Detailed information for compound 993857

Basic information

Technical information
  • TDR Targets ID: 993857
  • Name: (2R,3S,4R,5R,6S)-2-(hydroxymethyl)-6-[3-(4-me thylphenoxy)phenyl]oxane-3,4,5-triol
  • MW: 346.374 | Formula: C19H22O6
  • H donors: 4 H acceptors: 4 LogP: 1.35 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC[C@H]1O[C@@H](c2cccc(c2)Oc2ccc(cc2)C)[C@@H]([C@H]([C@@H]1O)O)O
  • InChi: 1S/C19H22O6/c1-11-5-7-13(8-6-11)24-14-4-2-3-12(9-14)19-18(23)17(22)16(21)15(10-20)25-19/h2-9,15-23H,10H2,1H3/t15-,16-,17+,18-,19+/m1/s1
  • InChiKey: DFTBZKANYGHGRH-FQBWVUSXSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • (2R,3S,4R,5R,6S)-2-(hydroxymethyl)-6-[3-(4-methylphenoxy)phenyl]tetrahydropyran-3,4,5-triol
  • (2R,3S,4R,5R,6S)-2-methylol-6-[3-(4-methylphenoxy)phenyl]tetrahydropyran-3,4,5-triol

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens solute carrier family 5 (sodium/glucose cotransporter), member 2 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus granulosus sodium:glucose cotransporter Get druggable targets OG5_127197 All targets in OG5_127197
Echinococcus multilocularis sodium:glucose cotransporter 2 Get druggable targets OG5_127197 All targets in OG5_127197
Schistosoma mansoni inositol transporter Get druggable targets OG5_127197 All targets in OG5_127197
Schistosoma japonicum ko:K03307 solute:Na+ symporter, SSS family, putative Get druggable targets OG5_127197 All targets in OG5_127197
Echinococcus granulosus sodium:myo inositol cotransporter Get druggable targets OG5_127197 All targets in OG5_127197
Schistosoma mansoni inositol transporter Get druggable targets OG5_127197 All targets in OG5_127197
Echinococcus multilocularis solute carrier family 5 Get druggable targets OG5_127197 All targets in OG5_127197
Schistosoma japonicum Sodium/myo-inositol cotransporter, putative Get druggable targets OG5_127197 All targets in OG5_127197
Schistosoma japonicum expressed protein Get druggable targets OG5_127197 All targets in OG5_127197
Echinococcus granulosus solute carrier family 5 Get druggable targets OG5_127197 All targets in OG5_127197
Echinococcus multilocularis sodium:myo inositol cotransporter Get druggable targets OG5_127197 All targets in OG5_127197
Echinococcus granulosus sodium:glucose cotransporter 2 Get druggable targets OG5_127197 All targets in OG5_127197
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni sodium/solute symporter 0.0046 0.0931 0.0931
Plasmodium vivax DNA polymerase alpha, putative 0.0159 0.3687 0.4242
Brugia malayi Nuclear hormone receptor family member nhr-14 0.001 0.0041 0.0001
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.1038 0.1091
Mycobacterium ulcerans putative regulatory protein 0.0036 0.0684 1
Schistosoma mansoni retinoid-x-receptor (RXR) 0.001 0.0041 0.0041
Giardia lamblia Kinase, CMGC MAPK 0.0051 0.1038 0.0902
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0021 0.0298 0.0298
Echinococcus multilocularis DNA polymerase zeta catalytic subunit 0.0129 0.2965 0.2965
Loa Loa (eye worm) hypothetical protein 0.0054 0.1131 0.1266
Loa Loa (eye worm) latrophilin receptor protein 2 0.0017 0.0217 0.0204
Schistosoma mansoni single-minded 0.0049 0.0996 0.0996
Echinococcus multilocularis dna polymerase epsilon catalytic subunit a 0.0129 0.2965 0.2965
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0021 0.0298 0.5
Brugia malayi Pre-SET motif family protein 0.021 0.4949 0.5705
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.001 0.0041 0.0041
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0505 0.0505
Trypanosoma cruzi DNA polymerase delta catalytic subunit, putative 0.0289 0.6884 0.7954
Brugia malayi DNA polymerase family B, exonuclease domain containing protein 0.0129 0.2965 0.3399
Trypanosoma cruzi UDP-glucoronosyl and UDP-glucosyl transferase, putative 0.0054 0.1131 0.1263
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0051 0.1038 0.1156
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0017 0.0217 0.0217
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0013 0.0107 0.0073
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0051 0.1038 0.1159
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.001 0.0041 0.0041
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0051 0.1038 0.1091
Echinococcus granulosus histone lysine methyltransferase setb 0.0031 0.0548 0.0548
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0021 0.0298 0.0017
Toxoplasma gondii histone lysine methyltransferase SET1 0.0056 0.118 0.133
Plasmodium vivax SET domain protein, putative 0.0031 0.0548 0.0596
Brugia malayi hypothetical protein 0.0164 0.3824 0.4398
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0031 0.0548 0.0548
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0013 0.0107 0.0073
Trichomonas vaginalis DNA helicase recq, putative 0.002 0.0284 0.0208
Leishmania major DNA polymerase epsilon catalytic subunit, putative 0.0129 0.2965 0.3348
Schistosoma mansoni hypothetical protein 0.0049 0.0986 0.0986
Onchocerca volvulus 0.0031 0.0548 0.0588
Leishmania major protein kinase, putative 0.0013 0.0118 0.0013
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0051 0.1038 0.1156
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0548 0.0548
Entamoeba histolytica DNA polymerase zeta catalytic subunit, putative 0.0057 0.1205 0.1359
Onchocerca volvulus 0.0029 0.0511 0.0546
Trichomonas vaginalis DNA polymerase alpha catalytic subunit, putative 0.0138 0.3181 0.3601
Brugia malayi intermediate filament protein 0.0054 0.1119 0.1253
Echinococcus multilocularis sodium:glucose cotransporter 2 0.0181 0.4246 0.4246
Loa Loa (eye worm) hypothetical protein 0.0046 0.0931 0.1034
Loa Loa (eye worm) hypothetical protein 0.0123 0.282 0.3229
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0041 0.0041
Echinococcus granulosus DNA polymerase zeta catalytic subunit 0.0129 0.2965 0.2965
Loa Loa (eye worm) RecQ helicase 0.002 0.0284 0.0282
Schistosoma mansoni steroid hormone receptor ad4bp 0.001 0.0041 0.0041
Echinococcus granulosus ATP dependent DNA helicase Q1 0.002 0.0284 0.0284
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.002 0.0284 0.029
Echinococcus granulosus FTZ F1 alpha 0.001 0.0041 0.0041
Toxoplasma gondii DNA polymerase family B protein 0.0057 0.1205 0.1359
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.1038 0.1091
Echinococcus multilocularis mitogen activated protein kinase 3 0.0051 0.1038 0.1038
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0017 0.0217 0.0217
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0041 0.0041
Mycobacterium leprae Possible regulatory protein 0.0013 0.0107 0.5
Brugia malayi hypothetical protein 0.0123 0.282 0.323
Brugia malayi Nuclear hormone receptor family member nhr-40 0.001 0.0041 0.0001
Onchocerca volvulus 0.0036 0.0684 0.0747
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0026 0.0434 0.0434
Loa Loa (eye worm) hypothetical protein 0.0057 0.1205 0.1353
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0051 0.1038 0.1091
Loa Loa (eye worm) hypothetical protein 0.0053 0.1094 0.1224
Trichomonas vaginalis DNA polymerase alpha catalytic subunit, putative 0.0072 0.1555 0.1696
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.001 0.0041 0.0041
Entamoeba histolytica DNA polymerase alpha catalytic subunit, putative 0.0066 0.1422 0.1611
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.1038 0.1091
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.001 0.0041 0.0041
Leishmania major protein kinase, putative 0.0013 0.0118 0.0013
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0041 0.0001
Trypanosoma cruzi DNA polymerase I alpha catalytic subunit, putative 0.0138 0.3181 0.3648
Schistosoma mansoni thyroid hormone receptor 0.0135 0.3113 0.3113
Loa Loa (eye worm) histone methyltransferase 0.001 0.0044 0.0003
Schistosoma mansoni DNA helicase recq1 0.002 0.0284 0.0284
Treponema pallidum exodeoxyribonuclease (exoA) 0.0021 0.0298 1
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0125 0.2867 0.2867
Loa Loa (eye worm) hypothetical protein 0.0164 0.3824 0.4397
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0013 0.0118 0.0086
Echinococcus granulosus solute carrier family 5 0.0181 0.4246 0.4246
Brugia malayi Latrophilin receptor protein 2 0.0017 0.0217 0.0205
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.001 0.0041 0.0041
Plasmodium falciparum DNA polymerase delta catalytic subunit 0.0361 0.8644 1
Brugia malayi Nuclear hormone receptor family member nhr-3 0.001 0.0041 0.0001
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0051 0.1038 0.0902
Plasmodium vivax DNA polymerase epsilon, catalytic subunit a, putative 0.0129 0.2965 0.3403
Trichomonas vaginalis ap endonuclease, putative 0.0021 0.0298 0.0224
Schistosoma mansoni hypothetical protein 0.0017 0.0217 0.0217
Onchocerca volvulus DNA polymerase delta catalytic subunit homolog 0.0361 0.8644 1
Schistosoma mansoni high-affinity choline transporter 0.0046 0.0931 0.0931
Echinococcus granulosus DNA polymerase delta catalytic subunit 0.0361 0.8644 0.8644
Echinococcus granulosus lamin dm0 0.0054 0.1119 0.1119
Schistosoma mansoni DNA helicase recq5 0.002 0.0284 0.0284
Schistosoma mansoni thyroid hormone receptor 0.0135 0.3113 0.3113
Plasmodium vivax DNA polymerase zeta catalytic subunit, putative 0.0129 0.2965 0.3403
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0021 0.0298 0.0306
Toxoplasma gondii DNA polymerase (pol2) superfamily protein 0.0159 0.3687 0.4242
Echinococcus granulosus DNA polymerase alpha catalytic subunit 0.0169 0.3942 0.3942
Echinococcus granulosus mitogen activated protein kinase 3 0.0051 0.1038 0.1038
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0031 0.0548 0.0548
Schistosoma mansoni aryl hydrocarbon receptor 0.0049 0.0996 0.0996
Schistosoma mansoni hypothetical protein 0.0037 0.0707 0.0707
Loa Loa (eye worm) hypothetical protein 0.001 0.0044 0.0003
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0029 0.0504 0.0538
Echinococcus multilocularis cpg binding protein 0.0031 0.0552 0.0552
Trichomonas vaginalis conserved hypothetical protein 0.0057 0.1205 0.1286
Echinococcus granulosus retinoic acid receptor rxr beta a 0.001 0.0041 0.0041
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0041 0.0001
Loa Loa (eye worm) hypothetical protein 0.0037 0.0707 0.0773
Trypanosoma brucei protein kinase, putative 0.0051 0.1038 0.0902
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0021 0.0298 0.0295
Brugia malayi bHLH-PAS transcription factor 0.0036 0.0684 0.0747
Loa Loa (eye worm) hypothetical protein 0.0026 0.0434 0.0456
Echinococcus multilocularis high affinity choline transporter 1 0.0046 0.0931 0.0931
Echinococcus multilocularis GPCR, family 2 0.0017 0.0217 0.0217
Brugia malayi DNA polymerase alpha catalytic subunit 0.0159 0.3687 0.4238
Leishmania major DNA polymerase zeta catalytic subunit, putative 0.0057 0.1205 0.1286
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0013 0.0118 0.0086
Echinococcus granulosus GPCR family 2 0.0017 0.0217 0.0217
Schistosoma mansoni inositol transporter 0.0181 0.4246 0.4246
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0021 0.0298 0.0017
Brugia malayi Sodium:solute symporter family protein 0.0046 0.0931 0.1034
Trichomonas vaginalis DNA helicase recq1, putative 0.002 0.0284 0.0208
Brugia malayi Steroid receptor seven-up type 2 0.001 0.0041 0.0001
Brugia malayi photoreceptor-specific nuclear receptor 0.001 0.0041 0.0001
Trichomonas vaginalis DNA helicase recq, putative 0.002 0.0284 0.0208
Schistosoma mansoni cpg binding protein 0.0031 0.0552 0.0552
Echinococcus granulosus aryl hydrocarbon receptor 0.0013 0.0107 0.0107
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.0013 0.0107 0.0076
Trypanosoma brucei DNA polymerase delta catalytic subunit, putative 0.0361 0.8644 1
Echinococcus granulosus lamin 0.0054 0.1119 0.1119
Brugia malayi nuclear receptor NHR-88 0.001 0.0041 0.0001
Schistosoma mansoni intermediate filament proteins 0.0054 0.1119 0.1119
Echinococcus granulosus sodium coupled monocarboxylate transporter 1 0.0046 0.0931 0.0931
Brugia malayi Calcitonin receptor-like protein seb-1 0.0054 0.1129 0.1264
Onchocerca volvulus 0.0049 0.0986 0.1098
Brugia malayi MAP kinase sur-1 0.0051 0.1038 0.1159
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0125 0.2867 0.2867
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0013 0.0118 0.0086
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.001 0.0041 0.0041
Loa Loa (eye worm) hypothetical protein 0.0123 0.282 0.3229
Echinococcus multilocularis aryl hydrocarbon receptor 0.0013 0.0107 0.0107
Trypanosoma cruzi DNA polymerase epsilon catalytic subunit, putative 0.0129 0.2965 0.3396
Brugia malayi Nuclear hormone receptor family member nhr-31 0.001 0.0041 0.0001
Echinococcus multilocularis dnaJ subfamily B 0.0416 1 1
Echinococcus granulosus sodium:myo inositol cotransporter 0.0181 0.4246 0.4246
Schistosoma mansoni hypothetical protein 0.0017 0.0217 0.0217
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0548 0.0548
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.0044 0.0044
Schistosoma mansoni RAR-like nuclear receptor 0.001 0.0041 0.0041
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0021 0.0298 0.0295
Trichomonas vaginalis DNA polymerase II, putative 0.0138 0.3181 0.3601
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.002 0.0284 0.0284
Schistosoma mansoni retinoic acid receptor RXR 0.001 0.0041 0.0041
Schistosoma mansoni survival motor neuron protein 0.0049 0.0986 0.0986
Plasmodium falciparum DNA polymerase zeta catalytic subunit, putative 0.0057 0.1205 0.1102
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.002 0.0284 0.0284
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.002 0.0284 0.0283
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0041 0.0001
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.002 0.0284 0.0283
Loa Loa (eye worm) hypothetical protein 0.0025 0.041 0.0428
Onchocerca volvulus Huntingtin homolog 0.0123 0.282 0.3229
Echinococcus granulosus survival motor neuron protein 1 0.0238 0.5633 0.5633
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.001 0.0041 0.0041
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.001 0.0041 0.0041
Onchocerca volvulus DNA polymerase homolog 0.0129 0.2965 0.3398
Brugia malayi Bloom's syndrome protein homolog 0.002 0.0284 0.0283
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.0548 0.0548
Entamoeba histolytica recQ family helicase, putative 0.002 0.0284 0.029
Brugia malayi GH02984p 0.0046 0.0931 0.1034
Onchocerca volvulus 0.0046 0.0931 0.1034
Echinococcus granulosus dna polymerase epsilon catalytic subunit a 0.0129 0.2965 0.2965
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0511 0.0546
Brugia malayi Pre-SET motif family protein 0.0031 0.0548 0.0589
Echinococcus granulosus sodium:glucose cotransporter 2 0.0181 0.4246 0.4246
Echinococcus granulosus ATP dependent DNA helicase Q5 0.002 0.0284 0.0284
Loa Loa (eye worm) hypothetical protein 0.001 0.0044 0.0003
Giardia lamblia DNA polymerase delta, catalytic subunit 0.0361 0.8644 1
Schistosoma mansoni DNA polymerase alpha catalytic subunit 0.0021 0.03 0.03
Echinococcus multilocularis FTZ F1 alpha 0.001 0.0041 0.0041
Echinococcus multilocularis thyroid hormone receptor alpha 0.0135 0.3113 0.3113
Schistosoma mansoni DNA polymerase delta catalytic subunit 0.0361 0.8644 0.8644
Trypanosoma cruzi DNA polymerase delta catalytic subunit, putative 0.0361 0.8644 1
Echinococcus granulosus mitogen activated protein kinase 0.0051 0.1038 0.1038
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.001 0.0041 0.0041
Loa Loa (eye worm) DNA polymerase epsilon catalytic subunit 0.0072 0.1555 0.1759
Schistosoma mansoni DNA polymerase epsilon catalytic subunit 0.0129 0.2965 0.2965
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.002 0.0284 0.029
Loa Loa (eye worm) hypothetical protein 0.0031 0.0548 0.0588
Brugia malayi Intermediate filament tail domain containing protein 0.0054 0.1119 0.1253
Echinococcus multilocularis survival motor neuron protein 1 0.0238 0.5633 0.5633
Loa Loa (eye worm) hypothetical protein 0.0013 0.0107 0.0076
Onchocerca volvulus DNA polymerase epsilon catalytic subunit A homolog 0.0129 0.2965 0.3398
Schistosoma mansoni DNA polymerase alpha catalytic subunit 0.0169 0.3942 0.3942
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0054 0.1129 0.1264
Onchocerca volvulus 0.0054 0.1119 0.1252
Brugia malayi exodeoxyribonuclease III family protein 0.0021 0.0298 0.0299
Loa Loa (eye worm) hypothetical protein 0.0054 0.1119 0.1252
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0041 0.0001
Schistosoma mansoni blooms syndrome DNA helicase 0.001 0.0035 0.0035
Schistosoma mansoni cpg binding protein 0.0031 0.0552 0.0552
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0021 0.0298 0.0306
Loa Loa (eye worm) hypothetical protein 0.0057 0.1205 0.1353
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0041 0.0001
Loa Loa (eye worm) hypothetical protein 0.0025 0.041 0.0428
Leishmania major DNA polymerase delta catalytic subunit, putative 0.0361 0.8644 1
Onchocerca volvulus 0.0054 0.1119 0.1252
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0548 0.0548
Toxoplasma gondii exonuclease III APE 0.0021 0.0298 0.0306
Echinococcus granulosus single minded 2 0.0036 0.0684 0.0684
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0051 0.1038 0.1156
Echinococcus multilocularis lamin dm0 0.0054 0.1119 0.1119
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.001 0.0041 0.0041
Schistosoma mansoni lamin 0.0054 0.1119 0.1119
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0063 0.1342 0.1342
Echinococcus granulosus intermediate filament protein 0.0054 0.1119 0.1119
Schistosoma mansoni lamin 0.0054 0.1119 0.1119
Trichomonas vaginalis ap endonuclease, putative 0.0021 0.0298 0.0224
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0041 0.0001
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0021 0.0298 0.0298
Toxoplasma gondii DNA polymerase 0.0361 0.8644 1
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.0044 0.0044
Echinococcus multilocularis solute carrier family 5 0.0181 0.4246 0.4246
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.001 0.0044 0.0011
Onchocerca volvulus 0.0013 0.0107 0.0076
Brugia malayi hypothetical protein 0.0238 0.5633 0.65
Trypanosoma brucei DNA polymerase zeta catalytic subunit, putative 0.0129 0.2965 0.3207
Trypanosoma cruzi DNA polymerase zeta catalytic subunit, putative 0.0057 0.1205 0.135
Echinococcus multilocularis mitogen activated protein kinase 0.0051 0.1038 0.1038
Echinococcus granulosus bloom syndrome protein 0.002 0.0284 0.0284
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0021 0.0298 0.5
Schistosoma mansoni Tr4/Tr2 (homologue) 0.001 0.0041 0.0041
Schistosoma mansoni hypothetical protein 0.0017 0.0217 0.0217
Trichomonas vaginalis set domain proteins, putative 0.0239 0.5659 0.6503
Brugia malayi Nuclear hormone receptor family member nhr-1 0.001 0.0041 0.0001
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0051 0.1038 0.1165
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0021 0.0298 0.0017
Toxoplasma gondii DNA polymerase family B protein 0.0129 0.2965 0.3403
Loa Loa (eye worm) hypothetical protein 0.0072 0.1555 0.1759
Entamoeba histolytica DNA polymerase delta catalytic subunit, putative 0.0361 0.8644 1
Echinococcus multilocularis ecdysone induced protein 78C 0.001 0.0041 0.0041
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0051 0.1038 0.1156
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.0548 0.0596
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0054 0.1119 0.1252
Loa Loa (eye worm) hypothetical protein 0.0046 0.0931 0.1034
Echinococcus multilocularis musashi 0.0054 0.1119 0.1119
Schistosoma mansoni hypothetical protein 0.0017 0.0217 0.0217
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0017 0.0217 0.0205
Trichomonas vaginalis DNA polymerase zeta catalytic subunit, putative 0.0361 0.8644 1
Schistosoma mansoni DNA polymerase zeta catalytic subunit 0.0129 0.2965 0.2965
Entamoeba histolytica recQ family DNA helicase 0.001 0.0044 0.0011
Schistosoma mansoni serine/threonine protein kinase 0.0051 0.1038 0.1038
Schistosoma mansoni hypothetical protein 0.0416 1 1
Plasmodium falciparum DNA polymerase alpha catalytic subunit A 0.0066 0.1422 0.136
Loa Loa (eye worm) hypothetical protein 0.0072 0.1555 0.1759
Brugia malayi DNA polymerase family B containing protein 0.0129 0.2965 0.3399
Trypanosoma cruzi DNA polymerase epsilon catalytic subunit, putative 0.0129 0.2965 0.3396
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0041 0.0001
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.0013 0.0107 0.5
Echinococcus multilocularis lamin 0.0054 0.1119 0.1119
Brugia malayi latrophilin 2 splice variant baaae 0.0037 0.0707 0.0774
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0049 0.0986 0.1098
Brugia malayi Nuclear hormone receptor family member nhr-49 0.001 0.0041 0.0001
Schistosoma mansoni blooms syndrome DNA helicase 0.001 0.0044 0.0044
Schistosoma mansoni ap endonuclease 0.0021 0.0298 0.0298
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0017 0.0217 0.0217
Brugia malayi DNA polymerase delta catalytic subunit 0.0361 0.8644 1
Schistosoma mansoni ap endonuclease 0.0021 0.0298 0.0298
Brugia malayi PAS domain containing protein 0.0049 0.0996 0.111
Schistosoma mansoni inositol transporter 0.0181 0.4246 0.4246
Echinococcus granulosus high affinity choline transporter 1 0.0046 0.0931 0.0931
Giardia lamblia DNA polymerase alpha subunit A 0.0097 0.2182 0.227
Loa Loa (eye worm) hypothetical protein 0.0238 0.5633 0.65
Loa Loa (eye worm) hypothetical protein 0.002 0.0284 0.0282
Echinococcus granulosus sodium:glucose cotransporter 0.0181 0.4246 0.4246
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.001 0.0041 0.0041
Plasmodium vivax DNA polymerase delta catalytic subunit, putative 0.0361 0.8644 1
Giardia lamblia DNA polymerase epsilon, catalytic subunit 0.0129 0.2965 0.3207
Schistosoma mansoni hypothetical protein 0.0125 0.2867 0.2867
Schistosoma mansoni coup transcription factor 0.001 0.0041 0.0041
Echinococcus multilocularis bloom syndrome protein 0.002 0.0284 0.0284
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.001 0.0044 0.0011
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.001 0.0041 0.0041
Brugia malayi steroid hormone receptor 0.001 0.0041 0.0001
Echinococcus multilocularis DNA polymerase alpha catalytic subunit 0.0169 0.3942 0.3942
Schistosoma mansoni nuclear hormone receptor 0.001 0.0041 0.0041
Brugia malayi nuclear hormone receptor 0.001 0.0041 0.0001
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.002 0.0284 0.0279
Loa Loa (eye worm) hypothetical protein 0.019 0.4447 0.5121
Echinococcus multilocularis DNA polymerase delta catalytic subunit 0.0361 0.8644 0.8644
Onchocerca volvulus 0.0239 0.5659 0.653
Loa Loa (eye worm) intermediate filament protein 0.0054 0.1119 0.1252
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0021 0.0298 0.0224
Echinococcus multilocularis transfer RNA-Lys 0.0036 0.0684 0.0684
Trichomonas vaginalis DNA polymerase alpha catalytic subunit, putative 0.0129 0.2965 0.3348
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0041 0.0041
Leishmania major DNA polymerase I alpha catalytic subunit, putative 0.0138 0.3181 0.3601
Toxoplasma gondii transporter, solute:sodium symporter (SSS) family protein 0.0046 0.0931 0.1041
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0041 0.0041
Echinococcus granulosus cpg binding protein 0.0031 0.0552 0.0552
Onchocerca volvulus Huntingtin homolog 0.0123 0.282 0.3229
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.002 0.0284 0.0208
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.021 0.4949 0.5705
Loa Loa (eye worm) DNA polymerase epsilon catalytic subunit 0.0057 0.1205 0.1353
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0013 0.0118 0.0086
Loa Loa (eye worm) hypoxia-induced factor 1 0.0152 0.3512 0.4034
Echinococcus multilocularis sodium:myo inositol cotransporter 0.0181 0.4246 0.4246
Echinococcus granulosus ecdysone induced protein 78C 0.001 0.0041 0.0041
Brugia malayi CXXC zinc finger family protein 0.0029 0.0511 0.0547
Plasmodium falciparum DNA polymerase epsilon catalytic subunit A, putative 0.0072 0.1555 0.152
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0017 0.0217 0.0217
Loa Loa (eye worm) hypothetical protein 0.0017 0.0217 0.0204
Echinococcus granulosus Aryl hydrocarbon receptor nuclear 0.0013 0.0107 0.0107
Brugia malayi Nuclear hormone receptor family member nhr-41 0.001 0.0041 0.0001
Onchocerca volvulus DNA polymerase alpha catalytic subunit homolog 0.019 0.4447 0.5121
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0054 0.1129 0.1264
Schistosoma mansoni cpg binding protein 0.0029 0.0511 0.0511
Loa Loa (eye worm) hypothetical protein 0.0054 0.1129 0.1264
Trypanosoma brucei DNA polymerase alpha catalytic subunit 0.0138 0.3181 0.3465
Trypanosoma brucei DNA polymerase epsilon catalytic subunit, putative 0.0129 0.2965 0.3207
Brugia malayi ecdysteroid receptor 0.001 0.0041 0.0001
Brugia malayi hypoxia-induced factor 1 0.0152 0.3512 0.4035
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0021 0.0298 0.0298
Echinococcus multilocularis sodium coupled monocarboxylate transporter 1 0.0046 0.0931 0.0931
Trichomonas vaginalis DNA polymerase delta catalytic subunit, putative 0.0129 0.2965 0.3348
Loa Loa (eye worm) DNA-directed DNA polymerase III 0.0361 0.8644 1
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0026 0.0434 0.0434
Loa Loa (eye worm) ATP-dependent DNA helicase 0.002 0.0284 0.0282
Echinococcus multilocularis Aryl hydrocarbon receptor nuclear 0.0013 0.0107 0.0107
Brugia malayi cytoplasmic intermediate filament protein 0.0029 0.0504 0.0538
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.1038 0.1091

Activities

Activity type Activity value Assay description Source Reference
EC50 (binding) = 540 nM Inhibition of human SGLT2 expressed in CHO cells assessed as intracellular accumulation of [14C]alpha-methyl glucopyranoside ChEMBL. 18707880

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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