Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | nitric oxide synthase 2, inducible | Starlite/ChEMBL | References |
Mus musculus | nitric oxide synthase 2, inducible | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0065 | 1 | 0.5 |
Trypanosoma cruzi | p450 reductase, putative | 0.0065 | 1 | 0.5 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0065 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0065 | 1 | 1 |
Trypanosoma cruzi | NADPH-dependent FMN/FAD containing oxidoreductase, putative | 0.0065 | 1 | 0.5 |
Leishmania major | p450 reductase, putative | 0.0065 | 1 | 1 |
Schistosoma mansoni | cytochrome P450 reductase | 0.0065 | 1 | 1 |
Mycobacterium ulcerans | formate dehydrogenase H FdhF | 0.0065 | 1 | 0.5 |
Plasmodium falciparum | nitric oxide synthase, putative | 0.0065 | 1 | 0.5 |
Trypanosoma brucei | NADPH-cytochrome p450 reductase, putative | 0.0065 | 1 | 0.5 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.0065 | 1 | 1 |
Schistosoma mansoni | 5-methyl tetrahydrofolate-homocysteine methyltransferase reductase | 0.004 | 0.2291 | 0.2291 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0065 | 1 | 0.5 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0065 | 1 | 0.5 |
Plasmodium vivax | NADPH-cytochrome p450 reductase, putative | 0.0065 | 1 | 1 |
Giardia lamblia | Hypothetical protein | 0.0057 | 0.7709 | 0.5 |
Brugia malayi | FAD binding domain containing protein | 0.0065 | 1 | 1 |
Giardia lamblia | Nitric oxide synthase, inducible | 0.0057 | 0.7709 | 0.5 |
Echinococcus granulosus | NADPH dependent diflavin oxidoreductase 1 | 0.0065 | 1 | 1 |
Leishmania major | NADPH-cytochrome p450 reductase-like protein | 0.0065 | 1 | 1 |
Chlamydia trachomatis | sulfite reductase | 0.004 | 0.2291 | 0.5 |
Echinococcus granulosus | NADPH cytochrome P450 reductase | 0.0065 | 1 | 1 |
Echinococcus multilocularis | NADPH dependent diflavin oxidoreductase 1 | 0.0065 | 1 | 1 |
Trichomonas vaginalis | sulfite reductase, putative | 0.0065 | 1 | 1 |
Echinococcus multilocularis | NADPH cytochrome P450 reductase | 0.0065 | 1 | 1 |
Trypanosoma brucei | NADPH-dependent diflavin oxidoreductase 1 | 0.0065 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | = 20 % | Reduction of plasma nitrate level in LPS-challenged BALB/c mouse at 30 mg/kg, po | ChEMBL. | 19374401 |
Cp (ADMET) | = 39 ng/ml | Drug level in LPS-challenged BALB/c mouse plasma at 30 mg/kg, po after 6 hrs | ChEMBL. | 19374401 |
EC50 (binding) | = 0.087 uM | Inhibition of human iNOS expressed in HEK293 cells assessed as NO production by transient transfection assay | ChEMBL. | 19374401 |
EC50 (binding) | = 0.66 uM | Inhibition of mouse iNOS expressed in HEK293 cells assessed as NO production in by transient transfection assay | ChEMBL. | 19374401 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.