Detailed information for compound 993267

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 344.408 | Formula: C18H24N4O3
  • H donors: 1 H acceptors: 3 LogP: 3.33 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: N#CN1CCCCN1C(=O)C(C(C)C)NC(=O)OCc1ccccc1
  • InChi: 1S/C18H24N4O3/c1-14(2)16(17(23)22-11-7-6-10-21(22)13-19)20-18(24)25-12-15-8-4-3-5-9-15/h3-5,8-9,14,16H,6-7,10-12H2,1-2H3,(H,20,24)
  • InChiKey: OCAFABUKPVDIBK-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens cathepsin L Starlite/ChEMBL References
Homo sapiens cathepsin B Starlite/ChEMBL References
Homo sapiens cathepsin K Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni cathepsin B-like peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
Cryptosporidium hominis cryptopain precursor Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin b Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma cruzi cruzipain precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium parvum cryptopain - cysteine proteinase secreted, possible transmembrane domain near N-terminus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin b Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) cathepsin B Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin F homolog Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin B-like peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania braziliensis cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin B-like peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma cruzi cysteine peptidase C (CPC), putative Get druggable targets OG5_127800 All targets in OG5_127800
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin L cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Giardia lamblia Cathepsin B precursor Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium yoelii berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative Get druggable targets OG5_126607 All targets in OG5_126607
Neospora caninum Cathepsin L, related Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Giardia lamblia Cathepsin B precursor Get druggable targets OG5_127800 All targets in OG5_127800
Schistosoma japonicum Cathepsin L-like proteinase precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin b Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 2a Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K01373 cathepsin F [EC3.4.22.41], putative Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Entamoeba histolytica cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Giardia lamblia Cathepsin B precursor Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi cathepsin B-like cysteine proteinase Get druggable targets OG5_127800 All targets in OG5_127800
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Toxoplasma gondii cathepsin CPL Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K01363 cathepsin B [EC3.4.22.1], putative Get druggable targets OG5_127800 All targets in OG5_127800
Neospora caninum Cathepsin B-like protease (Precursor), related Get druggable targets OG5_127800 All targets in OG5_127800
Loa Loa (eye worm) ctsf protein Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania donovani cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni SmCB2 peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
Loa Loa (eye worm) fibroinase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum expressed protein Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania donovani cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-3 Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-4 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin B-like peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Brugia malayi Papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin b Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma brucei gambiense cysteine peptidase C (CPC), putative,CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like, putative Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Toxoplasma gondii cathepsin B Get druggable targets OG5_127800 All targets in OG5_127800
Plasmodium berghei berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 2b Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like Get druggable targets OG5_127800 All targets in OG5_127800
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Plasmodium falciparum cysteine proteinase falcipain 3 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase C (CPC), putative Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Plasmodium falciparum dipeptidyl aminopeptidase 1 cathepsin B 339 aa 368 aa 26.9 %
Plasmodium falciparum cysteine proteinase falcipain 1 cathepsin L 333 aa 359 aa 30.1 %
Plasmodium falciparum cysteine proteinase falcipain 1 cathepsin K 329 aa 349 aa 33.2 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus dna polymerase eta 0.0021 0.0181 0.0218
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0059 0.0821 0.4232
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0015 0.0074 0.0115
Trypanosoma cruzi trypanothione reductase, putative 0.0042 0.0527 0.1684
Echinococcus granulosus histone lysine methyltransferase setb 0.0033 0.0378 0.059
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0176 0.2807 0.276
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0033 0.0377 0.0314
Entamoeba histolytica cysteine proteinase, putative 0.0033 0.0377 0.1704
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0102 0.1553 0.1491
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0032 0.0369 0.3415
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0962 0.0903
Entamoeba histolytica cysteine proteinase, putative 0.0033 0.0377 0.1704
Loa Loa (eye worm) hypothetical protein 0.0018 0.0123 0.005
Echinococcus granulosus geminin 0.0186 0.2985 0.5505
Entamoeba histolytica phosphofructokinase, putative 0.012 0.1851 1
Schistosoma mansoni serine/threonine protein kinase 0.0058 0.0799 0.0739
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0369 0.0306
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0059 0.0821 0.4232
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.012 0.1851 1
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0067 0.0954 0.4981
Giardia lamblia Cathepsin B precursor 0.0015 0.0074 0.0102
Leishmania major importin beta-1 subunit, putative 0.0025 0.0242 0.099
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0059 0.0821 0.4232
Plasmodium vivax mitochondrial import inner membrane translocase subunit TIM10, putative 0.0052 0.0712 0.8561
Echinococcus granulosus thioredoxin glutathione reductase 0.0042 0.0536 0.0888
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0059 0.0821 0.1425
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0181 0.0648
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0033 0.0378 0.3517
Schistosoma mansoni aldehyde dehydrogenase 0.0067 0.0954 0.0895
Brugia malayi Papain family cysteine protease containing protein 0.0033 0.0377 0.0377
Plasmodium vivax vivapain-2 0.0059 0.0821 1
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0105 0.1612 0.8663
Trypanosoma cruzi cysteine proteinase, putative 0.0033 0.0377 0.1136
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0041 0.0518 0.0456
Trypanosoma cruzi DNA polymerase eta, putative 0.0021 0.0181 0.0422
Brugia malayi cathepsin L precursor 0.0015 0.0074 0.0074
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0023 0.0203 0.1823
Mycobacterium tuberculosis Probable reductase 0.0095 0.1432 0.7656
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0369 0.0306
Giardia lamblia Cysteine protease 0.0015 0.0074 0.0102
Schistosoma mansoni hypothetical protein 0.0186 0.2985 0.294
Loa Loa (eye worm) hypothetical protein 0.0021 0.0181 0.0108
Brugia malayi Papain family cysteine protease containing protein 0.0015 0.0074 0.0074
Echinococcus granulosus expressed protein 0.0052 0.0712 0.122
Trichomonas vaginalis ap endonuclease, putative 0.0021 0.0181 0.0117
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0074 0.0009
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0033 0.0377 0.0314
Schistosoma mansoni ap endonuclease 0.0021 0.0181 0.0117
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0015 0.0074 0.0009
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0058 0.0799 0.411
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0021 0.0181 0.1363
Entamoeba histolytica cysteine protease, putative 0.0033 0.0377 0.1704
Toxoplasma gondii cathepsin CPC2 0.0015 0.0074 0.0098
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0015 0.0074 0.0115
Brugia malayi RNA recognition motif domain containing protein 0.0067 0.0962 0.0962
Schistosoma mansoni hypothetical protein 0.0036 0.0435 0.0372
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0181 0.0648
Plasmodium vivax importin-beta 2, putative 0.0031 0.034 0.3639
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0067 0.0954 0.1676
Brugia malayi cathepsin L-like precursor 0.0041 0.0518 0.0518
Entamoeba histolytica cysteine protease, putative 0.0033 0.0377 0.1704
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0962 0.0903
Trichomonas vaginalis ran, putative 0.0023 0.0203 0.0139
Plasmodium falciparum mitochondrial import inner membrane translocase subunit TIM10, putative 0.0052 0.0712 0.8561
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0021 0.0181 0.0648
Echinococcus multilocularis cathepsin b 0.0176 0.2807 0.5168
Toxoplasma gondii aldehyde dehydrogenase 0.0067 0.0954 1
Leishmania major cathepsin L-like protease 0.0059 0.0821 0.4232
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0041 0.0518 0.0456
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0095 0.1432 0.7656
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0058 0.0799 0.411
Trypanosoma cruzi cysteine peptidase, putative 0.0018 0.0123 0.0211
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0021 0.0181 0.0652
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0059 0.0821 0.0761
Entamoeba histolytica cysteine proteinase, putative 0.0059 0.0821 0.4204
Loa Loa (eye worm) 6-phosphofructokinase 0.012 0.1851 0.179
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0021 0.0181 0.154
Trypanosoma brucei DNA polymerase kappa, putative 0.0015 0.0069 0.0021
Brugia malayi Thioredoxin reductase 0.0042 0.0527 0.0527
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0032 0.0369 0.3556
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0102 0.1553 0.1498
Echinococcus multilocularis mitogen activated protein kinase 0.0058 0.0799 0.1383
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0962 0.0903
Trichomonas vaginalis ap endonuclease, putative 0.0021 0.0181 0.0117
Trypanosoma brucei unspecified product 0.0021 0.0181 0.0648
Mycobacterium ulcerans DNA polymerase IV 0.0021 0.0181 0.0116
Entamoeba histolytica phosphofructokinase, putative 0.012 0.1851 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0015 0.0074 0.0009
Echinococcus multilocularis GPCR, family 2 0.0017 0.0105 0.0075
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0032 0.0369 0.1701
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0021 0.0181 0.0219
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0181 0.0648
Leishmania major cathepsin L-like protease 0.0059 0.0821 0.4232
Schistosoma mansoni hypothetical protein 0.0186 0.2985 0.294
Brugia malayi exodeoxyribonuclease III family protein 0.0021 0.0181 0.0181
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0059 0.0821 0.0761
Leishmania major cathepsin L-like protease 0.0059 0.0821 0.4232
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0017 0.0105 0.0075
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0176 0.2807 0.276
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0015 0.0074 0.0009
Trichomonas vaginalis glutaminase, putative 0.0599 1 1
Plasmodium falciparum cysteine proteinase falcipain 1 0.0033 0.0377 0.4123
Loa Loa (eye worm) hypothetical protein 0.0053 0.0719 0.065
Echinococcus multilocularis 6 phosphofructokinase 0.012 0.1851 0.3366
Brugia malayi Papain family cysteine protease containing protein 0.0015 0.0074 0.0074
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0018 0.0123 0.0123
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0023 0.0203 0.013
Toxoplasma gondii mitochondrial import inner membrane translocase subunit TIM10, putative 0.0052 0.0712 0.7275
Trichomonas vaginalis CMGC family protein kinase 0.0058 0.0799 0.0739
Brugia malayi RNA, U transporter 1 0.0087 0.1299 0.1299
Mycobacterium tuberculosis Probable dehydrogenase 0.0095 0.1432 0.7656
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0059 0.0821 0.0753
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0018 0.0123 0.005
Schistosoma mansoni cathepsin s 0.0018 0.0123 0.0058
Echinococcus granulosus mitogen activated protein kinase 0.0058 0.0799 0.1383
Trypanosoma brucei protein kinase, putative 0.0058 0.0799 0.411
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0017 0.0105 0.0075
Schistosoma mansoni cathepsin F (C01 family) 0.0059 0.0821 0.0761
Plasmodium falciparum serine repeat antigen 1 0.0015 0.0074 0.0115
Brugia malayi 6-phosphofructokinase 0.012 0.1851 0.1851
Loa Loa (eye worm) transcription factor SMAD2 0.0131 0.205 0.1991
Trypanosoma cruzi cruzipain precursor, putative 0.0018 0.0123 0.0211
Loa Loa (eye worm) hypothetical protein 0.0017 0.0105 0.0031
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0033 0.0377 0.0314
Leishmania major GTP-binding protein, putative 0.0023 0.0203 0.0772
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0015 0.0074 0.0009
Onchocerca volvulus Cathepsin L homolog 0.0059 0.0821 0.1791
Toxoplasma gondii TIM10 family protein, putative 0.0052 0.0712 0.7275
Plasmodium vivax serine-repeat antigen (SERA) 0.0015 0.0074 0.0115
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0102 0.1553 0.2805
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0015 0.0074 0.0115
Loa Loa (eye worm) TAR-binding protein 0.0067 0.0962 0.0895
Schistosoma mansoni cathepsin F (C01 family) 0.0041 0.0518 0.0456
Echinococcus granulosus cathepsin b 0.0176 0.2807 0.5168
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0033 0.0377 0.1745
Brugia malayi Papain family cysteine protease containing protein 0.0033 0.0377 0.0377
Leishmania major cathepsin L-like protease 0.0059 0.0821 0.4232
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0059 0.0821 0.4232
Trypanosoma brucei importin beta-1 subunit, putative 0.0031 0.034 0.154
Onchocerca volvulus Cathepsin F homolog 0.0059 0.0821 0.1791
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0015 0.0074 0.0115
Loa Loa (eye worm) thioredoxin reductase 0.0042 0.0527 0.0456
Trypanosoma cruzi cysteine peptidase, putative 0.0033 0.0377 0.1136
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.012 0.1851 1
Brugia malayi Cathepsin L-like precursor 0.0041 0.0518 0.0518
Brugia malayi Cathepsin L-like precursor 0.0059 0.0821 0.0821
Giardia lamblia Cathepsin L precursor 0.0015 0.0074 0.0102
Brugia malayi MAP kinase sur-1 0.0058 0.0799 0.0799
Trypanosoma cruzi cysteine peptidase, putative 0.0059 0.0821 0.2756
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0015 0.0074 0.0115
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0059 0.0821 0.0761
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0021 0.0181 0.0219
Brugia malayi Latrophilin receptor protein 2 0.0017 0.0105 0.0105
Entamoeba histolytica cysteine protease, putative 0.0033 0.0377 0.1704
Echinococcus granulosus cathepsin L 0.0033 0.0377 0.0587
Schistosoma mansoni glutaminase 0.0599 1 1
Entamoeba histolytica cysteine protease, putative 0.0033 0.0377 0.1704
Trichomonas vaginalis DNA polymerase eta, putative 0.0021 0.0181 0.0116
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0015 0.0074 0.0009
Onchocerca volvulus 0.0059 0.0821 0.1791
Giardia lamblia Cathepsin L-like protease 0.0015 0.0074 0.0102
Echinococcus granulosus mitogen activated protein kinase 3 0.0058 0.0799 0.1383
Giardia lamblia Cysteine protease 0.0015 0.0074 0.0102
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0181 0.0648
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0033 0.0377 0.0314
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0042 0.0527 0.2586
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0059 0.0821 0.0761
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.012 0.1851 1
Trichomonas vaginalis CMGC family protein kinase 0.0058 0.0799 0.0739
Brugia malayi Cathepsin L-like precursor 0.0018 0.0123 0.0123
Onchocerca volvulus 0.026 0.4245 1
Trypanosoma brucei trypanothione reductase 0.0042 0.0527 0.2586
Entamoeba histolytica cysteine protease, putative 0.0033 0.0377 0.1704
Brugia malayi ImpB/MucB/SamB family protein 0.0021 0.0181 0.0181
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0015 0.0074 0.0074
Brugia malayi Cathepsin L-like precursor 0.0059 0.0821 0.0821
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0059 0.0821 0.0761
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0059 0.0821 0.0761
Trypanosoma cruzi cysteine peptidase, putative 0.0059 0.0821 0.2756
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0015 0.0074 0.0009
Giardia lamblia Hypothetical protein 0.0015 0.0074 0.0102
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0242 0.0178
Trichomonas vaginalis phosphofructokinase, putative 0.012 0.1851 0.1797
Loa Loa (eye worm) ctsf protein 0.0059 0.0821 0.0753
Plasmodium vivax unspecified product 0.0015 0.0074 0.0115
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0059 0.0821 0.4232
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0327 0.537 0.5336
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0181 0.0422
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0021 0.0181 0.0116
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0015 0.0074 0.0115
Mycobacterium ulcerans 6-phosphofructokinase 0.012 0.1851 0.1797
Loa Loa (eye worm) cathepsin B 0.0065 0.0919 0.0852
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0176 0.2807 0.276
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0021 0.0181 0.0652
Trichomonas vaginalis CMGC family protein kinase 0.0058 0.0799 0.0739
Schistosoma mansoni hypothetical protein 0.0017 0.0105 0.004
Loa Loa (eye worm) hypothetical protein 0.0036 0.0435 0.0364
Plasmodium falciparum serine repeat antigen 5 0.0015 0.0074 0.0115
Toxoplasma gondii preprocathepsin c precursor, putative 0.0015 0.0074 0.0098
Plasmodium vivax glutathione reductase, putative 0.0042 0.0527 0.611
Loa Loa (eye worm) 6-phosphofructokinase 0.012 0.1851 0.179
Plasmodium falciparum serine repeat antigen 9 0.0015 0.0074 0.0115
Echinococcus granulosus cysteine protease 0.0033 0.0377 0.0587
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0181 0.0648
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0015 0.0074 0.0009
Entamoeba histolytica cysteine protease, putative 0.0033 0.0377 0.1704
Plasmodium falciparum serine repeat antigen 6 0.0015 0.0074 0.0115
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0021 0.0181 0.0108
Entamoeba histolytica cysteine protease, putative 0.0033 0.0377 0.1704
Brugia malayi Cathepsin L-like precursor 0.0059 0.0821 0.0821
Plasmodium falciparum serine repeat antigen 3 0.0015 0.0074 0.0115
Leishmania major cathepsin L-like protease 0.0059 0.0821 0.4232
Giardia lamblia DINP protein human, muc B family 0.0021 0.0181 0.1354
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0015 0.0074 0.0115
Brugia malayi cathepsin F-like cysteine proteinase 0.0015 0.0074 0.0074
Giardia lamblia Cathepsin B precursor 0.0015 0.0074 0.0102
Trypanosoma cruzi major cysteine proteinase, putative 0.0015 0.0074 0.0032
Schistosoma mansoni ran 0.0023 0.0203 0.0139
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0021 0.0181 0.0606
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0015 0.0074 0.0009
Plasmodium falciparum importin beta, putative 0.0031 0.034 0.3639
Echinococcus multilocularis cathepsin L 0.0015 0.0074 0.0016
Brugia malayi RNA binding protein 0.0067 0.0962 0.0962
Echinococcus granulosus GTP binding nuclear protein Ran 0.0023 0.0203 0.026
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0015 0.0074 0.0009
Giardia lamblia Cathepsin B precursor 0.0015 0.0074 0.0102
Trypanosoma brucei unspecified product 0.0015 0.0069 0.0021
Echinococcus multilocularis importin subunit beta 1 0.0031 0.034 0.0518
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0181 0.0648
Brugia malayi Pre-SET motif family protein 0.0033 0.0378 0.0378
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0242 0.0178
Echinococcus granulosus cathepsin b 0.0176 0.2807 0.5168
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0032 0.0369 0.4018
Giardia lamblia Cysteine protease 0.0015 0.0074 0.0102
Leishmania major ATP-dependent phosphofructokinase 0.012 0.1851 1
Schistosoma mansoni ap endonuclease 0.0021 0.0181 0.0117
Brugia malayi TAR-binding protein 0.0067 0.0962 0.0962
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0067 0.0962 0.0895
Echinococcus multilocularis cathepsin L cysteine protease 0.0059 0.0821 0.1425
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0033 0.0378 0.0315
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0015 0.0074 0.0009
Loa Loa (eye worm) glutathione reductase 0.0042 0.0527 0.0456
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0023 0.0203 0.0502
Plasmodium vivax vivapain-1 0.0033 0.0377 0.4123
Brugia malayi Papain family cysteine protease containing protein 0.0059 0.0821 0.0821
Echinococcus granulosus GPCR family 2 0.0017 0.0105 0.0075
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0015 0.0074 0.0009
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0023 0.0203 0.026
Onchocerca volvulus 0.0059 0.0821 0.1791
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0032 0.0369 1
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0017 0.0105 0.0075
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0021 0.0181 0.0116
Echinococcus multilocularis geminin 0.0186 0.2985 0.5505
Schistosoma mansoni cathepsin B (C01 family) 0.0015 0.0074 0.0009
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0059 0.0821 0.4232
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0176 0.2807 0.276
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0015 0.0074 0.0115
Loa Loa (eye worm) hypothetical protein 0.0031 0.034 0.0268
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0015 0.0074 0.0115
Leishmania major cathepsin L-like protease 0.0059 0.0821 0.4232
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0181 0.0648
Treponema pallidum exodeoxyribonuclease (exoA) 0.0021 0.0181 0.0652
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0041 0.0518 0.1652
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0015 0.0074 0.0009
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0059 0.0821 0.0761
Loa Loa (eye worm) glutaminase 0.0599 1 1
Loa Loa (eye worm) phosphofructokinase 0.012 0.1851 0.179
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0021 0.0181 0.0648
Entamoeba histolytica cysteine protease, putative 0.0033 0.0377 0.1704
Plasmodium vivax 6-phosphofructokinase, putative 0.0032 0.0369 0.4018
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0067 0.0954 0.1676
Brugia malayi glutaminase DH11.1 0.0599 1 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0067 0.0954 0.0895
Loa Loa (eye worm) hypothetical protein 0.0041 0.0518 0.0447
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0059 0.0821 0.1425
Giardia lamblia Cathepsin L precursor 0.0015 0.0074 0.0102
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.012 0.1851 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0053 0.0719 0.0719
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0021 0.0181 0.0425
Loa Loa (eye worm) latrophilin receptor protein 2 0.0017 0.0105 0.0031
Entamoeba histolytica cysteine protease, putative 0.0033 0.0377 0.1704
Brugia malayi Cathepsin L-like precursor 0.0059 0.0821 0.0821
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0015 0.0074 0.0115
Schistosoma mansoni hypothetical protein 0.0017 0.0105 0.004
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0059 0.0821 0.0761
Plasmodium falciparum cysteine proteinase falcipain 3 0.0059 0.0821 1
Giardia lamblia Cathepsin L precursor 0.0015 0.0074 0.0102
Schistosoma mansoni mitochondrial import inner membrane translocase subunit tim10 0.0052 0.0712 0.0651
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0059 0.0821 0.0761
Toxoplasma gondii exonuclease III APE 0.0021 0.0181 0.1309
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0033 0.0377 0.1136
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0059 0.0821 0.0761
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0015 0.0074 0.0009
Echinococcus multilocularis thioredoxin glutathione reductase 0.0042 0.0536 0.0888
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0059 0.0821 0.0761
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0058 0.0799 0.8252
Mycobacterium ulcerans glutaminase 0.0599 1 1
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0058 0.0799 0.2677
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0015 0.0074 0.0009
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0067 0.0954 0.4981
Leishmania major DNA polymerase kappa, putative 0.0021 0.0181 0.0648
Echinococcus granulosus snurportin 1 0.0327 0.537 1
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0023 0.0203 0.1823
Trypanosoma brucei DNA polymerase kappa, putative 0.0015 0.0069 0.0021
Plasmodium falciparum serine repeat antigen 4 0.0015 0.0074 0.0115
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0015 0.0074 0.0115
Schistosoma mansoni hypothetical protein 0.0327 0.537 0.534
Toxoplasma gondii thioredoxin reductase 0.0042 0.0527 0.5192
Plasmodium vivax vivapain-3 0.0033 0.0377 0.4123
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0102 0.1553 0.2805
Plasmodium vivax vivapain-2 0.0059 0.0821 1
Giardia lamblia Cathepsin B precursor 0.0065 0.0919 1
Echinococcus granulosus cathepsin L cysteine protease 0.0033 0.0377 0.0587
Giardia lamblia Cathepsin B precursor 0.0065 0.0919 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0067 0.0954 0.0895
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0021 0.0181 0.0652
Onchocerca volvulus 0.0033 0.0378 0.0729
Plasmodium falciparum glutathione reductase 0.0042 0.0527 0.611
Entamoeba histolytica deoxycytidyl transferase, putative 0.0021 0.0181 0.0602
Plasmodium vivax 6-phosphofructokinase, putative 0.0032 0.0369 0.4018
Schistosoma mansoni hypothetical protein 0.0017 0.0105 0.004
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0181 0.0648
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0095 0.1432 0.7656
Mycobacterium ulcerans aldehyde dehydrogenase 0.0067 0.0954 0.0895
Brugia malayi ImpB/MucB/SamB family protein 0.0021 0.0181 0.0181
Plasmodium falciparum thioredoxin reductase 0.0042 0.0527 0.611
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0023 0.0203 0.0502
Toxoplasma gondii 6-phosphofructokinase 0.0032 0.0369 0.3415
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0021 0.0181 0.0117
Trypanosoma brucei cysteine peptidase C (CPC) 0.0065 0.0919 0.4783
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.012 0.1851 0.6513
Trypanosoma cruzi importin beta-1 subunit, putative 0.0025 0.0242 0.0644
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0962 0.0903
Trypanosoma cruzi cysteine peptidase, putative 0.0059 0.0821 0.2756
Echinococcus multilocularis snurportin 1 0.0327 0.537 1
Trypanosoma brucei importin beta-1 subunit, putative 0.0031 0.034 0.154
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0017 0.0105 0.0105
Entamoeba histolytica cysteine protease, putative 0.0059 0.0821 0.4204
Leishmania major cathepsin L-like protease 0.0059 0.0821 0.4232
Schistosoma mansoni cathepsin C 0.0015 0.0074 0.0009
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0021 0.0181 0.0218
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0015 0.0074 0.0009
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0181 0.0422
Trypanosoma cruzi cysteine peptidase, putative 0.0059 0.0821 0.2756
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0059 0.0821 0.0761
Echinococcus multilocularis cathepsin b 0.0176 0.2807 0.5168
Giardia lamblia Cysteine protease 0.0015 0.0074 0.0102
Plasmodium falciparum serine repeat antigen 8 0.0015 0.0074 0.0115
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0065 0.0919 0.4783
Trichomonas vaginalis CMGC family protein kinase 0.0058 0.0799 0.0739
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0015 0.0074 0.0009
Echinococcus multilocularis cysteine protease 0.0059 0.0821 0.1425
Entamoeba histolytica cysteine protease, putative 0.0033 0.0377 0.1704
Plasmodium vivax SET domain protein, putative 0.0033 0.0378 0.4138
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0023 0.0203 0.0772
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0032 0.0369 1
Onchocerca volvulus 0.0059 0.0821 0.1791
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0059 0.0821 0.0761
Brugia malayi Importin beta-1 subunit 0.0031 0.034 0.034
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0102 0.1553 0.1498
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0369 0.0306
Leishmania major trypanothione reductase 0.0042 0.0527 0.2586
Brugia malayi phosphofructokinase 0.012 0.1851 0.1851
Brugia malayi fibroinase precursor 0.0015 0.0074 0.0074
Entamoeba histolytica cysteine proteinase 1, putative 0.0033 0.0377 0.1704
Echinococcus multilocularis dna polymerase eta 0.0021 0.0181 0.0218
Schistosoma mansoni cathepsin S (C01 family) 0.0015 0.0074 0.0009
Echinococcus granulosus cathepsin L 0.0015 0.0074 0.0016
Giardia lamblia Cathepsin L precursor 0.0015 0.0074 0.0102
Trichomonas vaginalis phosphofructokinase, putative 0.012 0.1851 0.1797
Loa Loa (eye worm) hypothetical protein 0.0059 0.0821 0.0753
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0074 0.0009
Trypanosoma cruzi cysteine protease, putative 0.0033 0.0377 0.1136
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0059 0.0821 0.4232
Loa Loa (eye worm) hypothetical protein 0.0033 0.0378 0.0306
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0181 0.0648
Onchocerca volvulus 0.0059 0.0821 0.1791
Loa Loa (eye worm) transport to inner mitochondrial membrane family member 0.0052 0.0712 0.0643
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0021 0.0181 0.0425
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0015 0.0074 0.0009
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0032 0.0369 0.4018
Schistosoma mansoni 6-phosphofructokinase 0.012 0.1851 0.1797
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0058 0.0799 0.411
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0015 0.0074 0.0115
Entamoeba histolytica cysteine protease, putative 0.0033 0.0377 0.1704
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0059 0.0821 0.0761
Entamoeba histolytica cysteine proteinase, putative 0.0033 0.0377 0.1704
Entamoeba histolytica cysteine proteinase 2 0.0033 0.0377 0.1704
Brugia malayi latrophilin 2 splice variant baaae 0.0036 0.0435 0.0435
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0058 0.0799 0.2677
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0369 0.0306
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0058 0.0799 0.2677
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0021 0.0181 1
Plasmodium falciparum serine repeat antigen 7 0.0015 0.0074 0.0115
Brugia malayi glutathione reductase 0.0042 0.0527 0.0527
Mycobacterium tuberculosis Conserved hypothetical protein 0.0021 0.0181 0.0648
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0181 0.0422
Giardia lamblia Cathepsin B precursor 0.0015 0.0074 0.0102
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0102 0.1553 0.2805
Toxoplasma gondii cathepsin CPL 0.0059 0.0821 0.8497
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0015 0.0074 0.0009
Loa Loa (eye worm) RNA binding protein 0.0067 0.0962 0.0895
Brugia malayi Pre-SET motif family protein 0.0229 0.3708 0.3708
Brugia malayi Cathepsin L-like cysteine proteinase 0.0041 0.0518 0.0518
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0059 0.0821 0.0761
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0378 0.0315
Echinococcus multilocularis mitogen activated protein kinase 3 0.0058 0.0799 0.1383
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0059 0.0821 0.0761
Schistosoma mansoni importin beta-1 0.0031 0.034 0.0277
Brugia malayi Cathepsin L-like precursor 0.0041 0.0518 0.0518
Trypanosoma brucei unspecified product 0.0015 0.0069 0.0021
Toxoplasma gondii phosphofructokinase PFKII 0.0032 0.0369 0.3415
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0181 0.0648
Echinococcus multilocularis cathepsin L 0.0033 0.0377 0.0587
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0015 0.0074 0.0102
Onchocerca volvulus Cathepsin L homolog 0.0059 0.0821 0.1791
Brugia malayi Papain family cysteine protease containing protein 0.0015 0.0074 0.0074
Entamoeba histolytica cysteine protease, putative 0.0033 0.0377 0.1704
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0014 0.0065 0.0065
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0017 0.0105 0.0075
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0181 0.0648
Leishmania major cathepsin L-like protease 0.0059 0.0821 0.4232
Schistosoma mansoni hypothetical protein 0.0017 0.0105 0.004
Schistosoma mansoni 6-phosphofructokinase 0.012 0.1851 0.1797
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0059 0.0821 0.0761
Echinococcus granulosus cathepsin l1 0.0059 0.0821 0.1425
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0181 0.0648
Echinococcus granulosus tar DNA binding protein 0.0067 0.0962 0.1691
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0181 0.0422
Echinococcus multilocularis tar DNA binding protein 0.0067 0.0962 0.1691
Loa Loa (eye worm) hypothetical protein 0.0041 0.0518 0.0447
Trichomonas vaginalis set domain proteins, putative 0.026 0.4245 0.4207
Trypanosoma cruzi cruzipain precursor, putative 0.0059 0.0821 0.2756
Brugia malayi MH2 domain containing protein 0.0131 0.205 0.205
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0059 0.0821 1
Giardia lamblia Encystation-specific protease 0.0015 0.0074 0.0102
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0059 0.0821 0.4232
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0102 0.1553 0.1553
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0059 0.0821 0.4232
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0015 0.0074 0.0009
Brugia malayi cathepsin Z-like cysteine proteinase 0.0015 0.0074 0.0074
Loa Loa (eye worm) cysteine protease 0.0059 0.0821 0.0753
Onchocerca volvulus 0.0059 0.0821 0.1791
Plasmodium falciparum serine repeat antigen 2 0.0015 0.0074 0.0115
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0015 0.0074 0.0009
Mycobacterium ulcerans DNA polymerase IV 0.0021 0.0181 0.0116
Loa Loa (eye worm) hypothetical protein 0.0018 0.0123 0.005
Trypanosoma brucei DNA polymerase eta, putative 0.0021 0.0181 0.0648
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0059 0.0821 0.0761
Plasmodium vivax serine-repeat antigen (SERA) 0.0015 0.0074 0.0115
Trichomonas vaginalis phosphofructokinase, putative 0.012 0.1851 0.1797
Echinococcus granulosus cathepsin L cysteine proteinase 0.0059 0.0821 0.1425
Entamoeba histolytica cysteine proteinase, putative 0.0033 0.0377 0.1704
Toxoplasma gondii HEAT repeat-containing protein 0.0031 0.034 0.3092
Leishmania major DNA polymerase eta, putative 0.0021 0.0181 0.0648
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0015 0.0074 0.0009
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0021 0.0181 0.0218
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0059 0.0821 0.0761
Echinococcus multilocularis cathepsin L cysteine protease 0.0059 0.0821 0.1425
Giardia lamblia Cathepsin B precursor 0.0015 0.0074 0.0102
Brugia malayi 6-phosphofructokinase 0.012 0.1851 0.1851
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0378 0.0315
Leishmania major cysteine peptidase A (CPA) 0.0059 0.0821 0.4232
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0059 0.0821 0.0761
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0015 0.0074 0.0115
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0023 0.0203 0.1613
Loa Loa (eye worm) hypothetical protein 0.0018 0.0123 0.005
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0059 0.0821 0.0761
Echinococcus multilocularis cysteine protease 0.0059 0.0821 0.1425
Trypanosoma cruzi major cysteine proteinase, putative 0.0015 0.0074 0.0032
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0059 0.0821 1
Onchocerca volvulus 0.0041 0.0518 0.1065
Brugia malayi cathepsin Z-like cysteine proteinase 0.0015 0.0074 0.0074
Echinococcus granulosus cathepsin l cysteine peptidase 0.0059 0.0821 0.1425
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0053 0.0719 0.065
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0369 0.0306
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0105 0.1612 0.8663
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0059 0.0821 0.0761
Echinococcus multilocularis dna polymerase kappa 0.0021 0.0181 0.0218
Mycobacterium tuberculosis Probable oxidoreductase 0.0105 0.1612 0.8663
Plasmodium vivax unspecified product 0.0033 0.0377 0.4123
Plasmodium vivax unspecified product 0.0018 0.0123 0.0767
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0059 0.0821 0.0761
Echinococcus multilocularis expressed protein 0.0052 0.0712 0.122
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0378 0.0315
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0369 0.0306
Echinococcus granulosus dna polymerase kappa 0.0021 0.0181 0.0218
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0059 0.0821 0.0761
Brugia malayi Mitochondrial import inner membrane translocase subunit TIM10 0.0052 0.0712 0.0712
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0015 0.0074 0.0102
Brugia malayi cathepsin B-like cysteine proteinase 0.0176 0.2807 0.2807
Trypanosoma cruzi cysteine proteinase, putative 0.0033 0.0377 0.1136
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0033 0.0377 0.0314
Toxoplasma gondii cathepsin CPC1 0.0015 0.0074 0.0098
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0023 0.0203 0.1549
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0015 0.0074 0.0009
Giardia lamblia Cathepsin L precursor 0.0015 0.0074 0.0102
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0032 0.0357 0.0551
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0058 0.0799 0.0731
Toxoplasma gondii cathepsin B 0.0065 0.0919 0.9602
Loa Loa (eye worm) hypothetical protein 0.0176 0.2807 0.2753
Brugia malayi cathepsin F-like cysteine proteinase 0.0018 0.0123 0.0123
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0033 0.0377 0.1745
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0058 0.0799 0.2677
Onchocerca volvulus 0.0059 0.0821 0.1791
Trypanosoma brucei DNA polymerase kappa, putative 0.0015 0.0069 0.0021
Echinococcus granulosus 6 phosphofructokinase 0.012 0.1851 0.3366
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0015 0.0074 0.0009
Loa Loa (eye worm) fibroinase 0.0059 0.0821 0.0753
Entamoeba histolytica hypothetical protein 0.0025 0.0242 0.0945
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0059 0.0821 0.4232
Entamoeba histolytica cysteine proteinase, putative 0.0041 0.0518 0.25
Entamoeba histolytica Ran family GTPase 0.0023 0.0203 0.0726
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0181 0.0648
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0033 0.0378 0.059
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0059 0.0821 0.0761
Giardia lamblia Kinase, CMGC MAPK 0.0058 0.0799 0.8594
Entamoeba histolytica cysteine protease, putative 0.0033 0.0377 0.1704
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0095 0.1432 0.7656
Giardia lamblia Cathepsin L precursor 0.0015 0.0074 0.0102
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0105 0.1612 0.4297
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0023 0.0203 0.0203
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0033 0.0378 0.059
Echinococcus granulosus cathepsin l1 0.0041 0.0518 0.0854
Giardia lamblia Cathepsin B precursor 0.0065 0.0919 1
Plasmodium vivax thioredoxin reductase, putative 0.0042 0.0527 0.611
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0021 0.0181 0.0108
Trichomonas vaginalis importin beta-1, putative 0.0025 0.0242 0.0178
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0015 0.0074 0.0009
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0015 0.0074 0.0009
Loa Loa (eye worm) MH2 domain-containing protein 0.0131 0.205 0.1991
Schistosoma mansoni DNA polymerase eta 0.0021 0.0181 0.0116
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0095 0.1432 0.7656
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0059 0.0821 0.0753
Brugia malayi Cathepsin L-like precursor 0.0059 0.0821 0.0821
Entamoeba histolytica cysteine proteinase, putative 0.0059 0.0821 0.4204
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0176 0.2807 1
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0229 0.3708 0.3661
Brugia malayi Calcitonin receptor-like protein seb-1 0.0053 0.0719 0.0719
Schistosoma mansoni terminal deoxycytidyl transferase 0.0021 0.0181 0.0116
Loa Loa (eye worm) hypothetical protein 0.0041 0.0518 0.0447
Entamoeba histolytica phosphofructokinase, putative 0.012 0.1851 1
Schistosoma mansoni aldehyde dehydrogenase 0.0067 0.0954 0.0895
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0102 0.1553 0.2805
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0032 0.0369 0.0306
Brugia malayi Cathepsin L-like precursor 0.0059 0.0821 0.0821
Schistosoma mansoni ran 0.0023 0.0203 0.0139
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0065 0.0919 0.086
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0015 0.0074 0.0102
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.0015 0.0074 0.0102
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0962 0.0903
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0065 0.0919 0.3115
Giardia lamblia Cathepsin L-like protease 0.0015 0.0074 0.0102
Echinococcus granulosus importin subunit beta 1 0.0031 0.034 0.0518
Giardia lamblia Hypothetical protein 0.0015 0.0074 0.0102
Brugia malayi cathepsin L-like cysteine proteinase 0.0015 0.0074 0.0074
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0065 0.0919 0.086
Trichomonas vaginalis phosphofructokinase, putative 0.012 0.1851 0.1797
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0059 0.0821 0.4232
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0102 0.1553 0.1498
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0021 0.0181 0.154
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0032 0.0369 0.166
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0015 0.0074 0.0009
Schistosoma mansoni cathepsin F (C01 family) 0.0059 0.0821 0.0761
Onchocerca volvulus 0.0059 0.0821 0.1791

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 1 nM Inhibition of human recombinant cathepsin K ChEMBL. 18571402
IC50 (binding) = 11 nM Inhibition of human recombinant cathepsin B ChEMBL. 18571402
IC50 (binding) = 145 nM Inhibition of human recombinant cathepsin L ChEMBL. 18571402

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.