TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 602.555 | Formula: C29H27F5N6O3
H donors: 2 H acceptors: 4 LogP: 3.68 Rotable bonds: 11
Rule of 5 violations (Lipinski): 2
SMILES: O=C(Nc1ccc(c(c1)C(F)(F)F)N1CCN(CC1)CC(c1ccc(cc1F)F)(Cn1cncn1)O)/C=C/c1ccco1
InChi: 1S/C29H27F5N6O3/c30-20-3-6-23(25(31)14-20)28(42,17-40-19-35-18-36-40)16-38-9-11-39(12-10-38)26-7-4-21(15-24(26)29(32,33)34)37-27(41)8-5-22-2-1-13-43-22/h1-8,13-15,18-19,42H,9-12,16-17H2,(H,37,41)/b8-5+
InChiKey: FUFSQOCUAPXSRE-VMPITWQZSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Plasmodium falciparum	tubulin beta chain	0.0022	0.0675	0.18
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0022	0.0685	0.1827
Echinococcus granulosus	proteasome prosome macropain	0.007	0.3751	0.3751
Trichomonas vaginalis	DNA polymerase IV / kappa, putative	0.0019	0.0483	0.0805
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0022	0.0685	0.1827
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0016	0.0271	0.0396
Schistosoma mansoni	hypothetical protein	0.0016	0.0271	0.0271
Leishmania major	beta tubulin	0.0022	0.0675	0.059
Schistosoma mansoni	terminal deoxycytidyl transferase	0.0019	0.0483	0.0483
Echinococcus multilocularis	Tubulin beta 2C chain	0.0022	0.0675	0.0675
Loa Loa (eye worm)	hypothetical protein	0.0034	0.1429	0.1832
Echinococcus granulosus	Tubulin beta 2C chain	0.0022	0.0675	0.0675
Leishmania major	proteasome beta 5 subunit, putative	0.007	0.3751	1
Brugia malayi	beta-tubulin, identical	0.0022	0.0675	0.0989
Onchocerca volvulus		0.0022	0.0685	0.0809
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0483	0.1286
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0022	0.0685	0.1143
Onchocerca volvulus		0.0022	0.0685	0.0809
Trypanosoma brucei	DNA polymerase IV, putative	0.0019	0.0483	0.1286
Trypanosoma cruzi	cysteine peptidase, putative	0.0022	0.0685	0.1827
Entamoeba histolytica	cysteine protease, putative	0.0022	0.0685	0.1143
Plasmodium falciparum	proteasome subunit beta type-5	0.007	0.3751	1
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0015	0.0218	0.0581
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0022	0.0685	0.1827
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0015	0.0218	0.0364
Brugia malayi	carbohydrate phosphorylase	0.0105	0.5996	0.8778
Echinococcus granulosus	Tubulin beta 2C chain	0.0022	0.0675	0.0675
Schistosoma mansoni	hypothetical protein	0.0016	0.0271	0.0271
Leishmania major	cathepsin L-like protease	0.0022	0.0685	0.0621
Loa Loa (eye worm)	tubulin beta-4 chain	0.0022	0.0675	0.0691
Giardia lamblia	Glycogen phosphorylase	0.0105	0.5996	1
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0049	0.2428	0.3555
Brugia malayi	Cathepsin L-like precursor	0.0022	0.0685	0.1003
Leishmania major	beta tubulin	0.0022	0.0675	0.059
Echinococcus granulosus	glycogen phosphorylase	0.0105	0.5996	0.5996
Loa Loa (eye worm)	transcription factor SMAD2	0.0118	0.683	1
Plasmodium vivax	vivapain-2	0.0022	0.0685	0.1827
Brugia malayi	Cathepsin L-like precursor	0.0022	0.0685	0.1003
Loa Loa (eye worm)	tubulin beta chain	0.0022	0.0675	0.0691
Trypanosoma cruzi	DNA polymerase eta, putative	0.0019	0.0483	0.1286
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0022	0.0685	0.1143
Schistosoma mansoni	tubulin subunit beta	0.0022	0.0675	0.0675
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0022	0.0675	0.1126
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0483	0.1286
Schistosoma mansoni	tubulin subunit beta	0.0022	0.0675	0.0675
Leishmania major	beta tubulin	0.0022	0.0675	0.059
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0022	0.0685	0.1143
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0022	0.0685	0.0685
Giardia lamblia	Beta tubulin	0.0022	0.0675	0.035
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0483	0.1286
Onchocerca volvulus		0.0022	0.0685	0.0809
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0022	0.0685	0.1143
Echinococcus granulosus	dna polymerase kappa	0.0019	0.0483	0.0483
Mycobacterium tuberculosis	Proteasome beta subunit PrcB; assembles with alpha subunit PrcA.	0.007	0.3751	1
Entamoeba histolytica	deoxycytidyl transferase, putative	0.0019	0.0483	0.0805
Entamoeba histolytica	glycogen phosphorylase, putative	0.0045	0.2179	0.3634
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0022	0.0685	0.1143
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0022	0.0685	0.1143
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0016	0.0271	0.0079
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0483	0.1286
Trypanosoma brucei	proteasome subunit beta type-5, putative	0.007	0.3751	1
Leishmania major	beta tubulin	0.0022	0.0675	0.059
Trypanosoma cruzi	cysteine peptidase, putative	0.0022	0.0685	0.1827
Echinococcus multilocularis	dna polymerase kappa	0.0019	0.0483	0.0483
Echinococcus granulosus	glycogen phosphorylase	0.0105	0.5996	0.5996
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0022	0.0685	0.1143
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0022	0.0685	0.0685
Schistosoma mansoni	glycogen phosphorylase	0.0045	0.2179	0.2179
Leishmania major	cathepsin L-like protease	0.0022	0.0685	0.0621
Plasmodium vivax	tubulin beta chain, putative	0.0022	0.0675	0.18
Trypanosoma brucei	beta tubulin	0.0022	0.0675	0.18
Schistosoma mansoni	hypothetical protein	0.0168	1	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0022	0.0685	0.1143
Echinococcus granulosus	dna polymerase eta	0.0019	0.0483	0.0483
Schistosoma mansoni	tubulin subunit beta	0.0022	0.0675	0.0675
Echinococcus multilocularis	Tubulin beta 2C chain	0.0022	0.0675	0.0675
Schistosoma mansoni	proteasome catalytic subunit 3 (T01 family)	0.007	0.3751	0.3751
Entamoeba histolytica	tubulin family protein	0.0022	0.0675	0.1126
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0022	0.0685	0.1143
Echinococcus multilocularis	glycogen phosphorylase	0.0105	0.5996	0.5996
Echinococcus multilocularis	tubulin beta 1 chain	0.0022	0.0675	0.0675
Loa Loa (eye worm)	tubulin beta-2A chain	0.0022	0.0675	0.0691
Brugia malayi	Cathepsin L-like precursor	0.0022	0.0685	0.1003
Echinococcus multilocularis	Glycosyl transferase, family 35	0.0105	0.5996	0.5996
Trypanosoma brucei	DNA polymerase IV, putative	0.0019	0.0483	0.1286
Trypanosoma cruzi	cysteine peptidase, putative	0.0022	0.0685	0.1827
Echinococcus granulosus	GPCR family 2	0.0016	0.0271	0.0271
Brugia malayi	Cathepsin L-like precursor	0.0015	0.0218	0.0319
Echinococcus granulosus	Tubulin beta 2C chain	0.0022	0.0675	0.0675
Trypanosoma brucei	DNA polymerase eta, putative	0.0019	0.0483	0.1286
Mycobacterium ulcerans	proteasome PrcB	0.007	0.3751	1
Leishmania major	cathepsin L-like protease	0.0022	0.0685	0.0621
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0022	0.0685	0.1827
Trypanosoma brucei	DNA polymerase kappa, putative	0.0013	0.0107	0.0285
Leishmania major	beta tubulin	0.0022	0.0675	0.059
Entamoeba histolytica	glycogen phosphorylase, putative	0.0105	0.5996	1
Echinococcus multilocularis	beta tubulin	0.0022	0.0675	0.0675
Leishmania major	beta tubulin	0.0022	0.0675	0.059
Trypanosoma cruzi	cysteine peptidase, putative	0.0022	0.0685	0.1827
Plasmodium vivax	vivapain-2	0.0022	0.0685	0.1827
Schistosoma mansoni	hypothetical protein	0.0016	0.0271	0.0271
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0015	0.0218	0.0364
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0049	0.2428	0.3555
Schistosoma mansoni	glycogen phosphorylase	0.0105	0.5996	0.5996
Trichomonas vaginalis	tubulin alpha chain, putative	0.0022	0.0675	0.1126
Onchocerca volvulus		0.0022	0.0685	0.0809
Trichomonas vaginalis	tubulin gamma chain, putative	0.0022	0.0675	0.1126
Loa Loa (eye worm)	hypothetical protein	0.0049	0.2428	0.3342
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0483	0.1286
Brugia malayi	ImpB/MucB/SamB family protein	0.0019	0.0483	0.0706
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0483	0.1286
Brugia malayi	latrophilin 2 splice variant baaae	0.0034	0.1429	0.2093
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0022	0.0685	0.1827
Trichomonas vaginalis	tubulin, putative	0.0022	0.0675	0.1126
Loa Loa (eye worm)	beta-tubulin	0.0022	0.0675	0.0691
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0022	0.0685	0.1143
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0022	0.0685	0.1143
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0019	0.0483	0.1286
Brugia malayi	Cathepsin L-like precursor	0.0015	0.0218	0.0319
Echinococcus multilocularis	cysteine protease	0.0022	0.0685	0.0685
Trichomonas vaginalis	tubulin beta chain, putative	0.0022	0.0675	0.1126
Onchocerca volvulus		0.0022	0.0685	0.0809
Brugia malayi	Cathepsin L-like precursor	0.0022	0.0685	0.1003
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0022	0.0685	0.1143
Onchocerca volvulus	Cathepsin L homolog	0.0022	0.0685	0.0809
Echinococcus granulosus	tubulin subunit beta	0.0022	0.0675	0.0675
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0016	0.0271	0.0271
Leishmania major	beta tubulin	0.0022	0.0675	0.059
Leishmania major	cathepsin L-like protease	0.0022	0.0685	0.0621
Loa Loa (eye worm)	BEN-1 protein	0.0022	0.0675	0.0691
Onchocerca volvulus		0.0022	0.0685	0.0809
Echinococcus multilocularis	Tubulin beta 2C chain	0.0022	0.0675	0.0675
Trypanosoma brucei	unspecified product	0.0013	0.0107	0.0285
Schistosoma mansoni	glycogen phosphorylase	0.0105	0.5996	0.5996
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0022	0.0685	0.1827
Leishmania major	cathepsin L-like protease	0.0022	0.0685	0.0621
Schistosoma mansoni	tubulin subunit beta	0.0022	0.0675	0.0675
Echinococcus multilocularis	dna polymerase eta	0.0019	0.0483	0.0483
Loa Loa (eye worm)	MH2 domain-containing protein	0.0118	0.683	1
Echinococcus granulosus	tubulin beta 1 chain	0.0022	0.0675	0.0675
Brugia malayi	Papain family cysteine protease containing protein	0.0022	0.0685	0.1003
Mycobacterium ulcerans	glycogen phosphorylase GlgP	0.0045	0.2179	0.5191
Trypanosoma brucei	DNA polymerase IV, putative	0.0019	0.0483	0.1286
Chlamydia trachomatis	glycogen phosphorylase	0.0105	0.5996	0.5
Trypanosoma cruzi	beta tubulin, putative	0.0022	0.0675	0.18
Giardia lamblia	Beta tubulin	0.0022	0.0675	0.035
Schistosoma mansoni	cathepsin F (C01 family)	0.0022	0.0685	0.0685
Leishmania major	beta tubulin	0.0022	0.0675	0.059
Echinococcus multilocularis	glycogen phosphorylase	0.0105	0.5996	0.5996
Plasmodium vivax	proteasome subunit beta type-5, putative	0.007	0.3751	1
Echinococcus multilocularis	tubulin subunit beta	0.0022	0.0675	0.0675
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0022	0.0685	0.1827
Giardia lamblia	Beta tubulin	0.0022	0.0675	0.035
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0022	0.0685	0.1827
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0022	0.0685	0.0707
Schistosoma mansoni	hypothetical protein	0.0168	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0022	0.0685	0.1827
Trypanosoma brucei	beta tubulin	0.0022	0.0675	0.18
Trypanosoma brucei	beta tubulin	0.0022	0.0675	0.18
Leishmania major	beta tubulin	0.0022	0.0675	0.059
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0022	0.0685	0.1827
Schistosoma mansoni	cathepsin F (C01 family)	0.0015	0.0218	0.0218
Loa Loa (eye worm)	tubulin beta-1 chain	0.0022	0.0675	0.0691
Entamoeba histolytica	cysteine proteinase, putative	0.0022	0.0685	0.1143
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0022	0.0685	0.1143
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0015	0.0218	0.0319
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0022	0.0685	0.1143
Loa Loa (eye worm)	proteasome A-type and B-type family protein	0.007	0.3751	0.5343
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0022	0.0685	0.1143
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0685	0.0707
Trypanosoma cruzi	proteasome subunit beta type-5, putative	0.007	0.3751	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0022	0.0685	0.1143
Entamoeba histolytica	proteasome subunit beta type 5 precursor, putative	0.007	0.3751	0.6256
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0483	0.1286
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0022	0.0685	0.0685
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0483	0.1286
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0022	0.0685	0.1143
Entamoeba histolytica	cysteine proteinase, putative	0.0015	0.0218	0.0364
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0022	0.0685	0.0707
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0022	0.0685	0.1143
Entamoeba histolytica	cysteine proteinase, putative	0.0022	0.0685	0.1143
Loa Loa (eye worm)	fibroinase	0.0022	0.0685	0.0707
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0483	0.04
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0022	0.0685	0.1827
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0022	0.0685	0.1143
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0022	0.0685	0.1827
Giardia lamblia	Proteasome subunit beta type 5 precursor	0.007	0.3751	0.5928
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0016	0.0271	0.0271
Echinococcus granulosus	terminal deoxycytidyl transferase rev1	0.0019	0.0483	0.0483
Trypanosoma brucei	beta tubulin	0.0022	0.0675	0.18
Leishmania major	cathepsin L-like protease	0.0022	0.0685	0.0621
Toxoplasma gondii	proteasome subunit beta type, putative	0.007	0.3751	1
Echinococcus multilocularis	GPCR, family 2	0.0016	0.0271	0.0271
Echinococcus multilocularis	geminin	0.0168	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0022	0.0685	0.1143
Toxoplasma gondii	cathepsin CPL	0.0022	0.0685	0.0033
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0483	0.1286
Schistosoma mansoni	rab geranylgeranyl transferase alpha subunit	0.0019	0.0483	0.0483
Onchocerca volvulus	Glycogen phosphorylase homolog	0.0105	0.5996	1
Loa Loa (eye worm)	ImpB/MucB/SamB family protein	0.0019	0.0483	0.04
Leishmania major	beta tubulin	0.0022	0.0675	0.059
Echinococcus multilocularis	tubulin, beta 4A class IVa	0.0022	0.0675	0.0675
Loa Loa (eye worm)	BEN-1 protein	0.0022	0.0675	0.0691
Brugia malayi	Cathepsin L-like precursor	0.0022	0.0685	0.1003
Brugia malayi	ImpB/MucB/SamB family protein	0.0019	0.0483	0.0706
Echinococcus granulosus	cathepsin l1	0.0022	0.0685	0.0685
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0019	0.0483	0.1286
Trypanosoma brucei	DNA polymerase kappa, putative	0.0013	0.0107	0.0285
Echinococcus multilocularis	cathepsin L cysteine protease	0.0022	0.0685	0.0685
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0022	0.0685	0.1143
Loa Loa (eye worm)	cysteine protease	0.0022	0.0685	0.0707
Trichomonas vaginalis	Family T1, proteasome beta subunit, threonine peptidase	0.007	0.3751	0.6256
Brugia malayi	Tubulin beta-1 chain	0.0022	0.0675	0.0989
Trichomonas vaginalis	glycogen phosphorylase, putative	0.0105	0.5996	1
Leishmania major	beta tubulin	0.0022	0.0675	0.059
Echinococcus granulosus	beta tubulin	0.0022	0.0675	0.0675
Echinococcus granulosus	cathepsin l1	0.0015	0.0218	0.0218
Echinococcus multilocularis	Tubulin beta 2C chain	0.0022	0.0675	0.0675
Leishmania major	cysteine peptidase A (CPA)	0.0022	0.0685	0.0621
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0019	0.0483	0.1286
Entamoeba histolytica	glycogen phosphorylase, putative	0.0105	0.5996	1
Onchocerca volvulus	Cathepsin L homolog	0.0022	0.0685	0.0809
Leishmania major	beta tubulin	0.0022	0.0675	0.059
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0022	0.0685	0.1143
Schistosoma mansoni	tubulin subunit beta	0.0022	0.0675	0.0675
Leishmania major	beta tubulin	0.0022	0.0675	0.059
Entamoeba histolytica	glycogenphosphorylase, putative	0.0045	0.2179	0.3634
Leishmania major	cathepsin L-like protease	0.0022	0.0685	0.0621
Schistosoma mansoni	hypothetical protein	0.0016	0.0271	0.0271
Echinococcus granulosus	Tubulin beta 2C chain	0.0022	0.0675	0.0675
Trichomonas vaginalis	glycogen phosphorylase, putative	0.0105	0.5996	1
Echinococcus granulosus	Glycosyl transferase family 35	0.0105	0.5996	0.5996
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0022	0.0685	0.1143
Echinococcus granulosus	tubulin beta 4A class IVa	0.0022	0.0675	0.0675
Leishmania major	beta tubulin	0.0022	0.0675	0.059
Loa Loa (eye worm)	glycogen phosphorylase	0.0105	0.5996	0.8738
Entamoeba histolytica	tubulin family protein	0.0022	0.0675	0.1126
Onchocerca volvulus	Cathepsin F homolog	0.0022	0.0685	0.0809
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0019	0.0483	0.1286
Trypanosoma cruzi	cruzipain precursor, putative	0.0022	0.0685	0.1827
Brugia malayi	Cathepsin L-like precursor	0.0022	0.0685	0.1003
Schistosoma mansoni	hypothetical protein	0.0034	0.1429	0.1429
Mycobacterium tuberculosis	Probable glycogen phosphorylase GlgP	0.0045	0.2179	0.5191
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0022	0.0685	0.1143
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0016	0.0271	0.0271
Schistosoma mansoni	tubulin subunit beta	0.0022	0.0675	0.0675
Leishmania major	beta tubulin	0.0022	0.0675	0.059
Brugia malayi	Proteasome A-type and B-type family protein	0.007	0.3751	0.5492
Brugia malayi	cathepsin L-like precursor	0.0015	0.0218	0.0319
Brugia malayi	Latrophilin receptor protein 2	0.0016	0.0271	0.0396
Trypanosoma cruzi	proteasome subunit beta type-5, putative	0.007	0.3751	1
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0022	0.0675	0.1126
Trypanosoma brucei	unspecified product	0.0013	0.0107	0.0285
Entamoeba histolytica	glycogen phosphorylase, putative	0.0045	0.2179	0.3634
Brugia malayi	MH2 domain containing protein	0.0118	0.683	1
Echinococcus granulosus	Tubulin beta 2C chain	0.0022	0.0675	0.0675
Echinococcus multilocularis	cathepsin L cysteine protease	0.0022	0.0685	0.0685
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0483	0.1286
Echinococcus multilocularis	cysteine protease	0.0022	0.0685	0.0685
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0016	0.0271	0.0271
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0271	0.0079
Echinococcus multilocularis	Tubulin beta 2C chain	0.0022	0.0675	0.0675
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0022	0.0685	0.1143
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0049	0.2428	0.3342
Leishmania major	beta tubulin	0.0022	0.0675	0.059
Echinococcus multilocularis	beta tubulin	0.0022	0.0675	0.0675
Onchocerca volvulus		0.0022	0.0685	0.0809
Schistosoma mansoni	DNA polymerase eta	0.0019	0.0483	0.0483
Schistosoma mansoni	cathepsin F (C01 family)	0.0022	0.0685	0.0685
Mycobacterium leprae	proteasome (beta subunit) PrcB	0.007	0.3751	0.5
Trypanosoma brucei	unspecified product	0.0019	0.0483	0.1286
Leishmania major	cathepsin L-like protease	0.0022	0.0685	0.0621
Loa Loa (eye worm)	ctsf protein	0.0022	0.0685	0.0707
Echinococcus multilocularis	terminal deoxycytidyl transferase rev1	0.0019	0.0483	0.0483
Echinococcus multilocularis	proteasome (prosome, macropain)	0.007	0.3751	0.3751
Leishmania major	beta tubulin	0.0022	0.0675	0.059
Trypanosoma brucei	DNA polymerase kappa, putative	0.0013	0.0107	0.0285
Trichomonas vaginalis	DNA polymerase eta, putative	0.0019	0.0483	0.0805
Echinococcus granulosus	beta tubulin	0.0022	0.0675	0.0675
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0022	0.0685	0.1827
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0022	0.0685	0.1827
Leishmania major	beta tubulin	0.0022	0.0675	0.059
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0022	0.0685	0.0685

Activities

Activity type	Activity value	Assay description	Source	Reference
MIC80 (functional)	= 0.25 ug ml-1	Antifungal activity against Candida albicans ATCC Y0109 after 24 hrs by micro-broth dilution method	ChEMBL.	21531485
MIC80 (functional)	= 0.25 ug ml-1	Antifungal activity against Cryptococcus neoformans ATCC BLS108 after 72 hrs by micro-broth dilution method	ChEMBL.	21531485

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL1797027

Bibliographic References

No literature references available for this target.

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Detailed information for compound 993504