Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Metabotropic glutamate receptor 5 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0119 | 0.2574 | 1 |
Treponema pallidum | NADH oxidase | 0.0041 | 0.0312 | 0.5 |
Trypanosoma brucei | trypanothione reductase | 0.0118 | 0.2529 | 1 |
Loa Loa (eye worm) | glutathione reductase | 0.0118 | 0.2529 | 1 |
Plasmodium vivax | glutathione reductase, putative | 0.0118 | 0.2529 | 1 |
Schistosoma mansoni | metabotropic glutamate receptor 2 3 (mglur group 2) | 0.0056 | 0.0739 | 0.0441 |
Leishmania major | trypanothione reductase | 0.0118 | 0.2529 | 1 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0041 | 0.0312 | 0.5 |
Echinococcus granulosus | metabotropic glutamate receptor 2 | 0.0041 | 0.0317 | 0.0022 |
Plasmodium falciparum | thioredoxin reductase | 0.0118 | 0.2529 | 1 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0268 | 0.6874 | 0.8837 |
Echinococcus granulosus | metabotropic glutamate receptor 5 | 0.006 | 0.0871 | 0.2473 |
Echinococcus multilocularis | metabotropic glutamate receptor 5 | 0.006 | 0.0871 | 0.2473 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0118 | 0.2529 | 1 |
Brugia malayi | metabotropic glutamate receptor subtype 5a (mGluR5a), putative | 0.0044 | 0.0413 | 0.1634 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0118 | 0.2529 | 0.2985 |
Brugia malayi | Metabotropic glutamate receptor precursor. | 0.0049 | 0.0546 | 0.2158 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.0871 | 0.1642 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0298 | 0.7738 | 1 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0268 | 0.6874 | 0.8837 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase | 0.0041 | 0.0312 | 0.5 |
Plasmodium falciparum | glutathione reductase | 0.0118 | 0.2529 | 1 |
Echinococcus multilocularis | metabotropic glutamate receptor 2 | 0.0041 | 0.0317 | 0.0022 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0041 | 0.0312 | 0.5 |
Trichomonas vaginalis | mercuric reductase, putative | 0.0041 | 0.0312 | 0.5 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0298 | 0.7738 | 1 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0118 | 0.2529 | 1 |
Brugia malayi | Thioredoxin reductase | 0.0118 | 0.2529 | 1 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0298 | 0.7738 | 1 |
Mycobacterium tuberculosis | Probable reductase | 0.0268 | 0.6874 | 0.8837 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0268 | 0.6874 | 0.8837 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0298 | 0.7738 | 1 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0268 | 0.6874 | 0.8837 |
Trichomonas vaginalis | glutathione reductase, putative | 0.0041 | 0.0312 | 0.5 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase, LpdB | 0.0041 | 0.0312 | 0.5 |
Brugia malayi | glutathione reductase | 0.0118 | 0.2529 | 1 |
Toxoplasma gondii | thioredoxin reductase | 0.0118 | 0.2529 | 1 |
Chlamydia trachomatis | dihydrolipoyl dehydrogenase | 0.0041 | 0.0312 | 0.5 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0118 | 0.2529 | 1 |
Brugia malayi | dihydrolipoyl dehydrogenase, mitochondrial precursor, putative | 0.0041 | 0.0312 | 0.1234 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0268 | 0.6874 | 0.8837 |
Giardia lamblia | NADH oxidase lateral transfer candidate | 0.0041 | 0.0312 | 0.5 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0119 | 0.2574 | 1 |
Schistosoma mansoni | metabotropic glutamate receptor | 0.0041 | 0.0317 | 0.0005 |
Mycobacterium ulcerans | flavoprotein disulfide reductase | 0.0041 | 0.0312 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | > 3000 nM | Antagonist activity at rat mGluR5 expressed in HEK293A cells assessed as glutamate-induced calcium flux preincubated for 140 sec before glutamate challenge by calcium fluorescence assay | ChEMBL. | 19445453 |
Inhibition (functional) | > 70 % | Antagonist activity at cloned mGluR5 expressed in CHO cells co-transfected with chimeric G protein Gqi9 assessed as inhibition of glutamate-induced intracellular inositol phosphate accumulation at 10 uM by phosphoinositide hydrolysis assay | ChEMBL. | 19445453 |
Inhibition (functional) | < 70 % | Antagonist activity at cloned mGluR1 expressed in CHO cells co-transfected with chimeric G protein Gqi9 assessed as inhibition of glutamate-induced intracellular inositol phosphate accumulation at 10 uM by phosphoinositide hydrolysis assay | ChEMBL. | 19445453 |
Inhibition (functional) | < 70 % | Antagonist activity at cloned mGluR6 expressed in CHO cells co-transfected with chimeric G protein Gqi9 assessed as inhibition of glutamate-induced intracellular inositol phosphate accumulation at 10 uM by phosphoinositide hydrolysis assay | ChEMBL. | 19445453 |
Ki (binding) | = 2480 nM | Displacement of [3H]MPEP from rat brain recombinant mGluR5 expressed in HEK293T cells by scintillation counting | ChEMBL. | 19445453 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.