Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | Chorion peroxidase homolog | 0.0276 | 1 | 1 |
Schistosoma mansoni | peroxidasin | 0.0276 | 1 | 1 |
Schistosoma mansoni | peroxidasin | 0.0276 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0276 | 1 | 0.5 |
Onchocerca volvulus | Peroxidasin homolog | 0.0276 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0276 | 1 | 0.5 |
Onchocerca volvulus | 0.0276 | 1 | 1 | |
Loa Loa (eye worm) | animal heme peroxidase | 0.0276 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0276 | 1 | 0.5 |
Plasmodium falciparum | cytochrome c oxidase subunit 2, putative | 0.0047 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0276 | 1 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0276 | 1 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0276 | 1 | 0.5 |
Mycobacterium ulcerans | transmembrane cytochrome C oxidase (subunit II) CtaC | 0.0047 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0276 | 1 | 0.5 |
Brugia malayi | Peroxidasin | 0.0276 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0276 | 1 | 0.5 |
Mycobacterium tuberculosis | Probable transmembrane cytochrome C oxidase (subunit II) CtaC | 0.0047 | 0 | 0.5 |
Brugia malayi | Blistered cuticle protein 3 | 0.0276 | 1 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0276 | 1 | 0.5 |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.0276 | 1 | 0.5 |
Onchocerca volvulus | Peroxidase homolog | 0.0276 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0276 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0276 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0276 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0276 | 1 | 0.5 |
Onchocerca volvulus | Dual oxidase homolog | 0.0276 | 1 | 1 |
Schistosoma mansoni | cytochrome c oxidase subunit II | 0.0127 | 0.3479 | 0.3479 |
Wolbachia endosymbiont of Brugia malayi | cytochrome c oxidase, subunit 2 | 0.0155 | 0.4702 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0276 | 1 | 0.5 |
Onchocerca volvulus | Peroxidase homolog | 0.0276 | 1 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0276 | 1 | 0.5 |
Onchocerca volvulus | 0.0276 | 1 | 1 | |
Toxoplasma gondii | cytochrome C oxidase subunit IIb, putative | 0.0047 | 0 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0276 | 1 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0276 | 1 | 0.5 |
Echinococcus granulosus | peroxidasin | 0.0276 | 1 | 1 |
Plasmodium vivax | conserved Plasmodium protein, unknown function | 0.0108 | 0.2665 | 1 |
Echinococcus multilocularis | peroxidasin | 0.0276 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0276 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0276 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0276 | 1 | 0.5 |
Onchocerca volvulus | 0.0276 | 1 | 1 | |
Onchocerca volvulus | Peroxidasin homolog | 0.0276 | 1 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0276 | 1 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0276 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
pKb (functional) | = 4.54 | Antagonist activity at rat histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay | ChEMBL. | 18811133 |
pKb (functional) | = 5.53 | Antagonist activity at human histamine H4 receptor expressed in HEK293 cells coexpressing Gqi5 protein assessed as calcium flux by FLIPR assay | ChEMBL. | 18811133 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.