TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 414.41 | Formula: C24H18N2O5
H donors: 2 H acceptors: 4 LogP: 2.81 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: OC(=O)CCc1cccc2c1n(C)cc2C1=C(C(=O)NC1=O)c1coc2c1cccc2
InChi: 1S/C24H18N2O5/c1-26-11-16(15-7-4-5-13(22(15)26)9-10-19(27)28)20-21(24(30)25-23(20)29)17-12-31-18-8-3-2-6-14(17)18/h2-8,11-12H,9-10H2,1H3,(H,27,28)(H,25,29,30)
InChiKey: WLCGQIDCJUYXSX-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	glycogen synthase kinase 3 beta	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Giardia lamblia	Kinase, CMGC GSK	Get druggable targets OG5_126888	All targets in OG5_126888
Schistosoma japonicum	ko:K08822 glycogen synthase kinase 3 alpha, putative	Get druggable targets OG5_126888	All targets in OG5_126888
Plasmodium vivax	glycogen synthase kinase 3, putative	Get druggable targets OG5_126888	All targets in OG5_126888
Cryptosporidium parvum	hypothetical protein	Get druggable targets OG5_126888	All targets in OG5_126888
Entamoeba histolytica	protein kinase, putative	Get druggable targets OG5_126888	All targets in OG5_126888
Entamoeba histolytica	protein kinase domain containing protein	Get druggable targets OG5_126888	All targets in OG5_126888
Brugia malayi	intracellular kinase	Get druggable targets OG5_126888	All targets in OG5_126888
Theileria parva	glycogen synthase kinase, putative	Get druggable targets OG5_126888	All targets in OG5_126888
Echinococcus granulosus	protein kinase shaggy	Get druggable targets OG5_126888	All targets in OG5_126888
Candida albicans	hypothetical protein	Get druggable targets OG5_126888	All targets in OG5_126888
Candida albicans	second truncated form of RIM11 Serine/threonine protein kinase	Get druggable targets OG5_126888	All targets in OG5_126888
Neospora caninum	hypothetical protein	Get druggable targets OG5_126888	All targets in OG5_126888
Loa Loa (eye worm)	CMGC/GSK protein kinase	Get druggable targets OG5_126888	All targets in OG5_126888
Plasmodium falciparum	glycogen synthase kinase 3	Get druggable targets OG5_126888	All targets in OG5_126888
Plasmodium berghei	glycogen synthase kinase 3, putative	Get druggable targets OG5_126888	All targets in OG5_126888
Echinococcus multilocularis	protein kinase shaggy	Get druggable targets OG5_126888	All targets in OG5_126888
Leishmania major	glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270	Get druggable targets OG5_126888	All targets in OG5_126888
Cryptosporidium hominis	hypothetical protein	Get druggable targets OG5_126888	All targets in OG5_126888
Trypanosoma brucei	protein kinase, putative	Get druggable targets OG5_126888	All targets in OG5_126888
Babesia bovis	protein kinase domain containing protein	Get druggable targets OG5_126888	All targets in OG5_126888
Trichomonas vaginalis	CMGC family protein kinase	Get druggable targets OG5_126888	All targets in OG5_126888
Echinococcus granulosus	glycogen synthase kinase 3 beta	Get druggable targets OG5_126888	All targets in OG5_126888
Candida albicans	second truncated form of RIM11 Serine/threonine protein kinase	Get druggable targets OG5_126888	All targets in OG5_126888
Leishmania donovani	glycogen synthase kinase 3, putative	Get druggable targets OG5_126888	All targets in OG5_126888
Trypanosoma cruzi	glycogen synthase kinase 3, putative	Get druggable targets OG5_126888	All targets in OG5_126888
Leishmania mexicana	protein kinase, putative,glycogen synthase kinase, putative	Get druggable targets OG5_126888	All targets in OG5_126888
Trypanosoma congolense	protein kinase, putative	Get druggable targets OG5_126888	All targets in OG5_126888
Giardia lamblia	Kinase, CMGC GSK	Get druggable targets OG5_126888	All targets in OG5_126888
Toxoplasma gondii	cell-cycle-associated protein kinase GSK, putative	Get druggable targets OG5_126888	All targets in OG5_126888
Entamoeba histolytica	protein kinase domain containing protein	Get druggable targets OG5_126888	All targets in OG5_126888
Plasmodium knowlesi	glycogen synthase kinase 3, putative	Get druggable targets OG5_126888	All targets in OG5_126888
Plasmodium yoelii	Protein kinase domain, putative	Get druggable targets OG5_126888	All targets in OG5_126888
Trypanosoma brucei gambiense	protein kinase, putative,glycogen synthase kinase, putative	Get druggable targets OG5_126888	All targets in OG5_126888
Trichomonas vaginalis	CMGC family protein kinase	Get druggable targets OG5_126888	All targets in OG5_126888
Leishmania braziliensis	protein kinase, putative,glycogen synthase kinase, putative	Get druggable targets OG5_126888	All targets in OG5_126888
Candida albicans	Serine/threonine protein kinase required for induction of IME2 by Ime1p	Get druggable targets OG5_126888	All targets in OG5_126888
Schistosoma mansoni	glycogen synthase kinase 3-related (gsk3) (cmgc group III)	Get druggable targets OG5_126888	All targets in OG5_126888
Echinococcus multilocularis	glycogen synthase kinase 3 beta	Get druggable targets OG5_126888	All targets in OG5_126888
Loa Loa (eye worm)	CMGC/GSK protein kinase	Get druggable targets OG5_126888	All targets in OG5_126888
Leishmania infantum	glycogen synthase kinase 3	Get druggable targets OG5_126888	All targets in OG5_126888
Onchocerca volvulus		Get druggable targets OG5_126888	All targets in OG5_126888

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.001	0.0028	0.0022
Mycobacterium tuberculosis	Probable NADPH:adrenodoxin oxidoreductase FprB (adrenodoxin reductase) (AR) (ferredoxin-NADP(+) reductase)	0.0009	0.0013	0.0044
Onchocerca volvulus	Protein ultraspiracle homolog	0.001	0.0028	0.0072
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0098	0.1074	0.1063
Echinococcus granulosus	snurportin 1	0.0329	0.3805	0.3798
Trypanosoma cruzi	glycogen synthase kinase 3, putative	0.0058	0.0594	0.5476
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0413	0.0567
Trichomonas vaginalis	GTP-binding protein (z) alpha subunit, gnaz, putative	0.001	0.0028	0.0263
Echinococcus granulosus	guanine nucleotide binding protein G protein	0.001	0.0028	0.0015
Trypanosoma brucei	protein kinase, putative	0.0058	0.0594	0.5476
Toxoplasma gondii	thioredoxin reductase	0.0098	0.1074	1
Toxoplasma gondii	GTP-binding nuclear protein ran/tc4	0.0023	0.0174	0.1521
Toxoplasma gondii	type I fatty acid synthase, putative	0.0018	0.012	0.1015
Schistosoma mansoni	coup transcription factor	0.001	0.0028	0.0015
Schistosoma mansoni	ran	0.0023	0.0174	0.0162
Echinococcus granulosus	regulator of G protein signaling 7	0.0009	0.0015	0.0002
Echinococcus multilocularis	segment polarity protein dishevelled	0.0009	0.0015	0.0002
Mycobacterium leprae	PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC	0.0027	0.0226	0.0789
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.001	0.0028	0.0022
Loa Loa (eye worm)	G protein alpha subunit 3	0.001	0.0028	0.0022
Echinococcus multilocularis	guanine nucleotide binding protein subunit	0.001	0.0028	0.0015
Mycobacterium tuberculosis	Phenolpthiocerol synthesis type-I polyketide synthase PpsD	0.0025	0.0207	0.0723
Leishmania major	acetoin dehydrogenase e3 component-like protein	0.0034	0.031	0.2803
Schistosoma mansoni	hypothetical protein	0.0329	0.3805	0.3798
Schistosoma mansoni	GTP-binding protein (I) alpha-2 subunit gnai2	0.001	0.0028	0.0015
Echinococcus granulosus	GPCR family 2	0.0051	0.0508	0.0496
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.001	0.0028	0.0022
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0034	0.031	0.2803
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0034	0.031	0.2803
Mycobacterium tuberculosis	Polyketide synthase Pks2	0.0025	0.0198	0.0691
Schistosoma mansoni	GTP-binding protein (I) alpha-1subunit gnai1	0.001	0.0028	0.0015
Schistosoma mansoni	smad	0.0041	0.0394	0.0382
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0015	0.0003
Schistosoma mansoni	Smad4	0.0018	0.0124	0.0111
Echinococcus multilocularis	expressed protein	0.001	0.0028	0.0015
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0015	0.0003
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.001	0.0028	0.0015
Schistosoma mansoni	hypothetical protein	0.0051	0.0508	0.0496
Mycobacterium tuberculosis	Polyketide synthase Pks13	0.0038	0.0357	0.1244
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.001	0.0028	0.0015
Schistosoma mansoni	Smad4	0.0041	0.0394	0.0382
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0175	0.023
Schistosoma mansoni	dihydrolipoamide dehydrogenase	0.0034	0.031	0.0298
Brugia malayi	MH1 domain containing protein	0.0041	0.0394	0.054
Trypanosoma brucei	GTP-binding nuclear protein rtb2, putative	0.0023	0.0174	0.1521
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.001	0.0028	0.0015
Brugia malayi	glutathione reductase	0.0098	0.1074	0.1502
Plasmodium falciparum	importin beta, putative	0.0031	0.027	0.243
Loa Loa (eye worm)	DIX domain-containing protein	0.0009	0.0015	0.0003
Plasmodium vivax	glutathione reductase, putative	0.0098	0.1074	1
Echinococcus multilocularis	dihydrolipoamide dehydrogenase	0.0034	0.031	0.0298
Echinococcus granulosus	regulator of G protein signaling 7	0.0009	0.0015	0.0002
Schistosoma mansoni	dishevelled	0.0009	0.0015	0.0002
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.001	0.0028	0.0015
Leishmania major	glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270	0.0058	0.0594	0.5476
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	0.0023	0.0174	0.1521
Schistosoma mansoni	hypothetical protein	0.0851	1	1
Brugia malayi	RNA, U transporter 1	0.0088	0.0944	0.1318
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0051	0.0508	0.0496
Brugia malayi	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein	0.0025	0.0203	0.0269
Trichomonas vaginalis	G protein (olf) alpha subunit, gnal, putative	0.001	0.0028	0.0263
Brugia malayi	hypothetical protein	0.0009	0.0015	0.0003
Loa Loa (eye worm)	hypothetical protein	0.001	0.0028	0.0022
Mycobacterium ulcerans	NADH dehydrogenase Ndh	0.0009	0.0013	0.0351
Echinococcus granulosus	Pleckstrin G protein interacting region	0.0009	0.0015	0.0002
Mycobacterium leprae	PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB	0.0021	0.0148	0.0517
Loa Loa (eye worm)	hypothetical protein	0.001	0.0028	0.0022
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0241	0.2763	0.3892
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.001	0.0028	0.0022
Loa Loa (eye worm)	CMGC/GSK protein kinase	0.0058	0.0594	0.0822
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.001	0.0028	0.0022
Trichomonas vaginalis	CMGC family protein kinase	0.0058	0.0594	1
Entamoeba histolytica	G protein alpha subunit, putative	0.001	0.0028	0.0263
Trypanosoma brucei	trypanothione reductase	0.0098	0.1074	1
Brugia malayi	Domain found in Dishevelled, Egl-10, and Pleckstrin family protein	0.0009	0.0015	0.0003
Brugia malayi	Beta-ketoacyl synthase, N-terminal domain containing protein	0.0025	0.0207	0.0276
Plasmodium vivax	dihydrolipoyl dehydrogenase, mitochondrial, putative	0.0034	0.031	0.2803
Mycobacterium ulcerans	polyketide synthase	0.0025	0.0207	0.581
Brugia malayi	guanine nucleotide-binding protein alpha-3 subunit, putative	0.001	0.0028	0.0022
Echinococcus multilocularis	GTP binding nuclear protein Ran	0.0023	0.0174	0.0162
Mycobacterium tuberculosis	Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate	0.0009	0.0013	0.0044
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0034	0.031	0.2803
Echinococcus multilocularis	guanine nucleotide binding protein subunit	0.001	0.0028	0.0015
Mycobacterium ulcerans	polyketide synthase Pks9	0.0017	0.0105	0.2941
Mycobacterium tuberculosis	NADPH:adrenodoxin oxidoreductase FprA (NADPH-ferredoxin reductase)	0.0009	0.0013	0.0044
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	0.0023	0.0174	0.1521
Schistosoma mansoni	GTP-binding protein alpha subunit	0.001	0.0028	0.0015
Echinococcus granulosus	guanine nucleotide binding protein subunit	0.001	0.0028	0.0015
Brugia malayi	Guanine nucleotide-binding protein alpha-12 subunit, putative	0.001	0.0028	0.0022
Mycobacterium ulcerans	phenolpthiocerol synthesis type-I polyketide synthase PpsB	0.0021	0.0148	0.4155
Brugia malayi	Guanine nucleotide-binding protein alpha-6 subunit, putative	0.001	0.0028	0.0022
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0241	0.2763	0.2754
Mycobacterium tuberculosis	Probable thioredoxin reductase TrxB2 (TRXR) (TR)	0.0009	0.0013	0.0044
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0161	0.1811	0.2545
Brugia malayi	nuclear hormone receptor	0.001	0.0028	0.0022
Entamoeba histolytica	protein kinase domain containing protein	0.0058	0.0594	1
Mycobacterium ulcerans	NADPH:adrenodoxin oxidoreductase FprA	0.0009	0.0013	0.0351
Onchocerca volvulus		0.001	0.0028	0.0072
Loa Loa (eye worm)	hypothetical protein	0.001	0.0028	0.0022
Echinococcus granulosus	Smad4	0.0041	0.0394	0.0382
Loa Loa (eye worm)	hypothetical protein	0.001	0.0028	0.0022
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0241	0.2763	0.2754
Echinococcus multilocularis	smad	0.0041	0.0394	0.0382
Schistosoma mansoni	dep domain containing protein	0.0009	0.0015	0.0002
Giardia lamblia	NADH oxidase lateral transfer candidate	0.0034	0.031	0.5119
Mycobacterium ulcerans	phenolpthiocerol synthesis type-I polyketide synthase PpsD	0.0025	0.0207	0.581
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.025	0.2868	1
Loa Loa (eye worm)	hypothetical protein	0.001	0.0028	0.0022
Brugia malayi	hypothetical protein	0.001	0.0028	0.0022
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.001	0.0028	0.0022
Brugia malayi	Nuclear hormone receptor-like 1	0.001	0.0028	0.0022
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0051	0.0508	0.0701
Brugia malayi	intracellular kinase	0.0058	0.0594	0.0822
Schistosoma mansoni	RAR-like nuclear receptor	0.001	0.0028	0.0015
Mycobacterium ulcerans	phenolpthiocerol synthesis type-I polyketide synthase PpsA	0.0021	0.0148	0.4155
Loa Loa (eye worm)	MH1 domain-containing protein	0.0041	0.0394	0.054
Loa Loa (eye worm)	heterotrimeric G protein alpha subunit	0.001	0.0028	0.0022
Treponema pallidum	NADH oxidase	0.0034	0.031	1
Schistosoma mansoni	fyve finger-containing phosphoinositide kinase fyv1	0.0009	0.0015	0.0002
Echinococcus multilocularis	mothers against decapentaplegic 6	0.0018	0.0124	0.0111
Echinococcus granulosus	guanine nucleotide binding protein G protein	0.001	0.0028	0.0015
Mycobacterium ulcerans	flavoprotein disulfide reductase	0.0034	0.031	0.8685
Onchocerca volvulus		0.0024	0.0188	0.0823
Entamoeba histolytica	protein kinase, putative	0.0058	0.0594	1
Schistosoma mansoni	GTP-binding protein (I) alpha subunit gnai	0.001	0.0028	0.0015
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.001	0.0028	0.0015
Mycobacterium tuberculosis	Probable thioesterase TesA	0.0021	0.0157	0.0547
Trichomonas vaginalis	GTP-binding protein alpha subunit, gna, putative	0.001	0.0028	0.0263
Loa Loa (eye worm)	fatty acid synthase	0.0025	0.0203	0.027
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0034	0.031	0.2803
Schistosoma mansoni	smad1 5 8 and	0.0041	0.0394	0.0382
Loa Loa (eye worm)	steroid hormone receptor	0.001	0.0028	0.0022
Schistosoma mansoni	trimeric G-protein alpha o subunit	0.001	0.0028	0.0015
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.001	0.0028	0.0022
Schistosoma mansoni	ran	0.0023	0.0174	0.0162
Mycobacterium ulcerans	polyketide synthase	0.0027	0.0226	0.6337
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0161	0.1811	0.2545
Mycobacterium tuberculosis	Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot	0.0034	0.031	0.1081
Mycobacterium tuberculosis	Probable membrane bound polyketide synthase Pks6	0.0038	0.0357	0.1244
Schistosoma mansoni	thyroid hormone receptor	0.001	0.0028	0.0015
Echinococcus granulosus	gtp binding protein I alpha 1subunit	0.001	0.0028	0.0015
Schistosoma mansoni	nuclear hormone receptor	0.001	0.0028	0.0015
Entamoeba histolytica	Ran family GTPase	0.0023	0.0174	0.2777
Loa Loa (eye worm)	hypothetical protein	0.0161	0.1811	0.2545
Loa Loa (eye worm)	nuclear factor I	0.0023	0.0175	0.023
Trypanosoma cruzi	trypanothione reductase, putative	0.0098	0.1074	1
Echinococcus multilocularis	TGF beta signal transducer SmadC	0.0041	0.0394	0.0382
Mycobacterium ulcerans	NADPH dependent 2,4-dienoyl-CoA reductase FadH	0.0009	0.0013	0.0351
Brugia malayi	Steroid receptor seven-up type 2	0.001	0.0028	0.0022
Schistosoma mansoni	smad1 5 8 and	0.0041	0.0394	0.0382
Brugia malayi	guanine nucleotide-binding protein G(o), alpha subunit, putative	0.001	0.0028	0.0022
Brugia malayi	dihydrolipoyl dehydrogenase, mitochondrial precursor, putative	0.0034	0.031	0.0421
Brugia malayi	Guanine nucleotide-binding protein alpha-3 subunit, putative	0.001	0.0028	0.0022
Schistosoma mansoni	GTP-binding protein alpha subunit gna	0.001	0.0028	0.0015
Trichomonas vaginalis	GTP-binding protein (q) alpha-11 subunit, gna11, putative	0.001	0.0028	0.0263
Echinococcus multilocularis	segment polarity protein dishevelled	0.0009	0.0015	0.0002
Loa Loa (eye worm)	MH2 domain-containing protein	0.0018	0.0124	0.0157
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0051	0.0508	0.0701
Loa Loa (eye worm)	glutathione reductase	0.0098	0.1074	0.1502
Brugia malayi	MH1 domain containing protein	0.0023	0.0175	0.023
Mycobacterium leprae	Probable NADPH:adrenodoxin oxidoreductase FprA (NADPH-FERREDOXIN REDUCTASE)	0.0009	0.0013	0.0044
Trichomonas vaginalis	importin beta-1, putative	0.0025	0.0201	0.3248
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0241	0.2763	0.2754
Brugia malayi	nuclear receptor NHR-88	0.001	0.0028	0.0022
Mycobacterium leprae	PROBABLE THIOESTERASE TESA	0.0021	0.0157	0.0547
Echinococcus multilocularis	mothers against decapentaplegic 5	0.0041	0.0394	0.0382
Loa Loa (eye worm)	hypothetical protein	0.001	0.0028	0.0022
Entamoeba histolytica	hypothetical protein	0.0025	0.0201	0.3248
Trichomonas vaginalis	GTP-binding protein (O) alpha subunit, gnao, putative	0.001	0.0028	0.0263
Mycobacterium tuberculosis	Phenolpthiocerol synthesis type-I polyketide synthase PpsA	0.0025	0.0207	0.0723
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.0225	0.2571	0.8963
Schistosoma mansoni	smad	0.0018	0.0124	0.0111
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.001	0.0028	0.0015
Loa Loa (eye worm)	hypothetical protein	0.0031	0.027	0.0365
Loa Loa (eye worm)	acyl carrier protein	0.0012	0.0044	0.0045
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.001	0.0028	0.0022
Loa Loa (eye worm)	CMGC/GSK protein kinase	0.0058	0.0594	0.0822
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.001	0.0028	0.0022
Mycobacterium ulcerans	thioredoxin reductase TrxB2	0.0009	0.0013	0.0351
Mycobacterium ulcerans	dihydrolipoamide dehydrogenase, LpdB	0.0034	0.031	0.8685
Trypanosoma cruzi	dihydrolipoyl dehydrogenase, putative	0.0034	0.031	0.2803
Trypanosoma brucei	dihydrolipoamide dehydrogenase	0.0034	0.031	0.2803
Loa Loa (eye worm)	hypothetical protein	0.011	0.1208	0.1692
Leishmania major	importin beta-1 subunit, putative	0.0025	0.0201	0.1779
Loa Loa (eye worm)	hypothetical protein	0.0252	0.2895	0.4079
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0241	0.2763	0.2754
Loa Loa (eye worm)	MH2 domain-containing protein	0.0605	0.708	1
Mycobacterium ulcerans	Type I modular polyketide synthase	0.0025	0.0207	0.581
Schistosoma mansoni	GTP-binding protein alpha subunit gna	0.001	0.0028	0.0015
Loa Loa (eye worm)	hypothetical protein	0.001	0.0028	0.0022
Toxoplasma gondii	hypothetical protein	0.0009	0.0015	0.0023
Brugia malayi	MH1 domain containing protein	0.0023	0.0175	0.023
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.001	0.0028	0.0015
Plasmodium falciparum	thioredoxin reductase	0.0098	0.1074	1
Echinococcus granulosus	segment polarity protein dishevelled	0.0009	0.0015	0.0002
Echinococcus granulosus	expressed protein	0.001	0.0028	0.0015
Brugia malayi	MH2 domain containing protein	0.0041	0.0394	0.054
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.001	0.0028	0.0022
Brugia malayi	mothers against decapentaplegic homolog 3	0.0018	0.0124	0.0157
Plasmodium falciparum	dihydrolipoyl dehydrogenase, apicoplast	0.0034	0.031	0.2803
Entamoeba histolytica	protein kinase domain containing protein	0.0058	0.0594	1
Mycobacterium tuberculosis	Probable NADPH dependent 2,4-dienoyl-CoA reductase FadH (2,4-dienoyl coenzyme A reductase) (4-enoyl-CoA reductase)	0.0009	0.0013	0.0044
Schistosoma mansoni	hypothetical protein	0.011	0.1208	0.1197
Echinococcus multilocularis	thyroid hormone receptor alpha	0.001	0.0028	0.0015
Trypanosoma brucei	importin beta-1 subunit, putative	0.0031	0.027	0.243
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.001	0.0028	0.0015
Mycobacterium tuberculosis	Probable oxidoreductase	0.025	0.2868	1
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0015	0.0003
Mycobacterium ulcerans	glutamate synthase subunit beta	0.0009	0.0013	0.0351
Brugia malayi	MH2 domain containing protein	0.0605	0.708	1
Trichomonas vaginalis	ran, putative	0.0023	0.0174	0.2777
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0051	0.0508	0.0496
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.001	0.0028	0.0015
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.001	0.0028	0.0022
Mycobacterium ulcerans	thioesterase TesA	0.0021	0.0157	0.4398
Schistosoma mansoni	hypothetical protein	0.0051	0.0508	0.0496
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0074	0.0088
Onchocerca volvulus		0.001	0.0028	0.0072
Onchocerca volvulus	Fatty acid synthase homolog	0.0046	0.045	0.2059
Onchocerca volvulus		0.0058	0.0594	0.2734
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.001	0.0028	0.0015
Brugia malayi	Thioredoxin reductase	0.0098	0.1074	0.1502
Mycobacterium ulcerans	phenolpthiocerol synthesis type-I polyketide synthase PpsE	0.0017	0.0105	0.2941
Echinococcus multilocularis	regulator of G protein signaling 7	0.0009	0.0015	0.0002
Schistosoma mansoni	GTP-binding protein (I) alpha-2 subunit gnai2	0.001	0.0028	0.0015
Trichomonas vaginalis	GTP-binding protein alpha subunit, gna, putative	0.001	0.0028	0.0263
Mycobacterium tuberculosis	Probable dehydrogenase	0.0225	0.2571	0.8963
Mycobacterium ulcerans	polyketide synthase Pks13	0.0038	0.0357	1
Brugia malayi	ecdysteroid receptor	0.001	0.0028	0.0022
Brugia malayi	hypothetical protein	0.0009	0.0015	0.0003
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.001	0.0028	0.0015
Schistosoma mansoni	retinoic acid receptor RXR	0.001	0.0028	0.0015
Plasmodium falciparum	glutathione reductase	0.0098	0.1074	1
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.001	0.0028	0.0015
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.0034	0.031	1
Schistosoma mansoni	GTP-binding protein (I) alpha-1subunit gnai1	0.001	0.0028	0.0015
Mycobacterium leprae	PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE	0.0017	0.0105	0.0366
Plasmodium vivax	glycogen synthase kinase 3, putative	0.0058	0.0594	0.5476
Schistosoma mansoni	GTP-binding protein alpha subunit	0.001	0.0028	0.0015
Trypanosoma brucei	importin beta-1 subunit, putative	0.0031	0.027	0.243
Mycobacterium tuberculosis	Probable polyketide synthase Pks7	0.0027	0.0226	0.0789
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.001	0.0028	0.0015
Leishmania major	2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein	0.0034	0.031	0.2803
Echinococcus multilocularis	protein kinase shaggy	0.0058	0.0594	0.0582
Schistosoma mansoni	z-protein (S1r protein)	0.0009	0.0015	0.0002
Leishmania major	dihydrolipoamide dehydrogenase, putative	0.0034	0.031	0.2803
Echinococcus granulosus	mothers against decapentaplegic 5	0.0041	0.0394	0.0382
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0051	0.0508	0.0496
Brugia malayi	steroid hormone receptor	0.001	0.0028	0.0022
Echinococcus granulosus	mothers against decapentaplegic 2	0.0018	0.0124	0.0111
Mycobacterium tuberculosis	Probable polyketide synthase Pks5	0.0025	0.0198	0.0691
Mycobacterium ulcerans	hypothetical protein	0.0009	0.0013	0.0351
Brugia malayi	latrophilin 2 splice variant baaae	0.011	0.1208	0.1692
Mycobacterium ulcerans	dihydrolipoamide dehydrogenase	0.0034	0.031	0.8685
Loa Loa (eye worm)	MH1 domain-containing protein	0.0018	0.0124	0.0157
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.001	0.0028	0.0022
Loa Loa (eye worm)	guanine nucleotide-binding protein alpha-12 subunit	0.001	0.0028	0.0022
Brugia malayi	oxidoreductase, zinc-binding dehydrogenase family protein	0.0048	0.0478	0.0659
Plasmodium vivax	GTP-binding nuclear protein RAN/TC4, putative	0.0023	0.0174	0.1521
Mycobacterium ulcerans	NADPH:adrenodoxin oxidoreductase FprA	0.0009	0.0013	0.0351
Brugia malayi	N-terminal motif family protein	0.0188	0.2138	0.3007
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.001	0.0028	0.0022
Mycobacterium leprae	PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD	0.0025	0.0207	0.0723
Trypanosoma cruzi	trypanothione reductase, putative	0.0034	0.031	0.2803
Echinococcus granulosus	thioredoxin glutathione reductase	0.0098	0.1074	0.1063
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.001	0.0028	0.0015
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0034	0.031	0.2803
Onchocerca volvulus		0.001	0.0028	0.0072
Plasmodium vivax	thioredoxin reductase, putative	0.0098	0.1074	1
Mycobacterium leprae	Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate	0.0009	0.0013	0.0044
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.0329	0.3805	0.5367
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0241	0.2763	0.2754
Echinococcus granulosus	FTZ F1 alpha	0.001	0.0028	0.0015
Loa Loa (eye worm)	AMP-binding enzyme family protein	0.0024	0.0188	0.0248
Echinococcus granulosus	importin subunit beta 1	0.0031	0.027	0.0258
Echinococcus granulosus	guanine nucleotide binding protein subunit	0.001	0.0028	0.0015
Echinococcus multilocularis	guanine nucleotide binding protein (G protein)	0.001	0.0028	0.0015
Mycobacterium ulcerans	NADH dehydrogenase	0.0009	0.0013	0.0351
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0508	0.0701
Brugia malayi	DIX domain containing protein	0.0009	0.0015	0.0003
Plasmodium falciparum	dihydrolipoyl dehydrogenase, mitochondrial	0.0034	0.031	0.2803
Loa Loa (eye worm)	guanine nucleotide-binding protein alpha-6 subunit	0.001	0.0028	0.0022
Trichomonas vaginalis	GTP-binding protein alpha subunit, gna, putative	0.001	0.0028	0.0263
Onchocerca volvulus	Mothers against decapentaplegic homolog	0.0018	0.0124	0.0522
Schistosoma mansoni	smad1 5 8 and	0.0041	0.0394	0.0382
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.025	0.2868	1
Toxoplasma gondii	type I fatty acid synthase, putative	0.0027	0.0226	0.2013
Plasmodium falciparum	glutathione reductase	0.0034	0.031	0.2803
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.0098	0.1074	0.3743
Plasmodium falciparum	GTP-binding nuclear protein RAN/TC4	0.0023	0.0174	0.1521
Trichomonas vaginalis	GTP-binding protein alpha subunit, gna, putative	0.001	0.0028	0.0263
Loa Loa (eye worm)	thioredoxin reductase	0.0098	0.1074	0.1502
Schistosoma mansoni	TGF-beta signal transducer Smad2	0.0041	0.0394	0.0382
Schistosoma mansoni	steroid hormone receptor ad4bp	0.001	0.0028	0.0015
Mycobacterium tuberculosis	Probable polyketide synthase Pks9	0.0014	0.0077	0.0268
Brugia malayi	AMP-binding enzyme family protein	0.0024	0.0188	0.0248
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.001	0.0028	0.0022
Echinococcus multilocularis	importin subunit beta 1	0.0031	0.027	0.0258
Brugia malayi	GTP-binding regulatory protein alpha chain - starfish, putative	0.001	0.0028	0.0022
Mycobacterium leprae	PROBABLE NADH DEHYDROGENASE NDH	0.0225	0.2571	0.8963
Onchocerca volvulus	Bile acid receptor homolog	0.001	0.0028	0.0072
Echinococcus granulosus	glycogen synthase kinase 3 beta	0.0058	0.0594	0.0582
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.001	0.0028	0.0015
Mycobacterium tuberculosis	Phenyloxazoline synthase MbtB (phenyloxazoline synthetase)	0.0024	0.0188	0.0654
Schistosoma mansoni	regulator of G protein signaling	0.0009	0.0015	0.0002
Mycobacterium leprae	Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas	0.0027	0.0226	0.0789
Echinococcus multilocularis	snurportin 1	0.0329	0.3805	0.3798
Echinococcus granulosus	protein kinase shaggy	0.0058	0.0594	0.0582
Schistosoma mansoni	hypothetical protein	0.0051	0.0508	0.0496
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0124	0.0157
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.001	0.0028	0.0022
Echinococcus multilocularis	Pleckstrin G protein, interacting region	0.0009	0.0015	0.0002
Trypanosoma brucei	dihydrolipoamide dehydrogenase, point mutation	0.0034	0.031	0.2803
Brugia malayi	Smad1	0.0041	0.0394	0.054
Toxoplasma gondii	HEAT repeat-containing protein	0.0031	0.027	0.243
Onchocerca volvulus	Rap guanine nucleotide exchange factor 1 homolog	0.0188	0.2138	1
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.001	0.0028	0.0015
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.001	0.0028	0.0022
Leishmania major	GTP-binding protein, putative	0.0023	0.0174	0.1521
Mycobacterium tuberculosis	Probable multifunctional mycocerosic acid synthase membrane-associated Mas	0.0027	0.0226	0.0789
Toxoplasma gondii	beta-ketoacyl synthase, N-terminal domain-containing protein	0.0017	0.0101	0.0835
Mycobacterium tuberculosis	Probable reductase	0.0225	0.2571	0.8963
Schistosoma mansoni	thyroid hormone receptor	0.001	0.0028	0.0015
Mycobacterium tuberculosis	Polyketide synthase Pks12	0.0027	0.0226	0.0789
Plasmodium vivax	dihydrolipoyl dehydrogenase, apicoplast, putative	0.0034	0.031	0.2803
Loa Loa (eye worm)	hypothetical protein	0.001	0.0028	0.0022
Giardia lamblia	Kinase, CMGC GSK	0.0058	0.0594	1
Loa Loa (eye worm)	hypothetical protein	0.001	0.0028	0.0022
Schistosoma mansoni	glycogen synthase kinase 3-related (gsk3) (cmgc group III)	0.0058	0.0594	0.0582
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.001	0.0028	0.0015
Echinococcus granulosus	smad	0.0041	0.0394	0.0382
Schistosoma mansoni	Smad4	0.0018	0.0124	0.0111
Mycobacterium ulcerans	dehydrogenase	0.0009	0.0013	0.0351
Mycobacterium ulcerans	ferredoxin reductase	0.0009	0.0013	0.0351
Mycobacterium ulcerans	monoxygenase	0.0009	0.0013	0.0351
Echinococcus multilocularis	guanine nucleotide binding protein (G protein)	0.001	0.0028	0.0015
Brugia malayi	Importin beta-1 subunit	0.0031	0.027	0.0365
Echinococcus granulosus	GTP binding nuclear protein Ran	0.0023	0.0174	0.0162
Mycobacterium tuberculosis	Probable polyketide synthase Pks8	0.0021	0.0152	0.0531
Brugia malayi	guanine nucleotide-binding protein G-o protein alpha subunit	0.001	0.0028	0.0022
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.001	0.0028	0.0015
Loa Loa (eye worm)	MH2 domain-containing protein	0.0041	0.0394	0.054
Echinococcus granulosus	TGF beta signal transducer SmadC	0.0041	0.0394	0.0382
Mycobacterium leprae	PROBABLE NADPH:ADRENODOXIN OXIDOREDUCTASE FPRB (ADRENODOXIN REDUCTASE) (AR) (FERREDOXIN-NADP(+) REDUCTASE)	0.0009	0.0013	0.0044
Trypanosoma brucei	dihydrolipoamide dehydrogenase	0.0034	0.031	0.2803
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.0225	0.2571	0.8963
Loa Loa (eye worm)	GTP-binding regulatory protein alpha chain	0.001	0.0028	0.0022
Echinococcus granulosus	ecdysone induced protein 78C	0.001	0.0028	0.0015
Brugia malayi	regulator of G-protein signaling egl-10	0.0009	0.0015	0.0003
Loa Loa (eye worm)	G protein signaling regulator EGL-10	0.0009	0.0015	0.0003
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0025	0.0201	0.3248
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0241	0.2763	0.2754
Schistosoma mansoni	hypothetical protein	0.0851	1	1
Brugia malayi	MH1 domain containing protein	0.0041	0.0394	0.054
Brugia malayi	alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase	0.0025	0.0203	0.0269
Mycobacterium tuberculosis	Probable polyketide synthase Pks1	0.0018	0.0122	0.0426
Brugia malayi	G-protein alpha subunit	0.001	0.0028	0.0022
Echinococcus granulosus	mothers against decapentaplegic 6	0.0018	0.0124	0.0111
Loa Loa (eye worm)	hypothetical protein	0.001	0.0028	0.0022
Brugia malayi	Domain found in Dishevelled, Egl-10, and Pleckstrin family protein	0.0009	0.0015	0.0003
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0241	0.2763	0.2754
Brugia malayi	guanine nucleotide-binding protein alpha-7 subunit, putative	0.001	0.0028	0.0022
Echinococcus multilocularis	mothers against decapentaplegic 2	0.0018	0.0124	0.0111
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0025	0.0201	0.3248
Schistosoma mansoni	GTP-binding protein (I) alpha-2 subunit gnai2	0.001	0.0028	0.0015
Echinococcus multilocularis	Smad4	0.0041	0.0394	0.0382
Onchocerca volvulus		0.001	0.0028	0.0072
Toxoplasma gondii	NADPH-glutathione reductase	0.0034	0.031	0.2803
Plasmodium falciparum	thioredoxin reductase	0.0034	0.031	0.2803
Brugia malayi	MH2 domain containing protein	0.0018	0.0124	0.0157
Loa Loa (eye worm)	hypothetical protein	0.001	0.0028	0.0022
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.001	0.0028	0.0022
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.025	0.2868	1
Mycobacterium tuberculosis	Possible dehydrogenase/reductase	0.0009	0.0013	0.0044
Schistosoma mansoni	GTP-binding protein (q) alpha-11 subunit gna11	0.001	0.0028	0.0015
Mycobacterium ulcerans	Type I modular polyketide synthase	0.0025	0.0207	0.581
Trichomonas vaginalis	glutathione reductase, putative	0.0034	0.031	0.5119
Mycobacterium tuberculosis	Phenolpthiocerol synthesis type-I polyketide synthase PpsC	0.0025	0.0207	0.0723
Loa Loa (eye worm)	transcription factor SMAD2	0.0605	0.708	1
Plasmodium falciparum	glycogen synthase kinase 3	0.0058	0.0594	0.5476
Giardia lamblia	GTP-binding nuclear protein RAN/TC4	0.0023	0.0174	0.2777
Mycobacterium leprae	PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA	0.0025	0.0207	0.0723
Leishmania major	trypanothione reductase	0.0098	0.1074	1
Echinococcus granulosus	segment polarity protein dishevelled	0.0009	0.0015	0.0002
Trypanosoma brucei	dihydrolipoyl dehydrogenase	0.0034	0.031	0.2803
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0241	0.2763	0.3892
Brugia malayi	GTP-binding nuclear protein RAN/TC4	0.0023	0.0174	0.0228
Onchocerca volvulus	Segment polarity protein dishevelled homolog	0.0009	0.0015	0.0011
Echinococcus multilocularis	glycogen synthase kinase 3 beta	0.0058	0.0594	0.0582
Mycobacterium ulcerans	Type I modular polyketide synthase	0.0025	0.0207	0.581
Trypanosoma cruzi	dihydrolipoyl dehydrogenase, putative	0.0034	0.031	0.2803
Brugia malayi	photoreceptor-specific nuclear receptor	0.0252	0.2895	0.4079
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.0225	0.2571	0.8963
Toxoplasma gondii	AMP-binding enzyme domain-containing protein	0.0013	0.0058	0.0427
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0034	0.031	0.2803
Leishmania major	dihydrolipoamide dehydrogenase, putative	0.0034	0.031	0.2803
Mycobacterium ulcerans	NADH dehydrogenase Ndh1	0.0009	0.0013	0.0351
Brugia malayi	Latrophilin receptor protein 2	0.0051	0.0508	0.0701
Brugia malayi	MH2 domain containing protein	0.0041	0.0394	0.054
Onchocerca volvulus		0.0044	0.0431	0.197
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.001	0.0028	0.0022
Echinococcus multilocularis	regulator of G protein signaling 7	0.0009	0.0015	0.0002
Mycobacterium leprae	THIOREDOXIN TRXC (TRX) (MPT46)	0.0009	0.0013	0.0044
Echinococcus multilocularis	ecdysone induced protein 78C	0.001	0.0028	0.0015
Toxoplasma gondii	pyruvate dehydrogenase complex subunit PDH-E3II	0.0034	0.031	0.2803
Echinococcus multilocularis	FTZ F1 alpha	0.001	0.0028	0.0015
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0051	0.0508	0.0496
Loa Loa (eye worm)	hypothetical protein	0.001	0.0028	0.0022
Toxoplasma gondii	cell-cycle-associated protein kinase GSK, putative	0.0058	0.0594	0.5476
Echinococcus multilocularis	GPCR, family 2	0.0051	0.0508	0.0496
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.001	0.0028	0.0072
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.0225	0.2571	0.8963
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.001	0.0028	0.0015
Mycobacterium leprae	Polyketide synthase Pks13	0.0038	0.0357	0.1244
Echinococcus granulosus	dihydrolipoamide dehydrogenase	0.0034	0.031	0.0298
Loa Loa (eye worm)	hypothetical protein	0.0188	0.2138	0.3007
Trichomonas vaginalis	mercuric reductase, putative	0.0034	0.031	0.5119
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0161	0.1811	0.2545
Mycobacterium ulcerans	thioesterase	0.0021	0.0157	0.4398
Mycobacterium ulcerans	NADPH:adrenodoxin oxidoreductase FprB	0.0009	0.0013	0.0351
Loa Loa (eye worm)	Smad1	0.0041	0.0394	0.054
Loa Loa (eye worm)	GTP-binding nuclear protein RAN/TC4	0.0023	0.0174	0.0228
Trichomonas vaginalis	CMGC family protein kinase	0.0058	0.0594	1
Brugia malayi	Guanine nucleotide-binding protein alpha-3 subunit, putative	0.001	0.0028	0.0022
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.001	0.0028	0.0022
Echinococcus multilocularis	gtp binding protein (I) alpha 1subunit	0.001	0.0028	0.0015
Mycobacterium tuberculosis	Polyketide synthetase MbtC (polyketide synthase)	0.0009	0.0009	0.0031
Schistosoma mansoni	dishevelled	0.0009	0.0015	0.0002
Schistosoma mansoni	hypothetical protein	0.0051	0.0508	0.0496
Schistosoma mansoni	importin beta-1	0.0031	0.027	0.0258
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.001	0.0028	0.0022
Giardia lamblia	Kinase, CMGC GSK	0.0058	0.0594	1
Mycobacterium ulcerans	multifunctional mycocerosic acid synthase membrane-associated Mas	0.0027	0.0226	0.6337
Plasmodium vivax	importin-beta 2, putative	0.0031	0.027	0.243
Chlamydia trachomatis	dihydrolipoyl dehydrogenase	0.0034	0.031	1
Echinococcus multilocularis	geminin	0.0851	1	1
Schistosoma mansoni	GTP-binding protein (q) alpha-11 subunit gna11	0.001	0.0028	0.0015
Trypanosoma cruzi	importin beta-1 subunit, putative	0.0025	0.0201	0.1779
Mycobacterium ulcerans	phenolpthiocerol synthesis type-I polyketide synthase PpsC	0.0027	0.0226	0.6337
Mycobacterium tuberculosis	Probable polyketide synthase Pks15	0.001	0.0027	0.0095
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.0034	0.031	1
Mycobacterium leprae	Probable polyketide synthase Pks1	0.0027	0.0226	0.0789
Onchocerca volvulus		0.0009	0.0015	0.0011

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 1.2 nM	Inhibition of human GSK3-beta by scintillation counting	ChEMBL.	19338355

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL490842

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 994966