Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | CMGC/CDK/CDC2 protein kinase | 0.00489717 | 0.0695471 | 0.0695471 |
Leishmania major | glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 | 0.0252804 | 1 | 1 |
Trypanosoma cruzi | cdc2-related kinase 1 | 0.00489717 | 0.0695471 | 0.0695471 |
Echinococcus granulosus | glycogen synthase kinase 3 beta | 0.0252804 | 1 | 1 |
Mycobacterium ulcerans | enoyl-(acyl carrier protein) reductase | 0.0122639 | 0.405824 | 1 |
Brugia malayi | intracellular kinase | 0.0252804 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | enoyl-ACP reductase | 0.0122639 | 0.405824 | 0.5 |
Chlamydia trachomatis | enoyl-acyl-carrier protein reductase | 0.0122639 | 0.405824 | 0.5 |
Plasmodium falciparum | enoyl-acyl carrier reductase | 0.0122639 | 0.405824 | 0.361412 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0252804 | 1 | 1 |
Loa Loa (eye worm) | CMGC/GSK protein kinase | 0.0252804 | 1 | 1 |
Mycobacterium leprae | NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) | 0.0122639 | 0.405824 | 0.5 |
Trypanosoma cruzi | cdc2-related kinase 3 | 0.00489717 | 0.0695471 | 0.0695471 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0252804 | 1 | 1 |
Onchocerca volvulus | 0.0252804 | 1 | 0.5 | |
Trypanosoma brucei | cdc2-related kinase 3 | 0.00489717 | 0.0695471 | 0.0695471 |
Echinococcus multilocularis | protein kinase shaggy | 0.0252804 | 1 | 1 |
Loa Loa (eye worm) | CMGC/CDK/CDK5 protein kinase | 0.00489717 | 0.0695471 | 0.0695471 |
Plasmodium vivax | enoyl-acyl carrier protein reductase | 0.0122639 | 0.405824 | 0.361412 |
Toxoplasma gondii | enoyl-acyl carrier reductase ENR | 0.0122639 | 0.405824 | 0.361412 |
Giardia lamblia | Kinase, CMGC GSK | 0.0252804 | 1 | 1 |
Trypanosoma cruzi | cdc2-related kinase 3 | 0.00489717 | 0.0695471 | 0.0695471 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0252804 | 1 | 1 |
Trichomonas vaginalis | hypothetical protein | 0.0122639 | 0.405824 | 0.361412 |
Loa Loa (eye worm) | hypothetical protein | 0.00460536 | 0.0562266 | 0.0562266 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0252804 | 1 | 1 |
Loa Loa (eye worm) | CMGC/GSK protein kinase | 0.0252804 | 1 | 1 |
Brugia malayi | Cytochrome P450 family protein | 0.00585279 | 0.113169 | 0.113169 |
Leishmania major | cell division related protein kinase 2,cdc2-related kinase | 0.00489717 | 0.0695471 | 0.0695471 |
Loa Loa (eye worm) | CMGC/CDK/CDC2 protein kinase | 0.00489717 | 0.0695471 | 0.0695471 |
Giardia lamblia | Kinase, CMGC GSK | 0.0252804 | 1 | 1 |
Trypanosoma cruzi | cdc2-related kinase 1 | 0.00489717 | 0.0695471 | 0.0695471 |
Trypanosoma brucei | protein kinase, putative | 0.0252804 | 1 | 1 |
Brugia malayi | Protein kinase domain containing protein | 0.00489717 | 0.0695471 | 0.0695471 |
Echinococcus multilocularis | glycogen synthase kinase 3 beta | 0.0252804 | 1 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.0252804 | 1 | 1 |
Leishmania major | cell division protein kinase 2,cdc2-related kinase | 0.00489717 | 0.0695471 | 0.0695471 |
Brugia malayi | cell division control protein 2 homolog | 0.00489717 | 0.0695471 | 0.0695471 |
Echinococcus granulosus | protein kinase shaggy | 0.0252804 | 1 | 1 |
Plasmodium falciparum | glycogen synthase kinase 3 | 0.0252804 | 1 | 1 |
Plasmodium vivax | glycogen synthase kinase 3, putative | 0.0252804 | 1 | 1 |
Trypanosoma cruzi | glycogen synthase kinase 3, putative | 0.0252804 | 1 | 1 |
Schistosoma mansoni | glycogen synthase kinase 3-related (gsk3) (cmgc group III) | 0.0252804 | 1 | 1 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.00585279 | 0.113169 | 0.113169 |
Mycobacterium tuberculosis | NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) | 0.0122639 | 0.405824 | 0.5 |
Toxoplasma gondii | cell-cycle-associated protein kinase GSK, putative | 0.0252804 | 1 | 1 |
Trypanosoma brucei | cdc2-related kinase 1 | 0.00489717 | 0.0695471 | 0.0695471 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (binding) | = 7 % | Displacement of [3H]CP-55940 from human recombinant CB1 receptor expressed in HEK293 cells at 1 uM | ChEMBL. | 11678659 |
Activity (binding) | = 10 % | Displacement of [3H]CP-55940 from human recombinant CB1 receptor expressed in HEK293 cells at 0.1 uM | ChEMBL. | 11678659 |
IC50 (functional) | = 600 ng/ml | Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2 by LDH reporter assay | ChEMBL. | 11678659 |
IC50 (functional) | = 1500 ng/ml | Antimalarial activity against chloroquine-sensitive Plasmodium falciparum D6 by LDH reporter assay | ChEMBL. | 11678659 |
IC50 (functional) | = 50 ug ml-1 | Antibacterial activity against Cryptococcus neoformans ATCC 90113 after 48 hrs by microplate assay | ChEMBL. | 11678659 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 | 11678659 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.