Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Protein kinase domain containing protein | 0.0046 | 0.023 | 0.0897 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0107 | 0.1501 | 0.1301 |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.0107 | 0.1501 | 0.1301 |
Trichomonas vaginalis | AGC family protein kinase | 0.0046 | 0.023 | 1 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.0116 | 0.168 | 0.62 |
Loa Loa (eye worm) | hypothetical protein | 0.0107 | 0.1501 | 0.1301 |
Loa Loa (eye worm) | hypothetical protein | 0.0107 | 0.1501 | 0.1301 |
Loa Loa (eye worm) | hypothetical protein | 0.0107 | 0.1501 | 0.1301 |
Toxoplasma gondii | AGC kinase | 0.0046 | 0.023 | 0.5 |
Trichomonas vaginalis | AGC family protein kinase | 0.0046 | 0.023 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0501 | 0.9712 | 0.9705 |
Trypanosoma brucei | rac serine-threonine kinase, putative | 0.0046 | 0.023 | 0.5 |
Brugia malayi | Calcium/calmodulin-dependent protein kinase type II alpha chain | 0.0125 | 0.1874 | 0.7296 |
Echinococcus granulosus | protein kinase C gamma type | 0.0048 | 0.026 | 0.0127 |
Trichomonas vaginalis | AGC family protein kinase | 0.0046 | 0.023 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0107 | 0.1501 | 0.1301 |
Echinococcus multilocularis | serine:threonine protein kinase N2 | 0.0124 | 0.1861 | 0.6975 |
Brugia malayi | Animal haem peroxidase family protein | 0.0107 | 0.1501 | 0.5844 |
Echinococcus granulosus | calcium:calmodulin dependent protein kinase type | 0.0143 | 0.2256 | 0.8665 |
Schistosoma mansoni | serine/threonine protein kinase | 0.008 | 0.0938 | 0.3025 |
Entamoeba histolytica | PH domain containing protein kinase, putative | 0.0079 | 0.0923 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0046 | 0.023 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0046 | 0.023 | 1 |
Brugia malayi | p70 ribosomal S6 kinase beta | 0.0046 | 0.023 | 0.0897 |
Brugia malayi | Animal haem peroxidase family protein | 0.0107 | 0.1501 | 0.5844 |
Echinococcus multilocularis | Protein kinase C, brain isozyme | 0.008 | 0.0938 | 0.3025 |
Echinococcus granulosus | protein kinase c epsilon type | 0.0158 | 0.2568 | 1 |
Brugia malayi | protein kinase C II. | 0.0158 | 0.2568 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0158 | 0.2568 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0468 | 0.9034 | 0.9012 |
Loa Loa (eye worm) | AGC/PKC/ETA protein kinase | 0.0158 | 0.2568 | 0.2393 |
Schistosoma mansoni | lipoxygenase | 0.0116 | 0.168 | 0.62 |
Loa Loa (eye worm) | hypothetical protein | 0.0107 | 0.1501 | 0.1301 |
Trichomonas vaginalis | AGC family protein kinase | 0.0046 | 0.023 | 1 |
Brugia malayi | Peroxidasin | 0.0107 | 0.1501 | 0.5844 |
Loa Loa (eye worm) | hypothetical protein | 0.0107 | 0.1501 | 0.1301 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0107 | 0.1501 | 0.1301 |
Schistosoma mansoni | protein kinase | 0.0143 | 0.2256 | 0.8665 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0107 | 0.1501 | 0.1301 |
Trichomonas vaginalis | AGC family protein kinase | 0.0046 | 0.023 | 1 |
Schistosoma mansoni | peroxidasin | 0.0107 | 0.1501 | 0.5435 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0107 | 0.1501 | 0.1301 |
Echinococcus granulosus | serine:threonine protein kinase N2 | 0.0079 | 0.0923 | 0.2964 |
Loa Loa (eye worm) | hypothetical protein | 0.0107 | 0.1501 | 0.1301 |
Loa Loa (eye worm) | hypothetical protein | 0.0107 | 0.1501 | 0.1301 |
Schistosoma mansoni | protein kinase | 0.0143 | 0.2256 | 0.8665 |
Echinococcus multilocularis | serine threonine protein kinase | 0.0048 | 0.026 | 0.0127 |
Echinococcus granulosus | peroxidasin | 0.0107 | 0.1501 | 0.5435 |
Trichomonas vaginalis | AGC family protein kinase | 0.0046 | 0.023 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0107 | 0.1501 | 0.1301 |
Brugia malayi | Protein kinase domain containing protein | 0.0046 | 0.023 | 0.0897 |
Echinococcus granulosus | protein kinase c iota type | 0.0079 | 0.0908 | 0.2898 |
Loa Loa (eye worm) | hypothetical protein | 0.0107 | 0.1501 | 0.1301 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | 0.0116 | 0.168 | 0.62 |
Echinococcus multilocularis | peroxidasin | 0.0107 | 0.1501 | 0.5435 |
Echinococcus granulosus | Protein kinase C brain isozyme | 0.008 | 0.0938 | 0.3025 |
Schistosoma mansoni | peroxidasin | 0.0107 | 0.1501 | 0.5435 |
Brugia malayi | Hr1 repeat family protein | 0.0046 | 0.023 | 0.0897 |
Brugia malayi | hypothetical protein | 0.0107 | 0.1501 | 0.5844 |
Echinococcus multilocularis | protein kinase c iota type | 0.0079 | 0.0908 | 0.2898 |
Brugia malayi | Animal haem peroxidase family protein | 0.0107 | 0.1501 | 0.5844 |
Brugia malayi | Blistered cuticle protein 3 | 0.0107 | 0.1501 | 0.5844 |
Echinococcus multilocularis | protein kinase c epsilon type | 0.0158 | 0.2568 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0107 | 0.1501 | 0.5844 |
Loa Loa (eye worm) | hypothetical protein | 0.0468 | 0.9034 | 0.9012 |
Schistosoma mansoni | protein kinase | 0.0143 | 0.2256 | 0.8665 |
Trichomonas vaginalis | AGC family protein kinase | 0.0046 | 0.023 | 1 |
Echinococcus multilocularis | calcium:calmodulin dependent protein kinase type | 0.0143 | 0.2256 | 0.8665 |
Loa Loa (eye worm) | hypothetical protein | 0.0107 | 0.1501 | 0.1301 |
Trichomonas vaginalis | AGC family protein kinase | 0.0046 | 0.023 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0046 | 0.023 | 1 |
Loa Loa (eye worm) | calcium/calmodulin-dependent protein kinase subunit type II alpha | 0.0125 | 0.1874 | 0.1682 |
Loa Loa (eye worm) | hypothetical protein | 0.0468 | 0.9034 | 0.9012 |
Schistosoma mansoni | lipoxygenase | 0.0081 | 0.0953 | 0.3092 |
Loa Loa (eye worm) | hypothetical protein | 0.0107 | 0.1501 | 0.1301 |
Schistosoma mansoni | atypical protein kinase C | 0.0079 | 0.0908 | 0.2898 |
Loa Loa (eye worm) | hypothetical protein | 0.0107 | 0.1501 | 0.1301 |
Schistosoma mansoni | serine/threonine protein kinase | 0.008 | 0.0938 | 0.3025 |
Brugia malayi | Animal haem peroxidase family protein | 0.0107 | 0.1501 | 0.5844 |
Loa Loa (eye worm) | hypothetical protein | 0.0107 | 0.1501 | 0.1301 |
Brugia malayi | Protein kinase domain containing protein | 0.0046 | 0.023 | 0.0897 |
Onchocerca volvulus | 0.0468 | 0.9034 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | = 55 % | Inhibition of human TERT expressed in BJ1 cells at 1 uM after 24 hrs by SEAP assay realtive to control | ChEMBL. | 18571928 |
Inhibition (binding) | = 60 % | Inhibition of human TERT expressed in BJ1 cells at 10 uM after 24 hrs by SEAP assay realtive to control | ChEMBL. | 18571928 |
Inhibition (binding) | = 62 % | Inhibition of human TERT expressed in H1299 cells at 100 uM after 24 hrs by SEAP assay realtive to control | ChEMBL. | 18571928 |
Inhibition (binding) | = 65 % | Inhibition of human TERT expressed in BJ1 cells at 100 uM after 24 hrs by SEAP assay realtive to control | ChEMBL. | 18571928 |
Inhibition (binding) | = 85 % | Inhibition of human TERT expressed in H1299 cells at 10 uM after 24 hrs by SEAP assay realtive to control | ChEMBL. | 18571928 |
Inhibition (ADMET) | = 86 % | Cytotoxicity against human TERT immortalized BJ1 cells at 100 uM after 48 hrs by MTT assay relative to control | ChEMBL. | 18571928 |
Inhibition (binding) | = 87 % | Inhibition of human TERT expressed in H1299 cells at 1 uM after 24 hrs by SEAP assay realtive to control | ChEMBL. | 18571928 |
Inhibition (ADMET) | = 91 % | Cytotoxicity against human TERT immortalized BJ1 cells at 10 uM after 48 hrs by MTT assay relative to control | ChEMBL. | 18571928 |
Inhibition (ADMET) | = 91 % | Cytotoxicity against human TERT immortalized BJ1 cells at 1 uM after 48 hrs by MTT assay relative to control | ChEMBL. | 18571928 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.