Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | acetylcholinesterase | 0.1383 | 0.5 | 0.5 |
Echinococcus granulosus | carboxylesterase 5A | 0.1383 | 0.5 | 0.5 |
Loa Loa (eye worm) | carboxylesterase | 0.1383 | 0.5 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.1383 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1383 | 0.5 | 0.5 |
Echinococcus multilocularis | carboxylesterase 5A | 0.1383 | 0.5 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.1383 | 0.5 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.1383 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1383 | 0.5 | 0.5 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.1383 | 0.5 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.1383 | 0.5 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.1383 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | = 30 % | Inhibition of erythroid differentiation in human K562 cell assessed benzidine positive cells at 300 uM after 6 days by benzidine staining assay | ChEMBL. | 19072686 |
IC50 (functional) | = 247 uM | Antiproliferative activity against human K562 cells after 4 days | ChEMBL. | 19072686 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.