Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | cAMP-dependent protein kinase regulatory subunit | 0.0017 | 0.0041 | 0.1404 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0001 | 0.0001 |
Toxoplasma gondii | protein kinase G AGC kinase family member PKG | 0.0017 | 0.0041 | 0.1404 |
Entamoeba histolytica | Ras guanine nucleotide exchange factor, putative | 0.0028 | 0.0114 | 0.5 |
Loa Loa (eye worm) | G protein signaling regulator EGL-10 | 0.004 | 0.0191 | 0.0191 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0475 | 0.3112 | 0.3112 |
Schistosoma mansoni | neuropathy target esterase/swiss cheese-related protein | 0.0017 | 0.0041 | 0.0059 |
Brugia malayi | isocitrate dehydrogenase | 0.0048 | 0.0248 | 0.0247 |
Loa Loa (eye worm) | AGC/PKG protein kinase | 0.0017 | 0.0041 | 0.0041 |
Schistosoma mansoni | camp-dependent protein kinase type II regulatory subunit | 0.0017 | 0.0041 | 0.0059 |
Echinococcus granulosus | Protein son of sevenless | 0.0028 | 0.0114 | 0.0257 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB | 0.002 | 0.0057 | 0.172 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0017 | 0.0041 | 0.0091 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsA | 0.0024 | 0.0089 | 0.3076 |
Echinococcus granulosus | Smad4 | 0.0025 | 0.0095 | 0.0214 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks1 | 0.0018 | 0.0042 | 0.1068 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA | 0.0024 | 0.0089 | 0.4065 |
Loa Loa (eye worm) | cyclic-nucleotide gated cation channel | 0.0017 | 0.0041 | 0.0041 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0114 | 0.0114 |
Brugia malayi | MH1 domain containing protein | 0.0025 | 0.0095 | 0.0094 |
Onchocerca volvulus | 0.0017 | 0.0041 | 0.0076 | |
Brugia malayi | RasGEF domain containing protein | 0.0028 | 0.0114 | 0.0113 |
Mycobacterium ulcerans | transcriptional regulatory protein | 0.0017 | 0.0041 | 0.0598 |
Echinococcus granulosus | rap guanine nucleotide exchange factor 1 | 0.0028 | 0.0114 | 0.0257 |
Echinococcus granulosus | cGMP dependent protein kinase 1 | 0.0017 | 0.0041 | 0.0091 |
Mycobacterium tuberculosis | Polyketide synthase Pks13 | 0.0037 | 0.017 | 0.6602 |
Brugia malayi | cAMP-dependent protein kinase regulatory chain, putative | 0.0017 | 0.0041 | 0.004 |
Entamoeba histolytica | Ras guanine nucleotide exchange factor, putative | 0.0028 | 0.0114 | 0.5 |
Echinococcus granulosus | TGF beta signal transducer SmadC | 0.0025 | 0.0095 | 0.0214 |
Schistosoma mansoni | smad1 5 8 and | 0.0025 | 0.0095 | 0.0139 |
Echinococcus granulosus | regulator of G protein signaling 7 | 0.004 | 0.0191 | 0.0429 |
Schistosoma mansoni | dishevelled | 0.004 | 0.0191 | 0.0279 |
Schistosoma mansoni | camp-dependent rap1 guanine-nucleotide exchange factor | 0.0027 | 0.0105 | 0.0153 |
Schistosoma mansoni | hypothetical protein | 0.0475 | 0.3112 | 0.4568 |
Echinococcus multilocularis | cyclic nucleotide gated cation channel | 0.0017 | 0.0041 | 0.0091 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0048 | 0.0248 | 1 |
Loa Loa (eye worm) | RasGEF domain-containing protein | 0.0028 | 0.0114 | 0.0114 |
Loa Loa (eye worm) | hypothetical protein | 0.1503 | 1 | 1 |
Entamoeba histolytica | Ras guanine nucleotide exchange factor, putative | 0.0028 | 0.0114 | 0.5 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsC | 0.0024 | 0.0089 | 0.3076 |
Onchocerca volvulus | Segment polarity protein dishevelled homolog | 0.004 | 0.0191 | 0.0356 |
Loa Loa (eye worm) | MH1 domain-containing protein | 0.0011 | 0.0001 | 0.0001 |
Schistosoma mansoni | ras GTP exchange factor son of sevenless | 0.0028 | 0.0114 | 0.0167 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0475 | 0.3112 | 0.704 |
Treponema pallidum | cyclic nucleotide binding protein | 0.0017 | 0.0041 | 0.5 |
Loa Loa (eye worm) | cAMP-dependent protein kinase regulatory subunit | 0.0017 | 0.0041 | 0.0041 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0017 | 0.0041 | 0.0091 |
Echinococcus multilocularis | isocitrate dehydrogenase 2 (NADP+) | 0.0048 | 0.0248 | 0.0559 |
Loa Loa (eye worm) | RasGEF domain-containing protein | 0.0028 | 0.0114 | 0.0114 |
Loa Loa (eye worm) | cyclic-nucleotide gated cation channel | 0.0017 | 0.0041 | 0.0041 |
Onchocerca volvulus | 0.0017 | 0.0041 | 0.0076 | |
Echinococcus granulosus | hyperpolarization activated cyclic | 0.0017 | 0.0041 | 0.0091 |
Brugia malayi | Beta-ketoacyl synthase, N-terminal domain containing protein | 0.0024 | 0.0089 | 0.0088 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.0016 | 0.0016 |
Echinococcus multilocularis | rap guanine nucleotide exchange factor 1 | 0.0028 | 0.0114 | 0.0257 |
Onchocerca volvulus | Fatty acid synthase homolog | 0.0044 | 0.022 | 0.0412 |
Mycobacterium tuberculosis | Probable membrane bound polyketide synthase Pks6 | 0.0037 | 0.017 | 0.6602 |
Mycobacterium tuberculosis | Conserved protein | 0.0017 | 0.0041 | 0.1017 |
Schistosoma mansoni | TGF-beta signal transducer Smad2 | 0.0025 | 0.0095 | 0.0139 |
Echinococcus multilocularis | cAMP dependent protein kinase type II regulatory | 0.0017 | 0.0041 | 0.0091 |
Trypanosoma cruzi | hypothetical protein | 0.0028 | 0.0114 | 0.3529 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0475 | 0.3112 | 0.704 |
Echinococcus multilocularis | cGMP dependent protein kinase 1 | 0.0017 | 0.0041 | 0.0091 |
Trypanosoma brucei | isocitrate dehydrogenase, putative | 0.0048 | 0.0248 | 1 |
Schistosoma mansoni | cyclic-nucleotide-gated cation channel | 0.0017 | 0.0041 | 0.0059 |
Loa Loa (eye worm) | MH1 domain-containing protein | 0.0025 | 0.0095 | 0.0095 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0475 | 0.3112 | 0.704 |
Toxoplasma gondii | cyclic nucleotide-binding domain-containing protein | 0.0017 | 0.0041 | 0.1404 |
Schistosoma mansoni | hyperpolarization activated cyclic nucleotide-gated potassium channel | 0.0017 | 0.0041 | 0.0059 |
Trypanosoma cruzi | hypothetical protein | 0.0028 | 0.0114 | 0.3529 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0017 | 0.0041 | 0.1017 |
Echinococcus granulosus | GPCR family 2 | 0.0475 | 0.3112 | 0.704 |
Mycobacterium leprae | Polyketide synthase Pks13 | 0.0037 | 0.017 | 1 |
Mycobacterium leprae | PROBABLE THIOESTERASE TESA | 0.002 | 0.0061 | 0.2064 |
Mycobacterium tuberculosis | Probable conserved transmembrane transport protein | 0.0017 | 0.0041 | 0.1017 |
Plasmodium falciparum | isocitrate dehydrogenase [NADP], mitochondrial | 0.0048 | 0.0248 | 1 |
Trypanosoma brucei | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0048 | 0.0248 | 1 |
Leishmania major | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0048 | 0.0248 | 1 |
Mycobacterium tuberculosis | Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) | 0.0023 | 0.0078 | 0.2608 |
Brugia malayi | DIX domain containing protein | 0.004 | 0.0191 | 0.019 |
Entamoeba histolytica | Ras guanine nucleotide exchange factor, putative | 0.0028 | 0.0114 | 0.5 |
Trichomonas vaginalis | ras GTP exchange factor, son of sevenless, putative | 0.0028 | 0.0114 | 1 |
Brugia malayi | N-terminal motif family protein | 0.0028 | 0.0114 | 0.0113 |
Toxoplasma gondii | cyclic nucleotide-binding domain-containing protein | 0.0017 | 0.0041 | 0.1404 |
Echinococcus multilocularis | potassium:sodium hyperpolarization activated | 0.0017 | 0.0041 | 0.0091 |
Echinococcus multilocularis | patatin phospholipase domain containing protein | 0.0017 | 0.0041 | 0.0091 |
Echinococcus granulosus | tar DNA binding protein | 0.0671 | 0.4421 | 1 |
Mycobacterium ulcerans | polyketide synthase | 0.0024 | 0.0089 | 0.4065 |
Schistosoma mansoni | smad | 0.0025 | 0.0095 | 0.0139 |
Brugia malayi | MH2 domain containing protein | 0.0025 | 0.0095 | 0.0094 |
Brugia malayi | MH1 domain containing protein | 0.0014 | 0.0019 | 0.0018 |
Onchocerca volvulus | 0.0043 | 0.021 | 0.0393 | |
Schistosoma mansoni | serine/threonine protein kinase | 0.0017 | 0.0041 | 0.0059 |
Mycobacterium ulcerans | hypothetical protein | 0.0017 | 0.0041 | 0.0598 |
Schistosoma mansoni | fyve finger-containing phosphoinositide kinase fyv1 | 0.004 | 0.0191 | 0.0279 |
Mycobacterium leprae | Conserved hypothetical protein | 0.0017 | 0.0041 | 0.0598 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0041 | 0.0041 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0017 | 0.0041 | 0.0059 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsB | 0.002 | 0.0057 | 0.172 |
Onchocerca volvulus | 0.0028 | 0.0114 | 0.0213 | |
Entamoeba histolytica | Ras guanine nucleotide exchange factor, putative | 0.0028 | 0.0114 | 0.5 |
Echinococcus granulosus | cyclic nucleotide gated cation channel alpha 3 | 0.0017 | 0.0041 | 0.0091 |
Echinococcus granulosus | cGMP dependent protein kinase | 0.0017 | 0.0041 | 0.0091 |
Mycobacterium ulcerans | polyketide synthase Pks13 | 0.0037 | 0.017 | 1 |
Echinococcus multilocularis | cyclic nucleotide gated cation channel alpha 3 | 0.0017 | 0.0041 | 0.0091 |
Loa Loa (eye worm) | hypothetical protein | 0.1027 | 0.6812 | 0.6812 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.1027 | 0.6812 | 0.6812 |
Mycobacterium tuberculosis | Probable thioesterase TesA | 0.002 | 0.0061 | 0.1888 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0017 | 0.0041 | 0.0059 |
Mycobacterium ulcerans | regulatory protein | 0.0017 | 0.0041 | 0.0598 |
Mycobacterium ulcerans | thioesterase | 0.002 | 0.0061 | 0.2064 |
Echinococcus multilocularis | Smad4 | 0.0025 | 0.0095 | 0.0214 |
Brugia malayi | Hypothetical UPF0028 protein ZK370.4 in chromosome III, putative | 0.0017 | 0.0041 | 0.004 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.0024 | 0.0089 | 0.4065 |
Entamoeba histolytica | Ras guanine nucleotide exchange factor, putative | 0.0028 | 0.0114 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.02 | 0.02 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks7 | 0.0026 | 0.0099 | 0.3519 |
Schistosoma mansoni | guanine-nucleotide-exchange-factor | 0.0028 | 0.0114 | 0.0167 |
Treponema pallidum | catabolite gene activator (Crp) | 0.0017 | 0.0041 | 0.5 |
Toxoplasma gondii | cyclic nucleotide-binding domain-containing protein | 0.0017 | 0.0041 | 0.1404 |
Echinococcus multilocularis | tar DNA binding protein | 0.0671 | 0.4421 | 1 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsA | 0.002 | 0.0057 | 0.172 |
Schistosoma mansoni | cyclic-nucleotide-gated cation channel | 0.0017 | 0.0041 | 0.0059 |
Entamoeba histolytica | Ras guanine nucleotide exchange factor, putative | 0.0028 | 0.0114 | 0.5 |
Entamoeba histolytica | Ras guanine nucleotide exchange factor, putative | 0.0028 | 0.0114 | 0.5 |
Schistosoma mansoni | cyclic-nucleotide-gated cation channel | 0.0017 | 0.0041 | 0.0059 |
Echinococcus multilocularis | rap guanine nucleotide exchange factor 6 | 0.0028 | 0.0114 | 0.0257 |
Trichomonas vaginalis | guanine nucleotide exchange factor, putative | 0.0028 | 0.0114 | 1 |
Echinococcus multilocularis | cyclic nucleotide gated cation channel | 0.0017 | 0.0041 | 0.0091 |
Toxoplasma gondii | type I fatty acid synthase, putative | 0.0026 | 0.0099 | 0.3798 |
Mycobacterium tuberculosis | Probable transcriptional regulatory protein Cmr | 0.0017 | 0.0041 | 0.1017 |
Brugia malayi | oxidoreductase, zinc-binding dehydrogenase family protein | 0.0046 | 0.0236 | 0.0235 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0475 | 0.3112 | 0.704 |
Mycobacterium tuberculosis | Polyketide synthase Pks12 | 0.0026 | 0.0099 | 0.3519 |
Echinococcus granulosus | hyperpolarization activated cyclic | 0.0017 | 0.0041 | 0.0091 |
Brugia malayi | MH1 domain containing protein | 0.0025 | 0.0095 | 0.0094 |
Echinococcus granulosus | NADP dependent isocitrate dehydrogenase | 0.0048 | 0.0248 | 0.0559 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0011 | 0.0001 | 0.0001 |
Trypanosoma cruzi | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0048 | 0.0248 | 1 |
Treponema pallidum | cyclic nucleotide binding protein | 0.0017 | 0.0041 | 0.5 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0374 | 0.243 | 0.243 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0017 | 0.0041 | 0.0059 |
Echinococcus granulosus | cGMP dependent protein kinase 1 | 0.0017 | 0.0041 | 0.0091 |
Mycobacterium tuberculosis | Probable conserved transmembrane protein | 0.0017 | 0.0041 | 0.1017 |
Echinococcus multilocularis | mothers against decapentaplegic 5 | 0.0025 | 0.0095 | 0.0214 |
Onchocerca volvulus | 0.004 | 0.0191 | 0.0356 | |
Mycobacterium leprae | Probable polyketide synthase Pks1 | 0.0026 | 0.0099 | 0.481 |
Entamoeba histolytica | Ras guanine nucleotide exchange factor, putative | 0.0028 | 0.0114 | 0.5 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0048 | 0.0248 | 1 |
Brugia malayi | MH2 domain containing protein | 0.0025 | 0.0095 | 0.0094 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsD | 0.0024 | 0.0089 | 0.3076 |
Echinococcus multilocularis | cAMP dependent protein kinase type I beta | 0.0017 | 0.0041 | 0.0091 |
Echinococcus granulosus | cAMP dependent protein kinase regulatory | 0.0017 | 0.0041 | 0.0091 |
Mycobacterium tuberculosis | Polyketide synthase Pks2 | 0.0024 | 0.0084 | 0.2857 |
Echinococcus granulosus | segment polarity protein dishevelled | 0.004 | 0.0191 | 0.0429 |
Brugia malayi | Domain found in Dishevelled, Egl-10, and Pleckstrin family protein | 0.004 | 0.0191 | 0.019 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD | 0.0024 | 0.0089 | 0.4065 |
Loa Loa (eye worm) | RNA binding protein | 0.0671 | 0.4421 | 0.4421 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0048 | 0.0248 | 0.0559 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0475 | 0.3112 | 0.3112 |
Echinococcus granulosus | smad | 0.0025 | 0.0095 | 0.0214 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsC | 0.0026 | 0.0099 | 0.481 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0017 | 0.0041 | 0.1017 |
Mycobacterium ulcerans | hypothetical protein | 0.0017 | 0.0041 | 0.0598 |
Brugia malayi | RasGEF domain containing protein | 0.0028 | 0.0114 | 0.0113 |
Schistosoma mansoni | smad1 5 8 and | 0.0025 | 0.0095 | 0.0139 |
Onchocerca volvulus | Rap guanine nucleotide exchange factor 1 homolog | 0.0028 | 0.0114 | 0.0213 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0017 | 0.0041 | 0.0059 |
Brugia malayi | N-terminal motif family protein | 0.0028 | 0.0114 | 0.0113 |
Schistosoma mansoni | ras GTP exchange factor son of sevenless | 0.0028 | 0.0114 | 0.0167 |
Echinococcus multilocularis | expressed conserved protein | 0.0017 | 0.0041 | 0.0091 |
Echinococcus multilocularis | hyperpolarization activated cyclic | 0.0017 | 0.0041 | 0.0091 |
Schistosoma mansoni | camp-dependent protein kinase regulatory chain | 0.0017 | 0.0041 | 0.0059 |
Plasmodium vivax | isocitrate dehydrogenase [NADP], mitochondrial, putative | 0.0048 | 0.0248 | 1 |
Brugia malayi | Domain found in Dishevelled, Egl-10, and Pleckstrin family protein | 0.004 | 0.0191 | 0.019 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC | 0.0026 | 0.0099 | 0.481 |
Giardia lamblia | CAMP-dependent protein kinase regulatory chain | 0.0017 | 0.0041 | 0.5 |
Onchocerca volvulus | 0.0023 | 0.0078 | 0.0145 | |
Brugia malayi | MH2 domain containing protein | 0.0374 | 0.243 | 0.2429 |
Schistosoma mansoni | neuropathy target esterase/swiss cheese-related protein | 0.0017 | 0.0041 | 0.0059 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0041 | 0.0041 |
Mycobacterium tuberculosis | Probable glutamine-transport ATP-binding protein ABC transporter GlnQ | 0.0017 | 0.0041 | 0.1017 |
Echinococcus granulosus | patatin phospholipase domain containing protein | 0.0017 | 0.0041 | 0.0091 |
Trypanosoma cruzi | isocitrate dehydrogenase, putative | 0.0048 | 0.0248 | 1 |
Loa Loa (eye worm) | Smad1 | 0.0025 | 0.0095 | 0.0095 |
Brugia malayi | N-terminal motif family protein | 0.0806 | 0.5331 | 0.5331 |
Entamoeba histolytica | Ras guanine nucleotide exchange factor, putative | 0.0028 | 0.0114 | 0.5 |
Mycobacterium leprae | Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas | 0.0026 | 0.0099 | 0.481 |
Toxoplasma gondii | hypothetical protein | 0.004 | 0.0191 | 0.7613 |
Echinococcus granulosus | regulator of G protein signaling 7 | 0.004 | 0.0191 | 0.0429 |
Entamoeba histolytica | Ras guanine nucleotide exchange factor, putative | 0.0028 | 0.0114 | 0.5 |
Echinococcus granulosus | potassium:sodium hyperpolarization activated | 0.0017 | 0.0041 | 0.0091 |
Echinococcus granulosus | cyclic nucleotide gated cation channel | 0.0017 | 0.0041 | 0.0091 |
Echinococcus multilocularis | Protein son of sevenless | 0.0028 | 0.0114 | 0.0257 |
Echinococcus granulosus | ras GTP exchange factor | 0.0028 | 0.0114 | 0.0257 |
Brugia malayi | Cyclic-nucleotide gated cation channel | 0.0017 | 0.0041 | 0.004 |
Brugia malayi | RNA binding protein | 0.0671 | 0.4421 | 0.442 |
Schistosoma mansoni | cyclic-nucleotide-gated cation channel | 0.0017 | 0.0041 | 0.0059 |
Brugia malayi | Smad1 | 0.0025 | 0.0095 | 0.0094 |
Schistosoma mansoni | camp-dependent protein kinase type II-alpha regulatory subunit | 0.0017 | 0.0041 | 0.0059 |
Schistosoma mansoni | tar DNA-binding protein | 0.0671 | 0.4421 | 0.6489 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0017 | 0.0041 | 0.0091 |
Schistosoma mansoni | hyperpolarization activated cyclic nucleotide-gated potassium channel | 0.0017 | 0.0041 | 0.0059 |
Echinococcus multilocularis | regulator of G protein signaling 7 | 0.004 | 0.0191 | 0.0429 |
Brugia malayi | regulator of G-protein signaling egl-10 | 0.004 | 0.0191 | 0.019 |
Schistosoma mansoni | camp-dependent protein kinase type I-beta regulatory subunit | 0.0017 | 0.0041 | 0.0059 |
Echinococcus granulosus | mothers against decapentaplegic 5 | 0.0025 | 0.0095 | 0.0214 |
Echinococcus multilocularis | Pleckstrin G protein, interacting region | 0.004 | 0.0191 | 0.0429 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.0019 | 0.0019 |
Echinococcus granulosus | cyclic nucleotide gated cation channel | 0.0017 | 0.0041 | 0.0091 |
Echinococcus multilocularis | isocitrate dehydrogenase | 0.0048 | 0.0248 | 0.0559 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0114 | 0.0114 |
Echinococcus granulosus | son of sevenless 1 | 0.0028 | 0.0114 | 0.0257 |
Schistosoma mansoni | hypothetical protein | 0.0017 | 0.0041 | 0.0059 |
Echinococcus multilocularis | segment polarity protein dishevelled | 0.004 | 0.0191 | 0.0429 |
Schistosoma mansoni | z-protein (S1r protein) | 0.004 | 0.0191 | 0.0279 |
Entamoeba histolytica | Ras guanine nucleotide exchange factor, putative | 0.0028 | 0.0114 | 0.5 |
Loa Loa (eye worm) | isocitrate dehydrogenase | 0.0048 | 0.0248 | 0.0248 |
Mycobacterium ulcerans | hypothetical protein | 0.0017 | 0.0041 | 0.0598 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.1503 | 1 | 1 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.0024 | 0.0089 | 0.4065 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsD | 0.0024 | 0.0089 | 0.4065 |
Echinococcus multilocularis | TGF beta signal transducer SmadC | 0.0025 | 0.0095 | 0.0214 |
Toxoplasma gondii | cyclic nucleotide-binding domain-containing protein | 0.0017 | 0.0041 | 0.1404 |
Loa Loa (eye worm) | fatty acid synthase | 0.0024 | 0.0086 | 0.0086 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0475 | 0.3112 | 0.3112 |
Trypanosoma cruzi | guanine nucleotide releasing protein, putative | 0.0028 | 0.0114 | 0.3529 |
Loa Loa (eye worm) | nuclear factor I | 0.0014 | 0.0019 | 0.0019 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0041 | 0.0041 |
Entamoeba histolytica | hypothetical protein | 0.0028 | 0.0114 | 0.5 |
Schistosoma mansoni | smad1 5 8 and | 0.0025 | 0.0095 | 0.0139 |
Loa Loa (eye worm) | RasGEF domain-containing protein | 0.0028 | 0.0114 | 0.0114 |
Echinococcus multilocularis | GPCR, family 2 | 0.0475 | 0.3112 | 0.704 |
Brugia malayi | RasGEF domain containing protein | 0.0028 | 0.0114 | 0.0113 |
Toxoplasma gondii | beta-ketoacyl synthase, N-terminal domain-containing protein | 0.0016 | 0.0031 | 0.0978 |
Mycobacterium ulcerans | polyketide synthase | 0.0026 | 0.0099 | 0.481 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0017 | 0.0041 | 0.0059 |
Echinococcus multilocularis | regulator of G protein signaling 7 | 0.004 | 0.0191 | 0.0429 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0191 | 0.0191 |
Schistosoma mansoni | hyperpolarization activated cyclic nucleotide-gated potassium channel | 0.0017 | 0.0041 | 0.0059 |
Mycobacterium tuberculosis | Probable multifunctional mycocerosic acid synthase membrane-associated Mas | 0.0026 | 0.0099 | 0.3519 |
Schistosoma mansoni | similar to Protein C20orf152 homolog | 0.0017 | 0.0041 | 0.0059 |
Treponema pallidum | catabolite gene activator | 0.0017 | 0.0041 | 0.5 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.0024 | 0.0089 | 0.4065 |
Schistosoma mansoni | tar DNA-binding protein | 0.0671 | 0.4421 | 0.6489 |
Echinococcus granulosus | voltage gated potassium channel | 0.0017 | 0.0041 | 0.0091 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0191 | 0.0191 |
Entamoeba histolytica | Ras guanine nucleotide exchange factor, putative | 0.0028 | 0.0114 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0671 | 0.4421 | 0.6489 |
Schistosoma mansoni | ras GTP exchange factor son of sevenless | 0.0028 | 0.0114 | 0.0167 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks5 | 0.0024 | 0.0084 | 0.2857 |
Brugia malayi | Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog | 0.0017 | 0.0041 | 0.004 |
Schistosoma mansoni | dishevelled | 0.004 | 0.0191 | 0.0279 |
Echinococcus multilocularis | son of sevenless 1 | 0.0028 | 0.0114 | 0.0257 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks8 | 0.002 | 0.0059 | 0.1777 |
Loa Loa (eye worm) | AMP-binding enzyme family protein | 0.0023 | 0.0078 | 0.0078 |
Loa Loa (eye worm) | hypothetical protein | 0.0806 | 0.5331 | 0.5331 |
Onchocerca volvulus | Rap guanine nucleotide exchange factor 1 homolog | 0.0806 | 0.5331 | 1 |
Echinococcus granulosus | cAMP dependent protein kinase type II regulatory | 0.0017 | 0.0041 | 0.0091 |
Schistosoma mansoni | ras GTP exchange factor | 0.0028 | 0.0114 | 0.0167 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0025 | 0.0095 | 0.0095 |
Schistosoma mansoni | hypothetical protein | 0.0475 | 0.3112 | 0.4568 |
Schistosoma mansoni | hypothetical protein | 0.0475 | 0.3112 | 0.4568 |
Schistosoma mansoni | dep domain containing protein | 0.004 | 0.0191 | 0.0279 |
Echinococcus multilocularis | cyclic nucleotide gated cation channel | 0.0017 | 0.0041 | 0.0091 |
Mycobacterium ulcerans | multifunctional mycocerosic acid synthase membrane-associated Mas | 0.0026 | 0.0099 | 0.481 |
Echinococcus granulosus | cAMP dependent protein kinase type I beta | 0.0017 | 0.0041 | 0.0091 |
Echinococcus granulosus | rap guanine nucleotide exchange factor 6 | 0.0028 | 0.0114 | 0.0257 |
Echinococcus multilocularis | segment polarity protein dishevelled | 0.004 | 0.0191 | 0.0429 |
Mycobacterium ulcerans | thioesterase TesA | 0.002 | 0.0061 | 0.2064 |
Brugia malayi | Egg laying defective protein 4 | 0.0017 | 0.0041 | 0.004 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0374 | 0.243 | 0.243 |
Brugia malayi | TAR-binding protein | 0.0671 | 0.4421 | 0.442 |
Echinococcus granulosus | cyclic nucleotide gated cation channel | 0.0017 | 0.0041 | 0.0091 |
Schistosoma mansoni | cyclic nucleotide-gated ion channel | 0.0017 | 0.0041 | 0.0059 |
Loa Loa (eye worm) | TAR-binding protein | 0.0671 | 0.4421 | 0.4421 |
Schistosoma mansoni | camp-dependent protein kinase type I-beta regulatory subunit | 0.0017 | 0.0041 | 0.0059 |
Brugia malayi | Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog | 0.0017 | 0.0041 | 0.004 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0671 | 0.4421 | 0.442 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0671 | 0.4421 | 0.4421 |
Echinococcus multilocularis | ras GTP exchange factor | 0.0028 | 0.0114 | 0.0257 |
Echinococcus granulosus | Pleckstrin G protein interacting region | 0.004 | 0.0191 | 0.0429 |
Echinococcus multilocularis | voltage gated potassium channel | 0.0017 | 0.0041 | 0.0091 |
Loa Loa (eye worm) | DIX domain-containing protein | 0.004 | 0.0191 | 0.0191 |
Brugia malayi | hypothetical protein | 0.004 | 0.0191 | 0.019 |
Schistosoma mansoni | hypothetical protein | 0.0475 | 0.3112 | 0.4568 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.1503 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0671 | 0.4421 | 0.6489 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0048 | 0.0248 | 0.0559 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0048 | 0.0248 | 0.0559 |
Trichomonas vaginalis | ras GTP exchange factor, putative | 0.0028 | 0.0114 | 1 |
Schistosoma mansoni | hypothetical protein | 0.1027 | 0.6812 | 1 |
Echinococcus multilocularis | cAMP dependent protein kinase regulatory | 0.0017 | 0.0041 | 0.0091 |
Schistosoma mansoni | tar DNA-binding protein | 0.0671 | 0.4421 | 0.6489 |
Mycobacterium ulcerans | transmembrane transport protein | 0.0017 | 0.0041 | 0.0598 |
Echinococcus multilocularis | cGMP dependent protein kinase 1 | 0.0017 | 0.0041 | 0.0091 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0017 | 0.0041 | 0.0059 |
Schistosoma mansoni | Smad4 | 0.0025 | 0.0095 | 0.0139 |
Echinococcus multilocularis | smad | 0.0025 | 0.0095 | 0.0214 |
Mycobacterium tuberculosis | Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) | 0.0048 | 0.0248 | 1 |
Brugia malayi | hypothetical protein | 0.004 | 0.0191 | 0.019 |
Brugia malayi | MH1 domain containing protein | 0.0014 | 0.0019 | 0.0018 |
Brugia malayi | Cyclic-nucleotide gated cation channel, C. elegans tax-4 ortholog | 0.0017 | 0.0041 | 0.004 |
Mycobacterium ulcerans | hypothetical protein | 0.0017 | 0.0041 | 0.0598 |
Chlamydia trachomatis | cAMP-dependent protein kinase regulatory subunit | 0.0017 | 0.0041 | 0.5 |
Echinococcus granulosus | segment polarity protein dishevelled | 0.004 | 0.0191 | 0.0429 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0191 | 0.0191 |
Echinococcus multilocularis | hyperpolarization activated cyclic | 0.0017 | 0.0041 | 0.0091 |
Schistosoma mansoni | NADP-specific isocitrate dehydrogenase | 0.0048 | 0.0248 | 0.0363 |
Trichomonas vaginalis | ras GTP exchange factor, putative | 0.0028 | 0.0114 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0475 | 0.3112 | 0.3112 |
Brugia malayi | Isocitrate dehydrogenase | 0.0048 | 0.0248 | 0.0247 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0017 | 0.0041 | 0.0091 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0017 | 0.0041 | 0.0059 |
Toxoplasma gondii | type I fatty acid synthase, putative | 0.0017 | 0.0041 | 0.1408 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.0017 | 0.0041 | 0.0041 |
Brugia malayi | AMP-binding enzyme family protein | 0.0023 | 0.0078 | 0.0077 |
Schistosoma mansoni | regulator of G protein signaling | 0.004 | 0.0191 | 0.0279 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
IZ (functional) | = 12 mm | Antimicrobial activity against Escherichia coli UPCC 1195 assessed as clearing zone at 30 ug after 24 hrs | ChEMBL. | 12193012 |
IZ (functional) | = 14 mm | Antimicrobial activity against Candida albicans UPCC 2168 assessed as clearing zone at 30 ug after 48 hrs | ChEMBL. | 12193012 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.