Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | leukotriene A 4 hydrolase | 0.293397 | 1 | 1 |
Mycobacterium ulcerans | aminopeptidase N PepN | 0.0158702 | 0 | 0.5 |
Leishmania major | aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 | 0.0158702 | 0 | 0.5 |
Trypanosoma cruzi | metallo-peptidase, Clan MA(E) Family M1 | 0.0158702 | 0 | 0.5 |
Plasmodium falciparum | M1-family alanyl aminopeptidase, putative | 0.0158702 | 0 | 0.5 |
Trypanosoma cruzi | puromycin-sensitive aminopeptidase-like protein, putative | 0.0158702 | 0 | 0.5 |
Plasmodium falciparum | M1-family alanyl aminopeptidase | 0.0158702 | 0 | 0.5 |
Trypanosoma brucei | Aminopeptidase M1, putative | 0.0158702 | 0 | 0.5 |
Toxoplasma gondii | aminopeptidase N protein | 0.0158702 | 0 | 0.5 |
Leishmania major | puromycin-sensitive aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 | 0.0158702 | 0 | 0.5 |
Onchocerca volvulus | 0.0158702 | 0 | 0.5 | |
Trypanosoma brucei | Aminopeptidase M1, putative | 0.0158702 | 0 | 0.5 |
Trypanosoma brucei | metallo-peptidase, Clan MA(E) Family M1 | 0.0158702 | 0 | 0.5 |
Trichomonas vaginalis | Clan MA, family M1, aminopeptidase N-like metallopeptidase | 0.0158702 | 0 | 0.5 |
Trypanosoma brucei | aminopeptidase, putative | 0.0158702 | 0 | 0.5 |
Trypanosoma cruzi | Aminopeptidase M1, putative | 0.0158702 | 0 | 0.5 |
Trypanosoma cruzi | aminopeptidase, putative | 0.0158702 | 0 | 0.5 |
Trypanosoma cruzi | aminopeptidase, putative | 0.0158702 | 0 | 0.5 |
Toxoplasma gondii | aminopeptidase N, putative | 0.0158702 | 0 | 0.5 |
Plasmodium vivax | M1-family alanyl aminopeptidase, putative | 0.0158702 | 0 | 0.5 |
Toxoplasma gondii | aminopeptidase n, putative | 0.0158702 | 0 | 0.5 |
Plasmodium vivax | M1-family alanyl aminopeptidase, putative | 0.0158702 | 0 | 0.5 |
Loa Loa (eye worm) | leukotriene A4 hydrolase | 0.293397 | 1 | 1 |
Schistosoma mansoni | leukotriene A4 hydrolase (M01 family) | 0.293397 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.137339 | 0.437681 | 1 |
Trypanosoma cruzi | metallo-peptidase, clan MA(E), family M1, putative | 0.0158702 | 0 | 0.5 |
Onchocerca volvulus | 0.0158702 | 0 | 0.5 | |
Leishmania major | aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 | 0.0158702 | 0 | 0.5 |
Echinococcus multilocularis | leukotriene A 4 hydrolase | 0.293397 | 1 | 1 |
Entamoeba histolytica | aminopeptidase, putative | 0.0158702 | 0 | 0.5 |
Trypanosoma cruzi | puromycin-sensitive aminopeptidase-like protein, putative | 0.0158702 | 0 | 0.5 |
Trichomonas vaginalis | Clan MA, family M1, aminopeptidase N-like metallopeptidase | 0.0158702 | 0 | 0.5 |
Trypanosoma cruzi | metallo-peptidase, clan MA(E), family M1, putative | 0.0158702 | 0 | 0.5 |
Onchocerca volvulus | 0.0158702 | 0 | 0.5 | |
Leishmania major | aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 | 0.0158702 | 0 | 0.5 |
Mycobacterium ulcerans | aminopeptidase N PepN | 0.0158702 | 0 | 0.5 |
Trichomonas vaginalis | Clan MA, family M1, aminopeptidase N-like metallopeptidase | 0.0158702 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 6.39 uM | Antimalarial activity against Plasmodium falciparum W2 assessed as plasmodial LDH activity after 72 hrs | ChEMBL. | 21530018 |
IC50 (functional) | = 7.67 uM | Antimalarial activity against Plasmodium falciparum D6 assessed as plasmodial LDH activity after 72 hrs | ChEMBL. | 21530018 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 | 21530018 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.