0516
Entamoeba histolytica cysteine protease, putative 0.0033 0.0329 0.307
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0036 0.0402 0.3424
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0065 0.1033 0.2966
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0176 0.3484 0.5461
Onchocerca volvulus 0.0059 0.0906 0.3367
Giardia lamblia Cathepsin B precursor 0.0065 0.1033 1
Echinococcus granulosus cathepsin L cysteine proteinase 0.0059 0.0906 0.1319
Echinococcus multilocularis mitogen activated protein kinase 3 0.0053 0.0772 0.1108
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0176 0.3484 0.5461
Brugia malayi Papain family cysteine protease containing protein 0.0033 0.0329 0.0329
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0059 0.0919 0.144
Brugia malayi Papain family cysteine protease containing protein 0.0059 0.0906 0.0906
Entamoeba histolytica cysteine proteinase, putative 0.0033 0.0329 0.307
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0176 0.3484 0.5461
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0059 0.0906 0.8671
Leishmania major cathepsin L-like protease 0.0059 0.0906 0.8671
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0059 0.0906 0.0906
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0059 0.0906 0.8671
Onchocerca volvulus 0.0059 0.0906 0.3367
Onchocerca volvulus 0.0059 0.0906 0.3367
Entamoeba histolytica cysteine protease, putative 0.0033 0.0329 0.307
Onchocerca volvulus Cathepsin L homolog 0.0059 0.0906 0.3367
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0041 0.0513 0.4574
Plasmodium falciparum importin beta, putative 0.0029 0.0241 0.1336
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0059 0.0906 0.8671
Entamoeba histolytica cysteine protease, putative 0.0033 0.0329 0.307
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0059 0.0906 0.8671
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0163 0.3192 0.3192
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0033 0.0329 0.2662
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0059 0.0906 0.8671
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0078 0.1327 0.1988
Leishmania major cathepsin L-like protease 0.0059 0.0906 0.8671
Brugia malayi Papain family cysteine protease containing protein 0.0033 0.0329 0.0329
Echinococcus granulosus cathepsin l1 0.0041 0.0513 0.0696
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0059 0.0906 0.8671
Trichomonas vaginalis sucrase-isomaltase, putative 0.0036 0.0402 0.3424
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0041 0.0513 0.4574
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0053 0.0772 0.5571
Leishmania major importin beta-1 subunit, putative 0.0023 0.0121 0.0495
Echinococcus multilocularis cathepsin b 0.0176 0.3484 0.5408
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0059 0.0906 0.8671
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0053 0.0772 0.2217
Loa Loa (eye worm) fibroinase 0.0059 0.0906 0.0906
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0121 0.0495
Echinococcus multilocularis lysosomal alpha glucosidase 0.0163 0.3192 0.4944
Loa Loa (eye worm) hypothetical protein 0.0059 0.0906 0.0906
Entamoeba histolytica cysteine proteinase, putative 0.0033 0.0329 0.307
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.0074 0.0556
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.0772 0.7279
Echinococcus granulosus neutral alpha glucosidase AB 0.0036 0.0402 0.0521
Onchocerca volvulus 0.0094 0.168 1
Schistosoma mansoni cathepsin F (C01 family) 0.0059 0.0906 0.142
Entamoeba histolytica cysteine protease, putative 0.0033 0.0329 0.307
Leishmania major cathepsin L-like protease 0.0059 0.0906 0.8671
Toxoplasma gondii cathepsin CPL 0.0059 0.0906 0.6637
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0059 0.0906 0.8671
Echinococcus granulosus importin subunit beta 1 0.0029 0.0241 0.0266
Echinococcus granulosus mitogen activated protein kinase 0.0053 0.0772 0.1108
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0053 0.0772 0.7279
Entamoeba histolytica cysteine proteinase 2 0.0033 0.0329 0.307
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0078 0.1327 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0059 0.0906 0.8671
Entamoeba histolytica cysteine protease, putative 0.0033 0.0329 0.307
Brugia malayi Cathepsin L-like precursor 0.0041 0.0513 0.0513
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0078 0.1327 1
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0074 0.0074
Trypanosoma cruzi cysteine peptidase, putative 0.0059 0.0906 0.26
Echinococcus multilocularis mitogen activated protein kinase 0.0053 0.0772 0.1108
Loa Loa (eye worm) cysteine protease 0.0059 0.0906 0.0906
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0059 0.0906 0.8671
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0059 0.0906 0.8671
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0402 0.3424
Trypanosoma brucei cysteine peptidase C (CPC) 0.0065 0.1033 1
Entamoeba histolytica cysteine protease, putative 0.0033 0.0329 0.307
Entamoeba histolytica cysteine protease, putative 0.0033 0.0329 0.307
Giardia lamblia Cathepsin B precursor 0.0065 0.1033 1
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0059 0.0919 0.0919
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0055 0.0831 0.0831
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0059 0.0906 0.8671
Plasmodium vivax unspecified product 0.0033 0.0329 0.248
Loa Loa (eye worm) hypothetical protein 0.0176 0.3484 0.3484
Entamoeba histolytica hypothetical protein 0.0023 0.0121 0.0571
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0036 0.0402 0.262
Toxoplasma gondii cathepsin B 0.0065 0.1033 0.7654
Echinococcus multilocularis lysosomal alpha glucosidase 0.0163 0.3192 0.4944
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0036 0.0402 0.3948
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0402 0.3424
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0121 0.0348
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0027 0.02 0.1004
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0053 0.0772 0.7279
Brugia malayi Glycosyl hydrolases family 31 protein 0.0036 0.0402 0.0402
Trypanosoma cruzi cysteine proteinase, putative 0.0033 0.0329 0.0945
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0078 0.1327 0.5
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0471 1 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0059 0.0906 0.8671
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0059 0.0906 0.8671
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0059 0.0906 0.8671
Echinococcus granulosus cysteine protease 0.0033 0.0329 0.0405
Trypanosoma cruzi cysteine protease, putative 0.0033 0.0329 0.0945
Entamoeba histolytica cysteine protease, putative 0.0033 0.0329 0.307
Plasmodium vivax vivapain-3 0.0033 0.0329 0.248
Echinococcus granulosus cathepsin l cysteine peptidase 0.0059 0.0906 0.1319
Plasmodium vivax vivapain-1 0.0033 0.0329 0.248
Onchocerca volvulus 0.0059 0.0906 0.3367
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0059 0.0906 0.8671
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0078 0.1327 0.1988
Brugia malayi MAP kinase sur-1 0.0053 0.0772 0.0772
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0078 0.1327 0.5
Schistosoma mansoni alpha glucosidase 0.0036 0.0402 0.0631
Brugia malayi Cathepsin L-like precursor 0.0059 0.0906 0.0906
Toxoplasma gondii HEAT repeat-containing protein 0.0029 0.0241 0.1336
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0051 0.0735 0.4744
Echinococcus multilocularis cathepsin b 0.0176 0.3484 0.5408
Plasmodium vivax importin-beta 2, putative 0.0029 0.0241 0.1818
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0059 0.0906 0.8671
Entamoeba histolytica cysteine protease, putative 0.0033 0.0329 0.307
Brugia malayi Cathepsin L-like precursor 0.0059 0.0906 0.0906
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0074 0.0074
Entamoeba histolytica cysteine protease, putative 0.0059 0.0906 1
Brugia malayi Importin beta-1 subunit 0.0029 0.0241 0.0241
Brugia malayi MH2 domain containing protein 0.0119 0.2234 0.2234
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0059 0.0906 0.1319
Entamoeba histolytica cysteine proteinase, putative 0.0033 0.0329 0.307
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0036 0.0402 0.3948
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0059 0.0906 0.8671
Trypanosoma brucei protein kinase, putative 0.0053 0.0772 0.7279
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0036 0.0402 0.0402
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.0772 0.7279
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0059 0.0906 0.8671
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0078 0.1327 1
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0402 0.1155
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0053 0.0772 0.7279
Leishmania major cathepsin L-like protease 0.0059 0.0906 0.8671
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0241 0.1746
Loa Loa (eye worm) cathepsin B 0.0065 0.1033 0.1033
Schistosoma mansoni cathepsin F (C01 family) 0.0059 0.0906 0.142

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 6 nM Inhibition of human recombinant cathepsin K ChEMBL. 18571402
IC50 (binding) = 32 nM Inhibition of human recombinant cathepsin B ChEMBL. 18571402
IC50 (binding) = 355 nM Inhibition of human recombinant cathepsin L ChEMBL. 18571402

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.